Abe Megumi 阿部恵

… Alternative Names

ABE Megumi 阿部恵

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Researcher Number	20568688
Other IDs
Affiliation (Current)	2025: 公益財団法人田附興風会, 医学研究所北野病院内分泌・代謝・腎臓研究部, 研究員
Affiliation (based on the past Project Information) *help	2016: 公益財団法人田附興風会, 医学研究所第3研究部, 研究員 2014 – 2015: 京都大学, 生命科学研究科, 助教 2014: 京都大学病院, 臨床研究総合センター, 助教 2012 – 2013: 京都大学, 医学(系)研究科(研究院), 助教 2010 – 2012: 京都大学, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Metabolomics / Endocrinology Except Principal Investigator Endocrinology
Keywords	Principal Investigator PPARγ / PPARganmma / PPARgamma / エネルギー代謝調節 / ピオグリタゾン / 脂肪細胞 / 種差 / 脂肪細胞分化 / 糖代謝 / ラットモデル … More / セイピン / 遺伝子変異ラット / 動物モデル / レプチン / 糖尿病 … More Except Principal Investigator レプチン / セイピン / 脂肪萎縮症 / 高脂肪食 / 慢性炎症 / インスリン抵抗性 / 炎症 / 肥満 / ニューロメジンU / レプチン抵抗性 / 疾患特異的iPS細胞 / ラット / 精子低形成 / 精神発達遅滞 / ラットモデル / 糖尿病 / 脂肪 Less

Elucidation of functional significance of PPAR gamma on energy metabolism using PPAR gamma mutant rats.Principal Investigator
- Principal Investigator
  
  AIZAWA-ABE Megumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  The Tazuke Kofukai
  Kyoto University
The role of neuromedin U in leptin resistance
- Principal Investigator
  
  AOTANI Daisuke
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Endocrinology
- Research Institution
  Kyoto University
Study on the pathophysiological roles of seipin, a generalized lipodystrophy causative gene product
- Principal Investigator
  
  Ebihara Ken
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Endocrinology
- Research Institution
  Jichi Medical University
  Kyoto University
Generation of gene targeted rat models with obesity and lipodystrophy for elucidating the mechanism of leptin actionPrincipal Investigator
- Principal Investigator
  
  ABE Megumi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Kyoto University
Development of new therapies with leptin for the treatment of metabolic syndrome
- Principal Investigator
  
  EBIHARA Ken
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Kyoto University

All 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] Impaired adipogenic capacity in induced pluripotent stem cells from lipodystrophic patients with BSCL2 mutations2016
- Author(s)
  1.E. Mori, J. Fujikura, M. Noguchi, K. Nakao, M. Matsubara, M. Sone, D. Taura, T. Kusakabe, K. Ebihara, T. Tanaka, K. Hosoda, K. Takahashi, I. Asaka, N. Inagaki, K. Nakao
- Journal Title
  
  Metablism
  
  Volume: 65 Issue: 4 Pages: 543-556
- DOI
  10.1016/j.metabol.2015.12.015
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461347, KAKENHI-PROJECT-26461333, KAKENHI-PROJECT-26461380, KAKENHI-PUBLICLY-25126711, KAKENHI-PROJECT-26860557, KAKENHI-PROJECT-24390237, KAKENHI-PROJECT-25293211, KAKENHI-PROJECT-16K15495, KAKENHI-PROJECT-26461330
[Journal Article] Fat Mass Reduction With Adipocyte Hypertrophy and Insulin Resistance in Heterozygous PPARγ Mutant Rats.2016
- Author(s)
  Gumbilai V, Ebihara K, Aizawa-Abe M, Ebihara C, Zhao M, Yamamoto Y, Mashimo T, Hosoda K, Serikawa T, Nakao K.
- Journal Title
  
  Diabetes
  
  Volume: 65(10) Issue: 10 Pages: 2954-65
- DOI
  10.2337/db15-1422
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26290033, KAKENHI-PROJECT-26461335
[Journal Article] Leptin improves fatty liver independently of insulin sensitization and appetite suppression in hepatocyte-specific Pten-deficient mice with insulin hypersensitivity.2015
- Author(s)
  Yamamoto-Kataoka S, Ebihara K, Aizawa-Abe M, Nishio M, Kusakabe T, Yamamoto Y, Aotani D, Sakai T, Zhao M, Ebihara C, Gumbilai VM, Hosoda K, Suzuki A, Nakao K
- Journal Title
  
  Horm Metab Res
  
  Volume: 47 Issue: 03 Pages: 168-175
- DOI
  10.1055/s-0034-1395531
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390237, KAKENHI-PUBLICLY-25126719, KAKENHI-PLANNED-26114005, KAKENHI-PROJECT-26640081, KAKENHI-PROJECT-26670458, KAKENHI-PROJECT-24240120
[Journal Article] ・Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis.2015
- Author(s)
  Ebihara C, Ebihara K, Aizawa-Abe M, Mashimo T, Tomita T, Zhao M, Gumbilai VM, Kusakabe T, Yamamoto Y, Aotani D, Yamamoto-Kataoka S, Sakai T, Hosoda K, Serikawa T, Nakao K
- Journal Title
  
