yamakawa naoki 山川直樹

… Alternative Names

山川直樹ヤマカワナオキ

YAMAKAWA Naoki 山川直樹

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Researcher Number	20583040
Other IDs
Affiliation (Current)	2025: 就実大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 就実大学, 薬学部, 教授 2018: 就実大学, 薬学部, 准教授 2013 – 2017: 就実大学, 薬学部, 講師 2012: 慶應義塾大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Drug development chemistry / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related Except Principal Investigator Drug development chemistry
Keywords	Principal Investigator 非ステロイド系抗炎症薬 / 医薬品探索 / 抗炎症薬 / 非ステロイド性抗炎症薬 / NSAIDs / ヘムオキシゲナーゼ-1 / Nrf2 / 抗炎症 / 酸化ストレス / 活性酸素 … More / 抗酸化作用 / 核因子赤血球系2-関連因子2 / 鎮痛薬 / 創薬化学 … More Except Principal Investigator モノクローナル抗体 / 炎症生サイトカイン / 滑膜細胞 / 炎症性サイトカイン / シノビオリン / CD81 / テトラスパニン / 関節リウマチ Less

Quantitative structure-activity relationship analysis of anti-inflammatory drugs with activate Nrf2Principal Investigator
- Principal Investigator
  
  山川直樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Shujitsu University
Development of non-steroidal anti-inflammatory analgesics which have TRP channel antagonism effectPrincipal Investigator
- Principal Investigator
  
  Yamakawa Naoki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Shujitsu University
Development of novel therapeutic compounds for rheumatoid arthritis targeting CD81
- Principal Investigator
  
  Nakanishi Tohru
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Shujitsu University
Synthesis and evaluation of new non steroidal anti inflammatory drugs for clinically usefulPrincipal Investigator
- Principal Investigator
  
  Yamakawa Naoki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Shujitsu University
Identification of molecular mechanism for actions of NSAID and its application for drug developmentPrincipal Investigator
- Principal Investigator
  
  YAMAKAWA Naoki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Shujitsu University
  Keio University

All 2024 2023 2019 2018 2017 2016 2015 2014 2013 2012

All Journal Article Presentation

[Journal Article] Antinociception by fluoro-loxoprofen, a novel non-steroidal anti-inflammatory drug with less ulcerogenic effects, in rat models of inflammatory pain2019
- Author(s)
  Asano Teita、Hattori Tomoki、Tanaka Ken-ichiro、Yamakawa Naoki、Suemasu Shintaro、Aida Shuji、Kataoka Marika、Mizushima Tohru、Takenaga Mitsuko
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 844 Pages: 253-258
- DOI
  10.1016/j.ejphar.2018.12.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08334
[Journal Article] Identification of Mepenzolate Derivatives With Long-Acting Bronchodilatory Activity2018
- Author(s)
  Yamakawa Naoki and Tanaka Ken-Ichiro、Yamashita Yasunobu、Asano Teita、Kanda Yuki、Takafuji Ayaka、Kawahara Masahiro、Takenaga Mitsuko、Fukunishi Yoshifumi、Mizushima Tohru
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 9
- DOI
  10.3389/fphar.2018.00344
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08334
[Journal Article] Crystal face identification by Raman microscopy for assessment of crystal habit of a drug.2015
- Author(s)
  Moriyama K., Furuno N., Yamakawa N.
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 480 Issue: 1-2 Pages: 101-106
- DOI
  10.1016/j.ijpharm.2015.01.031
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26860082
[Journal Article] Superiority of pulmonary administration of mepenzolate bromide over other routes as treatment for chronic obstructive pulmonary disease2014
- Author(s)
  Tanaka, K., Kurotsu, S., Asano, T., Yamakawa, N., Kobayashi, D., Yamashita, Y., Yamazaki, H., Ishihara, T., Watanabe, H., Maruyama, T., Suzuki, H. and Mizushima, T
- Journal Title
  
