Ogura Hideki 小椋英樹

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OGURA Hideki 小椋英樹

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Researcher Number	20573174
Other IDs	https://orcid.org/0000-0002-2116-0340
Affiliation (Current)	2025: 兵庫医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2025: 兵庫医科大学, 医学部, 准教授 2020 – 2022: 兵庫医科大学, 医学部, 講師 2018 – 2019: 兵庫医科大学, 医学部, 助教 2014: 北海道大学, 遺伝子病制御研究所, その他 2014: 北海道大学, 遺伝子病制御研究所, 特任助教 … More 2013: 大阪大学, 生命機能研究科, 助教 2012: 大阪大学, 医学(系)研究科(研究院), 助教 2011: 大阪大学, 大学院・医学系研究科, 助教 2010 – 2011: 大阪大学, 医学系研究科, 助教 Less
Review Section/Research Field	Principal Investigator Immunology / Basic Section 49070:Immunology-related / Basic Section 54020:Connective tissue disease and allergy-related Except Principal Investigator Basic Section 54030:Infectious disease medicine-related / Basic Section 55010:General surgery and pediatric surgery-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields
Keywords	Principal Investigator 自己免疫 / T細胞 / 炎症アンプ / NF-kB / 潰瘍性大腸炎 / 炎症性腸疾患 / サイトカイン / 腸内細菌叢 / 腸炎 / T cell … More / autoimmune disease / IBD / 非免疫細胞 / STAT3 / ZFP1 / IL-6Amp / IL-6 / CCL20 / IL-17A / 関節炎 / 自己免疫疾患 / Ccl20 / IL-17 / 線維芽細胞 / 慢性炎症 / 4ステップモデル / IL-6 Amp / IL-6アンプ … More Except Principal Investigator ウイルス感染症 / 腸内細菌 / 腸内細菌叢 / 回腸嚢炎 / 潰瘍性大腸炎 / MHC class II / アレルギー / 主要組織適合遺伝子複合体 / ユビキチン化 Less

T細胞ライブラリを基盤とした自己免疫・がんにおける抗原特異的T細胞の解析Principal Investigator
- Principal Investigator
  
  小椋英樹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Hyogo Medical University
Interrogation of HLA-restricted virus-specific bona fide CTLs toward emerging SARS-CoV-2
- Principal Investigator
  
  石戸聡
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Hyogo Medical University
潰瘍性大腸炎における腸内細菌叢ー免疫系の相互作用の解析Principal Investigator
- Principal Investigator
  
  小椋英樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Hyogo Medical University
The alteration of gut microbiome during treatment of pouchitis in patients with ulcerative colitis.
- Principal Investigator
  
  Uchino Motoi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Hyogo Medical University
Analysis of pathological CD4+ T cells on a novel inflammatory bowel disease modelPrincipal Investigator
- Principal Investigator
  
  Ogura Hideki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Hyogo Medical University
Exploration of diseases caused by MARCH dysregulation
- Principal Investigator
  
  ishido satoshi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Hyogo Medical University
慢性炎症に重要な炎症アンプの分子基盤の解析Principal Investigator
- Principal Investigator
  
  小椋英樹
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Hokkaido University
The novel molecular mechanism regulating the Inflammation AmplifierPrincipal Investigator
- Principal Investigator
  
  OGURA Hideki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Hokkaido University
  Osaka University
Screening of the target genes of IL-6 Amp that promotes autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  OGURA Hideki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Osaka University

All 2014 2013 2011 2010 Other

All Journal Article Presentation Book

[Book] 炎症と免疫　IL-6アンプと血液脳関門への病原Th17の侵入口形成2013
- Author(s)
  上村　大輔、小椋　英樹、村上　正晃
- Total Pages
  9
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-24790472
[Book] 臨床免疫・アレルギー科　インフラメーションアンプルートと関与分子2013
- Author(s)
  小椋　英樹、村上　正晃
- Total Pages
  9
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-24790472
[Journal Article] Inflammation Amplifier, a New Paradigm in Cancer Biology2014
- Author(s)
  Atsumi T, Singh R, et al.
- Journal Title
  