  Hum Mol Genet
  
  Volume: 24 Issue: 15 Pages: 4238-4249
- DOI
  10.1093/hmg/ddv156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461333, KAKENHI-PROJECT-24390237, KAKENHI-PROJECT-26290033
[Journal Article] Leptin restores the insulinotropic effect of exenatide in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and high-fat diet2014
- Author(s)
  T. Sakai, T. Kusakabe, K. Ebihara, D. Aotani, S. Yamamoto-Kataoka, Z. Mingming, VM. Gumbilai, C. Ebihara, M. Aizawa-Abe, Y. Yamamoto, M. Noguchi, J. Fujikura, K. Hosoda, N. Inagaki, K. Nakao
- Journal Title
  
  Am J Physiol Endocrinol Metab.
  
  Volume: 307 Issue: 8 Pages: 712-719
- DOI
  10.1152/ajpendo.00272.2014
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22126012, KAKENHI-PROJECT-24390237, KAKENHI-PUBLICLY-25126711, KAKENHI-PROJECT-25461347, KAKENHI-PROJECT-26461330, KAKENHI-PROJECT-26670458
[Journal Article] In vitro characterization and engraftment of adipocytes derived from human induced pluripotent stem cells and embryonic stem cells.2013
- Author(s)
  M. Noguchi, K. Hosoda, E. Mori, M. Nakane, K. Nakao, D. Taura, Y. Yamamoto, T. Kusakabe, M. Sone, H. Sakurai, J. Fujikura, K. Ebihara, K. Nakao
- Journal Title
  
  Stem Cells and Development
  
  Volume: 22(21) Issue: 21 Pages: 2895-2905
- DOI
  10.1089/scd.2013.0113
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21229013, KAKENHI-PLANNED-22126012, KAKENHI-PUBLICLY-23126513, KAKENHI-PROJECT-23591305, KAKENHI-PROJECT-24390237, KAKENHI-PROJECT-25293211, KAKENHI-PROJECT-25461347
[Journal Article] Intracerebroventricular administration of C-type natriuretic peptide suppresses food intake via activation of the melanocortin system in mice.2013
- Author(s)
  N. Yamada-Goto, G. Katsuura, K. Ebihara, M. Inuzuka, Y. Ochi, Y. Yamashita, T. Kusakabe, A. Yasoda, N. Asahara-Satoh, H. Ariyasu, K. Hosoda, K. Nakao.
- Journal Title
  
  Diabetes
  
  Volume: 62(5) Issue: 5 Pages: 1500-1504
- DOI
  10.2337/db12-0718
- NAID
  120005244943
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229013, KAKENHI-PLANNED-22126012, KAKENHI-PROJECT-23659476, KAKENHI-PROJECT-23791054, KAKENHI-PROJECT-24390237, KAKENHI-PROJECT-24590719, KAKENHI-PROJECT-24591326, KAKENHI-PROJECT-24790943, KAKENHI-PUBLICLY-23126514
[Journal Article] Early Changes of Abdominal Adiposity Detected with Weekly Dual Bioelectrical Impedance Analysis During Calorie Restriction.2013
- Author(s)
  M. Ida, M. Hirata, S. Odori, E. Mori, E. Kondo, J. Fujikura, T. Kusakabe, K. Ebihara, K. Hosoda, K. Nakao.
- Journal Title
  
  Obesity
  
  Volume: 21(9) Issue: 9
- DOI
  10.1002/oby.20300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229013, KAKENHI-PLANNED-22126012, KAKENHI-PROJECT-24390237
[Journal Article] Generation of leptin-deficient Lepmkyo/Lepmkyo rats and identification of leptin-responsive genes in the liver.2013
- Author(s)
  M. Aizawa-Abe, K. Ebihara, C. Ebihara, T. Mashimo, A. Takizawa, T. Tomita, T. Kusakabe, Y. Yamamoto, D. Aotani, S. Yamamoto-Kataoka, T. Sakai, K. Hosoda, T. Serikawa, K. Nakao
- Journal Title
  
  Physiol Genomics.
  
  Volume: 45(17) Issue: 17 Pages: 786-793
- DOI
  10.1152/physiolgenomics.00040.2013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21229013, KAKENHI-PLANNED-22126012, KAKENHI-PROJECT-24390237
[Journal Article] Intracerebroventricular administration of C-type natriuretic peptide suppresses food intake via activation of the melanocortin system in mice.2012
- Author(s)
  N. Yamada-Goto, G. Katsuura, K. Ebihara, M. Inuzuka, Y. Ochi, Y. Yamashita, T. Kusakabe, A. Yasoda, N. Asahara- Satoh, H. Ariyasu, K. Hosoda. K. Nakao
- Journal Title
  
  J Neuroendocrinol
  
  Volume: (掲載決定)
- NAID
  120005244943
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390237
[Journal Article] Functional Magnetic Resonance Imaging Analysis of Food-Related Brain Activity in Patients with Lipodystrophy Undergoing Leptin Replacement Therapy2012
- Author(s)
  Aotani D, Nakao K, et al
- Journal Title
  
  J Clin Endocrinol Metab.
  