  Sci Rep
  
  Volume: 4 Pages: 4510-4510
- Data Source
  KAKENHI-PROJECT-24790113
[Journal Article] Synthesis and biological comparison of enantiomers of mepenzolate bromide, a muscarinic receptor antagonist with bronchodilatory and anti-inflammatory activities2014
- Author(s)
  Yamashita, Y., Tanaka, K., Asano, T., Yamakawa, N., Kobayashi, D., Ishihara, T., Hanaya, K., Shoji, M., Sugai, T., Wada, M., Mashimo, T., Fukunishi, Y. and Mizushima, T
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 22 Pages: 3488-3497
- Data Source
  KAKENHI-PROJECT-24790113
[Journal Article] Structure-activity relationship of celecoxib and rofecoxib for the membrane permeabilizing activity2014
- Author(s)
  Yamakawa, N., Suzuki, K., Yamashita, Y., Katsu, T., Hanaya, K., Shoji, M., Sugai, T. and Mizushima, T
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 22 Pages: 2529-2534
- Data Source
  KAKENHI-PROJECT-24790113
[Journal Article] Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease2013
- Author(s)
  Tanaka, K., Ishihara, T., Sugizaki, T., Kobayashi, D., Yamashita, Y., Tahara, K., Yamakawa, N., Iijima, K., Mogushi, K., Tanaka, H., Sato, K., Suzuki, H. and Mizushima, T
- Journal Title
  
  Nat Commun
  
  Volume: 4 Pages: 2686-2686
- Data Source
  KAKENHI-PROJECT-24790113
[Journal Article] Suppression of Alzheimer's Disease-Related Phenotypes by Geranylgeranylacetone in Mice2013
- Author(s)
  Hoshino, T., Suzuki, K., Matsushima, T., Yamakawa, N., Suzuki, T. and Mizushima, T
- Journal Title
  
  PLoS One
  
  Volume: 8 Pages: 76306-76306
- NAID
  120005365906
- Data Source
  KAKENHI-PROJECT-24790113
[Journal Article] Suppression of UV-induced wrinkle formation by induction of HSP70 expression in mice2013
- Author(s)
  Matsuda, M., Hoshino, T., Yamakawa, N., Tahara, K., Adachi, H., Sobue, G., Maji, D., Ihn, H. and Mizushima, T
- Journal Title
  
  J Invest Dermatol
  
  Volume: 132 Pages: 919-928
- Data Source
  KAKENHI-PROJECT-24790113
[Journal Article] Prostaglandin E1 -containing nanoparticles improve walking activity in an experimental rat model of intermittent claudication2013
- Author(s)
  Ishihara, T., Yamashita, Y., Takasaki, N., Yamamoto, S., Hayashi, E., Tahara, K., Takenaga, M., Yamakawa, N., Kasahara, T. and Mizushima, T
- Journal Title
  
  J Pharm Pharmacol
  
  Volume: 65 Pages: 1187-1194
- Data Source
  KAKENHI-PROJECT-24790113
[Journal Article] Comparison of pharmacokinetics between loxoprofen and its derivative with lower ulcerogenic activity, fluoro-loxoprofen2013
- Author(s)
  Yamakawa, N., Suemasu, S., Watanabe, H., Tahara, K., Tanaka, K., Okamoto, Y., Ohtsuka, M., Maruyama, T. and Mizushima, T
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 28 Pages: 118-124
- NAID
  130004933526
- Data Source
  KAKENHI-PROJECT-24790113
[Journal Article] Comparison of pharmacokinetics between loxoprofen and its derivative with lower ulcerogenic activity, fluoro-loxoprofen.2013
- Author(s)
  Yamakawa N, Suemasu S, Watanabe H, Tahara K, Tanaka K-i, Okamoto Y, Ohtsuka M, Maruyama T and Mizushima T
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 28 Pages: 118-124
- NAID
  130004933526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790113
[Journal Article] Expression of 150-kDa oxygen-regulated protein (ORP150) stimulates bleomycin-induced pulmonary fibrosis and dysfunction in mice2012
- Author(s)
  Tanaka, K., Shirai, A., Ito, Y., Namba, T., Tahara, K., Yamakawa, N. and Mizushima, T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 425 Pages: 818-824
- Data Source
  KAKENHI-PROJECT-24790113
[Journal Article] Synthesis and Biological Evaluation of Derivatives of 2-{2-Fluoro-4-[(2-oxocyclopentyl)methyl ]phenyl}propanoic Acid : Nonsteroidal Anti-Inflammatory Drugs with Low Gastric Ulcerogenic Activity2012
- Author(s)
  Yamakawa, N., Suemasu, S., Okamoto, Y., Tanaka, K., Ishihara, T., Asano, T., Miyata, K., Otsuka, M. and Mizushima, T
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 55 Pages: 5143-5150
- Data Source
  KAKENHI-PROJECT-24790113
[Journal Article] Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: Non-steroidal anti-inflammatory drugs with low gastric ulcerogenic activity.2012
- Author(s)
  Yamakawa. N. et al.
- Journal Title
  
  J. Med. Chem.
  
  Volume: 55 Pages: 5143-5150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790113
[Journal Article] Identification of a unique nsaid, fluoro-loxoprofen with gastroprotective activity2012
- Author(s)
  Suemasu, S., Yamakawa, N., Ishihara, T., Asano, T., Tahara, K., Tanaka, K., Matsui, H., Okamoto, Y., Otsuka, M., Takeuchi, K., Suzuki, H. and Mizushima, T
- Journal Title
  
