Hikawa Hidemasa 氷川英正

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HIKAWA Hidemasa 氷川英正

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Researcher Number	20550619
Other IDs	https://orcid.org/0000-0002-7819-3012
Affiliation (Current)	2024: 東邦大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2023: 東邦大学, 薬学部, 准教授 2015 – 2021: 東邦大学, 薬学部, 准教授 2013 – 2015: 東邦大学, 薬学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Chemical pharmacy
Keywords	Principal Investigator 水 / ベンジル化 / 炭素－水素結合活性化 / ベンジルアルコール / パラジウム / 脱水 / グリーンケミストリー / 環境負荷低減型 / Friedel-Crafts / 転位反応 … More / 金触媒 / Friedel-Crafts 反応 / 環境調和 / C－H結合活性化 / 炭素ー水素結合活性化 / イミダゾキノリン / キナゾリノン / イサト酸無水物 / 多成分連結反応 / フェニレンジアミン / ベンゾイミダゾール / グリーンケミストリ－ / 脱水型ベンジル化 / スルホンアミド Less

水を溶媒とするニトロアニリンの触媒的脱水型Friedel-Craftsアルキル化反応Principal Investigator
- Principal Investigator
  
  氷川英正
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Toho University
Direct functionalization of benzylic C-H bond using pai-benzylpalladium system in water.Principal Investigator
- Principal Investigator
  
  HIKAWA Hidemasa
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Toho University
Pd-catalyzed dehydrative transformation using C-H bond activation in water.Principal Investigator
- Principal Investigator
  
  HIKAWA Hidemasa
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Toho University
A novel strategy for benzylation and C-H activation by the (eta3-benzyl)palladium(II) system in water.Principal Investigator
- Principal Investigator
  
  HIKAWA Hidemasa
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Toho University

All 2024 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Direct Use of Benzylic Alcohols for Multicomponent Synthesis of 2-Aryl Quinazolinones Utilizing the π-Benzylpalladium(II) System in Water2021
- Author(s)
  Hikawa, H.; Nakayama, T.; Takahashi, M.; Kikkawa, S.; Azumaya, I.
- Journal Title
  
  Adv. Synth. Catal.
  
  Volume: 363 Issue: 16 Pages: 4075-4084
- DOI
  10.1002/adsc.202100535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07003
[Journal Article] Water-promoted dehydrative coupling of 2-aminopyridines in heptane via a borrowing hydrogen strategy.2021
- Author(s)
  Nakayama, T.; Hikawa, H.; Kikkawa, S.; Azumaya, I.
- Journal Title
  
  RSC Adv.
  
  Volume: 11 Issue: 37 Pages: 23144-23150
- DOI
  10.1039/d1ra04118e
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07003
[Journal Article] 1.A Borrowing Hydrogen Strategy for Dehydrative Coupling of Aminoisoquinolines with Benzyl Alcohols in Water.2020
- Author(s)
  Hikawa, H.; Tan, R.; Tazawa, A.; Kikkawa, S.; Azumaya, I.
- Journal Title
  
  Eur. J. Org. Chem.
  
  Volume: － Issue: 5 Pages: 539-547
- DOI
  10.1002/ejoc.201901606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07003
[Journal Article] Gold(III)/Sodium Diphenylphosphinobenzene-3-sulfonate (TPPMS) Catalyzed Dehydrative N-Benzylation of Electron-Deficient Anilines in Water2019
- Author(s)
  Hikawa, Hidemasa; Matsumoto, Mika; Tawara, Sayoko; Kikkawa, Shoko; Azumaya, Isao
- Journal Title
  
  Synthesis
  
  Volume: － Issue: 13 Pages: 2729-2736
- DOI
  10.1055/s-0037-1611519
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08179
[Journal Article] Gold(III)-Catalyzed Decarboxylative C3-Benzylation of Indole-3-carboxylic Acids with Benzylic Alcohols in Water2019
- Author(s)
  Hikawa, Hidemasa; Kotaki, Fumiya; Kikkawa, Shoko; Azumaya, Isao
- Journal Title
  
  Journal of Organic Chemistry
  
  Volume: 84 Issue: 4 Pages: 1972-1979
- DOI
  10.1021/acs.joc.8b02947
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08179
[Journal Article] 4.Platinum(II)-catalyzed dehydrative C3-benzylation of electron-deficient indoles with benzyl alcohols.2019
- Author(s)
  Hikawa, H.; Matsuura, Y.; Kikkawa, S.; Azumaya, I.
- Journal Title
  
  Org. Chem. Front.
  