  Volume: 97 Issue: 10 Pages: 3663-3671
- DOI
  10.1210/jc.2012-1872
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229013, KAKENHI-PLANNED-22126012, KAKENHI-PROJECT-22220003, KAKENHI-PROJECT-22591010, KAKENHI-PROJECT-23591274, KAKENHI-PROJECT-23659476, KAKENHI-PROJECT-23791054, KAKENHI-PROJECT-24390237, KAKENHI-PROJECT-24659444, KAKENHI-PUBLICLY-23126514
[Journal Article] Impairment of fear-conditioning responses and changes of brain neurotrophic factors in diet-induced obese mice2012
- Author(s)
  N.Yamada-Goto, K.Ebihara, K.Hosoda, K.Nakao, et al
- Journal Title
  
  J Neuroendocrinol
  
  Volume: (in press) Issue: 8 Pages: 1120-1125
- DOI
  10.1111/j.1365-2826.2012.02327.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229013, KAKENHI-PLANNED-22126012, KAKENHI-PROJECT-23659476, KAKENHI-PROJECT-23791054, KAKENHI-PROJECT-24390237, KAKENHI-PROJECT-24591326, KAKENHI-PROJECT-24790943, KAKENHI-PUBLICLY-23126514
[Journal Article] Amylin improves the effect of leptin on insulin sensitivity in leptin-resistant diet-induced obese mice2012
- Author(s)
  T.Kusakabe, K.Ebihara, K.Nakao, et al
- Journal Title
  
  Am J Physiol Endocrinol Metab
  
  Volume: 302 Issue: 8 Pages: E924-E931
- DOI
  10.1152/ajpendo.00198.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229013, KAKENHI-PROJECT-21591175, KAKENHI-PLANNED-22126012, KAKENHI-PROJECT-22591010, KAKENHI-PROJECT-23659476, KAKENHI-PROJECT-23791054, KAKENHI-PROJECT-24390237, KAKENHI-PUBLICLY-23126514
[Journal Article] GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function2012
- Author(s)
  Odori S, Nakao K, et al
- Journal Title
  
  Metabolism
  
  Volume: 62 Issue: 1 Pages: 70-78
- DOI
  10.1016/j.metabol.2012.06.010
- NAID
  120005242664
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229013, KAKENHI-PLANNED-22126012, KAKENHI-PROJECT-23791030, KAKENHI-PROJECT-24390237, KAKENHI-PROJECT-24659444
[Journal Article] Leptin activates hepatic 5’ AMP-Activated Protein Kinase through sympathetic nervous system and α1 adrenergic receptor: A potential mechanism for improvement of fatt Li Yver in lipodystrophy by leptin2012
- Author(s)
  Miyamoto L, Nakao K, et al
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287 Issue: 48 Pages: 40441-40447
- DOI
  10.1074/jbc.m112.384545
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229013, KAKENHI-PLANNED-22126012, KAKENHI-PROJECT-22591010, KAKENHI-PROJECT-23617009, KAKENHI-PROJECT-23659476, KAKENHI-PROJECT-23791054, KAKENHI-PROJECT-24390237, KAKENHI-PROJECT-24659444, KAKENHI-PUBLICLY-23126514
[Journal Article] Premature Atherosclerosis in a Japanese Diabetic Patient with Atypical Familial Partial Lipodystrophy and Hypertriglyceridemia2012
- Author(s)
  M. Iwanishi
- Journal Title
  
  Intern. Med.
  
  Volume: 51 Issue: 18 Pages: 2573-2579
- DOI
  10.2169/internalmedicine.51.7461
- NAID
  130002062378
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659476, KAKENHI-PROJECT-23791054, KAKENHI-PROJECT-24390237, KAKENHI-PUBLICLY-23126514
[Journal Article] Beneficial effects of leptin on glycaemic and lipid control in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and a high-fat diet2009
- Author(s)
  T. Kusakabe, K. Ebihara(12人中3番目)
- Journal Title
  
  Diabetologia
  
  Volume: 52 Issue: 4 Pages: 675-683
- DOI
  10.1007/s00125-009-1258-2
- ISSN
  0012-186X, 1432-0428
- Year and Date
  2009-01-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591175
[Journal Article] Beneficial effects of leptin on glycaemic and lipid control in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and a high-fat diet.2009
- Author(s)
  Kusakabe T, Ebihara K, et al.
- Journal Title
  
