TOYOSHIMA Takeshi 豊嶋健史

Researcher Number	20546569
Affiliation (based on the past Project Information) *help	2016: 九州大学, 歯学研究院, 共同研究員 2015 – 2016: 九州大学, 歯学研究科(研究院), 研究員 2013 – 2014: 九州大学, 歯学研究科(研究院), 助教 2011 – 2012: 九州大学, 大学病院, 助教 2010: Kyushu University, 大学院・歯学研究院, 助教 2010: 九州大学, 顎口腔外科, 助教 2009: Kyushu University, 大学病院, 助教
Review Section/Research Field	Principal Investigator Surgical dentistry Except Principal Investigator Surgical dentistry
Keywords	Principal Investigator 口腔扁平上皮癌 / 原発巣 / 分化度 / サイトケラチン / バイオマーカー / 分泌型RCAS1 / 膜型RCAS1 / アポトーシス / 分泌型 / 膜型 … More / RCAS1 / 白板症 / 血中 / 扁平上皮癌 / 末梢血 / 分化 / real-time PCR法 / 免疫組織化学的染色 / Gli2 / Δp63 … More Except Principal Investigator 口腔癌 / 口腔扁平上皮癌 / 上皮-間葉転換 / miR205 / ΔNp63 / ZEBファミリー / deltaNp63 / ZEB2 / ZEB1 / 上皮間葉転換 / 転移 / 浸潤 / 血行障害 / 遊離組織移植 / 微小血管吻合 / 虚血再灌流障害 / アポトーシス / T細胞 / オーダーメイドワクチン / 癌ペプチド / 腫瘍随伴性マクロファージ / 免疫チェックポイント分子 / 腫瘍免疫 / 腫瘍会合性マクロファージ / PD-L1 / RCAS1 / オーダーメイド免疫療法 Less

A study on the mechanism of invasion and metastasis thorough epithelial-mesenchymal transition in oral squamous cel carcinoma
- Principal Investigator
  
  Kawano Shintaro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kyushu University
Clinical application for biomarker RCAS1 in oral squamous cell carcinomaPrincipal Investigator
- Principal Investigator
  
  Toyoshima Takeshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kyushu University
Development of early diagnostic method and order-made immunotherapy for oral cancer by using anti-tumor T cells
- Principal Investigator
  
  Nakamura Seiji
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kyushu University
Prevention of ischemia-reperfusion injury in the free flap transplantation
- Principal Investigator
  
  SASAGURI Masaaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kyushu Dental College
  Kyushu University
Would Cytokeratin be a new prognostic marker of oral squamous cell carcinoma?Principal Investigator
- Principal Investigator
  
  TOYOSHIMA Takeshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kyushu University
Correlation between the expression patterns of cytokeratins/cell differentiations and the clinico-patholigical findings in oral squamous cell carcinomaPrincipal Investigator
- Principal Investigator
  
  TOYOSHIMA Takeshi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Surgical dentistry
- Research Institution
  Kyushu University

All 2016 2015 2014 2013 2012 2010 Other

All Journal Article Presentation

[Journal Article] Clinicopathological evaluation of pre-operative chemoradiotherapy with S-1 as a treatment for locally advanced oral squamous cell carcinoma2016
- Author(s)
  Kawano S, Zheng Y, Oobu K, Matsubara R, Goto Y, Chikui T, Yoshitake T, Kiyoshima T, Jinno T, Maruse Y, Mitate E, Kitamura R, Tanaka H, Toyoshima T, Sugiura T, Nakamura S
- Journal Title
  
  Oncology letters
  
  Volume: 11 Pages: 3369-3376
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26463014
[Journal Article] Increased expression of interleukin-6 predicts poor response to chemoradiotherapy and unfavorable prognosis in oral squamous cell carcinoma.2015
- Author(s)
  Jinno T, Kawano S, Maruse Y, Matsubara R, Goto Y, Sakamoto T, Hashiguchi Y, Kaneko N, Tanaka H, Kitamura R, Toyoshima T, Jinno A, Moriyama M, Oobu K, Kiyoshima T, Nakamura S.
- Journal Title
  
  Oncol Rep
  
  Volume: 33 Issue: 5 Pages: 2161-2168
- DOI
  10.3892/or.2015.3838
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24249091, KAKENHI-PROJECT-25870492, KAKENHI-PROJECT-26462788, KAKENHI-PROJECT-26463014, KAKENHI-PROJECT-25861955, KAKENHI-PROJECT-25463124
[Journal Article] Possible involvement of ΔNp63 downregulation in the invasion and metastasis of oral squamous cell carcinoma via induction of a mesenchymal phenotype2014
- Author(s)
  Yuichi Goto, Shintaro Kawano, Ryota Matsubara, Takahiro Kiyosue, Mitsuhiro Hirano, Teppei Jinno, Yasuyuki Maruse, Toyoshima Takeshi, Ryoji Kitamura, Hideaki Tanaka, Kazunari Oobu, Seiji Nakamura
- Journal Title
  
