NOZAKI Hiroaki 野崎洋明

Researcher Number	20547567
Affiliation (based on the past Project Information) *help	2016 – 2018: 新潟大学, 医歯学系, 助教 2013: 新潟大学, 医学部, 助教 2011 – 2012: 新潟大学, 医歯学系, 助教 2010 – 2011: Niigata University, 医歯学総合病院, 助教 2009: Niigata University, 医歯学総合病院, 特任助教
Review Section/Research Field	Principal Investigator Neurology Except Principal Investigator Neurology
Keywords	Principal Investigator HTRA1 / CARASIL / 脳小血管病 / 脳神経疾患 / 優性阻害効果 / dominant negative / cerebral small vessel disease / TGF-β1 / TGF-βファミリー / small vessel disease / BMP-4 / BMP-2 / TGF-β … More Except Principal Investigator … More HTRA1 / CARASIL / 蛋白質 / タンパク質 / 痴呆 / 病理学 / 循環器 / 脳神経疾患 / 脳小血管病 / 脳血管障害 / 認知症 / サイトカイ / 炎症 / モデルマウス / 微小循環 / TGF-β / 血管性認知症 / 周皮細胞 / 平滑筋細胞 / 脳小血管 / 血液脳関門 Less

HTRA1関連脳小血管病の罹患者数を推計する試みPrincipal Investigator
- Principal Investigator
  
  野崎洋明
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Strategies for overcoming vascular dementia focusing on dynamic functions of cerebral small vessels.
- Principal Investigator
  
  Onodera Osamu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Molecular mechanism for a cerebral small vessel disease caused by heterozygosity for novel mutations in HTRA1 genePrincipal Investigator
- Principal Investigator
  
  NOZAKI Hiroaki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Molecular pathogenesis of cerebral small vessel disease.
- Principal Investigator
  
  ONODERA Osamu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
A novel mechanism for inhibition of TGF-β family signaling by HTRA1Principal Investigator
- Principal Investigator
  
  NOZAKI Hiroaki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Neurology
- Research Institution
  Niigata University

All 2019 2018 2017 2016 2013 2012 2011 2010 Other

All Journal Article Presentation Book

[Book] Annual Review神経2011巻CARASILの臨床・病理像と病態機序2011
- Author(s)
  野崎洋明,西澤正豊,小野寺理
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-22390174
[Book] Annual Review神経2011巻CARASILの臨床・病理像と病態機序2011
- Author(s)
  野崎洋明
- Total Pages
  9
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-22390174
[Book] University of Washington, Seattle; CARASIL. GeneReviews2010
- Author(s)
  Onodera O, Nozaki H, Fukutake T.In : Pagon RA, Bird TD, Dolan CR, Stephens K, Adam MP
- Publisher
  Seattle (WA)(Internet)
- Data Source
  KAKENHI-PROJECT-22390174
[Book] CARASIL GeneReviews^<TM>2010
- Author(s)
  Onodera O, Nozaki H, Fukutake T
- Publisher
  In : Pagon RA, Bird TD, Dolan CR, Stephens K, Adam MP, Seattle (WA) : University of Washington, Seattle(Internet)
- Data Source
  KAKENHI-PROJECT-22390174
[Journal Article] Histopathologic features of an autopsied patient with cerebral small vessel disease and a heterozygous HTRA1 mutation2018
- Author(s)
  Ito Junko、Nozaki Hiroaki、Toyoshima Yasuko、Abe Takashi、Sato Aki、Hashidate Hideki、Igarashi Shuichi、Onodera Osamu、Takahashi Hitoshi、Kakita Akiyoshi
- Journal Title
  
  Neuropathology
  
  Volume: 38 Issue: 4 Pages: 428-432
- DOI
  10.1111/neup.12473
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26117006, KAKENHI-PROJECT-16H02656, KAKENHI-PROJECT-17K09775
[Journal Article] 遺伝性脳小血管障害の神経病理2018
- Author(s)
  齋藤理恵, 伊藤慎治, 野崎洋明, 柿田明美
- Journal Title
  