  Diabetologia 52
  
  Pages: 675-683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591175
[Presentation] PPARγ遺伝子ヘテロ変異ラットの作成と解析2016
- Author(s)
  阿部恵、Valentino Gumbilai、海老原健、海老原千尋、趙明明、山本祐二、細田公則、稲垣暢也、真下知士、芹川忠夫、中尾一和
- Organizer
  第37回日本肥満学会
- Place of Presentation
  東京ファッションタウン(東京都江東区）
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-26461335
[Presentation] Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis2015
- Author(s)
  Ebihara C, Ebihara K, Aizawa-Abe M, Yamamoto Y, Yamamoto-Kataoka S, Zhao M, Gumbilai V, Hosoda K, Serikawa T, Nakao K
- Organizer
  Obesity Week 2015 / TOS Annual Meeting & ASMBS Annual Meeting
- Place of Presentation
  米国、ロサンゼルス
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] セイピン欠損（SKO）ラットを用いた先天性全身性脂肪萎縮症原因遺伝子セイピンの生理的意義の解明2015
- Author(s)
  海老原千尋、海老原　健、阿部　恵、真下知士、細田公則、芹川忠夫、中尾一和
- Organizer
  第29回日本糖尿病・肥満動物学会
- Place of Presentation
  京都市、京都大学医学部創立百周年記念施設「芝蘭会館」
- Year and Date
  2015-02-13
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] セイピン欠損（SKO）ラットを用いた先天性全身性脂肪萎縮症原因遺伝子セイピンの生理的意義の解明2015
- Author(s)
  海老原千尋、海老原　健、阿部　恵、真下知士、細田公則、芹川忠夫、中尾一和
- Organizer
  第88回日本内分泌学会学術総会
- Place of Presentation
  東京、ホテルニューオータニ
- Year and Date
  2015-04-27
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] Pathophysiological role of Bscl2/Seipin haploinsufficiency in adiposity and metabolism2015
- Author(s)
  Chihiro Ebihara, Ken Ebihara, Megumi Aizawa-Abe, Mingming Zhao, Valentino Gumbilai, Yuji Yamamoto, Kiminori Hosoda, Kazuwa Nakao
- Organizer
  The Endocrine Sosiety’s 97th Annual Meeting
- Place of Presentation
  米国、サンディエゴ
- Year and Date
  2015-03-07
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis2015
- Author(s)
  Ebihara C, Ebihara K, Aizawa-Abe M, Yamamoto Y, Yamamoto-Kataoka S, Zhao M, Gumbilai V, Hosoda K, Serikawa T, Nakao K
- Organizer
  Keystone Symposia: Diabetes
- Place of Presentation
  日本、京都
- Year and Date
  2015-10-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis2015
- Author(s)
  Ebihara C, Ebihara K, Aizawa-Abe M, Mashimo T, Tomita T, Zhao M, Gumbilai V, Kusakabe T, Yamamoto Y, Aotani D, Yamamoto-Kataoka S, Sakai T, Hosoda K, Serikawa T, Nakao K
- Organizer
  22nd European Congress on Obesity
- Place of Presentation
  チェコ共和国、プラハ
- Year and Date
  2015-05-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] 疾患モデルラットを用いた脂肪細胞関連遺伝子の病態生理的意義の解明2014
- Author(s)
  海老原　健、阿部　恵、細田公則、中尾一和
- Organizer
  第37回日本高血圧学会総会
- Place of Presentation
  横浜市、パシフィコ横浜
- Year and Date
  2014-10-18
- Invited
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] Improvement effect of thiazolidine on fatty liver and type 2 diabetes requires adipose tissue: An evidence from the comparison between mice and rats2014
- Author(s)
  Chihiro Ebihara, Ken Ebihara, Megumi Aizawa-Abe, Yuji Yamamoto, Sachiko Yamamoto-Kataoka, Mingming Zhao, Valentino Gumbilai, Kiminori Hosoda, Kazuwa Nakao
- Organizer
  The Endocrine Sosiety’s 96th Annual Meeting
- Place of Presentation
  米国、シカゴ
- Year and Date
  2014-06-22
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] 脂肪細胞由来ホルモン、レプチンのトランスレーショナルリサーチ2014
- Author(s)
  海老原　健、阿部　恵、細田公則、中尾一和
- Organizer
  第32回内分泌代謝学サマーセミナー
- Place of Presentation
  山梨県、河口湖富士レークホテル
- Year and Date
  2014-07-10
- Invited
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] Translational Research of Leptin for Lipodystrophy in Japan2014
- Author(s)
  Ken Ebihara, Megumi Aizawa-Abe, Kiminori Hosoda, Toru Kusakabe, Daisuke Aotani, Kazuwa Nakao
- Organizer
  Lipodystrophy in 2014: Leptin and Beyond
- Place of Presentation
  米国、アナーバー
- Year and Date
  2014-10-18
- Invited
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] 脂肪萎縮症におけるレプチンの黒色表皮腫改善効果2013
- Author(s)
  日下部徹、海老原健、髭　秀樹、阿部　恵、青谷大介、片岡祥子、酒井　建、海老原千尋、藤倉純二、細田公則、中尾一和
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本市、ホテル日航熊本他
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] The human lipodystrophy gene product, seipin plays physiological roles beyond the adipose tissue2013
- Author(s)
  Ken Ebihara, Megumi Aizawa-Abe, Tshutomu Tomita, Toru Kusakabe, Yuji Yamamoto, Daisuke Aotani, Sachiko Yamamoto-Kataoka, Takeru Sakai, Valentino Milton Gumbilai, Mingming Zhao, Kiminori Hosoda and Kazuwa Nakao.
- Organizer
  The Endocrine Society’s 95th Annual Meeting & Expo
- Place of Presentation
  アメリカ、サンフランシスコ
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] レプチンによる脂肪肝改善メカニズムの解明-肝特異的Pten欠損マウスを用いた検討-2013
- Author(s)
  片岡祥子、海老原健、阿部　恵、日下部徹、山本祐二、青谷大介、酒井　建、海老原千尋、細田公則、中尾一和
- Organizer
