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AKIYAMA TOMOHIKO  秋山 智彦

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AKIYAMA Tomohiko  秋山 智彦

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Researcher Number 20570691
Other IDs
Affiliation (Current) 2025: 横浜市立大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2022 – 2023: 横浜市立大学, 医学部, 助教
2020 – 2021: 慶應義塾大学, 医学部(信濃町), 講師
2018 – 2019: 慶應義塾大学, 医学部(信濃町), 助教
2017: 慶應義塾大学, 医学部(信濃町), 特任助教
2010 – 2011: 東京大学, 大学院・新領域創成科学研究科, 特任研究員
Review Section/Research Field
Principal Investigator
Biological Sciences / Basic Section 43010:Molecular biology-related / Developmental biology / Applied animal science
Except Principal Investigator
Developmental biology
Keywords
Principal Investigator
分化制御 / 多能性幹細胞 / 細胞分化 / 多能性 / エンハンサー / 幹細胞 / クロマチン / 転写制御 / ES細胞 / 分化 … More / クロマチン構造 / 転写調節 / ヒト多能性幹細胞 / ヒストン脱メチル化酵素 / 配置制御 / 転写制御因子 / 高次クロマチン構造 / ヒトES細胞 / UTX / 自己複製 / エンハンサー複製 / エピジェネティクス / 転写マシナリー / 性差 / エンハンサー制御 / 転写因子ネットワーク / シスエレメント / 転写因子 / オープンクロマチン / ATACシーケンス / 神経分化 / 骨格筋分化 / 発生・分化 / 発生 … More
Except Principal Investigator
Zscan4 / マウス胚性幹細胞 / ノックアウト / マウス発生学 / 遺伝子機能解析 / テロメア伸長 / ゲノム安定化 / 若返り / 組織幹細胞 / ZSCAN4 Less
  • Research Projects

    (8 results)
  • Research Products

    (16 results)
  • Co-Researchers

    (9 People)
  •  ES細胞の分化過程において切り替わる転写調節機構の解明Principal Investigator

    • Principal Investigator
      秋山 智彦
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43010:Molecular biology-related
    • Research Institution
      Yokohama City University
  •  Maintenance and regeneration of enhancer loops involved in pluripotencyPrincipal Investigator

    • Principal Investigator
      秋山 智彦
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Yokohama City University
  •  転写装置の性差形成機構の解明Principal Investigator

    • Principal Investigator
      秋山 智彦
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Keio University
  •  幹細胞のエンハンサー機能を支えるクロマチン継承機構Principal Investigator

    • Principal Investigator
      秋山 智彦
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Keio University
  •  The roles of histone demethylases in transcriptional process involved in cell differentiationPrincipal Investigator

    • Principal Investigator
      Akiyama Tomohiko
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43010:Molecular biology-related
    • Research Institution
      Keio University
  •  Elucidating of transcription factor network during the differentiation of human ES cellsPrincipal Investigator

    • Principal Investigator
      AKIYAMA TOMOHIKO
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Developmental biology
    • Research Institution
      Keio University
  •  Novel molecular mechanisms for enabling the maintenance and rejuvenation of tissue stem cells

    • Principal Investigator
      KO Minoru
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Developmental biology
    • Research Institution
      Keio University
  •  Replacement of core histones in nuclear transferPrincipal Investigator

    • Principal Investigator
      AKIYAMA Tomohiko
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Applied animal science
    • Research Institution
      The University of Tokyo

All 2020 2019 2018 2017 2011

All Journal Article Presentation

  • [Journal Article] Generation and Profiling of 2,135 Human ESC Lines for the Systematic Analyses of Cell States Perturbed by Inducing Single Transcription Factors2020

    • Author(s)
      Nakatake Y、Ko S B.H.、Sharov A A.、Wakabayashi S、Murakami M、Sakota M、Chikazawa N、Ookura C、Sato S、Ito N、Ishikawa-Hirayama M、Mak Siu S、Jakt Lars M、Ueno T、Hiratsuka K、Matsushita M、Goparaju S K、Akiyama T、Ishiguro K、Oda M、Gouda N、Umezawa A、Akutsu H、Nishimura K、Matoba R、Ohara O、Ko M S.H.
    • Journal Title

