Yu Jian 于健

Researcher Number	20587860
Other IDs
Affiliation (Current)	2025: 大阪大学, 蛋白質研究所, 特任准教授(常勤)
Affiliation (based on the past Project Information) *help	2022 – 2023: 大阪大学, 蛋白質研究所, 特任准教授(常勤) 2021: 北海道大学, 電子科学研究所, 特任助教 2020 – 2021: 北海道大学, 先端生命科学研究院, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 43040:Biophysics-related Except Principal Investigator Basic Section 43020:Structural biochemistry-related
Keywords	Principal Investigator 合成因子相互作用 / 相互作用 / 合成酵素 / 構造解析 / 膜タンパク質 / TC構成因子 / バクテリアセルロース Except Principal Investigator クライオ電子顕微鏡 / ウイルス蛋白質 / シグナル伝達阻害 … More / 結晶解析 / クライオ電顕 / 複合体解析 / 超遠心分析 / 表面プラズモン共鳴 / NMR / リン酸化 / クライオ電顕解析 / 相互作用解析 / JAK-STAT Less

Molecular basis of counteraction against the JAK-STAT signaling pathway by virus
- Principal Investigator
  
  Ose Toyoyuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Hokkaido University
Interaction analysis bewteen subunits of bacterial cellulose synthasePrincipal Investigator
- Principal Investigator
  
  Yu Jian
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Osaka University
  Hokkaido University

All 2023 2022 2021

All Journal Article Presentation

[Journal Article] STAP-2-Derived Peptide Suppresses TCR-Mediated Signals to Initiate Immune Responses2023
- Author(s)
  Sasaki Yuto、Saitoh Kodai、Kagohashi Kota、Ose Toyoyuki、Kawahara Shoya、Kitai Yuichi、Muromoto Ryuta、Sekine Yuichi、Ichii Michiko、Yoshimura Akihiko、Oritani Kenji、Kashiwakura Jun-ichi、Matsuda Tadashi
- Journal Title
  
  The Journal of Immunology
  
  Volume: 211 Issue: 5 Pages: 755-766
- DOI
  10.4049/jimmunol.2200942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K18170, KAKENHI-PROJECT-23K07812, KAKENHI-PROJECT-21K08451, KAKENHI-PROJECT-21H02408
[Journal Article] A peptide derived from adaptor protein STAP-2 inhibits tumor progression by downregulating epidermal growth factor receptor signaling2023
- Author(s)
  Maemoto Taiga、Kitai Yuichi、Takahashi Runa、Shoji Haruka、Yamada Shunsuke、Takei Shiho、Ito Daiki、Muromoto Ryuta、Kashiwakura Jun-ichi、Handa Haruka、Hashimoto Ari、Hashimoto Shigeru、Ose Toyoyuki、Oritani Kenji、Matsuda Tadashi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 1 Pages: 102724-102724
- DOI
  10.1016/j.jbc.2022.102724
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08451, KAKENHI-PROJECT-22K06890, KAKENHI-PROJECT-22K07203, KAKENHI-PROJECT-21K15251, KAKENHI-PROJECT-21H02408
[Journal Article] Importance of accessibility to the extracellular juxtamembrane stalk region of membrane protein for substrate recognition by viral ubiquitin ligase K52022
- Author(s)
  Kajikawa Mizuho、Hata Mizuki、Ishimura Maho、Imaizumi Nanae、Kimura Minako、Miyano Kei、Ose Toyoyuki、Asai Daisuke、Ishido Satoshi、Kanamoto Taisei
- Journal Title
  
  Biochemical Journal
  
  Volume: 479 Issue: 20 Pages: 2261-2278
- DOI
  10.1042/bcj20220288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06934, KAKENHI-PROJECT-20K12657, KAKENHI-PROJECT-21H02408
[Journal Article] The BcsD subunit of type I bacterial cellulose synthase interacts dynamically with the BcsAB catalytic core complex2022
- Author(s)
  Kondo Tatsuya, Nakamura Yui, Nojima Shingo, Yao Min, Imai Tomoya
- Journal Title
  
  FEBS Letters
  
  Volume: 596 Issue: 23 Pages: 3069-3086
- DOI
  10.1002/1873-3468.14495
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H00950, KAKENHI-PROJECT-20K06570
[Journal Article] Dynamic Control of Microbial Movement by Photoswitchable ATP Antagonists2022
- Author(s)
  Sampreeth Thayyil, Yukinori Nishigami, Jahirul Islam, P K Hashim, Ken'ya Furuta, Kazuhiro Oiwa, Jian Yu, Min Yao,Toshiyuki Nakagaki, and Nobuyuki Tamaoki
- Journal Title
  