  第86回日本内分泌学会学術総会
- Place of Presentation
  仙台市、仙台国際センター
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] レプチン欠損Lepmkyo/Lepmkyoラットを用いた肝臓におけるレプチン感受性遺伝子の同定2013
- Author(s)
  阿部　恵、海老原健、海老原千尋、日下部徹、青谷大介、酒井　建、片岡祥子、趙　明明、バレンチノ　ガンブリアイ、山本祐二、細田公則、中尾一和
- Organizer
  第34回日本肥満学会
- Place of Presentation
  東京都、東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] 先天性全身性脂肪萎縮症６歳児症例におけるレプチン補充療法の有用性2013
- Author(s)
  海老原千尋、海老原健、阿部　恵、日下部徹、青谷大介、片岡祥子、酒井　建、趙　明明、Gumbilai Valentino、細田公則、中尾一和
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本市、ホテル日航熊本他
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] Impact of successful leptin replacement therapy in Japan on adult and child, systemic and partial lipodystrophy.2013
- Author(s)
  Kazuwa Nakao, Kiminori Hosoda, Ken Ebihara, Toru Kusakabe, Megumi Aizawa-Abe, Daisuke Aotani.
- Organizer
  The 2013 Obesity Week
- Place of Presentation
  アメリカ、アトランタ
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] レプチンによる膵臓内脂肪蓄積の減少とインクレチン作用の増強2013
- Author(s)
  酒井　建、日下部徹、海老原健、青谷大介、片岡祥子、趙　明明、Milton Valentino、海老原千尋、阿部　恵、藤倉純二、山本祐二、細田公則、中尾一和
- Organizer
  第34回日本肥満学会
- Place of Presentation
  東京都、東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] The role of neuromedin U in glucose homeostasis.2013
- Author(s)
  Daisuke Aotani, Ken Ebihara, Toru Kusakabe, Megumi Aizawa-Abe, Sachiko Kataoka, Takeru Sakai, Chihiro Ebihara, Kiminori Hosoda, Kazuwa Nakao.
- Organizer
  The 2013 Obesity Week
- Place of Presentation
  アメリカ、アトランタ
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] 新規モデルラットを用いたチアゾリジン誘導体（TZD）の脂肪肝改善メカニズムの解明2013
- Author(s)
  海老原千尋、海老原健、阿部　恵、日下部徹、青谷大介、片岡祥子、酒井　建、趙　明明、Valentino Gumbilai、細田公則、中尾一和
- Organizer
  第86回日本内分泌学会学術総会
- Place of Presentation
  仙台市、仙台国際センター
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] ニューロメジンＵのインスリン抵抗性における意義2013
- Author(s)
  青谷大介、海老原健、日下部徹、阿部　恵、片岡祥子、酒井　建、海老原千尋、藤倉純二、細田公則、中尾一和
- Organizer
  第34回日本肥満学会
- Place of Presentation
  東京都、東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] 部分性脂肪萎縮症に対するレプチン補充療法の有用性2013
- Author(s)
  青谷大介、海老原健、日下部徹、阿部　恵、片岡祥子、酒井　建、海老原千尋、藤倉純二、細田公則、中尾一和
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本市、ホテル日航熊本他
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] 肥満2型糖尿病治療におけるレプチン/GLP-1受容体作動薬共投与の有用性2013
- Author(s)
  酒井　建、日下部徹、海老原健、青谷大介、片岡祥子、海老原千尋、阿部　恵、山本祐二、藤倉純二、細田公則、中尾一和
- Organizer
  第86回日本内分泌学会学術総会
- Place of Presentation
  仙台市、仙台国際センター
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] Development of leptindeficient Lep^<mkyo>/Lep^<mkyo> rat-evidence for its superiority over Lep^<ob>/Lep^<ob> mouse as a model for human obesity2012
- Author(s)
  阿部恵
- Organizer
  15thInternational & 14thEuropean Congress of Endocrinology
- Place of Presentation
  フィレンツェ(イタリア)
- Data Source
  KAKENHI-PROJECT-22591010
[Presentation] 遺伝子改変ラットを用いたチアゾリジンの脂肪肝に対する効果の種族差の検討2012
- Author(s)
  阿部恵、海老原健、海老原千尋、口下部徹、青谷大介、片岡祥子、酒井建、趙明明、Valentino MJ Gumbilai , 細田公則、芹川忠夫、中尾一和
- Organizer
  第85回日本内分泌学会学術総会
- Place of Presentation
  名古屋市、名古屋国際会議場
- Year and Date
  2012-04-19
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] Development of Leptin Deficient Rats-Evidence of Superiority Over Lepob/Lepob Mice as a Model For Human Obesity2012
- Author(s)
  M. Aizawa-Abe
- Organizer
  19th European Congress on Obesity
- Place of Presentation
  Lyon, Frarnce
- Data Source
  KAKENHI-PROJECT-22591010
[Presentation] Development of Leptin Deficient Rats-Evidence of Superiority Over Lepob/Lepob Mice as a Model For Human Obesity.2012
- Author(s)
  M. Aizawa-Abe, K. Ebihara, C. Ebihara, T. Kusakabe, T. Serikawa, D. Aotani, V.M.J. Gumbili, T. Mashimo, K. Nakao
- Organizer
  19th European Congress on Obesity
- Place of Presentation
  Lyon(Frarnce)
- Year and Date
  2012-05-10
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] 遺伝子改変ラットを用いたチアゾリジンの脂肪肝に対する効果の種族差の検討2012
- Author(s)
  阿部　恵
- Organizer
  第85回日本内分泌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22591010
[Presentation] Development of Leptin Deficient Rats-Evidence of Superiority Over Lepob/Lepob Mice as a Model For Human Obesity2012
- Author(s)
  阿部恵
- Organizer
  19th European Congress on Obesity
- Place of Presentation
  リヨン(フランス)
- Data Source
  KAKENHI-PROJECT-22591010
[Presentation] レプチンを用いた非アルコール性脂肪肝治療の可能性に関する検討2012
- Author(s)
  片岡祥子、海老原健、阿部恵、日下部徹、青谷大介、酒井建、藤倉純二、細田公則、中尾一和
- Organizer
  第109回日本内科学会総会
- Place of Presentation
  京都市、みやこめっせ
- Year and Date
  2012-04-14
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] レプチン、アミリン共投与による糖脂質代謝改善に関する検討2012