      Cell Reports

      Volume: 31 Issue: 7 Pages: 107655-107655

    • DOI

      10.1016/j.celrep.2020.107655

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08085, KAKENHI-PROJECT-18K06039, KAKENHI-PROJECT-19K06492, KAKENHI-PUBLICLY-20H04929, KAKENHI-PUBLICLY-20H05395
  • [Journal Article] Fatty Acid Synthesis Is Indispensable for Survival of Human Pluripotent Stem Cells2020

    • Author(s)
      Sho Tanosaki, Shugo Tohyama, Jun Fujita, Hiroki Nakanishi, Takayo Ohto-Nakanishi, Tomohiko Akiyama, Yuika Morita, Yoshikazu Kishino, Marina Okada, Hidenori Tani, Yusuke Soma, Kazuaki Nakajima, Hideaki Kanazawa, Masahiro Sugimoto, Minoru S.H. Ko, Makoto Suematsu, Keiichi Fukuda
    • Journal Title

      iScience

      Volume: 23 Issue: 9 Pages: 101535-101535

    • DOI

      10.1016/j.isci.2020.101535

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K21608, KAKENHI-PROJECT-17K07194, KAKENHI-PLANNED-20H05743, KAKENHI-PROJECT-19K06492, KAKENHI-PUBLICLY-20H04929, KAKENHI-PUBLICLY-20H05395, KAKENHI-PROJECT-19K22626
  • [Journal Article] Synthetic mRNA‐based differentiation method enables early detection of Parkinson's phenotypes in neurons derived from Gaucher disease‐induced pluripotent stem cells2020

    • Author(s)
      Akiyama Tomohiko(責任著者)、Sato Saeko、Ko Shigeru B. H.、Sano Osamu、Sato Sho、Saito Masayo、Nagai Hiroaki、Ko Minoru S. H.、Iwata Hidehisa
    • Journal Title

      STEM CELLS Translational Medicine

      Volume: 10 Issue: 4 Pages: 572-581

    • DOI

      10.1002/sctm.20-0302

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06492, KAKENHI-PUBLICLY-20H04929, KAKENHI-PUBLICLY-20H05395
  • [Journal Article] Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression2019

    • Author(s)
      Nishihara Koji、Shiga Takahiro、Nakamura Eri、Akiyama Tomohiko、Sasaki Takashi、Suzuki Sadafumi、Ko Minoru S.H.、Tada Norihiro、Okano Hideyuki、Akamatsu Wado
    • Journal Title

      Stem Cell Reports

      Volume: 12 Issue: 2 Pages: 305-318

    • DOI

      10.1016/j.stemcr.2018.12.018

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-17H05706, KAKENHI-PROJECT-16K09677, KAKENHI-PROJECT-26430207, KAKENHI-PROJECT-17K16130, KAKENHI-PROJECT-18K05691, KAKENHI-PROJECT-17K15129
  • [Journal Article] Induction of human pluripotent stem cells into kidney tissues by synthetic mRNAs encoding transcription factors.2019

    • Author(s)
      Hiratsuka K, Monkawa T, Akiyama T, Nakatake Y, Oda M, Goparaju SK, Kimura H, Chikazawa-Nohtomi N, Sato S, Ishiguro K, Yamaguchi S, Suzuki S, Morizane R, Ko SBH, Itoh H, Ko MSH
    • Journal Title

      Scientific reports

      Volume: 9 Issue: 1 Pages: 913-913

    • DOI

      10.1038/s41598-018-37485-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08085, KAKENHI-PROJECT-18K19304, KAKENHI-PROJECT-18K15399, KAKENHI-PROJECT-17H03634, KAKENHI-PROJECT-17K15129
  • [Journal Article] Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors2018

    • Author(s)
      Ida H., Akiyama T., Ishiguro K., Goparaju SK., Nakatake Y., Chikazawa-Nohtomi N., Sato S., Kimura H., Yokoyama Y., Nagino M., Ko MSH., Ko SBH.
    • Journal Title

      Stem Cell Res Ther.