  Clinical & Experimental Metastasis
  
  Volume: 214 Issue: 3 Pages: 289-306
- DOI
  10.1007/s10585-013-9628-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23792358, KAKENHI-PROJECT-24249091, KAKENHI-PROJECT-25870492
[Journal Article] Apoptotic function of tumor-associated antigen RCAS1 in oral squamous cell carcinoma2014
- Author(s)
  Hideaki Tanaka, Takeshi Toyoshima, Kenzo Sonoda, Ryoji Kitamura, Masaaki Sasaguri, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Seiji Nakamura
- Journal Title
  
  Journal of Translational Medicine
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249091
[Journal Article] Apoptotic function of tumor-associated antigen2014
- Author(s)
  Hideaki Tanaka, Takeshi Toyoshima, Kenzo Sonoda, Ryoji Kitamura, Masaaki Sasaguri, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Seiji Nakamura
- Journal Title
  
  RCAS1 in oral squamous cell carcinoma Journal of Translational Medicine
  
  Volume: (in print)
- Data Source
  KAKENHI-PROJECT-23792356
[Journal Article] Association of cytokeratin 17 expression with differentiation in oral squamous cell carcinoma.2012
- Author(s)
  Kitamura R, Toyoshima T, et al.
- Journal Title
  
  J Cancer Res Clin Oncol.
  
  Volume: 1 Pages: 110-120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23792356
[Journal Article] In vitro induction of specific CD8(+) T lymphocytes by tumor-associated antigenic peptides in patients with oral squamous cell carcinoma.2012
- Author(s)
  Toyoshima T, et al.
- Journal Title
  
  Cancer Lett.
  
  Volume: 1 Pages: 50-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23792356
[Journal Article] Association of cytokeratin 17 expression with differentiation in oral squamous cell carcinoma.2012
- Author(s)
  Kitamura R, Toyoshima T, Tanaka H, Kawano S, Kiyosue T, Matsubara R, Goto Y, Hirano M, Oobu K, Nakamura S.
- Journal Title
  
  J Cancer Res Clin Oncol.
  
  Volume: 138 Issue: 8 Pages: 1299-1310
- DOI
  10.1007/s00432-012-1202-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23792356
[Journal Article] In vitro induction of specific CD8(+) T lymphocytes by tumorassociated antigenic peptides in patients with oral squamous cell carcinoma2012
- Author(s)
  Toyoshima, T., Kumamaru, W., Hayashida, J.-N., Moriyama, M., Kitamura, R., Tanaka, H., Yamada, A., Itoh, K., and Nakamura, S.
- Journal Title
  
  Cancer Lett
  
  Volume: 322 Issue: 1 Pages: 86-91
- DOI
  10.1016/j.canlet.2012.02.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390518, KAKENHI-PROJECT-23501292, KAKENHI-PROJECT-24249091
[Journal Article] Association of cytokeratin 17 expression with differentiation in oral squamous cell carcinoma2012
- Author(s)
  Ryoji Kitamura, Takeshi Toyoshima, Hideaki Tanaka, Shintaro Kawano, Takahiro Kiyosue, Ryota Matsubara, Yuichi Goto, Kazunari Oobu, Seiji Nakamura
- Journal Title
  