  Volume: 6 Issue: 17 Pages: 3150-3157
- DOI
  10.1039/c9qo00831d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07003
[Journal Article] A borrowing hydrogen methodology: palladium-catalyzed dehydrative N-benzylation of 2-aminopyridines in water2018
- Author(s)
  Hikawa, Hidemasa; Imamura, Hirokazu; Kikkawa, Shoko; Azumaya, Isao
- Journal Title
  
  Green Chemistry
  
  Volume: 20 Issue: 13 Pages: 3044-3049
- DOI
  10.1039/c8gc01028e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08179
[Journal Article] A palladium-catalyzed dehydrative N-benzylation/C-H benzylation cascade of 2-morpholinoanilines on water.2018
- Author(s)
  Hikawa H.; Ichinose R.; Kikkawa S.; Azumaya I.
- Journal Title
  
  Green Chem.
  
  Volume: 20 Issue: 6 Pages: 1297-1305
- DOI
  10.1039/c7gc03780e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08179
[Journal Article] Palladium-catalyzed dehydrogenation of benzyl alcohols for construction of 2-arylbenzimidazoles “on water”.2018
- Author(s)
  Hikawa H.; Ichinose R.; Kikkawa S.; Azumaya I.
- Journal Title
  
  Asian J. Org. Chem.
  
  Volume: 7 Issue: 2 Pages: 416-423
- DOI
  10.1002/ajoc.201700618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08179
[Journal Article] Borrowing hydrogen methodology for N-benzylation using a π-benzylpalladium system in water2016
- Author(s)
  Hikawa H.; Koike T.; Izumi K.; Kikkawa S.; Azumaya I.
- Journal Title
  
  Adv. Synth. Catal.
  
  Volume: 358 Issue: 5 Pages: 784-791
- DOI
  10.1002/adsc.201501041
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460026
[Journal Article] Cobalt(II)/TPPMS-Catalyzed Dehydrative Nucleophilic Substitution of Alcohols in Water.2016
- Author(s)
  H. Hikawa, Y. Ijichi, S. Kikkawa, I. Azumaya
- Journal Title
  
  Eur. J. Org. Chem.
  
  Volume: - Issue: 3 Pages: 465-468
- DOI
  10.1002/ejoc.201601501
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08179
[Journal Article] Cationic palladium(II)-catalyzed dehydrative nucleophilic substitutions of benzhydryl alcohols with electron-deficient benzenethiols in water2016
- Author(s)
  H. Hikawa, Y. Machino, M. Toyomoto, S. Kikkawa, I. Azumaya
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 14 Issue: 29 Pages: 7038-7045
- DOI
  10.1039/c6ob01140c
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08179
[Journal Article] Palladium-catalyzed benzylic C-H benzylation via bis-benzylpalladium(II) complexes in water: an effective pathway for the direct construction of N-(1,2-diphenylethyl)anilines.2015
- Author(s)
  Hikawa H.; Izumi K.; Ino Y.; Kikkawa S.; Yokoyama Y.; Azumaya I.
- Journal Title
  
  Adv. Synth. Catal.
  
  Volume: 357 Issue: 5 Pages: 1037-1048
- DOI
  10.1002/adsc.201401017
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460026
[Journal Article] Direct substitution of benzylic alcohols with electron-deficient benzenethiols via π-benzylpalladium(II) in water.2015
- Author(s)
  Hikawa H.; Toyomoto M.; Kikkawa S.; Azumaya I.
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 13 Issue: 47 Pages: 11459-11465
- DOI
  10.1039/c5ob01717c
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460026
[Journal Article] Mercaptobenzoic acid-palladium(0) complexes as active catalysts for S-benzylation with benzylic alcohols via (eta3-benzyl)palladium(II) cation in water.2014
- Author(s)
  Hikawa, H.; Azumaya, I.
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 12 Issue: 31 Pages: 5964-5972
- DOI
  10.1039/c4ob00688g
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460026
[Journal Article] N- Benzylation /Benzylic C- H Amidation Cascade by the (η3- Benzyl) palladium System in Aqueous Media: An Effective Pathway for the Direct Construction of 3- Phenyl- 3, 4- dihydro- (2H) - 1, 2, 4- benzothiadiazine 1, 1-Dioxides2013
- Author(s)
  Hikawa, Hidemasa; Matsuda, Naoya; Suzuki, Hideharu; Yokoyama, Yuusaku; Azumaya, Isao,
- Journal Title
  