      Volume: 9, 277 Issue: 1 Pages: 1-10

    • DOI

      10.1186/s13287-018-1038-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K19304, KAKENHI-PROJECT-17H03634, KAKENHI-PROJECT-17K15129
  • [Journal Article] Efficient differentiation of human pluripotent stem cells into skeletal muscle cells by combining RNA-based MYOD1-expression and POU5F1-silencing.2018

    • Author(s)
      Akiyama T, Sato S, Chikazawa-Nohtomi N, Soma A, Kimura H, Wakabayashi S, Ko SBH, Ko MSH.
    • Journal Title

      Sci Rep.

      Volume: 8 Issue: 1 Pages: 1189-1189

    • DOI

      10.1038/s41598-017-19114-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04812, KAKENHI-PROJECT-17K15129
  • [Journal Article] Epigenetic manipulation facilitates the generation of skeletal muscle cells from pluripotent stem cells.2017

    • Author(s)
      Tomohiko Akiyama, Shunichi Wakabayashi, Atsumi Soma, Saeko Sato, Yuhki Nakatake, Mayumi Oda, Miyako Murakami, Miki Sakota, Nana Chikazawa-Nohtomi, Shigeru B. H. Ko, Minoru S. H. Ko
    • Journal Title

      Stem Cell International.

      Volume: 2017 Pages: 7215010-7215010

    • DOI

      10.1155/2017/7215010

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K14431, KAKENHI-PROJECT-15H04812, KAKENHI-PROJECT-17K15129
  • [Presentation] Transcriptome Manipulation to Facilitate the Differentiation of Human Pluripotent Stem Cells2018

    • Author(s)
      秋山 智彦
    • Organizer
      幹細胞シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K15129
  • [Presentation] マスター転写因子とヒストン脱メチル化酵素の関連性2018

    • Author(s)
      秋山智彦
    • Organizer
      第41回日本分子生物学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K15129
  • [Presentation] 2つのヒストン脱メチル化酵素により制御される転写調節機構2018

    • Author(s)
      秋山智彦
    • Organizer
      熊本大学発生医学研究所第348回発生研セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K15129
  • [Presentation] Accelerated differentiation of human pluripotent stem cells by ectopic expression of histone demethylase2017

    • Author(s)
      Tomohiko Akiyama
    • Organizer
      日本発生生物学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K15129
  • [Presentation] ヒトES細胞の直接分化誘導に関わるaccessible chromatin構造2017

    • Author(s)
      秋山 智彦
    • Organizer
      次世代生命科学研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K15129
  • [Presentation] ヒトES細胞-骨格筋変換に関わるaccessible chromatin構造2017

    • Author(s)
      秋山 智彦
    • Organizer
      エピジェネティクス研究会
    • Data Source
      KAKENHI-PROJECT-17K15129
  • [Presentation] 核移植胚におけるコアヒストン置換によるクロマチンの再構築2011

    • Author(s)
      秋山智彦・那順布和・青木不学
    • Organizer
      第52回日本哺乳動物卵子学会
    • Place of Presentation
      栃木県大田原市
    • Data Source
      KAKENHI-PROJECT-22780250
  • [Presentation] 核移植胚におけるコアヒストン置換によるクロマチンの再構築2011

    • Author(s)
      秋山智彦
    • Organizer
      第52回日本哺乳動物卵子学会
    • Place of Presentation
      国際医療福祉大学(栃木県大田原市)
    • Data Source
      KAKENHI-PROJECT-22780250
  • 1.  KO Minoru (50631199)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  中武 悠樹 (20415251)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  洪 繁 (90402578)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  小田 真由美 (80567511)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 5.  ISHIGURO Kei-ichiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  岡田 麻里奈
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  福田 恵一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  遠山 周吾
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  赤松 和土
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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