- Author(s)
  日下部徹、海老原健、酒井建、青谷大介、片岡祥子、海老原千尋、趙明明、Milton Valentino、阿部恵、藤倉純二、細田公則、中尾一和
- Organizer
  第85回日本内分泌学会学術総会
- Place of Presentation
  名古屋市、名古屋国際会議場
- Year and Date
  2012-04-19
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] Dual Bioimpedanc 法を用いた内臓脂肪量測定装置のスクリーニング機器としての有用性2012
- Author(s)
  阿部恵
- Organizer
  第85回日本内分泌学会学術総会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-22591010
[Presentation] fMR Iを用いた、脂肪萎縮症の食欲異常およびレプチン治療による効果の検討2012
- Author(s)
  青谷大介、海老原健、澤本伸克、日下部徹、阿部恵、片岡祥子、酒井建、細田公則、福山秀直、中尾一和
- Organizer
  第109回日本内科学会総会
- Place of Presentation
  京都市、みやこめっせ
- Year and Date
  2012-04-14
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] 肥満2型糖尿病に対するレプチン、アミリン共投与の有用性に関する検討2012
- Author(s)
  日下部徹、海老原健、酒井建、青谷大介、片岡祥子、海老原千尋、阿部恵、,藤倉純二、細田公則、中尾一和
- Organizer
  第109回日本内科学会総会
- Place of Presentation
  京都市、みやこめっせ
- Year and Date
  2012-04-14
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] レプチン/GLP-1受容体作動薬共投与による肥満2型糖尿病治療の有用性2012
- Author(s)
  酒井建、日下部徹、海老原健、青谷大介、片岡祥子、海老原千尋、山本祐二、阿部恵、藤倉純二、細田公則、中尾一和
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  横浜市、パシフィコ横浜
- Year and Date
  2012-05-17
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] Leptin Modulates brain activity associated with feeding behavior in patients with Lipodystrophy.2012
- Author(s)
  D. Aotani, K. Ebihara, N. Sawamoto, T. Kusakabe, M. Aizawa-Abe, S. Kataoka, T. Sakai, C. Ebihara, J. Fujikura, K. Hosoda, H. Fukuyama & K. Nakao.
- Organizer
  19th European Congress on Obesity
- Place of Presentation
  Lyon(Frarnce)
- Year and Date
  2012-05-10
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] 脂肪萎縮症原因遺伝子scipinの生体における意義に関する検討2012
- Author(s)
  海老原千尋、阿部恵、海老原健、Valentino Milton Gumbilai、日下部徹、青谷大介、酒井建、趙明明、山本祐二、細田公則、中尾一和
- Organizer
  第33回日本肥満学会
- Place of Presentation
  京都市、ホテルグランヴィア京都
- Year and Date
  2012-10-12
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] 肥満症治療におけるレプチンの可能性2012
- Author(s)
  海老原健、阿部恵、日下部徹、青谷大介、細田公則、中尾一和
- Organizer
  第33回日本肥満学会
- Place of Presentation
  京都市、ホテルグランヴィア京都
- Year and Date
  2012-10-12
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] Leptin Modulates brain activity associated with feeding behavior in patients with Lipodystrophy.2012
- Author(s)
  D. Aotani, K. Ebihara, N. Sawamoto, T. Kusakabe, M. Aizawa-Abe, S. Kataoka, T. Sakai, C. Ebihara, J. Fujikura, K. Hosoda, H. Fukuyama & K. Nakao.
- Organizer
  15th International & 14th European Congress of Endocrinology
- Place of Presentation
  Florence(Italy)
- Year and Date
  2012-05-05
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] Development of leptin deficient Lepmkyo/ Lepmkyo rat-evidence for its superiority over Lepob/ Lepob mouse as a model for human obesity.2012
- Author(s)
  M. Aizawa-Abe, K. Ebihara, C. Ebihara, T. Kusakabe, D. Aotani, V. Gumbili, T. Mashirao, T. Serikawa & K. Nakao
- Organizer
  15th International & 14th European Congress of Endocrinology
- Place of Presentation
  Florence(Italy)
- Year and Date
  2012-05-05
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] レプチン/GLP-1受容体作動薬共投与による肥満2型糖尿病治療の有用性2012
- Author(s)
  酒井建、日下部徹、海老原健、青谷大介、片岡祥子、海老原千尋、阿部恵、藤倉純二、山本祐二、細田公則、中尾一和
- Organizer
  第33回日本肥満学会
- Place of Presentation
  京都市、ホテルグランヴィア京都
- Year and Date
  2012-10-12
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] Development of leptin deficient Lepmkyo/ Lepmkyo　rat-evidence for its superiority over Lepob/ Lepob mouse as a model for human obesity2012
- Author(s)
  M. Aizawa-Abe
- Organizer
  15th International & 14th European Congress of Endocrinology
- Place of Presentation
  Florence, Italy
- Data Source
  KAKENHI-PROJECT-22591010
[Presentation] Benefical Effects of Combination Therapy With Lept in and Exenatide in a Mouse Model of Type2 Diabetes With Increased Adiposity2012
- Author(s)
  Takeru Sakai, Toru Kusakabe, Ken Ebihara, Daisuke Aotani, Sachiko Kataoka, Chihiro Ebihara, Yuj i Yamamoto, Megumi Abe, Junji Fujikura, Kiminori Hosoda, Kazuwa Nakao
- Organizer
  2nd scientific sessions American Diabetes Associatic
- Place of Presentation
  Philadelphia(University)
- Year and Date
  2012-06-10
- Data Source
  KAKENHI-PROJECT-24390237
[Presentation] 糖脂質代謝におけるレプチンの病態生理的意義に関する種族差の検討-レプチン欠損 ob/ob ラットの開発と解析-2011
- Author(s)
  阿部恵
- Organizer
  第84回日本内分泌学会学術総会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-22591010
[Presentation] レプチン欠損ob/obラットの開発と糖脂質代謝解析2011
- Author(s)
  阿部恵
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌市教育文化会館
- Data Source
