Matsunaga Kohichi 松永耕一

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MATSUNAGA Kohichi 松永耕一

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Researcher Number	20570162
Other IDs
Affiliation (Current)	2025: 群馬大学, 生体調節研究所, 助教
Affiliation (based on the past Project Information) *help	2025: 群馬大学, 生体調節研究所, 助教 2023: 群馬大学, 生体調節研究所, 助教 2011 – 2021: 群馬大学, 生体調節研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Pathological medical chemistry / General medical chemistry Except Principal Investigator Basic Section 49030:Experimental pathology-related / Pathological medical chemistry
Keywords	Principal Investigator Rab27 / インスリン分泌 / 調節性分泌 / β細胞 / Exophilin / インスリン / Rab27a / 皮膚細胞 / 細胞接着 / Exophilin-5 … More / 表皮水疱症 / 化合物ライブラリ / ケミカルバイオロジー / メンブレントラフィック / Rab GTPase / 膵β細胞 / オートファジー / insulin / 国際情報交流 / インスリン顆粒 … More Except Principal Investigator ヘミデスモソーム / 表皮損傷 / タンパク質複合体 / インテグリン / Rab27 / 細胞移動 / 表皮水疱症 / Rabタンパク質 / 細胞内膜輸送 / 細胞接着 / 表皮細胞 / ケミカルライブラリ / β細胞 / insulin / インスリン分泌 / ベータ細胞 / ケミカルバイオロジー / 糖尿病 / インスリン Less

新規細胞質ATP濃度促進化合物による神経変性疾患予防・治療薬の開発Principal Investigator
- Principal Investigator
  
  松永耕一
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Gunma University
Molecular regulation of cell adhesion machinery by epidermolysis bullosa-associated protein Exophilin-5Principal Investigator
- Principal Investigator
  
  Matsunaga Kohichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Gunma University
Homeostasis of the epidermal cells and its dysfunction in epidermolysis bullosa
- Principal Investigator
  
  Izumi Tetsuro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Gunma University
Molecular mechanisms of regulation of glucose-stimulated insulin secretion by novel small-molecule activators and inhibitors in pancreatic beta-cellsPrincipal Investigator
- Principal Investigator
  
  MATSUNAGA Kohichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Gunma University
Molecular mechanism of insulin granules exocytosis via the novel Exophilin-8 complexes.Principal Investigator
- Principal Investigator
  
  Matsunaga Kohichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Gunma University
Identification of activator of glucose-stimulated insulin secretion by high-throughput chemical screening
- Principal Investigator
  
  Ushigome Takeshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Gunma University
Role of Rab GTPases in the intracellular logistics of insulin granulePrincipal Investigator
- Principal Investigator
  
  MATSUNAGA Kohichi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Gunma University
Molecular basis of Rab27 GTPase-mediated regulated exocytosisPrincipal Investigator
- Principal Investigator
  
  MATSUNAGA Kohichi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Gunma University

All 2022 2021 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Cargo receptor Surf4 regulates endoplasmic reticulum export of proinsulin in pancreatic β-cells.2022
- Author(s)
  Saegusa K, Matsunaga K, Maeda M, Saito K, Izumi T, Sato K.
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 458-458
- DOI
  10.1038/s42003-022-03417-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06866, KAKENHI-PROJECT-21K19470, KAKENHI-PROJECT-20K15740, KAKENHI-PROJECT-20H03203
[Journal Article] Berberine is an insulin secretagogue targeting the KCNH6 potassium channel2021
- Author(s)
  Zhao MM, Lu J, Li S, Wang H, Cao X, Li Q, Shi TT, Matsunaga K, Chen C, Huang H, Izumi T, Yang JK.
- Journal Title
  
  Nat Commun
  
  Volume: 12 Issue: 1 Pages: 6342-6342
- DOI
  10.1038/s41467-021-26635-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03449
[Journal Article] Coixol amplifies glucose-stimulated insulin secretion via cAMP mediated signaling pathway.2019
- Author(s)
  Hameed A, Hafizur RM, Kahn MI, Jawed A, Wang H, Zhao M, Matsunaga K, Izumi T, Siddiqui S, Khan F, Adhikari A, and Sharma KR.
- Journal Title
  
  Eur. J. Pharmacol.
  
  Volume: 858 Pages: 172514-172514
- DOI
  10.1016/j.ejphar.2019.172514
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03449, KAKENHI-PROJECT-18K19554, KAKENHI-PROJECT-18K14647
[Journal Article] Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa2017
- Author(s)
  Fan Fushun、Matsunaga Kohichi、Wang Hao、Ishizaki Ray、Kobayashi Eri、Kiyonari Hiroshi、Mukumoto Yoshiko、Okunishi Katsuhide、Izumi Tetsuro
- Journal Title
  
