Sakamoto Naoya 坂本直也

… Alternative Names

SAKAMOTO Naoya 坂本直也

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Researcher Number	20571798
Affiliation (Current)	2025: 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長
Affiliation (based on the past Project Information) *help	2020 – 2025: 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長 2020: 国立研究開発法人国立がん研究センター, 国立がん研究センター・先端医療開発センター, ユニット長 2019: 広島大学, 医系科学研究科(医), 助教 2017 – 2018: 広島大学, 医歯薬保健学研究科(医), 助教 2016 – 2017: 広島大学, 医歯薬保健学研究院(医), 助教 … More 2012: 広島大学, 大学院・医歯薬保健学研究院, 特任助教 2011: 広島大学, 医歯(薬)学総合研究科, 特任助教 2011: 広島大学, 医歯薬保健学研究院, 特任助教 Less
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / Basic Section 49020:Human pathology-related / Experimental pathology / Human pathology Except Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 56030:Urology-related / Basic Section 50010:Tumor biology-related / Tumor biology / Digestive surgery
Keywords	Principal Investigator 胃がん / オルガノイド / 胃癌 / 消化管がん / 抗がん剤耐性 / 大腸がん / 抗癌剤耐性 / 幹細胞 / ゲノム / 癌 … More / 個別化医療 / ゲノム編集 / CRISPR/Cas9 / 上皮間葉転換 / 分泌型microRNA / 分泌型miRNA / microRNA / 唾液腺 / 消化器 … More Except Principal Investigator オルガノイド / 薬剤感受性 / 胃癌 / CML / Foxo3a / CML幹細胞 / がん幹細胞 / 去勢抵抗性前立腺癌 / 前立腺癌 / 癌 / マウスモデル / 遺伝子改変マウス / 新規分子標的 / 発癌の分子病態 / 治療抵抗性大腸癌 / 個別化医療 / FGF-FGFR / 繊維芽細胞成長因子 / 個別化療法 / リゾリン脂質代謝 / リポクオリティ / リゾホスフォリパーゼD / FOXO3a / beta-catenin / FOXO / 再発 / TKI抵抗性 / Gdpd3 / リゾフォスフォリパーゼD / リゾリン脂質 / Wnt-β-catenin / ゲノム編集 / Wnt/β-catenin / Wnt-beta-Catenin / Wnt-beta-catenin / 代謝 / Wnt/beta-catenin / Lgr4 / 抗がん剤抵抗性 / 薬剤耐性 / 泌尿器癌 / 胃がん / 免疫 / 化学療法 Less

胃がんオルガノイドにおけるスプライシング異常による抗がん剤耐性獲得機構の解析Principal Investigator
- Principal Investigator
  
  坂本直也
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  National Cancer Center Japan
胃癌オルガノイドを用いたリアルタイム免疫化学療法感受性システムのための基盤研究
- Principal Investigator
  
  田邊和照
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Hiroshima University
Analysis of the mechanism of acquisition of anticancer drug resistance using gastrointestinal cancer organoidsPrincipal Investigator
- Principal Investigator
  
  坂本直也
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  National Cancer Center Japan
Exploration of novel therapeutic targets for gastric cancer using patient-derived organoids
- Principal Investigator
  
  Tanabe Kazuaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Hiroshima University
Personalized medicine through the analysis of organoids derived from FGF-FGFR-activated CRPC
- Principal Investigator
  
  Teishima Jun
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kobe University
  Hiroshima University
Identification of novel driver genes in treatment-resistant colorectal cancer subtypes and development of therapeutic strategies
- Principal Investigator
  
  檜井孝夫
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Hiroshima University
Role of lysophospholipid metabolism enzyme Gdpd3 in regulating lipoquality in cancer stem cells
- Principal Investigator
  
  Kazuhito Naka
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Hiroshima University
Search for new therapeutic target against cancer stem cells using intestinal-/gastric type gastric cancer organoidPrincipal Investigator
- Principal Investigator
  
  Naoya Sakamoto
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  National Cancer Center Japan
  Hiroshima University
Establishment of personalized medicine through analysis of organoid derived from castration-resistant prostate cancer.
- Principal Investigator
  
  TEISHIMA JUN
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Hiroshima University
Basic research for gastric organoids using microgravity environment
- Principal Investigator
  
  Tanabe Kazuaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Hiroshima University
Role of Stemness Factor Lgr4 for Therapeutic Resistance in CML Stem Cells
- Principal Investigator
  
  Naka Kazuhito
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Hiroshima University
Establishment of the model of intestinal and gastric type gastric cancer using CRISPR/Cas9 and organoidPrincipal Investigator
- Principal Investigator
  
  Sakamoto Naoya
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Experimental pathology
- Research Institution
  Hiroshima University
Tumor-stromal cell interaction and epithelial-mesenchymal transition by secreted-microRNAPrincipal Investigator
- Principal Investigator
  
  SAKAMOTO Naoya
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  Hiroshima University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2012 2011

All Journal Article Presentation Patent

[Journal Article] Establishment of a novel overlay culture method that enables immune response assessment using gastric cancer organoids2024
- Author(s)
  H. Ota, K. Tanabe, Y. Saeki, Y. Takemoto, E. Chikuie, N. Sakamoto,Hideki Ordain
- Journal Title
  
  Heliyon
  
  Volume: 10 Issue: 1 Pages: e23520-e23520
- DOI
  10.1016/j.heliyon.2023.e23520
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08734
[Journal Article] Cancer-associated fibroblast-dependent and -independent invasion of gastric cancer cells.2022
- Author(s)
  Kondo R, Sakamoto N, Harada K, Hashimoto H, Morisue R, Yanagihara K, Kinoshita T, Kojima M, Ishii G.
- Journal Title
  
  J Cancer Res Clin Oncol.
  
  Volume: on line ahead of print Issue: 8 Pages: 5309-5319
- DOI
  10.1007/s00432-022-04484-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07013, KAKENHI-PROJECT-21H02931
[Journal Article] Cancer organoid applications to investigate chemotherapy resistance.2022
- Author(s)
  Harada K, Sakamoto N
- Journal Title
  
  Front Mol Biosci.
  