  神経内科
  
  Volume: 88 Pages: 516-523
- Data Source
  KAKENHI-PROJECT-17K09775
[Journal Article] 特集近年注目されている白質脳症 CARASIL-(Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy)2017
- Author(s)
  上村昌寛、野崎洋明、小野寺理
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 69 Pages: 25-33
- Data Source
  KAKENHI-PROJECT-16H02656
[Journal Article] A CARASIL Patient from Americas with Novel Mutation and Atypical Features: Case Presentation and Literature Review2017
- Author(s)
  Ibrahimi Muhammad、Nozaki Hiroaki、Lee Angelica、Onodera Osamu、Reichwein Raymond、Wicklund Matthew、El-Ghanem Mohammad
- Journal Title
  
  Cerebrovascular Diseases
  
  Volume: 44 Issue: 3-4 Pages: 135-140
- DOI
  10.1159/000477358
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117006, KAKENHI-PROJECT-16H02656
[Journal Article] CARASIL families from India with 3 novel null mutations in theHTRA1gene2017
- Author(s)
  Preethish-Kumar Veeramani、Nozaki Hiroaki、Tiwari Sarbesh、Vengalil Seena、Bhat Maya、Prasad Chandrajit、Onodera Osamu、Uemura Masahiro、Doniparthi Seshagiri、Saini Jitender、Nashi Saraswati、Polavarapu Kiran、Nalini Atchayaram
- Journal Title
  
  Neurology
  
  Volume: 89 Issue: 23 Pages: 2392-2394
- DOI
  10.1212/wnl.0000000000004710
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117006, KAKENHI-PROJECT-16H02656
[Journal Article] Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL)2017
- Author(s)
  Uemura M, Nozaki H, Onodera O.
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 69 Issue: 1 Pages: 25-33
- DOI
  10.11477/mf.1416200631
- ISSN
  1344-8129, 1881-6096
- Year and Date
  2017-01-01
- Data Source
  KAKENHI-PROJECT-16H02656
[Journal Article] Distinct molecular mechanisms of HTRA1 mutants in manifesting heterozygotes with CARASIL.2016
- Author(s)
  Nozaki H, Kato T, Nihonmatsu M, Saito Y, Mizuta I, Noda T, Koike R, Miyazaki K, Kaito M, Ito S, Makino M, Koyama A, Shiga A, Uemura M, Sekine Y, Murakami A, Moritani S, Hara K, Yokoseki A, Kuwano R, Endo N, Momotsu T, Yoshida M, Nishizawa M, Mizuno T, Onodera O
- Journal Title
  
  Neurology
  
  Volume: 86 Issue: 21 Pages: 1-10
- DOI
  10.1212/wnl.0000000000002694
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461276, KAKENHI-PLANNED-26117006, KAKENHI-PROJECT-16H02656
[Journal Article] Hereditary cerebral small-vessel disease2013
- Author(s)
  Nozaki H, Nishizawa M, Onodera O
- Journal Title
  
  Nihon Rinsho
  
  Volume: 71(3) Pages: 545-554
- NAID
  40019594384
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/23631251
- Data Source
  KAKENHI-PROJECT-23790983
[Journal Article] Consideration of the pathogenesis of CARASIL2012
- Author(s)
  Hiroaki Nozaki
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 52 Pages: 1360-1362
- NAID
  130004505162
- Data Source
  KAKENHI-PROJECT-23790983
[Journal Article] Consideration of the pathogenesis of CARASIL2012
- Author(s)
  Nozaki H
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 52(11) Pages: 1360-1362
- NAID
  130004505162
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/23196618
- Data Source
  KAKENHI-PROJECT-23790983
[Journal Article] Cerebral small-vessel disease protein HTRAI controls the amount of TGF-{beta}1 via cleavage of proTGF-{beta}l.2011
- Author(s)
  Shiga A, Nozaki H, Onodera O, et al.
- Journal Title
  
  Hum Mol Genetics 20(9)
  
  Pages: 1800-1810
- Data Source
  KAKENHI-PROJECT-21890079
[Journal Article] A novel mutation in the HTRA1 gene causes CARASIL without alopecia2011
- Author(s)
  Nishimoto Y, Shibata M, Nihonmatsu M, Nozaki H, Shiga A, Shirata A, Yamane K, Kosakai A, Takahashi K, Nishizawa M, Onodera O, Suzuki N
- Journal Title
  