  ADVANCED SYNTHESIS & CATALYSIS
  
  Volume: 355(11-12) Issue: 11-12 Pages: 2308-2320
- DOI
  10.1002/adsc.201300317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590147, KAKENHI-PROJECT-25460026
[Presentation] Au(Ⅲ)触媒を用いた脱水的 Bischler-Mohlau 型indole合成2024
- Author(s)
  ○雲野佑香1、中山拓1、吉川晶子1、東屋功1、氷川英正1 (1. 東邦大薬)
- Organizer
  日本薬学会第144年会（横浜）
- Data Source
  KAKENHI-PROJECT-23K06033
[Presentation] 水中におけるPd触媒を用いた多成分連結反応によるキナゾリノン合成2022
- Author(s)
  氷川英正、中山拓、高橋牧子、吉川晶子、東屋功
- Organizer
  日本薬学会第142年会（名古屋）
- Data Source
  KAKENHI-PROJECT-19K07003
[Presentation] 無極性溶媒中二価Pdにより触媒されるトリアリールオキサゾール類合成法の開発2022
- Author(s)
  中山拓、氷川英正、吉川晶子、東屋功
- Organizer
  日本薬学会第142年会（名古屋）
- Data Source
  KAKENHI-PROJECT-19K07003
[Presentation] 水を溶媒としたベンジルアルコールの触媒的脱水素化を経由するβ-カルボリン類の合成2022
- Author(s)
  小林正和、氷川英正、吉川晶子、東屋功
- Organizer
  日本薬学会第142年会（名古屋）
- Data Source
  KAKENHI-PROJECT-19K07003
[Presentation] 1-Butanolを溶媒とした2-aminobenzyl alcoholの脱水型三量化を経由する多環式キナゾリンの合成および構造解析2022
- Author(s)
  遠田知克、中山拓、氷川英正、吉川晶子、東屋功
- Organizer
  日本薬学会第142年会（名古屋）
- Data Source
  KAKENHI-PROJECT-19K07003
[Presentation] 水を溶媒としたベンジルアルコールの触媒的脱水素化を経由するイミダゾキノリンの合成2021
- Author(s)
  原田翔伍、氷川英正、中山拓、吉川晶子、東屋功
- Organizer
  日本薬学会141年会（広島）
- Data Source
  KAKENHI-PROJECT-19K07003
[Presentation] 水中におけるPd触媒を用いたaminoisoquinoline類のN－ベンジル化反応2021
- Author(s)
  氷川英正、丹里衣、田澤葵、吉川晶子、東屋功
- Organizer
  日本薬学会141年会（広島）
- Data Source
  KAKENHI-PROJECT-19K07003
[Presentation] ヘプタン中におけるPd（II）触媒を用いたチオサリチル酸の脱水型S－ベンジル化反応2020
- Author(s)
  田岡且行、中山拓、氷川英正、吉川晶子、東屋功
- Organizer
  日本薬学会第140年会（京都）
- Data Source
  KAKENHI-PROJECT-19K07003
[Presentation] Pt(II)触媒を用いた電子不足なインドールの脱水型ベンジル化反応2020
- Author(s)
  氷川英正、松浦祐希、吉川晶子、東屋功
- Organizer
  日本薬学会第140年会（京都）
- Data Source
  KAKENHI-PROJECT-19K07003
[Presentation] 水中における金触媒を用いたアントラニル酸の脱水型アリル化反応2020
- Author(s)
  山口歩、氷川英正、吉川晶子、東屋功
- Organizer
  日本薬学会第140年会（京都）
- Data Source
  KAKENHI-PROJECT-19K07003
[Presentation] 水中におけるPd触媒を用いたイサト酸無水物の脱水型連続反応2020
- Author(s)
  佐藤彰人、高橋牧子、氷川英正、吉川晶子、東屋功
- Organizer
  日本薬学会第140年会（京都）
- Data Source
  KAKENHI-PROJECT-19K07003
[Presentation] 水中での金触媒を用いたインドール-3-カルボン酸の脱炭酸的ベンジル化反応2019
- Author(s)
  氷川英正, 古滝史弥, 吉川晶子, 東屋功
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K08179
[Presentation] 水中における金触媒を用いた電子不足なアニリン類の脱水型C-ベンジル化反応2019
- Author(s)
  馬生聡大, 氷川英正, 吉川晶子, 東屋功
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K08179
[Presentation] Gold(III)-Catalyzed Decarboxylative C3-Benzylation of Indole-3-carboxylic Acids with Benzylic Alcohols in Water2019
- Author(s)
  H. Hikawa, F. Kotaki, S. Kikkawa, I. Azumaya
- Organizer
  27th International Society of Heterocyclic Chemistry Congress (27 ISHC)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07003
[Presentation] Borrowing hydrogen機構に基づく2-アミノピリジンのN-ベンジル化反応2018
- Author(s)
  中山拓, 吉川晶子, 氷川英正, 東屋功
- Organizer
  日本薬学会第138年会（金沢）
- Data Source
  KAKENHI-PROJECT-16K08179
[Presentation] 水溶性パラジウム触媒を用いた脱水型ベンジル化反応の開発2018
- Author(s)
  氷川英正
- Organizer
  第62回日本薬学会関東支部大会
- Invited
- Data Source
  KAKENHI-PROJECT-16K08179
[Presentation] 水を溶媒としたベンジルアルコールの触媒的脱水素化反応を経由するベンゾイミダゾールの合成2018
- Author(s)
  氷川英正, 一之瀬理沙, 吉川晶子, 東屋功
- Organizer
  日本プロセス化学会2018サマーシンポジウム
- Data Source
  KAKENHI-PROJECT-16K08179
[Presentation] 水を溶媒としたベンジルアルコールの触媒的脱水素化反応を経由するベンゾイミダゾールの合成2018
- Author(s)
  氷川英正, 一之瀬理沙, 吉川晶子, 東屋功
- Organizer
  日本薬学会第138年会（金沢）
- Data Source
  KAKENHI-PROJECT-16K08179
[Presentation] 水中でのCo(II)/TPPMS 触媒を用いたアルコールの脱水型置換反応2017
- Author(s)
  ◎氷川英正, 伊地知由紀子, 吉川晶子, 東屋功
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター(宮城県仙台市)
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K08179
[Presentation] 水中でのPd触媒を用いたメルカプト安息香酸のS-ベンジル化反応2015
- Author(s)
  氷川英正, 東屋功
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  神戸学院大学（兵庫県神戸市）
- Year and Date
  2015-03-26
- Data Source
  KAKENHI-PROJECT-25460026
[Presentation] 水中でのPd触媒を用いた電子求引性基を有するベンゼンチオールのS－ベンジル化反応2015
- Author(s)
  豊本真理子, 吉川晶子, 氷川英正, 東屋功
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  デザイン・クリエイティブセンター神戸(兵庫県神戸市)
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25460026
[Presentation] 水中でのパラジウム触媒を用いたN-ベンジル化/ベンジル位C-Hベンジル化連続反応の開発2015
- Author(s)
  氷川英正, 泉京江, 井野友加里, 吉川晶子, 横山祐作, 東屋功
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研修センター（千葉県・千葉市）
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-25460026
[Presentation] 水中でのπ-ベンジルPdを用いたN-ベンジル化/ベンジル位C-Hアミド化連続反応
- Author(s)
  氷川英正，松田直也，鈴木英治，横山祐作，東屋功
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市総合体育館（熊本県）
- Data Source
  KAKENHI-PROJECT-25460026
[Presentation] 水中でのPd触媒を用いたアニリンのベンジル化
- Author(s)
  泉京江，井野友加里，氷川英正，鈴木英治，横山祐作，東屋功
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市総合体育館（熊本県）
- Data Source
  KAKENHI-PROJECT-25460026