  Volume: Dec13: 9
- DOI
  10.3389/fmolb.2022.1067207
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07013
[Journal Article] BUB1B Overexpression Is an Independent Prognostic Marker and Associated with CD44, p53, and PD-L1 in Renal Cell Carcinoma.2021
- Author(s)
  Sekino Y, Han X, Kobayashi G, Babasaki T, Miyamoto S, Kobatake K, Kitano H, Ikeda K, Goto K, Inoue S, Hayashi T, Teishima J, Sakamoto N, Sentani K, Oue N, Yasui W, Matsubara A
- Journal Title
  
  Oncology
  
  Volume: - Issue: 4 Pages: 240-250
- DOI
  10.1159/000512446
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07434, KAKENHI-PROJECT-18K07017, KAKENHI-PROJECT-18K09134, KAKENHI-PROJECT-21K06904
[Journal Article] KHDRBS3 promotes multi-drug resistance and anchorage-independent growth in colorectal cancer.2021
- Author(s)
  Ukai S, Sakamoto N, Taniyama D, Harada K, Honma R, Maruyama R, Naka K, Hinoi T, Takakura Y, Shimizu W, Ohdan H, Yasui W
- Journal Title
  
  Cancer Sci
  
  Volume: 112 Issue: 3 Pages: 1196-1208
- DOI
  10.1111/cas.14805
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03443, KAKENHI-PROJECT-20H03517, KAKENHI-PROJECT-18K07017
[Journal Article] Annexin A10 Is Involved in the Induction of Pancreatic Duodenal homeobox in Gastric Cancer Tissue, Cells and Organoids2020
- Author(s)
  Ishikawa A, Sakamoto N, Honma R, Taniyama D, Fukada K, Hattori T, Sentani K, Oue N, Yanagihara K, Tanabe K, Ohdan H, Yasui W.
- Journal Title
  
  Oncol Rep
  
  Volume: 43 Pages: 581-590
- DOI
  10.3892/or.2019.7422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07017, KAKENHI-PROJECT-19K07434, KAKENHI-PROJECT-19H03443
[Journal Article] Immunohistochemical analysis of SLFN11 expression uncovers potential non-responders to DNA-damaging agents overlooked by tissue RNA-seq2020
- Author(s)
  Takashima Tsuyoshi、Sakamoto Naoya、Murai Junko、Taniyama Daiki、Honma Ririno、Ukai Shoichi、Maruyama Ryota、Kuraoka Kazuya、Rajapakse Vinodh N.、Pommier Yves、Yasui Wataru
- Journal Title
  
  Virchows Archiv
  
  Volume: 478 Issue: 3 Pages: 569-579
- DOI
  10.1007/s00428-020-02840-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03505, KAKENHI-PROJECT-18K07017
[Journal Article] Molecular biological analysis of 5-FU-resistant gastric cancer organoids; KHDRBS3 contributes to the attainment of features of cancer stem cell2020
- Author(s)
  Ukai S, Honma R, Sakamoto N, Yamamoto Y, Pham QT, Harada K, Takashima T, Taniyama D, Asai R, Fukada K, Naka K, Tanabe K, Ohdan K, Yasui W
- Journal Title
  
  Oncogene
  
  Volume: 39 Issue: 50 Pages: 7265-7278
- DOI
  10.1038/s41388-020-01492-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03443, KAKENHI-PROJECT-20H03517, KAKENHI-PROJECT-18K07017
[Journal Article] Oncogenic mutation in RAS‐RAF axis leads to increased expression of GREB1, resulting in tumor proliferation in colorectal cancer2020
- Author(s)
  Kochi Masatoshi、Hinoi Takao、Niitsu Hiroaki、Miguchi Masashi、Saito Yasufumi、Sada Haruki、Sentani Kazuhiro、Sakamoto Naoya、Oue Naohide、Tashiro Hirotaka、Sotomaru Yusuke、Yasui Wataru、Ohdan Hideki
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 10 Pages: 3540-3549
- DOI
  10.1111/cas.14558
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07434, KAKENHI-PROJECT-19H03443, KAKENHI-PROJECT-18K07016, KAKENHI-PROJECT-18K07017, KAKENHI-PROJECT-18K08694, KAKENHI-PROJECT-19H01056
[Journal Article] SPC18 Expression Is an Independent Prognostic Indicator of Patients with Esophageal Squamous Cell Carcinoma2020
- Author(s)
  Yamamoto Yuji、Oue Naohide、Asai Ryuichi、Katsuya Narutaka、Uraoka Naohiro、Sakamoto Naoya、Sentani Kazuhiro、Tanabe Kazuaki、Ohdan Hideki、Yasui Wataru
- Journal Title
  
  Pathobiology
  
  Volume: 87 Issue: 4 Pages: 254-261
- DOI
  10.1159/000506956
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07434, KAKENHI-PROJECT-19H03443, KAKENHI-PROJECT-18K07016, KAKENHI-PROJECT-18K07017
[Journal Article] UC-63+ contributes to gastric cancer progression through regulation of NF-κB signaling2020
- Author(s)
  Sakamoto N, Sekino Y, Fukada, Pham QT, Honma R, Taniyama D, Ukai S, Takashima T, Hattori T, Naka K, Tanabe K, Ohdan H, Yasui W
- Journal Title
  
  Gastric Cancer
  
  Volume: 23 Issue: 5 Pages: 863-873
- DOI
  10.1007/s10120-020-01070-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03443, KAKENHI-PROJECT-20H03517, KAKENHI-PROJECT-18K07017
[Journal Article] TUBB3 Is Associated with High-Grade Histology, Poor Prognosis, p53 Expression, and Cancer Stem Cell Markers in Clear Cell Renal Cell Carcinoma2020
- Author(s)
  Sekino Yohei、Han Xiangrui、Babasaki Takashi、Miyamoto Shunsuke、Kitano Hiroyuki、Kobayashi Go、Goto Keisuke、Inoue Shogo、Hayashi Tetsutaro、Teishima Jun、Sakamoto Naoya、Sentani Kazuhiro、Oue Naohide、Yasui Wataru、Matsubara Akio
- Journal Title
  