  Cancer Research
  
  Volume: 74 Issue: 1 Pages: 8-14
- DOI
  10.1158/0008-5472.can-13-2322
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J00819, KAKENHI-PROJECT-14F04789, KAKENHI-PROJECT-24249028, KAKENHI-PROJECT-24390098, KAKENHI-PROJECT-24790472, KAKENHI-PROJECT-26460574
[Journal Article] The Gateway Reflex, which is mediated by the inflammation amplifier, directs pathogenic immune cells into the CNS.2014
- Author(s)
  Sabharwal, L., Kamimura, D., Meng, J., Bando, H., Ogura, H., Nakayama, C., Jiang, J. J., Kumai, N., Suzuki, H., Atsumi, T., Arima, Y. & Murakami, M.
- Journal Title
  
  Journal of biochemistry
  
  Volume: 156 Issue: 6 Pages: 299-304
- DOI
  10.1093/jb/mvu057
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-14F04789, KAKENHI-PROJECT-24390098, KAKENHI-PROJECT-24590583, KAKENHI-PROJECT-24659221, KAKENHI-PROJECT-26460574, KAKENHI-PROJECT-26460575
[Journal Article] The reverse-direction method links mass experimental data to human diseases.2014
- Author(s)
  Ogura, H., Atsumi, T., Bando, H., Sabharwal, L., Yamada, M., Jiang, J. J., Nakamura, A., Arima, Y., Kamimura, D. & Murakami, M
- Journal Title
  
  Archivum immunologiae et therapiae experimentalis
  
  Volume: 62 Issue: 1 Pages: 41-45
- DOI
  10.1007/s00005-013-0255-9
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-14F04789, KAKENHI-PROJECT-24249028, KAKENHI-PROJECT-24390098, KAKENHI-PROJECT-24590583, KAKENHI-PROJECT-24790472, KAKENHI-PROJECT-26460574
[Journal Article] Disease-Association Analysis of an Inflammation-Related Feedback Loop.2013
- Author(s)
  Murakami M, Harada M, Kamimura D
- Journal Title
  
  Cell Reports
  
  Volume: 3 Issue: 3 Pages: 946-59
- DOI
  10.1016/j.celrep.2013.01.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J00819, KAKENHI-PROJECT-22500663, KAKENHI-PROJECT-22590931, KAKENHI-PROJECT-24249028, KAKENHI-PROJECT-24390098, KAKENHI-PROJECT-24590583, KAKENHI-PROJECT-24659221, KAKENHI-PROJECT-24790472
[Journal Article] The Gate Theory: How Regional Neural Activation Creates a Gateway for Immune Cells via an Inflammation Amplifier.2013
- Author(s)
  Ogura H, Y. Arima, D. Kamimura, M Murakami
- Journal Title
  
  Biomedical J
  
  Volume: 36 Issue: 6 Pages: 269-273
- DOI
  10.4103/2319-4170.113187
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24249028, KAKENHI-PROJECT-24659221, KAKENHI-PROJECT-24790472
[Journal Article] Local microbleeding facilitates IL-6-and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells2011
- Author(s)
  Murakami M*, Okuyama Y*, Ogura H*, Asano S, Arima Y, Tsuruoka M, Harada M, Kanamoto M, Sawa Y, Iwakura Y, Takatsu K, Kamimura D, Hirano T(* equally contributed to this paper.)
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 208(1) Pages: 103-114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790464
[Journal Article] Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells.2011
- Author(s)
  Murakami M, Ogura H, et al.(equally contributed to this paper)
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 208(1) Pages: 103-114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790464
[Journal Article] IL-6誘導性の"炎症アセプ"と自己免疫疾患2010
- Author(s)
  小椋英樹、村上正晃、平野俊夫
- Journal Title
  
  医学のあゆみサイトカインと疾患
  
  Volume: 234 Pages: 495-500
- Data Source
  KAKENHI-PROJECT-22790464
[Journal Article] IL-6誘導性の"炎症アンプ"と自己免疫疾患2010
- Author(s)
  小椋英樹、村上正晃、平野俊夫
- Journal Title
  