  Journal of Cancer Research and Clinical Oncology
  
  Volume: 138(8) Pages: 1299-1310
- Data Source
  KAKENHI-PROJECT-23792356
[Presentation] 口腔扁平上皮癌由来細胞株における腫瘍関連抗原RCAS1(receptor-binding caner antigen expressed on SiSo cells)の発現と機能についての検討2013
- Author(s)
  1. 田中秀明，豊嶋健史，園田顕三，北村亮二，川野真太郎，平野充広，神野哲平，中村誠司
- Organizer
  第 31 回日本口腔腫瘍学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23792356
[Presentation] 口腔扁平上皮癌におけるサイトケラチン17の免疫組織化学的検討2010
- Author(s)
  北村亮二・豊嶋健史・川野真太郎・大部一成・清末崇裕・松原良太・後藤雄一・中村誠司
- Organizer
  第29回日本口腔腫瘍学会
- Year and Date
  2010-01-27
- Data Source
  KAKENHI-PROJECT-21890186
[Presentation] 口腔扁平上皮癌におけるサイトケラチン17の発現についての検討2010
- Author(s)
  北村亮二・豊嶋健史・川野真太郎・清末崇裕・松原良太・後藤雄一・中村誠司
- Organizer
  第55回日本口腔外科学会総会・学術大会
- Year and Date
  2010-10-16
- Data Source
  KAKENHI-PROJECT-21890186
[Presentation] Immunohistochemical analysis of cytokeratin 17 in oral squamous cell carcinoma2010
- Author(s)
  R KITAMURA, T TOYOSHIMA, S KAWANO, T KIYOSUE, R MATSUBARA, Y GOTO, K OOBU, S NAKAMURA
- Organizer
  10th Congress of the European Association of Oral Medicine incorporating the World Workshop on Oral Medicine
- Year and Date
  2010-09-21
- Data Source
  KAKENHI-PROJECT-21890186
[Presentation] Immunohistochemical analysis of cytokeratin 17 in oral squamous cell carcinoma2010
- Author(s)
  R KITAMURA, T TOYOSHIMA, S KAWANO, T KIYOSUE, R MATSUBARA, Y GOTO, K OOBU, S NAKAMURA
- Year and Date
  2010-09-21
- Data Source
  KAKENHI-PROJECT-21890186
[Presentation] 口腔扁平上皮癌由来細胞株における腫瘍関連抗原RCAS1の発現と機能についての検討
- Author(s)
  田中秀明，豊嶋健史，園田顕三，北村亮二，川野真太郎，平野充広，神野哲平，丸瀬靖之，笹栗正明，大部一成，中村誠司
- Organizer
  第58回日本口腔外科学会総会•学術大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24249091
[Presentation] 口腔扁平上皮癌由来細胞株における腫瘍関連抗原RCAS1の発現、分泌と機能についての検討
- Author(s)
  田中秀明，豊嶋健史，園田顕三，北村亮二，川野真太郎，平野充広，神野哲平，丸瀬靖之，笹栗正明，大部一成，中村誠司
- Organizer
  第67回日本口腔科学会学術集会
- Place of Presentation
  栃木
- Data Source
  KAKENHI-PROJECT-24249091

1. Nakamura Seiji (60189040)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. SASAGURI Masaaki (00225898)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. MITSUYASU Takeshi (00380519)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Kawano Shintaro (00398067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 吉田裕樹 (40260715)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 山田亮 (50158177)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

TOYOSHIMA Takeshi 豊嶋 健史

Research Projects

Research Products

Co-Researchers

A study on the mechanism of invasion and metastasis thorough epithelial-mesenchymal transition in oral squamous cel carcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clinical application for biomarker RCAS1 in oral squamous cell carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of early diagnostic method and order-made immunotherapy for oral cancer by using anti-tumor T cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Prevention of ischemia-reperfusion injury in the free flap transplantation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Would Cytokeratin be a new prognostic marker of oral squamous cell carcinoma?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Correlation between the expression patterns of cytokeratins/cell differentiations and the clinico-patholigical findings in oral squamous cell carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Clinicopathological evaluation of pre-operative chemoradiotherapy with S-1 as a treatment for locally advanced oral squamous cell carcinoma2016

Author(s)

Journal Title

Data Source

[Journal Article] Increased expression of interleukin-6 predicts poor response to chemoradiotherapy and unfavorable prognosis in oral squamous cell carcinoma.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Possible involvement of ΔNp63 downregulation in the invasion and metastasis of oral squamous cell carcinoma via induction of a mesenchymal phenotype2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Apoptotic function of tumor-associated antigen RCAS1 in oral squamous cell carcinoma2014

Author(s)

Journal Title

Data Source

[Journal Article] Apoptotic function of tumor-associated antigen2014

Author(s)

Journal Title

Data Source

[Journal Article] Association of cytokeratin 17 expression with differentiation in oral squamous cell carcinoma.2012

Author(s)

Journal Title

Data Source

[Journal Article] In vitro induction of specific CD8(+) T lymphocytes by tumor-associated antigenic peptides in patients with oral squamous cell carcinoma.2012

Author(s)

Journal Title

Data Source

[Journal Article] Association of cytokeratin 17 expression with differentiation in oral squamous cell carcinoma.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vitro induction of specific CD8(+) T lymphocytes by tumorassociated antigenic peptides in patients with oral squamous cell carcinoma2012

Author(s)

Journal Title

DOI

Data Source

TOYOSHIMA Takeshi 豊嶋健史