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SUZUKAKE MASAMI  鈴掛 雅美 (増田 雅美)

ORCIDConnect your ORCID iD *help
… Alternative Names

増田雅美

MASUDA-SUZUKAKE Masami  鈴掛 雅美

増田 雅美

鈴掛 雅美(増田雅美)  スズカケ マサミ

鈴掛 雅美

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Researcher Number 20583751
Other IDs
Affiliation (Current) 2025: 公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, 主任研究員
2025: 公益財団法人東京都医学総合研究所, 臨床医科学研究分野, 主任研究員
Affiliation (based on the past Project Information) *help 2024: 公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, 主任研究員
2020 – 2021: 公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, 主任研究員
2019: 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 主任研究員
2014: 公益財団法人東京都医学総合研究所, その他部局等, 研究員
2012 – 2013: 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 研究員
2011: (財)東京都医学総合研究所, 認知症・高次脳機能研究分野, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 51030:Pathophysiologic neuroscience-related / Nerve anatomy/Neuropathology / Nerve anatomy/Neuropathology
Except Principal Investigator
Basic Section 59040:Nutrition science and health science-related
Keywords
Principal Investigator
タウ / モデルマウス / パーキンソン病 / 神経変性疾患 / αシヌクレイン / バイオマーカー / アルツハイマー病 / 脳内伝播 / タウタンパク質 / 伝播 … More / レビー小体 / 国際情報交換 / レビー小体型認知症 / プリオン / 国際情報交流 … More
Except Principal Investigator
混合病理 / 睡眠 / 認知症 Less
  • Research Projects

    (4 results)
  • Research Products

    (36 results)
  • Co-Researchers

    (4 People)
  •  認知症の混合病理進展プロセスに対する睡眠の寄与の解明

    • Principal Investigator
      皆川 栄子
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Analysis of the progression mechanism of neurodegenerative diseasesPrincipal Investigator

    • Principal Investigator
      MASUDA-SUZUKAKE Masami
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  神経変性疾患の進行過程を標的とした新規治療法の開発Principal Investigator

    • Principal Investigator
      鈴掛 雅美 (増田 雅美)
    • Project Period (FY)
      2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Development of novel therapeutic strategies against neurodegenerative diseases targeting on abnormal protein aggregatesPrincipal Investigator

    • Principal Investigator
      MASUDA-SUZUKAKE Masami
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science

All 2022 2021 2020 2019 2014 2013 2012 2011 Other

All Journal Article Presentation Book Patent

  • [Book] 認知症学(上)2011

    • Author(s)
      鈴掛 雅美、長谷川 成人
    • Total Pages
      5
    • Publisher
      日本臨牀社
    • Data Source
      KAKENHI-PROJECT-23700433
  • [Journal Article] Phosphorylation of endogenous α-synuclein induced by extracellular seeds initiates at the pre-synaptic region and spreads to the cell body.2022

    • Author(s)
      Awa S, Suzuki G, Masuda-Suzukake M, Nonaka T, Saito M, Hasegawa M.
    • Journal Title

      Scientific reports

      Volume: 12 Issue: 1 Pages: 1163-1163

    • DOI

      10.1038/s41598-022-04780-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07860, KAKENHI-PROJECT-21K07288
  • [Journal Article] Development of a novel tau propagation mouse model endogenously expressing 3 and 4 repeat tau isoforms2022

    • Author(s)
      Hosokawa M, Masuda-Suzukake M, Shitara H, Shimozawa A, Suzuki G, Kondo H, Nonaka T, Campbell W, Arai T, Hasegawa M
    • Journal Title

      Brain

      Volume: 145 Issue: 1 Pages: 349-361

    • DOI

      10.1093/brain/awab289

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07618, KAKENHI-PROJECT-19K07860, KAKENHI-PROJECT-21K07288, KAKENHI-PROJECT-22K07362
  • [Journal Article] 認知症の病態解明の進歩-疾患を規定するタウの線維構造.2021