  Oncology
  
  Volume: 98 Issue: 10 Pages: 689-698
- DOI
  10.1159/000506775
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07434, KAKENHI-PROJECT-18K07016, KAKENHI-PROJECT-18K07017, KAKENHI-PROJECT-18K09134
[Journal Article] Microtubule-associated protein tau (MAPT) is a promising independent prognostic marker and tumor suppressive protein in clear cell renal cell carcinoma.2020
- Author(s)
  Han X, Sekino Y, Babasaki T, Goto K, Inoue S, Hayashi T, Teishima J, Sakamoto N, Sentani K, Oue N, Yasui W, Matsubara A.
- Journal Title
  
  Urol Oncol.
  
  Volume: - Issue: 6 Pages: 9-17
- DOI
  10.1016/j.urolonc.2020.02.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07434, KAKENHI-PROJECT-18K07016, KAKENHI-PROJECT-18K07017, KAKENHI-PROJECT-18K09134
[Journal Article] Clinicopathological significance of claspin overexpression and its association with spheroid formation in gastric cancer.2019
- Author(s)
  Kobayashi G, Sentani K, Hattori T, Yamamoto Y, Imai T, Sakamoto N, Kuraoka K, Oue N, Sasaki N, Taniyama K, Yasui W.
- Journal Title
  
  Hum Pathol
  
  Volume: 84 Pages: 8-17
- DOI
  10.1016/j.humpath.2018.09.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07017, KAKENHI-PROJECT-16K08691, KAKENHI-PROJECT-18K07016, KAKENHI-PROJECT-19K07434
[Journal Article] Clinicopathological significance of RCAN2 production in gastric carcinoma.2019
- Author(s)
  Hattori Y, Sentani K, Shinmei S, Oo HZ, Hattori T, Imai T, Sekino Y, Sakamoto N, Oue N, Niitsu H, Hinoi T, Ohdan H, Yasui W.
- Journal Title
  
  Histopathology
  
  Volume: 74 Issue: 3 Pages: 430-442
- DOI
  10.1111/his.13764
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07017, KAKENHI-PROJECT-16K08691, KAKENHI-PROJECT-18K07016, KAKENHI-PROJECT-18K08694, KAKENHI-PROJECT-19K07434, KAKENHI-PROJECT-19H03443
[Journal Article] KIFC1 Inhibitor CW069 Induces Apoptosis and Reverses Resistance to Docetaxel in Prostate Cancer.2019
- Author(s)
  Sekino Y, Oue N, Koike Y, Shigematsu Y, Sakamoto N, Sentani K, Teishima J, Shiota M, Matsubara A, Yasui W.
- Journal Title
  
  J Clin Med.
  
  Volume: 8 Issue: 2 Pages: 225-225
- DOI
  10.3390/jcm8020225
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07017, KAKENHI-PROJECT-18K09134, KAKENHI-PROJECT-16K08691, KAKENHI-PROJECT-18K07016, KAKENHI-PROJECT-19K07434
[Journal Article] Molecular carcinogenesis of gastric cancer: Lauren classification, mucin phenotype expression, and cancer stem cells.2019
- Author(s)
  Oue N, Sentani K, Sakamoto N, Uraoka N, Yasui W.
- Journal Title
  
  Int J Clin Oncol.
  
  Volume: 印刷中 Issue: 7 Pages: 771-778
- DOI
  10.1007/s10147-019-01443-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08691, KAKENHI-PROJECT-18K07017, KAKENHI-PROJECT-19K07434
[Journal Article] SEC11A Expression Is Associated with Basal-Like Bladder Cancer and Predicts Patient Survival2019
- Author(s)
  Shigematsu Yoshinori、Oue Naohide、Sekino Yohei、Sakamoto Naoya、Sentani Kazuhiro、Uraoka Naohiro、Hayashi Tetsutaro、Teishima Jun、Matsubara Akio、Yasui Wataru
- Journal Title
  
  Pathobiology
  
  Volume: 86 Issue: 4 Pages: 208-216
- DOI
  10.1159/000497206
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07016, KAKENHI-PROJECT-18K07017, KAKENHI-PROJECT-18K09134, KAKENHI-PROJECT-19K07434, KAKENHI-PROJECT-19K09729
[Journal Article] Transcribed ultraconserved region Uc.63+ promotes resistance to cisplatin through regulation of androgen receptor signaling in bladder cancer.2019
- Author(s)
  Sekino Y, Sakamoto N, Ishikawa A, Honma R, Shigematsu Y, Hayashi T, Sentani K, Oue N, Teishima J, Matsubara A, Yasui W.
- Journal Title
  
  Oncol Rep.
  
  Volume: 41 Pages: 3111-3118
- DOI
  10.3892/or.2019.7039
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08691, KAKENHI-PROJECT-18K09134, KAKENHI-PROJECT-19K07434
[Journal Article] Transcribed ultraconserved region Uc.63+ promotes resistance to cisplatin through regulation of androgen receptor signaling in bladder cancer.2019
- Author(s)
  Sekino Y, Sakamoto N, Ishikawa A, Honma R, Shigematsu Y, Hayashi T, Sentani K, Oue N, Teishima J, Matsubara A, Yasui W.
- Journal Title
  
  Oncol Rep
  
  Volume: 41 Pages: 3111-3118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07017
[Journal Article] Protocadherin B9 promotes resistance to bicalutamide and is associated with the survival of prostate cancer patients.2019
- Author(s)
  Sekino Y, Oue N, Mukai S, Shigematsu Y, Goto K, Sakamoto N, Sentani K, Hayashi T, Teishima J, Matsubara A, Yasui W.
- Journal Title
  
