Hattori Yasunao 服部恭尚

… Alternative Names

hattori Yasunao 服部恭尚

服部恭尚ハットリヤスナオ

HATTORI Yasunao 服部恭尚

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Researcher Number	20567028
Other IDs
Affiliation (Current)	2025: 京都薬科大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2023: 京都薬科大学, 薬学部, 講師 2018 – 2019: 京都薬科大学, 薬学部, 講師 2014 – 2016: 京都薬科大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 38040:Bioorganic chemistry-related Except Principal Investigator Drug development chemistry / Chemical biology
Keywords	Principal Investigator Decahydroisoquinoline / Fused ring scaffold / Inhibitor / SARS 3CL protease / デカヒドロイソキノリン / 阻害剤 / SARS 3CLプロテアーゼ / COVID-19 Except Principal Investigator BACE1 / アルツハイマー病 … More / キヌレニンアミノトランスフェラーゼ / トリプトファン代謝 / キヌレン酸 / 統合失調症 / ピペリジン / ピロリジン / アミジノ基 / 低分子阻害剤 / SARS / プロテアーゼ阻害剤 / 医薬品化学 / 創薬科学 / 縮環構造 / 複合体構造解析 / 疎水性相互作用 / 阻害剤 / プロテアーゼ / 閉環メタセシス / 遷移状態アナログ / ヒドロキシエチルアミン Less

Optimization of SARS 3CL protease inhibitor and development of anti-COVID-19 drugPrincipal Investigator
- Principal Investigator
  
  hattori Yasunao
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Kyoto Pharmaceutical University
Development of novel therapeutic agents for schizophrenia based on kynurenine hypothesis
- Principal Investigator
  
  Fujigaki Hidetsugu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Fujita Health University
Development of novel BACE1 inhibitors based on the N-amidino nitrogen-containing ring structure
- Principal Investigator
  
  Kobayashi Kazuya
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyoto Pharmaceutical University
Development of novel BACE1 inhibitors: Structure activity relationship study based on the substrate sequence
- Principal Investigator
  
  KOBAYASHI Kazuya
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyoto Pharmaceutical University
Design of non-peptide inhibitors based on structure analyses of the protease/inhibitor complex
- Principal Investigator
  
  Akaji Kenichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyoto Pharmaceutical University

All 2024 2023 2022 2017 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Synthesis of a pyrrolidine analog of a tetrahydrofuran containing acetogenin, cis-solamin2015
- Author(s)
  Ohnishi K, Sakurai H, Katsuyama M, Kobayashi K, Makabe H, Teruya K, Akaji K, Hattori Y.
- Journal Title
  
  HETEROCYCLES
  
  Volume: 91 Issue: 3 Pages: 573-582
- DOI
  10.3987/com-14-13163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K01804, KAKENHI-PROJECT-25460160
[Journal Article] Evaluation of transition-state mimics in a superior BACE1 cleavage sequence as peptide-mimetic BACE1 inhibitors2015
- Author(s)
  Hattori Y, Kobayashi K, Deguchi A, Nohara Y, Akiyama T, Teruya K, Sanjoh A, Nakagawa A, Yamashita E, Akaji K
- Journal Title
  
  Bioorganic and Medicinal Chemistry
  
  Volume: 23 Issue: 17 Pages: 5626-5640
- DOI
  10.1016/j.bmc.2015.07.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K01804, KAKENHI-PROJECT-25460160
[Journal Article] Fused-ring structure of decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors2015
- Author(s)
  Shimamoto Y, Hattori Y, Kobayashi K, Teruya K, Sanjho A, Nakagawa A, Yamashita E, Akaji K.
- Journal Title
  