    • Author(s)
      1.鈴掛雅美、亀谷富由樹、長谷川成人.
    • Journal Title

      脳神経内科

      Volume: 95 Pages: 436-441

    • Data Source
      KAKENHI-PROJECT-19K07860
  • [Journal Article] Progression of phosphorylated α-synuclein in Macaca fuscata2021

    • Author(s)
      Ito Kawakami, Atsuko Motoda, Masashi Hashimoto, Aki Shimozawa, Masami Masuda-Suzukake, Reiko Ohtani, Mina Takase, Mari Kumashiro, Kazuyuki Samejima, Masato Hasegawa
    • Journal Title

      Brain pathology

      Volume: - Issue: 5

    • DOI

      10.1111/bpa.12952

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07860, KAKENHI-PROJECT-20K16660, KAKENHI-PUBLICLY-19H04988
  • [Journal Article] Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds.2021

    • Author(s)
      Macdonald JA, Chen JL, Masuda-Suzukake M, Schweighauser M, Jaunmuktane Z, Warner T, Holton JL, Grossman A, Berks R, Lavenir I, Goedert M.
    • Journal Title

      Acta Neuropathol Commun.

      Volume: 24 Issue: 1

    • DOI

      10.1186/s40478-021-01291-7

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07860
  • [Journal Article] Common Marmoset Model of α-Synuclein Propagation.2021

    • Author(s)
      Masuda-Suzukake M, Shimozawa A, Hashimoto M, Hasegawa M.
    • Journal Title

      Methods Mol Biol.

      Volume: 2322 Pages: 131-139

    • DOI

      10.1007/978-1-0716-1495-2_13

    • ISBN
      9781071614945, 9781071614952
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07860
  • [Journal Article] α-Synuclein filaments from transgenic mouse and human synucleinopathy-containing brains are major seed-competent species.2020

    • Author(s)
      Morgan SA, Lavenir I, Fan J, Masuda-Suzukake M, Passarella D, DeTure MA, Dickson DW, Ghetti B, Goedert M.
    • Journal Title

      J Biol Chem

      Volume: - Issue: 19 Pages: 6652-6664

    • DOI

      10.1074/jbc.ra119.012179

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07860
  • [Journal Article] Dextran sulphate-induced tau assemblies cause endogenous tau aggregation and propagation in wild-type mice2020

    • Author(s)
      Masami Masuda-Suzukake, Genjiro Suzuki, Masato Hosokawa, Takashi Nonaka, Michel Goedert, Masato Hasegawa
    • Journal Title

      Brain communications

      Volume: 2 Issue: 2

    • DOI

      10.1093/braincomms/fcaa091

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07860
  • [Journal Article] Silver staining (Campbell-Switzer) of neuronal α-synuclein assemblies induced by multiple system atrophy and Parkinson's disease brain extracts in transgenic mice.2019

    • Author(s)
      Lavenir I, Passarella D, Masuda-Suzukake M, Curry A, Holton JL, Ghetti B, Goedert M.
    • Journal Title

      Acta Neuropathol Commun.

      Volume: 7 Issue: 1

    • DOI

      10.1186/s40478-019-0804-5

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07860
  • [Journal Article] Animal models of synucleinopathies: prion-like propagation of alpha-synuclein in wild-type animals2019

    • Author(s)
      Masuda-Suzukake M.
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 154 Issue: 6 Pages: 301-305

    • DOI

      10.1254/fpj.154.301

    • NAID

      130007754370

    • ISSN
      0015-5691, 1347-8397
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07860
  • [Journal Article] Prion-like Propagation of Pathological α-Synuclein <i>in Vivo</i>2019

    • Author(s)
      Masuda-Suzukake M, Hasegawa M.
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 139 Issue: 7 Pages: 1007-1013

    • DOI

      10.1248/yakushi.18-00165-4

    • NAID

      130007670813

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2019-07-01
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07860
  • [Journal Article] Differential diagnosis of amyotrophic lateral sclerosis from Guillain-Barré syndrome by quantitative determination of TDP-43 in cerebrospinal fluid.2014

    • Author(s)
      Hosokawa M, Arai T, Yamashita M, Tsuji H, Nonaka T, Masuda-Suzukake M, Tamaoka A, Hasegawa M, Akiyama H.
    • Journal Title

      Int. J. Neurosci.