  KAKENHI-PROJECT-22591010
[Presentation] 糖脂質代謝におけるレプチンの病態生理的意義に関する種族差の検討-レプチン欠損ob/obラットの開発と解析-2011
- Author(s)
  阿部恵
- Organizer
  第84回日本内分泌学会学術総会
- Place of Presentation
  兵庫県神戸市神戸国際展示場
- Data Source
  KAKENHI-PROJECT-22591010
[Presentation] レプチン欠損 ob/ob ラットの開発と糖脂質代謝解析2011
- Author(s)
  阿部恵
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-22591010
[Presentation] Generation of a genetically obese leptin deficient rat.2010
- Author(s)
  阿部恵
- Organizer
  第70回米国糖尿病学会
- Place of Presentation
  アメリカ合衆国、フロリダ州オーランドOrange Country Convention Center
- Data Source
  KAKENHI-PROJECT-22591010
[Presentation] Generation of a genetically obese leptin deficient rat2010
- Author(s)
  阿部恵
- Organizer
  70ndscientific sessions American Diabetes Association
- Place of Presentation
  オーランド(アメリカ)
- Data Source
  KAKENHI-PROJECT-22591010
[Presentation] Investigation of physiological role of leptin in obesity induced hypertension using a new rat model.2010
- Author(s)
  阿部恵
- Organizer
  第33回日本高血圧学会総会
- Place of Presentation
  福岡県福岡市福岡国際会議場
- Data Source
  KAKENHI-PROJECT-22591010
[Presentation] 新規遺伝子変異動物作成技術を用いたレプチン遺伝子変異ラットの開発2010
- Author(s)
  阿部恵
- Organizer
  第31回日本肥満学会
- Place of Presentation
  群馬県前橋市煥乎堂前橋本店
- Data Source
  KAKENHI-PROJECT-22591010
[Presentation] Investigation of physiological role of leptin in obesity induced hypertension using a new rat model2010
- Author(s)
  阿部恵
- Organizer
  第33回日本高血圧学会総会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-22591010
[Presentation] Generation of a genetically obese leptin deficient rat2010
- Author(s)
  阿部恵
- Organizer
  11thInternational Congress on Obesity
- Place of Presentation
  ストックホルム(スウェーデン)
- Data Source
  KAKENHI-PROJECT-22591010
[Presentation] A case of cholangiocarcinoma in congenital generalized lipodystrophy2010
- Author(s)
  Megumi Aizawa-Abe
- Organizer
  14th International Congress of Endocrinology
- Place of Presentation
  Kyoto(Japan)
- Data Source
  KAKENHI-PROJECT-21591175
[Presentation] Generation of a genetically obese leptin deficient rat.2010
- Author(s)
  阿部恵
- Organizer
  第11回国際肥満学会
- Place of Presentation
  スウェーデン、ストックホルムInternational Fairs & Congress Center
- Data Source
  KAKENHI-PROJECT-22591010
[Presentation] A case of cholangiocarcinoma in congenital generalized lipodystrophy.2010
- Author(s)
  Megtmi Aizawa-Abe, Ken Ebihara, et al.
- Organizer
  14^<th> International Congress of Endocrinology
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-21591175
[Presentation] 新規遺伝子変異動物作成技術を用いたレプチン遺伝子変異ラットの開発2010
- Author(s)
  阿部恵
- Organizer
  第31回日本肥満学会
- Place of Presentation
  前橋市
- Data Source
  KAKENHI-PROJECT-22591010
[Presentation] Amyl in potentiates the leptin-induced enhancement of glucose and lipid metabolism in diet-induced obese mice2010
- Author(s)
  Toru Kusakabe
- Organizer
  14th International Congress of Endocrinology
- Place of Presentation
  Kyoto(Japan)
- Data Source
  KAKENHI-PROJECT-21591175
[Presentation] Gene analysis of congenital generalized lipodystrophy in Japan.2010
- Author(s)
  Toru Kusakabe, Ken Ebihara, et al.
- Organizer
  14^<th> International Congress of Endocrinology
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-21591175
[Presentation] Beneficial effects of leptin on glycemic and lipid control in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and a high-fat diet.2009
- Author(s)
  Toru Kusakabe, Ken Ebihara, et al
- Organizer
  The Endocrine Society 91^<th> Annual Meeting
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-21591175
[Presentation] Beneficial effects of leptin on glycemic and lipid control in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and a high-fat diet2009
- Author(s)
  Toru Kusakabe
- Organizer
  The Endocrine Society 91th Annual Meeting
- Place of Presentation
  Washington DC(USA)
- Data Source
  KAKENHI-PROJECT-21591175
[Presentation] The human lipodystrophy gene product, seipin plays physiological roles in the brain development and spermatogenesis in addition to the adipogenesis Translational Research of Leptin for Lipodystrophy in Japan
- Author(s)
  Chihiro Ebihara, Ken Ebihara, Megumi Aizawa-Abe, Tomoji Mashimo, Tsutomu Tomita, Mingming Zhao, Valentino Gumbilai, Yuji Yamamoto, Sachiko Yamamoto-Kataoka, Kiminori Hosoda, Tadao Serikawa, Kazuwa Nakao
- Organizer
  Lipodystrophy in 2014: Leptin and Beyond
- Place of Presentation
  米国、アナーバー
- Year and Date
  2014-10-17 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24390237