  Prostate
  
  Volume: 79 Issue: 2 Pages: 234-242
- DOI
  10.1002/pros.23728
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07017, KAKENHI-PROJECT-18K09134, KAKENHI-PROJECT-16K08691, KAKENHI-PROJECT-19K07434
[Journal Article] Synbiotics Suppress Colitis-Induced Tumorigenesis in a Colon-Specific Cancer Mouse Model2019
- Author(s)
  Saito Y, Hinoi T, Adachi T, Miguchi M, Niitsu H, Kochi M, Sada H, Sotomaru Y, Sakamoto N, Sentani K, Oue N, Yasui W, Tashiro H, Ohdan H.
- Journal Title
  
  PLoS One
  
  Volume: 14 Issue: 6 Pages: 0216393-0216393
- DOI
  10.1371/journal.pone.0216393
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07017, KAKENHI-PROJECT-18K08694, KAKENHI-PROJECT-19K07434, KAKENHI-PROJECT-19H03443
[Journal Article] Cancer Extracellular Vesicles Contribute to Stromal Heterogeneity by Inducing Chemokines in Cancer-Associated Fibroblasts2019
- Author(s)
  Naito Y, Yamamoto Y, Sakamoto N, Shimomura I, Kogure A, Kumazaki M, Yokoi A, Yashiro M, Kiyono T, Yanagihara K, Takahashi RU, Hirakawa K, Yasui W, Ochiya T.
- Journal Title
  
  Oncogene
  
  Volume: 38 Issue: 28 Pages: 5566-5579
- DOI
  10.1038/s41388-019-0832-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07017, KAKENHI-PROJECT-15H05791, KAKENHI-PROJECT-18H02883, KAKENHI-PROJECT-19H03443, KAKENHI-PROJECT-17H04991
[Journal Article] CD204-Positive Tumor-associated Macrophages Relate to Malignant Transformation of Colorectal Adenoma2019
- Author(s)
  TANIYAMA DAIKI、TANIYAMA KIYOMI、KURAOKA KAZUYA、YAMAMOTO HIDEKI、ZAITSU JUNICHI、SAITO AKIHISA、SAKAMOTO NAOYA、SENTANI KAZUHIRO、OUE NAOHIDE、YASUI WATARU
- Journal Title
  
  Anticancer Research
  
  Volume: 39 Issue: 6 Pages: 2767-2775
- DOI
  10.21873/anticanres.13403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07016, KAKENHI-PROJECT-18K07017, KAKENHI-PROJECT-19K07434, KAKENHI-PROJECT-19H03443
[Journal Article] miR-130b Promotes Sunitinib Resistance through Regulation of PTEN in Renal Cell Carcinoma2019
- Author(s)
  Sekino Yohei、Sakamoto Naoya、Sentani Kazuhiro、Oue Naohide、Teishima Jun、Matsubara Akio、Yasui Wataru
- Journal Title
  
  Oncology
  
  Volume: 97 Issue: 3 Pages: 164-172
- DOI
  10.1159/000500605
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07016, KAKENHI-PROJECT-18K07017, KAKENHI-PROJECT-18K09134, KAKENHI-PROJECT-19K07434
[Journal Article] IMP dehydrogenase-2 Drives Aberrant Nucleolar Activity and Promotes Tumorigenesis in Glioblastoma2019
- Author(s)
  Kofuji S, Hirayama A, Eberhardt AO, Kawaguchi R, Sakamoto N, Kitahara S, Wolfe K, Lange L, Onishi N, Uematsu M, Saya H, Soga T, Grummt I, Bierhoff H, Sasaki AT.
- Journal Title
  
  Nat Cell Biol
  
  Volume: 21 Issue: 8 Pages: 1003-1014
- DOI
  10.1038/s41556-019-0363-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07017, KAKENHI-PROJECT-18K07233, KAKENHI-PROJECT-18K08717, KAKENHI-PROJECT-18K08939, KAKENHI-PROJECT-19K07696, KAKENHI-PROJECT-19K18691
[Journal Article] Uc.416+A promotes epithelial-to-mesenchymal transition through miR-153 in renal cell carcinoma2018
- Author(s)
  Sekino Yohei、Sakamoto Naoya、Goto Keisuke、Honma Ririno、Shigematsu Yoshinori、Quoc Thang Pham、Sentani Kazuhiro、Oue Naohide、Teishima Jun、Kawakami Fumi、Karam Jose A、Sircar Kanishka、Matsubara Akio、Yasui Wataru
- Journal Title
  
  BMC Cancer
  
  Volume: 18 Issue: 1 Pages: 952-952
- DOI
  10.1186/s12885-018-4863-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07016, KAKENHI-PROJECT-18K07017, KAKENHI-PROJECT-16K08691
[Journal Article] Clinicopathological and Prognostic Significance of Epithelial Gremlin1 Expression in Gastric Cancer2018
- Author(s)
  Honma R, Sakamoto N, Ishikawa A, Taniyama D, Fukada K, Hattori T, Sentani K, Oue N, Tanabe K, Ohdan H, Yasui W.
- Journal Title
  
  Anticancer Res
  
  Volume: 38 Pages: 1419-1425
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07017
[Journal Article] TDO2 Overexpression Is Associated with Cancer Stem Cells and Poor Prognosis in Esophageal Squamous Cell Carcinoma2018
- Author(s)
  Pham Quoc Thang、Oue Naohide、Sekino Yohei、Yamamoto Yuji、Shigematsu Yoshinori、Sakamoto Naoya、Sentani Kazuhiro、Uraoka Naohiro、Yasui Wataru
- Journal Title
  
  Oncology
  
  Volume: 95 Issue: 5 Pages: 297-308
- DOI
  10.1159/000490725
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07016, KAKENHI-PROJECT-18K07017, KAKENHI-PROJECT-16K08691
[Journal Article] Overexpression of the transmembrane protein BST-2 induces Akt and Erk phosphorylation in bladder cancer.2017
- Author(s)
  Shigematsu Y, Oue N, Nishioka Y, Sakamoto N, Sentani K, Sekino Y, Mukai S, Teishima J, Matsubara A, Yasui W.
- Journal Title
  