      Volume: 124 Issue: 5 Pages: 344-349

    • DOI

      10.3109/00207454.2013.848440

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23700433, KAKENHI-PUBLICLY-24111556, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PUBLICLY-25110738
  • [Journal Article] A longitudinal study on alpha-synuclein in blood plasma as a biomarker for Parkinson’s disease.2013

    • Author(s)
      Foulds PG, Diggle P, Mitchell D, Parker A, Hasegawa M, Masuda-Suzukake M, Mann DMA, Allsop D.
    • Journal Title

      Sci. Rep.

      Volume: 3 Issue: 1 Pages: 2540-2540

    • DOI

      10.1038/srep02540

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23700433, KAKENHI-PUBLICLY-25110738
  • [Journal Article] Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains.2013

    • Author(s)
      Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann DM, Akiyama H, Hasegawa M.
    • Journal Title

      Cell Rep.

      Volume: 4 Issue: 1 Pages: 124-34

    • DOI

      10.1016/j.celrep.2013.06.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-23700433, KAKENHI-PUBLICLY-24111556, KAKENHI-PROJECT-24500429, KAKENHI-PUBLICLY-25110738
  • [Journal Article] Dipeptide repeat proteins are present in the p62 positive inclusions in patients with Frontotemporal Lobar Degeneration and Motor Neuron Disease associated with expansions in C9ORF72.2013

    • Author(s)
      Mann DMA, Rollinson S, Robinson AC, Callister J, Snowden JS, Gendron T, Petrucelli L, Masuda-Suzukake M, Hasegawa M, Davidson YS and Pickering-Brown S.
    • Journal Title

      Acta Neuropathol. Commun.

      Volume: 1 Issue: 1 Pages: 68-68

    • DOI

      10.1186/2051-5960-1-68

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23700433, KAKENHI-PUBLICLY-25110738
  • [Journal Article] Prion-like spreading of pathological alpha-synuclein in brain.2013

    • Author(s)
      Masuda-Suzukake M, Nonaka T, Hosokawa M., Oikawa T, Arai T, Akiyama H, Mann D, Hasegawa M
    • Journal Title

      Brain

      Volume: 136 Issue: 4 Pages: 1128-38

    • DOI

      10.1093/brain/awt037

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-23700433, KAKENHI-PUBLICLY-24111556, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PUBLICLY-25110738, KAKENHI-PUBLICLY-23110526
  • [Journal Article] Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer’s disease brain.2013

    • Author(s)
      Dan A, Takahashi M, Masuda-Suzukake M, Kametani F, Nonaka T, Kondo H, Akiyama H, Arai T, Mann DMA, Saito Y, Hatsuta H, Murayama S, Hasegawa M.
    • Journal Title

      Acta Neuropathol. Commun.

      Volume: 1 Issue: 1 Pages: 54-54

    • DOI

      10.1186/2051-5960-1-54

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23700433, KAKENHI-PUBLICLY-24111556, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24700371, KAKENHI-PUBLICLY-25110738
  • [Journal Article] Isomerase Pin1 Stimulates Dephosphorylation of Tau Protein at Cyclin-dependent Kinase (Cdk5)-dependent Alzheimer Phosphorylation Sites2013