  Neurology
  
  Volume: 76(15) Pages: 1353-5
- Data Source
  KAKENHI-PROJECT-22390174
[Journal Article] 【認知症:診断と治療の進歩】トピックス新規の認知症関連遺伝子の発見TGF-βファミリーシグナルの異常と遺伝性脳小血管病CARASILの分子病態の解析から2011
- Author(s)
  野崎洋明,西澤正豊,小野寺理
- Journal Title
  
  日本内科学会雑誌
  
  Volume: 100巻8号 Pages: 2207-2213
- Data Source
  KAKENHI-PROJECT-22390174
[Journal Article] Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-β1 via cleavage of proTGF-β12011
- Author(s)
  Shiga A, Nozaki H, Yokoseki A, Nihonmatsu M, Kawata H, Kato T, Koyama A, Arima. K, Ikeda M, Katada S, Toyoshima Y, Takahashi H, Tanaka A, Nakano I, Ikeuchi T, Nishizawa M, Onodera O
- Journal Title
  
  Hum Mol Genet
  
  Volume: 20(9) Pages: 1800-10
- Data Source
  KAKENHI-PROJECT-22390174
[Journal Article] 新規の認知症関連遺伝子の発見　TGF-βファミリーシグナルの異常と遺伝性脳小血管病　CARASILの分子病態の解析から2011
- Author(s)
  野崎洋明
- Journal Title
  
  日本内科学会雑誌
  
  Volume: 100 Pages: 2207-2213
- Data Source
  KAKENHI-PROJECT-22390174
[Journal Article] CARASILの分子病態学BRAIN and NERVE2010
- Author(s)
  志賀篤,野崎洋明,西澤正豊,小野寺理
- Journal Title
  
  神経研究の進歩
  
  Volume: 62巻6号 Pages: 595-599
- Data Source
  KAKENHI-PROJECT-22390174
[Journal Article] High Temperature Requirement Protein A1 による Bone Morphogenetic Protein-2/4シグナル伝達の阻害機序2010
- Author(s)
  野崎洋明
- Journal Title
  
  新潟医学会雑誌 1(124)
  
  Pages: 16-28
- NAID
  120006747842
- Data Source
  KAKENHI-PROJECT-21890079
[Journal Article] CARASILの分子病態機序2010
- Author(s)
  野崎洋明,志賀篤,西澤正豊,小野寺理
- Journal Title
  
  神経内科
  
  Volume: 72巻4号 Pages: 408-412
- NAID
  40017170126
- Data Source
  KAKENHI-PROJECT-22390174
[Journal Article] CARASILの分子病態学2010
- Author(s)
  志賀篤, 野崎洋明, 西澤正豊, 小野寺理
- Journal Title
  
  BRAIN and NERVE:神経研究の進歩
  
  Volume: 62巻6号 Pages: 595-599
- Data Source
  KAKENHI-PROJECT-22390174
[Journal Article] Cerebral small-vessel disease protein HTRA1 controls the amountof TGF-{beta}1 via cleavage of proTGF-{beta}1.
- Author(s)
  Shiga A, Nozaki H, Onodera O, etal.
- Journal Title
  
