Takayama Jun 高山順

Researcher Number	20574114
Other IDs	https://orcid.org/0000-0003-2803-6526
Affiliation (Current)	2025: 東北大学, 医学系研究科, 准教授 2025: 東北大学, 未来型医療創成センター, 准教授
Affiliation (based on the past Project Information) *help	2025: 東北大学, 医学系研究科, 准教授 2020 – 2021: 東北大学, 未来型医療創成センター, 准教授 2019: 東北大学, 未来型医療創成センター, 助教 2017: 国立研究開発法人理化学研究所, 革新知能統合研究センター, 研究員 2016: 国立研究開発法人理化学研究所, 生命システム研究センター, 研究員 2015: 国立研究開発法人理化学研究所, 生命システム研究センター, 特別研究員
Review Section/Research Field	Principal Investigator Basic Section 48040:Medical biochemistry-related / Basic Section 43060:System genome science-related / Developmental biology
Keywords	Principal Investigator 希少難病 / 大規模言語モデル / 全ゲノム解析 / 深層学習 / 基準ゲノム / バイオインフォマティクス / 次世代シークエンス / ゲノムコホート / 疾患ゲノム解析 / 次世代シークエンス解析 … More / 次世代シークエンシング / ヒトゲノム解析 / RNAiスクリーニング / イオンチャネル / 線虫 / カルシウムチャネル / カルシウム波 / 受精 / 受精カルシウム波 Less

Research Projects
(3 results)
Research Products
(15 results)

全ゲノム領域の変異効果予測を可能にするヒトゲノム言語モデルの開発Principal Investigator
- Principal Investigator
  
  高山順
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Tohoku University
NGS analysis of a large genome cohort by deep learningPrincipal Investigator
- Principal Investigator
  
  Takayama Jun
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43060:System genome science-related
- Research Institution
  Tohoku University
Elucidating the physiological significance of the fertilization calcium waves through the idenfication of novel channelsPrincipal Investigator
- Principal Investigator
  
  Takayama Jun
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Developmental biology
- Research Institution
  Institute of Physical and Chemical Research

All 2022 2021 2020 2019 2017 2016

All Journal Article Presentation

[Journal Article] Construction and integration of three de novo Japanese human genome assemblies toward a population-specific reference2021
- Author(s)
  Takayama Jun、Tadaka Shu、Yano Kenji、Katsuoka Fumiki、Gocho Chinatsu、Funayama Takamitsu、Makino Satoshi、Okamura Yasunobu、Kikuchi Atsuo、Sugimoto Sachiyo、Kawashima Junko、Otsuki Akihito、Sakurai-Yageta Mika、Yasuda Jun、Kure Shigeo、Kinoshita Kengo、Yamamoto Masayuki、Tamiya Gen
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 226-226
- DOI
  10.1038/s41467-020-20146-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06625, KAKENHI-PUBLICLY-19H05200, KAKENHI-PROJECT-19H03795, KAKENHI-PROJECT-17K07193
[Journal Article] 次世代シークエンス解析と基準ゲノム配列の広がり2021
- Author(s)
  高山順
- Journal Title
  
  月刊「細胞」
  
  Volume: 53(8) Pages: 44-46
- Data Source
  KAKENHI-PROJECT-19K06625
[Journal Article] In vivo Live Imaging of Calcium Waves and Other Cellular Processes during Fertilization in Caenorhabditis elegans2017
- Author(s)
  Jun Takayama, Masashi Fujita, Shuichi Onami
- Journal Title
  
  Bio-protocol
  
  Volume: 7 Issue: 7
- DOI
  10.21769/bioprotoc.2205
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18547
[Journal Article] The sperm TRP-3 channel mediates the onset of a Ca2+ wave in the fertilized C. elegans oocyte.2016
- Author(s)
  Jun Takayama and Shuichi Onami
- Journal Title
  