    • Author(s)
      Taeko Kimura, Koji Tsutsumi, Masato Taoka, Taro Saito, Masami Masuda-Suzukake, Koichi Ishiguro, Florian Plattner, Takafumi Uchida, Toshiaki Isobe, Masato Hasegawa, and Shin-ichi Hisanaga
    • Journal Title

      THE JOURNAL OF BIOLOGICAL CHEMISTRY

      Volume: 288 Issue: 11 Pages: 7968-7977

    • DOI

      10.1074/jbc.m112.433326

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J06148, KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23700433, KAKENHI-PUBLICLY-25110738, KAKENHI-PROJECT-25290024, KAKENHI-PUBLICLY-23110526
  • [Journal Article] Molecular analysis and biochemical classification of TDP-43 proteinopathy2012

    • Author(s)
      Tsuji H
    • Journal Title

      Brain

      Volume: 135(11) Issue: 11 Pages: 3380-91

    • DOI

      10.1093/brain/aws230

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22300118, KAKENHI-PROJECT-22590968, KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23500435, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-23700433, KAKENHI-PROJECT-24300133, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591249, KAKENHI-PROJECT-24591738, KAKENHI-PUBLICLY-23110526
  • [Journal Article] Methylene blue reduced abnormal tau accumulation in P301L tau transgenic mice.2012

    • Author(s)
      Hosokawa M
    • Journal Title

      PLoS One

      Volume: 7 Issue: 12 Pages: e52389-e52389

    • DOI

      10.1371/journal.pone.0052389

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-23700433, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PUBLICLY-23110526
  • [Journal Article] Epitope mapping of antibodies against TDP-43 and detection of protease-resistant fragments of pathological TDP-43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration2011

    • Author(s)
      Tsuji H, Nonaka T, Yamashita M, Suzukake M, Kametani F, Akiyama H, Mann D. M. A., Tamaoka A, Hasegawa M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 417 Issue: 1 Pages: 116-121

    • DOI

      10.1016/j.bbrc.2011.11.066

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591536, KAKENHI-PUBLICLY-23110526, KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23700433
  • [Patent] 新規タウオパチーモデルマウスの作製方法2013

    • Inventor(s)
      鈴掛雅美、長谷川成人
    • Industrial Property Rights Holder
      鈴掛雅美、長谷川成人
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-268257
    • Filing Date
      2013-12-26
    • Data Source
      KAKENHI-PROJECT-23700433
  • [Presentation] 野生型マウスを用いた新規タウ伝播モデル2019

    • Author(s)
      鈴掛雅美, Michel Goedert, 長谷川成人
    • Organizer
      第38回日本認知症学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K07860
  • [Presentation] Animal models of synucleinopathies: prion-like propagation of alpha-synuclein in non-transgenic animals.2019

    • Author(s)
      Masami Masuda-Suzukake, Masato Hasegawa.
    • Organizer
      6th Congress of Asian college of Neuropsychopharmacology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07860
  • [Presentation] 動物モデルにおけるαシヌクレイン伝播2019

    • Author(s)
      鈴掛雅美
    • Organizer
      第38回日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K07860
  • [Presentation] Prion-like spreading of pathological alpha-synuclein in brain, ポスター発表2013

    • Author(s)
      Masuda-Suzukake M, Nonaka T, Hosokawa M, Oikawa T, Arai T, Akiyama H, Mann D, Hasegawa M
    • Organizer
      The 11th International Conference on Alzheimer's and Parkinson's diseases
    • Place of Presentation
      Florence Italy
    • Year and Date
      2013-03-07
    • Data Source
      KAKENHI-PROJECT-23700433
  • [Presentation] レビー小体型認知症患者脳不溶性画分の脳内接種は野生型マウス脳内にレビー小体様病理を形成させる, 口頭発表2013

    • Author(s)
      鈴掛(増田)雅美、野中隆、細川雅人、笈川貴行、新井哲明、秋山治彦、David Mann、長谷川成人
    • Organizer
      第54回日本神経病理学会総会
    • Year and Date
      2013-04-25
    • Data Source
      KAKENHI-PROJECT-23700433
  • [Presentation] Prion-like propagation of pathological alpha-synuclein in brain, 口頭発表2013