1. 鈴木英治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hikawa Hidemasa 氷川 英正

HIKAWA Hidemasa 氷川 英正

Research Projects

Research Products

Co-Researchers

水を溶媒とするニトロアニリンの触媒的脱水型Friedel-Craftsアルキル化反応Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Direct functionalization of benzylic C-H bond using pai-benzylpalladium system in water.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pd-catalyzed dehydrative transformation using C-H bond activation in water.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A novel strategy for benzylation and C-H activation by the (eta3-benzyl)palladium(II) system in water.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Direct Use of Benzylic Alcohols for Multicomponent Synthesis of 2-Aryl Quinazolinones Utilizing the π-Benzylpalladium(II) System in Water2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Water-promoted dehydrative coupling of 2-aminopyridines in heptane via a borrowing hydrogen strategy.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 1.A Borrowing Hydrogen Strategy for Dehydrative Coupling of Aminoisoquinolines with Benzyl Alcohols in Water.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gold(III)/Sodium Diphenylphosphinobenzene-3-sulfonate (TPPMS) Catalyzed Dehydrative N-Benzylation of Electron-Deficient Anilines in Water2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gold(III)-Catalyzed Decarboxylative C3-Benzylation of Indole-3-carboxylic Acids with Benzylic Alcohols in Water2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 4.Platinum(II)-catalyzed dehydrative C3-benzylation of electron-deficient indoles with benzyl alcohols.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A borrowing hydrogen methodology: palladium-catalyzed dehydrative N-benzylation of 2-aminopyridines in water2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A palladium-catalyzed dehydrative N-benzylation/C-H benzylation cascade of 2-morpholinoanilines on water.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Palladium-catalyzed dehydrogenation of benzyl alcohols for construction of 2-arylbenzimidazoles “on water”.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Borrowing hydrogen methodology for N-benzylation using a π-benzylpalladium system in water2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cobalt(II)/TPPMS-Catalyzed Dehydrative Nucleophilic Substitution of Alcohols in Water.2016

Hikawa Hidemasa 氷川英正

HIKAWA Hidemasa 氷川英正