  Oncol Lett
  
  Volume: 14 Issue: 1 Pages: 999-1004
- DOI
  10.3892/ol.2017.6230
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08691, KAKENHI-PROJECT-16H06999
[Journal Article] Expression and function of Uc.160+, a transcribed ultraconserved region, in gastric cancer.2017
- Author(s)
  Honma R, Goto K, Sakamoto N, Sekino Y, Sentani K, Oue N, Yasui W.
- Journal Title
  
  Gastric Cancer
  
  Volume: 20 Issue: 6 Pages: 960-969
- DOI
  10.1007/s10120-017-0714-9
- NAID
  40021377334
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08691, KAKENHI-PROJECT-16H06999, KAKENHI-PROJECT-16K15247
[Journal Article] Clinicopathological significance of SPC18 in colorectal cancer: SPC18 participates in tumor progression.2017
- Author(s)
  Hattori T, Sentani K, Naohide O, Sakamoto N, Yasui W
- Journal Title
  
  Cancer Science
  
  Volume: 108(1) Issue: 1 Pages: 143-150
- DOI
  10.1111/cas.13121
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06999, KAKENHI-PROJECT-16K15247, KAKENHI-PROJECT-16K08691
[Journal Article] Overexpression of the Transmembrane Protein IQGAP3 Is Associated with Poor Survival of Patients with Gastric Cancer.2017
- Author(s)
  Oue N, Yamamoto Y, Oshima T, Asai R, Ishikawa A, Uraoka N, Sakamoto N, Sentani K, Yasui W.
- Journal Title
  
  Pathobiology
  
  Volume: - Issue: 3 Pages: 192-200
- DOI
  10.1159/000481890
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08691, KAKENHI-PROJECT-15H04713, KAKENHI-PROJECT-16H06999, KAKENHI-PROJECT-16H05230
[Journal Article] KIFC1 induces resistance to docetaxel and is associated with survival of prostate cancer patients2017
- Author(s)
  Sekino Y, Oue N, Shigematsu Y, Ishikawa A, Sakamoto N, Sentani K, Teishima J, Matsubara A, Yasui W
- Journal Title
  
  Urologic Oncology
  
  Volume: 35 Issue: 1 Pages: 13-31
- DOI
  10.1016/j.urolonc.2016.08.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04713, KAKENHI-PROJECT-16H06999, KAKENHI-PROJECT-16K08691
[Journal Article] Characteristic expression of fukutin in gastric cancer among atomic bomb survivors.2017
- Author(s)
  Pham TT, Oue N, Yamamoto M, Fujihara M, Ishida T, Mukai S, Sakamoto N, Sentani K, Yasui W.
- Journal Title
  
  Oncology Letter
  
  Volume: 13(2) Pages: 937-941
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06999
[Journal Article] The Expression of BTS-2 Enhances Cell Growth and Invasiveness in Renal Cell Carcinoma.2017
- Author(s)
  Pham QT, Oue N, Yamamoto Y, Shigematsu Y, Sekino Y, Sakamoto N, Sentani K, Uraoka N, Tiwari M, Yasui W
- Journal Title
  
  Anticancer Research
  
  Volume: 37 Pages: 2853-2860
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06999
[Journal Article] KIF11 Is Required for Spheroid Formation by Oesophageal and Colorectal Cancer Cells.2017
- Author(s)
  Imai T, Oue N, Sentani K, Sakamoto N, Uraoka N, Egi H, Hinoi T, Ohdan H, Yoshida K, Yasui W.
- Journal Title
  
  Anticancer Research
  
  Volume: 37(1) Pages: 47-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06999
[Journal Article] Overexpression of PCDHB9 promotes peritoneal metastasis and correlates with poor prognosis in patients with gastric cancer.2017
- Author(s)
  Mukai S, Oue N, Oshima T, Imai T, Sekino Y, Honma R, Sakamoto N, Sentani K, Kuniyasu H, Egi H, Tanabe K, Yoshida K, Ohdan H, Yasui W.
- Journal Title
  
  J Pathol
  
  Volume: 243 Issue: 1 Pages: 100-110
- DOI
  10.1002/path.4931
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08691, KAKENHI-PROJECT-17K19923, KAKENHI-PROJECT-15H04713, KAKENHI-PROJECT-16H05164, KAKENHI-PROJECT-16H06999, KAKENHI-PROJECT-16K15247, KAKENHI-PROJECT-16H05230
[Journal Article] Long-term follow-up study of gastric adenoma; tumor-associated macrophages are associated to carcinoma development in gastric adenoma.2017
- Author(s)
  Taniyama D, Taniyama K, Kuraoka K, Zaitsu J, Saito A, Nakatsuka H, Sakamoto N, Sentani K, Oue N, Yasui W.
- Journal Title
  
  Gastric Cancer
  
  Volume: 20 Issue: 6 Pages: 929-939
- DOI
  10.1007/s10120-017-0713-x
- NAID
  40021377278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08691, KAKENHI-PROJECT-16H06999
[Journal Article] Transcribed ultraconserved region Uc.63+ promotes resistance to docetaxel through regulation of androgen receptor signaling in prostate cancer.2017
- Author(s)
  Sekino Y, Sakamoto N, Goto K, Honma R, Shigematsu Y, Sentani K, Oue N, Teishima J, Matsubara A and Yasui W
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 55 Pages: 94259-94270
- DOI
  10.18632/oncotarget.21688
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08691, KAKENHI-PROJECT-16H06999, KAKENHI-PROJECT-15K10591, KAKENHI-PROJECT-16K15247
[Journal Article] BRAFV600E cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis.2017
- Author(s)
  Sakamoto N, Feng Y, Stolfi C, Kurosu Y, Green M, Lin J, Green ME, Sentani K, Yasui W, McMahon M, Hardiman KM, Spence JR, Horita N, Greenson JK, Kuick R, Cho KR, Fearon ER.
- Journal Title
  