  Human Molecular Genetics
  
  Volume: (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890079
[Presentation] The frequency of mutations in NOTCH3 or HTRA1 gene among 160 Japanese CSVD patients2019
- Author(s)
  野崎洋明
- Organizer
  第59回　日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] 遺伝性脳小血管病における微小出血の特徴2018
- Author(s)
  上村昌寛, 野崎洋明, 酒井直子先生, 小野寺理
- Organizer
  第43回日本脳卒中学会学術集会
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] The frequency of mutations in NOTCH3 or HTRA1 gene among Japanese CSVD patients2018
- Author(s)
  Hiroaki Nozaki, Masahiro Uemura, Osamu Onodera
- Organizer
  59th Annual Meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-17K09775
[Presentation] The prevalence estimates of HTRA1-associated cerebral small vessel disease.2017
- Author(s)
  Hiroaki Nozaki, Akihide Koyama, Masahiro Uemura, Taisuke Kato, Osamu Onodera.
- Organizer
  The 8th Korea-Japan Joint Stroke Conference.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09775
[Presentation] RVCL関連変異の細胞内局在についての検討．2017
- Author(s)
  笠原杏子, 加藤泰介, 野崎洋明, 小山哲秀, 小野寺理．
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] Distinct mechanisms of HTRA1 mutants in manifesting heterozygotes with CARASIL2017
- Author(s)
  野崎洋明, 加藤泰介, 水田依久子, 水野敏樹, 西澤正豊,小野寺理
- Organizer
  第114回日本内科学会総会
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] セリンプロテアーゼHTRA1の機能欠損は、脳小血管病を引き起こす; Serine protease HTRA1 deficiency induces arteriopathy in cerebral small vessels2017
- Author(s)
  Kato T, Sekine Y, Fujita N, Nozaki H, Hirokawa S, Sato T, Onodera O
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] The prevalence estimates of HTRA1-associated cerebral small vessel disease2017
- Author(s)
  Hiroaki Nozaki, Akihide Koyama, Masahiro Uemura, Taisuke Kato, Osamu Onodera
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] 家族性脳小血管病患者で同定された変異型HTRA1蛋白質のプロテアーゼ活性解析2017
- Author(s)
  上村昌寛, 野崎洋明, 加藤泰介, 小山哲秀, 小野寺理
- Organizer
  第47回新潟神経学夏季セミナー
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] The absence of hypertension and the presence of psychiatric symptoms suggest a genetic disorder among patients suspected for hereditary cerebral small vessel disease2017
- Author(s)
  Uemura M, Nozaki H, Sakai N, Onodera O
- Organizer
  The 8th Korea Joint Stroke Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] 家族性脳小血管病患者で報告された変異型HTRA1蛋白質の機能解析2017
- Author(s)
  上村昌寛, 野崎洋明, 加藤泰介, 小山哲秀, 小野寺理
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] The prevalence estimates of HTRA1-associated cerebral small vessel disease.2017
- Author(s)
  Hiroaki Nozaki, Akihide Koyama, Masahiro Uemura, Taisuke Kato, Osamu Onodera.
- Organizer
  XXⅢ World Congress of Neurology.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09775
[Presentation] Characteristic Brain Features of Manifesting　Heterozygotes With Cerebral Autosomal Recessive Arteriopathy With Subcortical Infarcts and Leukoencephalopathy.2017
- Author(s)
  Masahiro Uemura, Hiroaki Nozaki, Yumi Sekine, , Osamu Onodera et al.
- Organizer
  International stroke conference 2017
- Place of Presentation
  Houston (USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] Molecular analysis of mutant high-temperature requirement serine protease A1 identified in patients with familial cerebral small vessel disease2017
- Author(s)
  Uemura M, Nozaki H, Kato T, Koyama A, Onodera O
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] Protease activity analysis of mutant high-temperature requirement serine protease A1 identified in patients with familial cerebral small vessel disease2017
- Author(s)
  Uemura M, Nozaki H, Kato T, Koyama A, Onodera O
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] Distinct Molecular Mechanisms of Htra1 Mutants in Manifesting Heterozygotes With Carasil.2017
- Author(s)
  Hiroaki Nozaki, Taisuke Kato, Megumi Nihonmatsu, Yohei Saito, Osamu Onodera, et al.
- Organizer
  International stroke conference 2017
- Place of Presentation
  Houston (USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] The prevalence estimates of HTRA1-associated cerebral small vessel disease2017
- Author(s)
  Hiroaki Nozaki, Akihide Koyama, Masahiro Uemura, Taisuke Kato, Osamu Onodera
- Organizer
  The 8th Korea-Japan Joint Stroke Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] Distinct mechanisms of HTRA1 mutants in manifesting heterozygotes with CARASIL.2017
- Author(s)
  野崎洋明, 加藤泰介, 水田依久子, 水野敏樹, 西澤正豊, 小野寺理.
- Organizer
  第114回日本内科学会総会
- Data Source