  eLife
  
  Volume: 6 Pages: 1-23
- DOI
  10.7554/elife.26174
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09994, KAKENHI-PROJECT-15K08295, KAKENHI-PROJECT-26461484, KAKENHI-PROJECT-16K15211
[Presentation] 複数のRab27エフェクターExophilinsが制御する、インスリン顆粒開口放出機構2022
- Author(s)
  趙　クンリ、松永　耕一、水野　広一、王　昊、奥西　勝秀、泉　哲郎
- Organizer
  第65回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19H03449
[Presentation] 複数のRab27エフェクターExophilinsが制御する，インスリン顆粒開口放出機構2022
- Author(s)
  趙クンリ、松永耕一、水野公一、王昊、奥西勝秀、泉　哲郎
- Organizer
  第６５回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K06866
[Presentation] Coixol amplifies glucose stimulated insulin secretion through cAMP-PKA signaling cascade-independent of K-ATP Channels.2019
- Author(s)
  Abdul Hameed, Rahman M Hafizur, M Israr Khan, Hao Wang, Miaomiao Zhao, Kohichi Matsunaga, Tetsuro Izumi, Sonia Siddiqui, Faisal Khan, Achyut Adhikari, and Khaga Raj Sharma.
- Organizer
  The 11th Scientific Meeting of the Asian Association for the Study of Diabetes.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03449
[Presentation] Hymecromone potentiates glucose-stimulated insulin secretion through cAMP-PKA signaling pathway.2019
- Author(s)
  Rahman M Hafizur, M Israr Khan, Abdul Hameed, Kiran Maryam, Huma Aslam Bhatti, Munneb Ali, Zaheer-UI, Faisal Khan, Ghulam Abbas, Hao Wang, Kohichi Matsunaga, and Tetsuro Izumi
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19H03449
[Presentation] Exploring the insulin secretory mechanisms of hymecromone and eupatorin in mice islets.2019
- Author(s)
  Rahman M Hafizur, Abdul Hameed, M Israr Khan, Kiran Maryam, Muneeb Ali, Za-heer Ul-Haq, Hao Wang, Miaomiao Zhao, Kohichi Matsunaga, Tetsuro Izumi, Achyut Adhi-kari, Huma Aslam Bhatti.
- Organizer
  The 7th International Symposium-cum-Training Course on Molecular Medicine and Drug Research, Karachi, Pakistan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03449
[Presentation] リポタンパク質の分泌を制御するSFT-4/Surf4 ファミリータンパク質の発見とその機能解析2019
- Author(s)
  三枝　慶子、佐藤　美由紀、諸岡　信克、原　太一、松永　耕一、泉　哲郎、佐藤　健
- Organizer
  第92回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03449
[Presentation] Rab27エフェクター、Exophilin-8/MyRIP/Slac2cのインスリン分泌における役割2018
- Author(s)
  松永耕一、范福順、王昊、石崎玲、小林絵梨、清成寛、椋本淑子、奥西勝秀、泉哲郎
- Organizer
  第７０回日本細胞生物学会
- Data Source
  KAKENHI-PROJECT-15K08295
[Presentation] Rab27エフェクターExophilin8ノックアウトマウスのインスリン分泌制御における解析2016
- Author(s)
  范福順、松永耕一、泉哲郎
- Organizer
  日本糖尿病・肥満動物学会
- Place of Presentation
  大宮ソニックシティビル
- Year and Date
  2016-03-11
- Data Source
  KAKENHI-PROJECT-15K08295
[Presentation] インスリン分泌制御におけるExophilin8たんぱく質の機能解析2015
- Author(s)
  范福順、松永耕一、泉哲郎
- Organizer
  北関東医学会
- Place of Presentation
  群馬大学刀城会館
- Year and Date
  2015-10-01
- Data Source
  KAKENHI-PROJECT-15K08295

1. Ushigome Takeshi (60529551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. Izumi Tetsuro (00212952)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
3. 奥西勝秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Matsunaga Kohichi 松永 耕一

MATSUNAGA Kohichi 松永 耕一

Research Projects

Research Products

Co-Researchers

新規細胞質ATP濃度促進化合物による神経変性疾患予防・治療薬の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular regulation of cell adhesion machinery by epidermolysis bullosa-associated protein Exophilin-5Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Homeostasis of the epidermal cells and its dysfunction in epidermolysis bullosa

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms of regulation of glucose-stimulated insulin secretion by novel small-molecule activators and inhibitors in pancreatic beta-cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of insulin granules exocytosis via the novel Exophilin-8 complexes.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of activator of glucose-stimulated insulin secretion by high-throughput chemical screening

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of Rab GTPases in the intracellular logistics of insulin granulePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular basis of Rab27 GTPase-mediated regulated exocytosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Cargo receptor Surf4 regulates endoplasmic reticulum export of proinsulin in pancreatic β-cells.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Berberine is an insulin secretagogue targeting the KCNH6 potassium channel2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Coixol amplifies glucose-stimulated insulin secretion via cAMP mediated signaling pathway.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] 複数のRab27エフェクターExophilinsが制御する、インスリン顆粒開口放出機構2022

Author(s)

Organizer

Data Source

[Presentation] 複数のRab27エフェクターExophilinsが制御する，インスリン顆粒開口放出機構2022

Author(s)

Organizer

Matsunaga Kohichi 松永耕一

MATSUNAGA Kohichi 松永耕一