  Cell Reports
  
  Volume: 15 Issue: 3 Pages: 625-637
- DOI
  10.1016/j.celrep.2016.03.040
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K18547
[Presentation] 日本人基準ゲノム配列とオントロジーベースのAIによる疾患ゲノム解析の高精度化2022
- Author(s)
  高山順
- Organizer
  第56回糖尿病学の進歩
- Invited
- Data Source
  KAKENHI-PROJECT-19K06625
[Presentation] ゲノム医学における諸課題とAIへの期待2021
- Author(s)
  高山順
- Organizer
  第3回日本メディカルAI学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06625
[Presentation] 日本人基準ゲノムJG1の構築と小児希少疾患の全エクソーム解析への応用2020
- Author(s)
  高山順
- Organizer
  第27回日本遺伝子診療学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06625
[Presentation] Toward a Population-Specific Reference Genome:The Japanese Reference Genomes, JG1 and JG22020
- Author(s)
  Jun Takayama
- Organizer
  T2T/HPRC Consortium 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06625
[Presentation] A population-specific reference genome built by integrating three de novo Japanese genome assemblies2020
- Author(s)
  J. Takayama, S. Tadaka, K. Yano, F. Katsuoka, C. Gocho, T. Funayama, S. Makino, Y. Okamura, A. Kikuchi, J. Kawashima, A. Otsuki, J. Yasuda, S. Kure, K. Kinoshita, M. Yamamoto, G. Tamiya
- Organizer
  European Human Genetics Virtual Conference 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06625
[Presentation] 日本人基準ゲノムJG1の構築2019
- Author(s)
  高山　順
- Organizer
  日本人類遺伝学会第64回大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06625
[Presentation] 線虫C. elegansにおいて精子TRP-3チャネルが受精卵のカルシウム波を引き起こす.2016
- Author(s)
  高山順, 大浪修一
- Organizer
  日本発生生物学会秋季シンポジウム2016
- Place of Presentation
  三島市民文化会館（静岡県三島市）
- Year and Date
  2016-10-19
- Data Source
  KAKENHI-PROJECT-15K18547
[Presentation] The sperm-derived TRP family channel TRP-3 induces a calcium rise in the fertilized oocyte in C. elegans.2016
- Author(s)
  Jun Takayama, Hatsumi Okada, Shuichi Onami
- Organizer
  American Society for Cell Biology Annual Meeting 2016
- Place of Presentation
  San Francisco, USA
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18547
[Presentation] C. elegansの受精における二相性カルシウム波の分子基盤.2016
- Author(s)
  高山順, 大浪修一
- Organizer
  第54回日本生物物理学会年会
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-15K18547
[Presentation] The sperm TRP family channel TRP-3 induces a calcium wave in the fertilized oocyte of C. elegans.2016
- Author(s)
  Jun Takayama, Shuichi Onami
- Organizer
  The Allied Genetics Conference 2016
- Place of Presentation
  Orlando, USA
- Year and Date
  2016-07-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18547
[Presentation] 線虫の精子TRP-3チャネルは「受精のタイムキーパー」である.2016
- Author(s)
  高山順, 大浪修一
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K18547

Takayama Jun 高山 順

Research Projects

Research Products

全ゲノム領域の変異効果予測を可能にするヒトゲノム言語モデルの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

NGS analysis of a large genome cohort by deep learningPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the physiological significance of the fertilization calcium waves through the idenfication of novel channelsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Construction and integration of three de novo Japanese human genome assemblies toward a population-specific reference2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 次世代シークエンス解析と基準ゲノム配列の広がり2021

Author(s)

Journal Title

Data Source

[Journal Article] In vivo Live Imaging of Calcium Waves and Other Cellular Processes during Fertilization in Caenorhabditis elegans2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The sperm TRP-3 channel mediates the onset of a Ca2+ wave in the fertilized C. elegans oocyte.2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] 日本人基準ゲノム配列とオントロジーベースのAIによる疾患ゲノム解析の高精度化2022

Author(s)

Organizer

Data Source

[Presentation] ゲノム医学における諸課題とAIへの期待2021

Author(s)

Organizer

Data Source

[Presentation] 日本人基準ゲノムJG1の構築と小児希少疾患の全エクソーム解析への応用2020

Author(s)

Organizer

Data Source

[Presentation] Toward a Population-Specific Reference Genome:The Japanese Reference Genomes, JG1 and JG22020

Author(s)

Organizer

Data Source

[Presentation] A population-specific reference genome built by integrating three de novo Japanese genome assemblies2020

Author(s)

Organizer

Data Source

[Presentation] 日本人基準ゲノムJG1の構築2019

Author(s)

Organizer

Data Source

[Presentation] 線虫C. elegansにおいて精子TRP-3チャネルが受精卵のカルシウム波を引き起こす.2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] The sperm-derived TRP family channel TRP-3 induces a calcium rise in the fertilized oocyte in C. elegans.2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] C. elegansの受精における二相性カルシウム波の分子基盤.2016

Author(s)

Organizer

Place of Presentation

Takayama Jun 高山順