  KAKENHI-PROJECT-17K09775
[Presentation] CARASIL症候性キャリアの一例2017
- Author(s)
  野崎洋明, 伊藤絢子, 阿部崇, 豊島靖子,佐藤晶, 橋立英樹, 五十嵐修一, 高橋均, 小野寺理, 柿田明美
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] Molecular analysis of mutant high-temperature requirement serine protease A1 identified in patients with familial cerebral small vessel disease2017
- Author(s)
  Uemura M, Nozaki H, Kato T, Koyama A, Onodera O
- Organizer
  Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02656
[Presentation] MRI features of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy2013
- Author(s)
  野崎洋明
- Organizer
  AAN 65^<th> Annual meeting
- Place of Presentation
  San diego.USA
- Data Source
  KAKENHI-PROJECT-22390174
[Presentation] MRI Features of Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy2013
- Author(s)
  Nozaki H
- Organizer
  American Academy of Neurology 65th Annual Meeting,
- Place of Presentation
  San　Diego アメリカ合衆国
- Data Source
  KAKENHI-PROJECT-22390174
[Presentation] HTRA1変異ヘテロ接合体における脳小血管病の発症機序に関する研究2013
- Author(s)
  野崎　洋明
- Organizer
  遺伝性脳小血管病およびその類縁疾患の診断基準の確立と治療法の研究班　平成24年度班会議
- Place of Presentation
  KKRホテル東京（東京都）
- Data Source
  KAKENHI-PROJECT-23790983
[Presentation] Dominant negative効果をもつ変異型HTRA1はヘテロ接合体でも脳小血管病を引き起こす2013
- Author(s)
  野崎洋明,加藤泰介,二本松萌,齋藤洋兵,小山哲秀,志賀篤,西澤正豊,小野寺理
- Organizer
  第54回神経学会学術大会
- Place of Presentation
  東京
- Year and Date
  2013-05-31
- Data Source
  KAKENHI-PROJECT-23790983
[Presentation] 遺伝性脳小血管病の分子病態 update2012
- Author(s)
  野崎洋明
- Organizer
  J-CAN2012
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-22390174
[Presentation] HTRA1ミスセンス変異はヘテロ接合体でも脳小血管病を引き起こす2012
- Author(s)
  野崎洋明,二本松萌,齋藤洋兵,針生真弥,水野敏樹,水田依久子,志賀篤,小山哲秀,加藤泰介,野田智子,垣内無一,伊藤彰一,西澤正豊,小野寺理
- Organizer
  第53回神経学会学術大会
- Place of Presentation
  東京
- Year and Date
  2012-05-23
- Data Source
  KAKENHI-PROJECT-23790983
[Presentation] 片側アレルにのみHTRA1 ミスセンス変異を有する例でも脳小血管病を引き起こす2012
- Author(s)
  野崎洋明
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22390174
[Presentation] 片側アリルにのみHTRA1ミスセンス変異を有する例でも脳小血管病を引き起こす2012
- Author(s)
  野崎　洋明
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム（東京都）
- Data Source
  KAKENHI-PROJECT-23790983
[Presentation] CARASILの病態機序への考察2012
- Author(s)
  野崎洋明
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京
- Year and Date
  2012-05-25
- Data Source
  KAKENHI-PROJECT-22390174
[Presentation] CARASILの病態機序への考察2012
- Author(s)
  野崎　洋明
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム（東京都）
- Data Source
  KAKENHI-PROJECT-23790983
[Presentation] HTRA1 controls BMP2/4 signaling via cleavage of proBMP2/42010
- Author(s)
  H NOZAKI, A. SHIGA, M. NIHONMATSU, A. KOYAMA, O ONODERA, M. NISHIZAWA
- Organizer
  Implication for molecular pathogenesis of hereditary cerebral small vessel disease NEUROSCIENCE 2010
- Place of Presentation
  San Diego.USA
- Year and Date
  2010-11-14
- Data Source
  KAKENHI-PROJECT-22390174
[Presentation] HTRA1 controls BMP-2/4 signaling via cleavage of proBMP-2/42010
- Author(s)
  Nozaki H.
- Organizer
  implication for molecular pathogenesis of hereditary cerebral small vessel disease.
- Place of Presentation
  48^<th> Annual Meeting Neuroscience
- Data Source
  KAKENHI-PROJECT-21890079
[Presentation] HTRA1 controls BMP2/4 signaling via cleavage of proBMP2/4 : Implication for molecular pathogenesis of hereditary cerebral small vessel disease2010
- Author(s)
  H.NOZAKI, A.SHIGA, M.NIHONMATSU, A.KOYAMA, O.ONODERA, M.NISHIZAWA
- Organizer
  NEUROSCIENCE 2010
- Place of Presentation
  San Diego
- Year and Date
  2010-11-14
- Data Source
  KAKENHI-PROJECT-22390174
[Presentation] TGF-β経路は遺伝性脳小血管病で特異的に活性化される(TGF-βpathway is specifically activated in hereditary cerebral small-vessel disease)2010
- Author(s)
  二本松萌,志賀篤,野崎洋明,西澤正豊,小野寺理
- Organizer
  日本生化学会大会・日本分子生物学会年会合同大会83回・33回
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22390174
[Presentation] HTRA1 controls BMP-2/4 signaling via cleavage of proBMP-2/4 : implication for molecular pathogenesis of hereditary cerebral small vessel disease2010
- Author(s)
  Nozaki H
- Organizer
  48^<th>Annual Meeting Neuroscience 2010
- Place of Presentation
  San Diego, CA, US
- Year and Date
  2010-11-14
- Data Source
  KAKENHI-PROJECT-21890079
[Presentation] TGF-β経路は遺伝性脳小血管病で特異的に活性化される(TGF-β pathway is specifically activated in hereditary cerebral small-vessel disease)2010
- Author(s)
  二本松萌, 志賀篤, 野崎洋明, 西澤正豊, 小野寺理
- Organizer
  日本生化学会大会・日本分子生物学会年会合同大会83回・33回
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22390174