  医学のあゆみサイトカインと疾患
  
  Volume: 234 Pages: 495-500
- Data Source
  KAKENHI-PROJECT-22790464
[Presentation] NAF-1のクロマチンリモデリングを介した炎症回路の制御2014
- Author(s)
  Ogura H, Bando H, Meng J, Sabharwal L, Atsumi T, Murakami M
- Organizer
  日本エピジェネティクス研究会
- Place of Presentation
  東京大学（東京都文京区）
- Year and Date
  2014-05-26
- Data Source
  KAKENHI-PROJECT-24790472
[Presentation] Genome-Wide Screen of Negative Regulators of the Inflammation Amplifier, a Chemokine Inducer in Non-Immune Cells2013
- Author(s)
  Hideki Ogura, Rajeev Singh, Lavannya Sabharwal, Noriko Kumai, Azusa Okuyama, Toshio Hirano, and Masaaki Murakami
- Organizer
  第42回日本免疫学会
- Place of Presentation
  千葉幕張メッセ
- Data Source
  KAKENHI-PROJECT-24790472
[Presentation] A protein kinase, PKX is involved in the development of autoimmune diseases via regulating the IL-6 amplifier activation2011
- Author(s)
  諸井亜理紗、小椋英樹、村上正晃、他
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-22790464
[Presentation] A protein kinase, PKX is involved in the development of a utoimmune diseases via regulating the IL-6 amplifier activation2011
- Author(s)
  諸井亜理紗、小椋英樹、村上正晃, 他
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-22790464
[Presentation] An ENU-mutant mouse, which increased a stress signaling in naive T cells2011
- Author(s)
  KAMIMURA D, OGURA H, MURAKAMI M, 他
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-22790464
[Presentation] Zinc finger motif containing protein A, ZFA regulates IL-6 amplifier activation via regulating NF-kB activity and promotes anautoimmune arthritis2011
- Author(s)
  勝沼功吉、小椋英樹、村上正晃、他
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-22790464
[Presentation] A zinc finger motif containing potein, ZFZ regulates IL-6 amplifier activation via regulating NF-kB activity and promotes an autoimmune arthritis2011
- Author(s)
  小椋英樹、村上正晃、他
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-22790464
[Presentation] A Four-step Model for MHC Class II-Associated Autoimmune Diseases2011
- Author(s)
  OKUYAMA Y, OGURA H, MURAKAMI M, 他
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-22790464
[Presentation] A zinc finger motif containing protein regulttes the activation of the IL-6 amplifier, which is a critical for the development of an autoimmune arthritis (poster)2010
- Author(s)
  H.Ogura, M.Murakami, T.
- Organizer
  60^<th> Fujihara Seminar "Zinc Signaling and Cellular Funcrions"
- Place of Presentation
  大阪国際会議場
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-22790464
[Presentation] IL-6 plays roles not only for developing Th17 but also for inducing an IL-6 amplifier in autoimmune diseases (poster and oral presentation)2010
- Author(s)
  H.Ogura, M.Murakami, T.Hirano, et al.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸国際展示場
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-22790464
[Presentation] Specific antigen recognition by CD4+T cells is not required for a MHC class II-associated autoimmune arthritis (poster)2010
- Author(s)
  Okuyama Y, Ogura H, et al.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸国際展示場
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-22790464
[Presentation] IL-6-mediated STAT3 signaling in T cells directs the development of Th17 with a minimum effect on that of Treg in vivo (poster)2010
- Author(s)
  M.Harada, H.Ogura, et al.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸国際展示場
- Year and Date
  2010-08-23
- Data Source
  KAKENHI-PROJECT-22790464
[Presentation] IL-6 plays roles not only for developing Th17 but also for inducing an IL-6 amplifier in autoimmune diseases2010
- Author(s)
  H. Ogura, M. Murakami, Y. Okuyama, M. Tsuruoka, C. Kitabayashi, M. Kanamoto, M. Nishihara, Y. Iwakura, K. Takatsu, D. Kamimura, T. Hirano
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸国際展示場
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-22790464
[Presentation] A zinc finger motif containing protein regulttes the activation of the IL-6 amplifier, which is a critical for the development of an autoimmune arthritis2010
- Author(s)
  H. Ogura, H. Masaya, E. Sanda, Y. Okuyama, D Kamimura, M. Murakami, T. Hirano
- Organizer
  60^<th> Fujihara Seminar" Zinc Signaling and Cellular Funcrions"
- Place of Presentation
  大阪国際会議場
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-22790464
[Presentation] IL-6-meidated positive regulation of Foxp3^+ CD8^+ T cells is critical for the development of autoimmune diseases2010
- Author(s)
  Tsuruoka M, Nakagawa T, Kamimura D, Ogura H, Okuyama Y, Arima Y, Hirano T, Murakami M
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸国際展示場
- Year and Date
  2010-08-26
- Data Source
  KAKENHI-PROJECT-22790464
[Presentation] IL-6-mediated STAT3 signaling in T cells directs the development of Th17 with a minimum effect on that of Treg in vivo2010
- Author(s)
  M. Harada, M. Nishihara, H. Ogura, N. Ueda, M. Tsuruoka, C. Kitabayashi, F. Fuji, H. Aono, K. Ishihara, E. Huseby, U. A. K. Betz, M. Murakami, T. Hirano
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸国際展示場
- Year and Date
  2010-08-23
- Data Source
  KAKENHI-PROJECT-22790464
[Presentation] Specific antigen recognition by CD4+ T cells is not required for a MHC class II-associated autoimmune arthritis2010
- Author(s)
  Okuyama Y, Ogura H, Asano S, Kanamoto M, Arima Y, Iwakura Y, Takatsu K, Kamimura D, Murakami M, Hirano T
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸国際展示場
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-22790464
[Presentation] ZFZ (zinc finger motif containing protein Z) promotes the inflammation amplifier by regulating NF-κB DNA binding activity
- Author(s)
  Ogura H, Atsumi T, Meng J, Kamimura D, Murakami M
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24790472
[Presentation] ZFZ (zinc finger motif containing protein Z) promotes the inflammation amplifier by regulating NF-κB DNA binding activity
- Author(s)
  Ogura H, Atsumi T, Meng J, Kamimura D, Murakami M
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26460575
[Presentation] IL-6 amplifier, NF-kB-triggered positive-feedback for IL-6 signaling, is a key player in inflammation associated with various human diseases
- Author(s)
  Ogura H et al.,
- Organizer
  第41回日本免疫学会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-24790472