  Elife
  
  Volume: 6 Pages: 6-6
- DOI
  10.7554/elife.20331
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06999, KAKENHI-PROJECT-16K08691
[Journal Article] Overexpression of KIF11 in gastric cancer with intestinal mucin phenotype2016
- Author(s)
  Imai T, Oue N, Nishioka M, Mukai S, Oshima T, Sakamoto N, Sentani K, Matsusaki K, Yoshida K, Yasui W
- Journal Title
  
  Pathobiology
  
  Volume: 84 Issue: 1 Pages: 16-24
- DOI
  10.1159/000447303
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04713, KAKENHI-PROJECT-16H06999, KAKENHI-PROJECT-26461973, KAKENHI-PROJECT-16K08691, KAKENHI-PROJECT-16H05230
[Journal Article] Induction of KIFC1 expression in gastric cancer spheroids2016
- Author(s)
  Oue N, Mukai S, Imai T, Trang TBP, Oshima T, Sentani K, Sakamoto N, Yoshida K, Yasui W
- Journal Title
  
  Oncology Reports
  
  Volume: 36 Issue: 1 Pages: 349-355
- DOI
  10.3892/or.2016.4781
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04713, KAKENHI-PROJECT-16H06999, KAKENHI-PROJECT-26461973, KAKENHI-PROJECT-16K08691
[Journal Article] The transcribed-ultra conserved regions in prostate and gastric cancer: DNA hypermethylation and microRNA-associated regulation.2015
- Author(s)
  Keisuke Goto, Sho Ishikawa,Ririno Honma, Keiji Tanimoto, Naoya Sakamoto,Kazuhiro Sentani, Naohide Oue, Jun Teishima, Akio Matsubara and Wataru Yasui.
- Journal Title
  
  Oncogene
  
  Volume: 1 Issue: 27 Pages: 1-1
- DOI
  10.1038/onc.2015.445
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K11252, KAKENHI-PROJECT-15H04713, KAKENHI-PROJECT-25460416, KAKENHI-PROJECT-25460417, KAKENHI-PROJECT-26670175, KAKENHI-PROJECT-16H06999, KAKENHI-PROJECT-16K08691, KAKENHI-PROJECT-16K15247
[Journal Article] Liver intestine cadherin induction by epidermal growth factor receptor is associated with intestinal differentiation of gastric cancer2012
- Author(s)
  Sakamoto N, et. al.
- Journal Title
  
  Cancer Sci
  
  Volume: 103(9) Pages: 1744-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790403
[Journal Article] Liver-intestine cadherin induction by epidermal growth factor receptor is associated with intestinal differentiation of gastric cancer2012
- Author(s)
  Sakamoto N, et al
- Journal Title
  