  Bioorganic and Medicinal Chemistry
  
  Volume: 23 Issue: 4 Pages: 876-890
- DOI
  10.1016/j.bmc.2014.12.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K01804, KAKENHI-PROJECT-25460160
[Journal Article] Synthesis and evaluation of inhibitory activity of the curcumin derivatives toward the inhibitor of beta-site amyloid precursor protein cleaving enzyme 1.2014
- Author(s)
  Konno, H.; Endo, H.; Ise, S.; Miyazaki, K.; Aoki, H.; Sanjo, A.; Hattori, Y.; Akaji, K.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 24 Issue: 2 Pages: 685-690
- DOI
  10.1016/j.bmcl.2013.11.039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450145, KAKENHI-PROJECT-25460160
[Journal Article] Effect of prome-site sequence of retro-inverso-modified HTLV-1 protease inhibitor.2014
- Author(s)
  Awahara, C.; Tatsumi, T.; Furuta, S.; Shinjoh, G.; Konno, H.; Nosaka, K.; Kobayashi, K.; Hattori, Y.; Akaji, K.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 22 Issue: 8 Pages: 2482-2488
- DOI
  10.1016/j.bmc.2014.02.050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450145, KAKENHI-PROJECT-25460160
[Journal Article] Practical synthesis of peptide C-terminal aldehyde on a solid support2013
- Author(s)
  Konno, H.; Sema, Y.; Ishii, M.; Hattori, Y.; Nosaka, K.; Akaji, K.
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 54 Issue: 36 Pages: 4848-4850
- DOI
  10.1016/j.tetlet.2013.06.103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450145, KAKENHI-PROJECT-25460160
[Presentation] SARS-CoV 3CL proteaseを標的としたフタルイミド型阻害剤の合成研究2024
- Author(s)
  佐野陽菜、遠藤龍生、照屋健太、服部恭尚、矢野成和、今野博行
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PROJECT-21K05417
[Presentation] フタルイミド型SARS-CoV 3CL protease阻害剤の構造活性相関研究2023
- Author(s)
  佐野陽菜、及川慧人、遠藤龍生、照屋健太、服部恭尚、赤路健一、矢野成和、今野博行
- Organizer
  日本農芸化学会2023年度大会
- Data Source
  KAKENHI-PROJECT-21K05417
[Presentation] Design, Synthesis and Evaluation of NHPI-based SARS-CoV 3CL Protease Inhibitors2023
- Author(s)
  Ryusei Endo, Hinata Sano, Koki Makabe, Shigekazu Yano, Yasunao Hattori, Kenta Teruya and Hiroyuki Konno
- Organizer
  The 60th Japanese Peptide Symposium Schedule
- Data Source
  KAKENHI-PROJECT-21K05417
[Presentation] 1位を置換したデカヒドロイソキノリンを有する SARS 3CLプロテアーゼ阻害剤の設計と合成研究2022
- Author(s)
  板野一就、西脇侑司、島恭平、岸本翔、大西康司、吉澤慎一郎、小林数也、服部恭尚、赤路建一
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K05417
[Presentation] オキサ-デカリン型SARS 3CLプロテアーゼ阻害剤の設計と合成、阻害活性評価ならびに立体化学2022
- Author(s)
  服部恭尚、吉澤慎一郎、小林数也、赤路健一
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PROJECT-21K05417
[Presentation] N-アミジノピペリジン型BACE1阻害剤の合成2017
- Author(s)
  城寳大輝、小林数也、服部恭尚、赤路健一
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K18902
[Presentation] Evaluation of Hydroxymethylcarbonyl and Hydroxyethylamine Isosteres in a Superior BACE1 Cleavage Sequence for BACE1 Inhibitors2015
- Author(s)
  Kazuya Kobayashi, Yasunao Hattori, Ayaka Deguchi, Yukie Nohara, Tomomi Akiyama, Kenta Teruya, Akira Sanjoh, Atsushi Nakagawa, Eiki Yamashita, Kenichi Akaji
- Organizer
  7th International Peptide Symposium
- Place of Presentation
  Singapore
- Year and Date
  2015-12-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460160
[Presentation] ヒドロキシエチルアミン型BACE1阻害剤の立体選択的合成によるプライムサイト構造活性相関研究2014
- Author(s)
  川崎友紀、松原弘樹、井尻咲、宮城崇滉、出口綾香、小林数也、服部恭尚、赤路健一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25860093
[Presentation] ヒドロキシエチルアミン型BACE1阻害剤の立体選択的合成と活性評価
- Author(s)
  松原弘樹、井尻咲、川崎友紀、宮城崇滉、出口綾香、小林数也、服部恭尚、赤路健一
- Organizer
  第63回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25860093
[Presentation] ヒドロキシエチルアミン型BACE1阻害剤の活性立体配置の同定とプライムサイト構造活性相関研究
- Author(s)
  井尻咲、松原弘樹、川崎友紀、宮城崇滉、出口綾香、小林数也、服部恭尚、赤路健一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25860093

1. AKAJI Kenichi (60142296)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
2. KOBAYASHI Kazuya (80647868)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. Fujigaki Hidetsugu (00612631)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 毛利彰宏 (20597851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 今野博行 (50325247)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. DEGUCHI Ayaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 照屋健太

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Hattori Yasunao 服部 恭尚

hattori Yasunao 服部 恭尚

服部 恭尚 ハットリ ヤスナオ

HATTORI Yasunao 服部 恭尚

Research Projects

Research Products

Co-Researchers

Optimization of SARS 3CL protease inhibitor and development of anti-COVID-19 drugPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel therapeutic agents for schizophrenia based on kynurenine hypothesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel BACE1 inhibitors based on the N-amidino nitrogen-containing ring structure

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel BACE1 inhibitors: Structure activity relationship study based on the substrate sequence

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Design of non-peptide inhibitors based on structure analyses of the protease/inhibitor complex

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Synthesis of a pyrrolidine analog of a tetrahydrofuran containing acetogenin, cis-solamin2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of transition-state mimics in a superior BACE1 cleavage sequence as peptide-mimetic BACE1 inhibitors2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fused-ring structure of decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis and evaluation of inhibitory activity of the curcumin derivatives toward the inhibitor of beta-site amyloid precursor protein cleaving enzyme 1.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of prome-site sequence of retro-inverso-modified HTLV-1 protease inhibitor.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Practical synthesis of peptide C-terminal aldehyde on a solid support2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] SARS-CoV 3CL proteaseを標的としたフタルイミド型阻害剤の合成研究2024

Author(s)

Organizer

Data Source

[Presentation] フタルイミド型SARS-CoV 3CL protease阻害剤の構造活性相関研究2023

Author(s)

Organizer

Data Source

[Presentation] Design, Synthesis and Evaluation of NHPI-based SARS-CoV 3CL Protease Inhibitors2023

Author(s)

Organizer

Data Source

[Presentation] 1位を置換したデカヒドロイソキノリンを有する SARS 3CLプロテアーゼ阻害剤の設計と合成研究2022

Hattori Yasunao 服部恭尚

hattori Yasunao 服部恭尚

服部恭尚ハットリヤスナオ

HATTORI Yasunao 服部恭尚