1. EBIHARA Ken (70362514)

# of Collaborated Projects: 5 results

# of Collaborated Products: 52 results
2. KUSAKABE Toru (60452356)

# of Collaborated Projects: 3 results

# of Collaborated Products: 36 results
3. AOTANI Daisuke (80600494)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KATAOKA Sachiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SAKAI Takeru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. EBIHARA Chihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SONE Masakatsu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. YASODA Akihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 中尾一和

# of Collaborated Projects: 0 results

# of Collaborated Products: 9 results
10. 細田公則

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
11. 森潔

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 高橋和利

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 野口倫生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 真下知士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Abe Megumi 阿部 恵

ABE Megumi 阿部 恵

Research Projects

Research Products

Co-Researchers

Elucidation of functional significance of PPAR gamma on energy metabolism using PPAR gamma mutant rats.Principal Investigator

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The role of neuromedin U in leptin resistance

Principal Investigator

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Study on the pathophysiological roles of seipin, a generalized lipodystrophy causative gene product

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Generation of gene targeted rat models with obesity and lipodystrophy for elucidating the mechanism of leptin actionPrincipal Investigator

Principal Investigator

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Development of new therapies with leptin for the treatment of metabolic syndrome

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[Journal Article] Impaired adipogenic capacity in induced pluripotent stem cells from lipodystrophic patients with BSCL2 mutations2016

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[Journal Article] Fat Mass Reduction With Adipocyte Hypertrophy and Insulin Resistance in Heterozygous PPARγ Mutant Rats.2016

Author(s)

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[Journal Article] Leptin improves fatty liver independently of insulin sensitization and appetite suppression in hepatocyte-specific Pten-deficient mice with insulin hypersensitivity.2015

Author(s)

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[Journal Article] ・Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis.2015

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[Journal Article] Leptin restores the insulinotropic effect of exenatide in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and high-fat diet2014

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[Journal Article] In vitro characterization and engraftment of adipocytes derived from human induced pluripotent stem cells and embryonic stem cells.2013

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[Journal Article] Intracerebroventricular administration of C-type natriuretic peptide suppresses food intake via activation of the melanocortin system in mice.2013

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NAID

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[Journal Article] Early Changes of Abdominal Adiposity Detected with Weekly Dual Bioelectrical Impedance Analysis During Calorie Restriction.2013

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[Journal Article] Generation of leptin-deficient Lepmkyo/Lepmkyo rats and identification of leptin-responsive genes in the liver.2013

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Abe Megumi 阿部恵

ABE Megumi 阿部恵