  Cancer Sci
  
  Volume: 103(9) Pages: 1744-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790403
[Patent] ５ＦＵ耐性癌治療用医薬組成物2019
- Inventor(s)
  安井　弥，坂本直也，鵜飼翔一，本間りりの，仲　一仁
- Industrial Property Rights Holder
  国立大学法人広島大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-167410
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17H03578
[Presentation] Transcriptomic analysis of mucinous adenocarcinoma in genetically-engineered mouse model2023
- Author(s)
  Haruki Sada, Hiroaki Niitsu, Hikaru Nakahara, Masashi Miguchi, Naoya Sakamoto, Naohide Oue, Hirotaka Tashiro, Hideki Ohdan, Takao Hinoi
- Organizer
  AACR annual meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21448
[Presentation] 遺伝子改変マウスモデルにおける粘液産生大腸癌のトランスクリプトーム解析2022
- Author(s)
  佐田春樹、檜井孝夫、新津宏明、中原　輝、三口真司、坂本直也、大上直秀、田代裕尊、大段秀樹
- Organizer
  第33回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-23K21448
[Presentation] Genetically-engineered mouse model for colonic neoplasia presenting mucinous2022
- Author(s)
  Haruki Sada, Takao Hinoi, Hiroaki Niitsu, Hikaru Nakahara, Masashi Miguchi, Naoya Sakamoto, Naohide Oue, Hirotaka Tashiro, Hideki Ohdan
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K21448
[Presentation] Genetically-engineered mouse model for colonic neoplasia presenting mucinous and microsatellite unstable phenotype2022
- Author(s)
  Haruki Sada, Takao Hinoi， Hiroaki Niitsu, Masatoshi Miguchi, Naoya Sakamoto, Naohide Oue, Hirotaka Tashiro, Hideki Ohdan
- Organizer
  2022年 AACR ANNUAL MEETING
- Data Source
  KAKENHI-PROJECT-23K21448
[Presentation] 5-FU耐性胃癌オルガノイドの樹立およびその機能解析2020
- Author(s)
  鵜飼翔一、坂本直也、本間りりの、谷山大樹、高島剛志、仙谷和弘、大上直秀、安井弥
- Organizer
  第109回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K07017
[Presentation] 尿路上皮癌におけるSLFN11とDNA障害型抗がん剤の相関2020
- Author(s)
  谷山大樹、坂本直也、村井純子、高島剛志、林哲太郎、仙谷和弘、大上直秀、安井弥
- Organizer
  第109回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K07017
[Presentation] 消化管癌オルガノイドを用いたトリフルリジンの効用の検討2020
- Author(s)
  丸山諒太、坂本直也、谷山大樹、本間りりの、鵜飼翔一、仙谷和弘、大上直秀、安井弥
- Organizer
  第109回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K07017
[Presentation] 大腸癌の分子学的特徴と実験モデル2020
- Author(s)
  坂本直也、安井弥
- Organizer
  第79回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07017
[Presentation] 5-FU 耐性胃がんオルガノイドを用いたメタボローム解析2020
- Author(s)
  坂本直也、仲　一仁、鵜飼翔一、本間りりの、谷山大樹、高島剛志、仙谷和弘、大上直秀、安井弥
- Organizer
  第109回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K07017
[Presentation] Metabolome analysis using 5-FU resistant gastric cancer organoids2020
- Author(s)
  Naoya Sakamoto, Kazuhito Naka, Shoichi Ukai, Daiki Taniyama, Atsushi Ochiai, Wataru Yasui
- Organizer
  第31回消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-18K07017
[Presentation] オキサリプラチン耐性胃がんオルガノイドの樹立及びその機能的解析2020
- Author(s)
  原田健司、坂本直也、鵜飼翔一、Quoc Thang Pham、高島剛志、丸山諒太、本間りりの、谷山大樹、田邊和照、大段秀樹、安井弥
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07017
[Presentation] オキサリプラチン耐性胃がんオルガノイドの樹立及びその機能解析2020
- Author(s)
  原田健司、坂本直也、鵜飼翔一、高島剛志、丸山諒太、本間りりの、谷山大樹、仙谷和弘、大上直秀、安井弥
- Organizer
  第109回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K07017
[Presentation] 5-FU耐性胃癌オルガノイドの樹立とその癌遺伝子学的解析2020
- Author(s)
  鵜飼翔一、坂本直也、本間りりの、谷山大樹、Quoc Thang Pham、高島剛志、原田健司、仲　一仁、田邊和照、大段秀樹、安井弥
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07017
[Presentation] 大腸癌オルガノイドを用いたトリフルリジン効用の検討2020
- Author(s)
  丸山諒太、坂本直也、谷山大樹、常國健太、本間りりの、鵜飼翔一、檜井孝夫、大段秀樹、安井弥
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07017
[Presentation] 尿路上皮癌におけるSLFN11とDNA障害型抗がん剤の効果の関連2020
- Author(s)
  谷山大樹、坂本直也、村井純子、高島　剛、林哲太郎、亭島淳、松原昭郎、安井弥
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07017
[Presentation] Establishment and molecular biological analysis of 5-FU resistant gastric cancer organoids2020
- Author(s)
  Shoichi Ukai, Naoya Sakamoto, Ririno Honma, Daiki Taniyama, Quoc Thang Pham, Tsuyoshi Takashima, Kenji Harada, Kazuhito Naka, Kazuaki Tanabe, Hideki Ohdan, Wataru Yasui
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03517
[Presentation] オルガノイドを用いた前立腺研究2019
- Author(s)
  関野陽平、後藤景介、井上省吾、林哲太郎、亭島淳、坂本直也、仙谷和弘、大上直秀、安井弥、松原昭郎
- Organizer
  第35回前立線シンポジウム
- Data Source
  KAKENHI-PROJECT-18K09134
[Presentation] オルガノイドを用いた癌幹細胞特異的な遺伝子・分子異常の解析.2019
- Author(s)
  坂本直也、本間りりの、鵜飼翔一、仙谷和弘、大上直秀、安井　弥
- Organizer
  第108回日本病理学会総会、シンポジウム 5「オルガノイドとPDX」
- Invited
- Data Source
  KAKENHI-PROJECT-18K07017
[Presentation] KIFC1 Inhibitor CW069 Induces Apoptosis and Reverses Resistance to Docetaxel in Prostate Cancer.2019
- Author(s)
  Sekino Y, Koike Y, Sakamoto N, Shiota M, Shigematsu Y, Sentani K, Oue N, Teishima J, Yasui W, Matsubara A
- Organizer
  34th Annual EAU Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09134
[Presentation] 前立腺癌における claspin の臨床病理学的分析2019
- Author(s)
  馬場崎隆志、仙谷和弘、小林剛、関野陽平、浦岡直礼、坂本直也、塩田真己、大上直秀、亭島淳、松原昭郎、安井弥
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K09134
[Presentation] Protocadherin B9 promotes resistance to bicalutamide and is associated with the survival of prostate cancer patients.2019
- Author(s)
  Sekino Y, Goto K, Sakamoto N, Oue N, Sentani K, Hayashi T, Teishima J, Yasui W, Matsubara A.
- Organizer
  34th Annual EAU Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09134
[Presentation] KIFC1 Inhibitor CW069 Induces Apoptosis and Reverses Resistance to Docetaxel in Prostate Cancer.2018
- Author(s)
  Sekino Y, Koike Y, Shigematsu Y, Hattori T, Sakamoto N, Shiota M, Sentani K, Oue N, Teishima J, Matsubara A, Yasui W
- Organizer
  第77回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-18K09134
[Presentation] CRISPR/Cas9による胃型・腸型胃がんオルガノイドモデルの樹立及び薬剤感受性の検討2017
- Author(s)
  坂本直也
- Organizer
  第28回日本消化器癌発生学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06999
[Presentation] A gastric cancer organoid library provides a hopeful resource for drug screening2017
- Author(s)
  本間りりの、坂本直也、石川　洸、仙谷和弘、大上直秀、安井　弥
- Organizer
  第76回日本癌学会
- Data Source
  KAKENHI-PROJECT-16H06999
[Presentation] Stem cell derived organoid: a promising tool for basic and clinical research2017
- Author(s)
  Sakamoto Naoya
- Organizer
  Bridging Gaps in Oncology 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06999
[Presentation] MiR-148aの胃癌における発現低下とMMP7と介した浸潤への関与2012
- Author(s)
  坂本直也
- Organizer
  第21回日本癌転移学会
- Place of Presentation
  広島
- Year and Date
  2012-07-13
- Data Source
  KAKENHI-PROJECT-23790403
[Presentation] 胃癌で発現が低下しているmiR-148a は MMP7 を標的とし、浸潤に関与する2012
- Author(s)
  坂本直也
- Organizer
  第71回日本癌学会
- Place of Presentation
  札幌
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-23790403
[Presentation] MiR-148a の胃癌における発現低下と MMP7 を介した浸潤への関与2012
- Author(s)
  坂本直也
- Organizer
  第21回日本癌転移学会
- Place of Presentation
  広島
- Year and Date
  2012-07-13
- Data Source
  KAKENHI-PROJECT-23790403
[Presentation] 胃癌におけるmiR-148aの発現低下とMMP7を介した浸潤への関与2012
- Author(s)
  坂本直也
- Organizer
  第101回日本病理学会
- Place of Presentation
  東京
- Year and Date
  2012-04-27
- Data Source
  KAKENHI-PROJECT-23790403
[Presentation] 胃癌における DNA メチル化による miR-148a の低下と MMP7 を介した浸潤への関与2012
- Author(s)
  坂本直也
- Organizer
  第101回日本病理学会
- Place of Presentation
  東京
- Year and Date
  2012-04-27
- Data Source
  KAKENHI-PROJECT-23790403
[Presentation] 胃癌で発現が低下しているmiR-148aはMMP7と標的とし、浸潤に関与する2012
- Author(s)
  坂本直也
- Organizer
  第71回日本癌学会
- Place of Presentation
  札幌
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-23790403
[Presentation] スキルス胃癌組織を用いたCAST 法による解析: 新規マーカーTM9SF3 の同定2011
- Author(s)
  坂本直也
- Organizer
  第20回がん転移学会学術集会
- Year and Date
  2011-06-30
- Data Source
  KAKENHI-PROJECT-23790403
[Presentation] MICRORNA EXPRESSION PROFILES IN GASTRIC CANCER：MIR-148 IS INVOLVED IN GASTRIC CANCER INVASION BY REPRESSION OF MMP7 EXPRESSION2011
- Author(s)
  坂本直也
- Organizer
  The 9th International Gastric Cancer Congress
- Place of Presentation
  ソウル(韓国)
- Data Source
  KAKENHI-PROJECT-23790403
[Presentation] 胃癌で発現低下しているmiR-148a は MMP7 を標的とし、浸潤に関与する2011
- Author(s)
  坂本直也
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-23790403
[Presentation] 胃癌におけるmicroRNA発現解析2011
- Author(s)
  坂本直也
- Organizer
  第100回日本病理学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790403
[Presentation] スキルス胃癌組織を用いたCAST法による解析：新規マーカーTM9SF3の同定2011
- Author(s)
  坂本直也
- Organizer
  第20回がん転移学会学術集会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-23790403
[Presentation] MIR-148A, DOWN-REGULATED IN GASTRIC CANCER, TARGETS MMP7 AND PARTICIPATES IN TUMOR INVASION2011
- Author(s)
  坂本直也
- Organizer
  The 21th International Symposium of the Hiroshima Cancer Seminar
- Place of Presentation
  広島
- Year and Date
  2011-11-06
- Data Source
  KAKENHI-PROJECT-23790403
[Presentation] MIR-148A, DOWN-REGULATED IN GASTRIC CANCER, TARGETS MMP7 AND PARTICIPATES IN TUMOR INVASION2011
- Author(s)
  坂本直也
- Organizer
  The 21 th International Symposium of the Hiroshima cancer Seminor
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23790403
[Presentation] miR-148a, down-regulated in gastric cancer, targets MMP7 and participates in invasion.2011
- Author(s)
  坂本直也
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23790403
[Presentation] 胃癌における miR-148a の発現低下と MMP7 を介した浸潤への関与2011
- Author(s)
  坂本直也
- Organizer
  第22回消化器癌発生学会
- Place of Presentation
  佐賀
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PROJECT-23790403
[Presentation] 胃癌におけるmiR-148aの発現低下とMMP7を介した浸潤への関与2011
- Author(s)
  坂本直也
- Organizer
  第22回消化器癌発生学会総会
- Place of Presentation
  佐賀
- Data Source
  KAKENHI-PROJECT-23790403
[Presentation] 胃癌における microRNA 発現解析2011
- Author(s)
  坂本直也
- Organizer
  第100回日本病理学会総会
- Place of Presentation
  横浜
- Year and Date
  2011-04-28
- Data Source
  KAKENHI-PROJECT-23790403
[Presentation] microRNA expression profiles in gastric cancer: miR-148a is down-regulated in gastric cancer and involved in gastric cancer invasion by repression of MMP7 expression2011
- Author(s)
  坂本直也
- Organizer
  9thInternational Gastric Cancer Congress
- Place of Presentation
  Seoul (Korea)
- Year and Date
  2011-04-22
- Data Source
  KAKENHI-PROJECT-23790403

