Shiga Hisashi 志賀永嗣

… Alternative Names

SHIGA Hisashi 志賀永嗣

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Researcher Number	20583355
Other IDs
Affiliation (Current)	2025: 東北大学, 大学病院, 助教
Affiliation (based on the past Project Information) *help	2025: 東北大学, 大学病院, 助教 2019 – 2023: 東北大学, 大学病院, 助教 2014: 東北大学, 大学病院, 特任助手 2013: 東北大学, 医学(系)研究科(研究院), 助教 2012: 東北大学, 大学病院, 医員 2010 – 2011: 東北大学, 病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology
Keywords	Principal Investigator 炎症性腸疾患 / チオプリン / NUDT15 / クローン病 / 潰瘍性大腸炎 / 細胞実験 / 薬物トランスポーター / CRISPR screening / 胎児 / NUDT15遺伝子多型 … More / 遺伝子変異 / 薬物代謝酵素 / 薬理ゲノム / チオプリン製剤 / bax / エピジェネティクス / 脱メチル化剤 / DNAメチル化 / バイサルフェート / アポトーシス / エピゲノム / allelic imbalance / NKX2.3 / NKX2. 3 / 感受性遺伝子 Less

CRISPRスクリーニングで紐解く炎症性腸疾患治療薬の作用と新規治療戦略Principal Investigator
- Principal Investigator
  
  志賀永嗣
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tohoku University
炎症性腸疾患患者のチオプリンに暴露された胎児の遺伝的選択・変異に関する検討Principal Investigator
- Principal Investigator
  
  志賀永嗣
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tohoku University
Development of a method for measuring the activity of the newly identified thiopurine metabolizing enzyme NUDT15Principal Investigator
- Principal Investigator
  
  Shiga Hisashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tohoku University
DNA methylation profiles of CD4+ effector memory T cells show distinct differences between Crohn's disease and ulcerative colitisPrincipal Investigator
- Principal Investigator
  
  SHIGA Hisashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
Functional analysis of SNPs associated with ulcerative colitis in the NKX2. 3 gene.Principal Investigator
- Principal Investigator
  
  SHIGA Hisashi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University

All 2023 2012 2011

All Journal Article

[Journal Article] Usefulness and difficulties with the thiopurine pharmacogenomic NUDT15 genotyping test: Analysis of real-world data in Japan2023
- Author(s)
  Kakuta Yoichi、Kato Motohiro、Shimoyama Yusuke、Naito Takeo、Moroi Rintaro、Kuroha Masatake、Shiga Hisashi、Kinouchi Yoshitaka、Masamune Atsushi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 153 Issue: 3 Pages: 161-169
- DOI
  10.1016/j.jphs.2023.09.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08024, KAKENHI-PROJECT-21K07955
[Journal Article] 炎症性腸疾患の遺伝的要因・疾患感受性遺伝子2012
- Author(s)
  木内喜孝、高橋成一、遠藤克哉、志賀永嗣、下瀬川徹
- Journal Title
  
  日本臨床
  
  Volume: 70 Pages: 66-71
- Data Source
  KAKENHI-PROJECT-22890019
[Journal Article] 症性腸疾患の遺伝的要因・疾患感受性遺伝子2012
- Author(s)
  木内喜孝、志賀永嗣, 他
- Journal Title
  
  日本臨床
  
  Volume: 70 Pages: 66-71
- Data Source
  KAKENHI-PROJECT-22890019
[Journal Article] Increased expression of NKX2.3 mRNA transcribed from the risk haplotype for ulcerative colitis in the involved colonic mucosa2011
- Author(s)
  Arai T, Shiga H, et al
- Journal Title
  
  Hum Immunol
  
  Volume: 72 Pages: 587-591
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890019
[Journal Article] Increased expression of NKX2. 3 mRNA transcribed from the risk haplotype for ulcerative colitis in the involved colonic mucosa2011
- Author(s)
  Arai T, Kakuta Y, Kinouchi Y, Kimura T, Negoro K, Aihara H, Endo K, Shiga H, Kanazawa Y, Kuroha M, Moroi R, Nagasawa H, Shimodaira Y, Takahashi S, Shimosegawa T
- Journal Title
  
  Hum Immunol
  
  Volume: 72(7) Pages: 587-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890019
[Journal Article] IBDの遺伝子異常-GWASがもたらした病態研究の糸口-2011
- Author(s)
  木内喜孝、荒井壮、金澤義丈、角田洋一、遠藤克哉、志賀永嗣、高橋成一、下瀬川徹
- Journal Title
  
  Intestine
  
  Volume: 15 Pages: 415-421
- Data Source
  KAKENHI-PROJECT-22890019

1. 角田洋一 (50509205)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. 岩城英也 (30999644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Shiga Hisashi 志賀 永嗣

SHIGA Hisashi 志賀 永嗣

Research Projects

Research Products

Co-Researchers

CRISPRスクリーニングで紐解く炎症性腸疾患治療薬の作用と新規治療戦略Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

炎症性腸疾患患者のチオプリンに暴露された胎児の遺伝的選択・変異に関する検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a method for measuring the activity of the newly identified thiopurine metabolizing enzyme NUDT15Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

DNA methylation profiles of CD4+ effector memory T cells show distinct differences between Crohn's disease and ulcerative colitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of SNPs associated with ulcerative colitis in the NKX2. 3 gene.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Usefulness and difficulties with the thiopurine pharmacogenomic NUDT15 genotyping test: Analysis of real-world data in Japan2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 炎症性腸疾患の遺伝的要因・疾患感受性遺伝子2012

Author(s)

Journal Title

Data Source

[Journal Article] 症性腸疾患の遺伝的要因・疾患感受性遺伝子2012

Author(s)

Journal Title

Data Source

[Journal Article] Increased expression of NKX2.3 mRNA transcribed from the risk haplotype for ulcerative colitis in the involved colonic mucosa2011

Author(s)

Journal Title

Data Source

[Journal Article] Increased expression of NKX2. 3 mRNA transcribed from the risk haplotype for ulcerative colitis in the involved colonic mucosa2011

Author(s)

Journal Title

Data Source

[Journal Article] IBDの遺伝子異常-GWASがもたらした病態研究の糸口-2011

Author(s)

Journal Title

Data Source

Shiga Hisashi 志賀永嗣

SHIGA Hisashi 志賀永嗣