1. ONODERA Osamu (20303167)

# of Collaborated Projects: 2 results

# of Collaborated Products: 32 results
2. 豊島靖子 (20334675)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. SATO Toshiya (90359703)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 加藤泰介 (30598496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
5. 小山哲秀 (90622209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
6. Kakita Akiyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. MIZUNO Toshiki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. MIZUTA Ikuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NOZAKI Hiroaki 野崎 洋明

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HTRA1関連脳小血管病の罹患者数を推計する試みPrincipal Investigator

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Strategies for overcoming vascular dementia focusing on dynamic functions of cerebral small vessels.

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Molecular mechanism for a cerebral small vessel disease caused by heterozygosity for novel mutations in HTRA1 genePrincipal Investigator

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Molecular pathogenesis of cerebral small vessel disease.

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A novel mechanism for inhibition of TGF-β family signaling by HTRA1Principal Investigator

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[Book] Annual Review神経2011巻CARASILの臨床・病理像と病態機序2011

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[Book] Annual Review神経2011巻CARASILの臨床・病理像と病態機序2011

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[Book] University of Washington, Seattle; CARASIL. GeneReviews2010

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[Book] CARASIL GeneReviews^<TM>2010

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[Journal Article] Histopathologic features of an autopsied patient with cerebral small vessel disease and a heterozygous HTRA1 mutation2018

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[Journal Article] 遺伝性脳小血管障害の神経病理2018

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[Journal Article] 特集 近年注目されている白質脳症 CARASIL-(Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy)2017

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[Journal Article] A CARASIL Patient from Americas with Novel Mutation and Atypical Features: Case Presentation and Literature Review2017

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[Journal Article] CARASIL families from India with 3 novel null mutations in theHTRA1gene2017

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[Journal Article] Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL)2017

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NOZAKI Hiroaki 野崎洋明

[Journal Article] 特集近年注目されている白質脳症 CARASIL-(Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy)2017

[Journal Article] 新規の認知症関連遺伝子の発見　TGF-βファミリーシグナルの異常と遺伝性脳小血管病　CARASILの分子病態の解析から2011