1. Tanabe Kazuaki (40379847)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. Naka Kazuhito (70372688)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. TEISHIMA JUN (20397962)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. 林哲太郎 (60612835)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. 井上省吾 (90457177)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. 大段秀樹 (10363061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 弓削類 (20263676)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 松原昭郎 (10239064)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. 安井弥 (40191118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
10. 神明俊輔 (70749936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 小畠浩平 (10749998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 後藤景介 (30784251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 関野陽平 (30837810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 池田健一郎 (50624863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 日向信之 (10598816)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 檜井孝夫 (10444689)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 下村学 (60457249)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 外丸祐介 (90309352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 仙谷和弘 (30508164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
20. 池上恒雄 (80396712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 高倉有二 (20581698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. HINO Takao

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
23. 村井純子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 大上直秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results
25. 谷本圭司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakamoto Naoya 坂本 直也

SAKAMOTO Naoya 坂本 直也

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胃がんオルガノイドにおけるスプライシング異常による抗がん剤耐性獲得機構の解析Principal Investigator

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Analysis of the mechanism of acquisition of anticancer drug resistance using gastrointestinal cancer organoidsPrincipal Investigator

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Search for new therapeutic target against cancer stem cells using intestinal-/gastric type gastric cancer organoidPrincipal Investigator

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Establishment of the model of intestinal and gastric type gastric cancer using CRISPR/Cas9 and organoidPrincipal Investigator

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Tumor-stromal cell interaction and epithelial-mesenchymal transition by secreted-microRNAPrincipal Investigator

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[Journal Article] Establishment of a novel overlay culture method that enables immune response assessment using gastric cancer organoids2024

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Sakamoto Naoya 坂本直也

SAKAMOTO Naoya 坂本直也