  Biochem Pharmacol
  
  Volume: 84 Pages: 1470-1481
- NAID
  10031061701
- Data Source
  KAKENHI-PROJECT-24790113
[Presentation] 非ステロイド性抗炎症薬のNrf2活性化作用と構造活性相関に関する検討2024
- Author(s)
  亀山藍衣、田坂祐一、出石恭久、北村佳久、山川直樹
- Organizer
  日本薬学会144年会
- Data Source
  KAKENHI-PROJECT-22K06572
[Presentation] 非ステロイド性抗炎症薬の抗酸化作用に関する基礎的検討2024
- Author(s)
  山川直樹、古澤阿実、亀山藍衣、田坂祐一
- Organizer
  日本薬学会144年会
- Data Source
  KAKENHI-PROJECT-22K06572
[Presentation] 非ステロイド性抗炎症薬の化学構造とNrf2活性化作用の関連に関する基礎的検討2023
- Author(s)
  田坂祐一、長尾春花、穐山遥香、山川直樹
- Organizer
  日本薬学会143年会
- Data Source
  KAKENHI-PROJECT-22K06572
[Presentation] Cytotoxic effects of aspirin derivatives modified with halogen.2018
- Author(s)
  Yamakawa N and Katsu T
- Organizer
  ASEAN-JAPAN Genome Medicine Reserch Promotion Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08334
[Presentation] フルオロロキソプロフェン異性体の合成と薬理活性の評価2018
- Author(s)
  杉本早紀、浅野帝太、山川直樹
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K08334
[Presentation] ハロゲン修飾されたアスピリン誘導体の膜傷害作用2017
- Author(s)
  橋本千聡、谷田滉季、山川直樹
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K08334
[Presentation] Evaluation of the Membrane Permeabilizing Activity of Aspirin derivatives Modified with Halogen.2017
- Author(s)
  Yamakawa N
- Organizer
  The 8th International Meeting on Halogen Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08334
[Presentation] ロキソプロフェンを基盤としたCOX－2阻害薬の創製2016
- Author(s)
  山川直樹、勝孝、大塚雅巳、水島徹
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K08334

1. Nakanishi Tohru (30243463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 渡辺雅彦 (00182949)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 新井祐志 (50347449)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 長塚仁 (70237535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 田坂祐一 (00574758)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

yamakawa naoki 山川 直樹

山川 直樹 ヤマカワ ナオキ

YAMAKAWA Naoki 山川 直樹

Research Projects

Research Products

Co-Researchers

Quantitative structure-activity relationship analysis of anti-inflammatory drugs with activate Nrf2Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of non-steroidal anti-inflammatory analgesics which have TRP channel antagonism effectPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel therapeutic compounds for rheumatoid arthritis targeting CD81

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Synthesis and evaluation of new non steroidal anti inflammatory drugs for clinically usefulPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of molecular mechanism for actions of NSAID and its application for drug developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Antinociception by fluoro-loxoprofen, a novel non-steroidal anti-inflammatory drug with less ulcerogenic effects, in rat models of inflammatory pain2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of Mepenzolate Derivatives With Long-Acting Bronchodilatory Activity2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crystal face identification by Raman microscopy for assessment of crystal habit of a drug.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Superiority of pulmonary administration of mepenzolate bromide over other routes as treatment for chronic obstructive pulmonary disease2014

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis and biological comparison of enantiomers of mepenzolate bromide, a muscarinic receptor antagonist with bronchodilatory and anti-inflammatory activities2014

Author(s)

Journal Title

Data Source

[Journal Article] Structure-activity relationship of celecoxib and rofecoxib for the membrane permeabilizing activity2014

Author(s)

Journal Title

Data Source

[Journal Article] Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease2013

Author(s)

Journal Title

Data Source

[Journal Article] Suppression of Alzheimer's Disease-Related Phenotypes by Geranylgeranylacetone in Mice2013

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Suppression of UV-induced wrinkle formation by induction of HSP70 expression in mice2013

Author(s)

Journal Title

Data Source

[Journal Article] Prostaglandin E1 -containing nanoparticles improve walking activity in an experimental rat model of intermittent claudication2013

Author(s)

Journal Title

Data Source

yamakawa naoki 山川直樹

山川直樹ヤマカワナオキ

YAMAKAWA Naoki 山川直樹

[Presentation] 非ステロイド性抗炎症薬の化学構造とNrf2活性化作用の関連に関する基礎的検討2023