    • Author(s)
      Masuda-Suzukake M, Nonaka T, Hosokawa M, Oikawa T, Arai T, Akiyama T, Mann D, Hasegawa M
    • Organizer
      第86回日本生化学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-09-13
    • Data Source
      KAKENHI-PROJECT-23700433
  • [Presentation] Prion-like spreading of pathological alpha-synuclein in brain.2013

    • Author(s)
      Masami Masuda-Suzukake, Takashi Nonaka, Masato Hosokawa, Takayuki Oikawa, Tetsuaki Arai, Haruhiko Akiyama, David Mann, Masato Hasegawa.
    • Organizer
      The 11th international conference on Alzheimer's and Parkinson's diseases
    • Place of Presentation
      フィレンツエ、イタリア
    • Data Source
      KAKENHI-PROJECT-23700433
  • [Presentation] αシヌクレイン線維の脳内接種は野生型マウス脳にレビー小体様病理を形成させる, 口頭発表2012

    • Author(s)
      鈴掛(増田)雅美、笈川貴行、細川雅人、野中隆、秋山治彦、長谷川成人
    • Organizer
      第31回日本認知症学会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2012-10-26
    • Data Source
      KAKENHI-PROJECT-23700433
  • [Presentation] αシヌクレイン線維の脳内接種は野生型マウス脳にレビー小体様病理を形成させる2012

    • Author(s)
      鈴掛(増田)雅美、笈川貴行、細川雅人、野中隆、秋山治彦、長谷川成人
    • Organizer
      第31回 日本認知症学会
    • Place of Presentation
      つくば国際会議場
    • Data Source
      KAKENHI-PROJECT-23700433
  • [Presentation] Evaluation of tau aggregation inhibitors and immunization with phosphorylated tau peptides in tauopathy model mice, ポスター発表2011

    • Author(s)
      Suzukake M, T Watanabe S, Suzuki N, Hisanaga S, Hasegawa M
    • Organizer
      Alzheimer's association International Conference 2011
    • Place of Presentation
      Paris France
    • Year and Date
      2011-07-18
    • Data Source
      KAKENHI-PROJECT-23700433
  • [Presentation] Evaluation of the tau aggregation inhibitors and immunization with phosphorylated tau peptides in tauopathy model mice.2011

    • Author(s)
      Masami SUZUKAKE, Sayuri T WATANABE, Nobuyuki SUZUKI, Shin-ihi HISANAGA, Masato HASEGAWA.
    • Organizer
      Alzheimer's association international conference 2011
    • Place of Presentation
      Porte de versailles (Paris, France)
    • Data Source
      KAKENHI-PROJECT-23700433
  • [Presentation] Prion-like propagation of pathological alpha-synuclein in brain

    • Author(s)
      Masami Masuda-Suzukake, Takashi Nonaka, Masato Hosokawa, Takayuki Oikawa, Tetsuaki Arai, Haruhiko Akiyama, David Mann, Masato Hasegawa
    • Organizer
      第86回 日本生化学会大会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-23700433
  • [Presentation] レビー小体型認知症患者脳不溶性画分の脳内接種は野生型マウス脳にレビー小体様病理を形成させる

    • Author(s)
      鈴掛(増田)雅美、野中 隆、細川 雅人、笈川 貴行、 新井 哲明、秋山 治彦、David Mann、長谷川 成人
    • Organizer
      第54回 日本神経病理学会総会
    • Place of Presentation
      タワーホール船堀(東京)
    • Data Source
      KAKENHI-PROJECT-23700433
  • 1.  皆川 栄子 (20726252)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  HOSOKAWA Masato
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  秋山 治彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  長谷川 成人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 6 results

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