1. ishido satoshi (10273781)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 加藤完 (20632946)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 孫安生 (30447924)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 池内浩基 (80319863)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. Uchino Motoi (00388810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 上村大輔 (20391922)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 池田正孝 (80335356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 中西裕美子 (10614274)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 堀尾勇規 (10838999)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 皆川知洋 (70839000)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 桑原隆一 (90839010)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 藤本ゆかり (00362616)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 神谷亘 (60551421)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 平田淳一 (50509057)

# of Collaborated Projects: 1 results

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15. 村上正晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Ogura Hideki 小椋 英樹

OGURA Hideki 小椋 英樹

Research Projects

Research Products

Co-Researchers

T細胞ライブラリを基盤とした自己免疫・がんにおける抗原特異的T細胞の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Interrogation of HLA-restricted virus-specific bona fide CTLs toward emerging SARS-CoV-2

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

潰瘍性大腸炎における腸内細菌叢ー免疫系の相互作用の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The alteration of gut microbiome during treatment of pouchitis in patients with ulcerative colitis.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of pathological CD4+ T cells on a novel inflammatory bowel disease modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration of diseases caused by MARCH dysregulation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

慢性炎症に重要な炎症アンプの分子基盤の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The novel molecular mechanism regulating the Inflammation AmplifierPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Screening of the target genes of IL-6 Amp that promotes autoimmune diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 炎症と免疫 IL-6アンプと血液脳関門への病原Th17の侵入口形成2013

Author(s)

Total Pages

Publisher

Data Source

[Book] 臨床免疫・アレルギー科 インフラメーションアンプルートと関与分子2013

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Inflammation Amplifier, a New Paradigm in Cancer Biology2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Gateway Reflex, which is mediated by the inflammation amplifier, directs pathogenic immune cells into the CNS.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The reverse-direction method links mass experimental data to human diseases.2014

Ogura Hideki 小椋英樹

OGURA Hideki 小椋英樹

[Book] 炎症と免疫　IL-6アンプと血液脳関門への病原Th17の侵入口形成2013

[Book] 臨床免疫・アレルギー科　インフラメーションアンプルートと関与分子2013