  Chemistry A European Journal
  
  Volume: 28 Issue: 30
- DOI
  10.1002/chem.202200807
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06570, KAKENHI-PLANNED-21H05310, KAKENHI-PLANNED-18H05420
[Journal Article] Substrate specificity of glycoside hydrolase family 1 β-glucosidase AtBGlu42 from Arabidopsis thaliana and its molecular mechanism2021
- Author(s)
  Horikoshi Shu、Saburi Wataru、Yu Jian、Matsuura Hideyki、Cairns James R Ketudat、Yao Min、Mori Haruhide
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 86 Issue: 2 Pages: 231-245
- DOI
  10.1093/bbb/zbab200
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06570
[Presentation] Characterization of measles virus V protein by NMR spectroscopy2023
- Author(s)
  Kaho Morita, Nanaka Goda, Madoka Kimoto, Daiki Ito, Min Yao, Hiroyuki Kumeta, Toyoyuki Ose
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21H02408
[Presentation] Introduction of viral protein study in Hokkaido2023
- Author(s)
  Toyoyuki Ose
- Organizer
  WORKSHP: Virology and Structure Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02408
[Presentation] OneDep: Unified System for Deposition, Biocuration, and Validation of Macromolecular Structures2022
- Author(s)
  Jian Yu
- Organizer
  The 17th Conference of the Asian Crystallographic Association.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06570
[Presentation] Mechanistic analysis of type I interferon pathway inhibition by Measles virus V protein2022
- Author(s)
  Daiki Ito, Madoka Kimoto, Hirohata Kiichi, Maruno Takahiro, Uchiyama Susumu, Min Yao, Toyoyuki Ose
- Organizer
  生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21H02408
[Presentation] Characterization of the minimum region of measles virus V protein to interact with STAT22022
- Author(s)
  Goda Nanaka, Kimoto Madoka, Ito Daiki, Morita Kaho, Kumeta Hiroyuki, Yao Min, Ose Toyoyuki
- Organizer
  日本生物物理学会
- Data Source
  KAKENHI-PROJECT-21H02408
[Presentation] Prediction of ligand-protein binding site2022
- Author(s)
  于健
- Organizer
  2022年PF-UA第7回タンパク質結晶構造解析中級者向け講習会。
- Invited
- Data Source
  KAKENHI-PROJECT-20K06570
[Presentation] 狂犬病ウイルスのP蛋白質が宿主のJAK-STAT経路を阻害する分子機構の解明2022
- Author(s)
  Aoi Sugiyama，Miku Minami，Yukihiko Sugita，Mika Hirose，Shunsuke Kita，Katsumi Maenaka，Min Yao，Toyoyuki Ose
- Organizer
  日本生物物理学会
- Data Source
  KAKENHI-PROJECT-21H02408
[Presentation] Characterization of the minimum region of measles virus V protein for the interaction with STAT22022
- Author(s)
  Goda Nanaka, Kimoto Madoka, Ito Daiki, Morita Kaho, Kumeta Hiroyuki, Yao Min,Ose Toyoyuki
- Organizer
  生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21H02408
[Presentation] Interaction and functional analysis between Breast tumor kinase and an adaptor protein2022
- Author(s)
  Shiho Takei, Yuki Matsuo, Ryo Kanda, Junki Nakasako, Katsumi Maenaka, Tadashi Matsuda, Min Yao and Toyoyuki Ose
- Organizer
  日本蛋白質科学会
- Data Source
  KAKENHI-PROJECT-21H02408
[Presentation] タイプＩインターフェロン経路を阻害する麻疹ウイルスＶタンパク質の機能解析2022
- Author(s)
  Daiki Ito, Madoka Kimoto, Hirohata Kiichi, Maruno Takahiro, Uchiyama Susumu, Min Yao, Toyoyuki Ose
- Organizer
  日本生物物理学会
- Data Source
  KAKENHI-PROJECT-21H02408
[Presentation] native SADの利用　Vincent Olieric（PSI）について2021
- Author(s)
  于健
- Organizer
  PF-UAのタンパク質結晶構造解析ユーザーグループ（PX-UG）第6回タンパク質結晶構造解析中級者向け講習会
- Invited
- Data Source
  KAKENHI-PROJECT-20K06570

1. Ose Toyoyuki (80380525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
2. 久米田博之 (00399966)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 杉田征彦 (00734469)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MIYANO Kei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. MUROMOTO Ryuta

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. IMAI Tomoya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 松田正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 鍛代悠一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 近藤辰哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 姚閔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 柏倉淳一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 杉田征彦(杉田征彦)

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yu Jian 于 健

Research Projects

Research Products

Co-Researchers

Molecular basis of counteraction against the JAK-STAT signaling pathway by virus

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Interaction analysis bewteen subunits of bacterial cellulose synthasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] STAP-2-Derived Peptide Suppresses TCR-Mediated Signals to Initiate Immune Responses2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A peptide derived from adaptor protein STAP-2 inhibits tumor progression by downregulating epidermal growth factor receptor signaling2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Importance of accessibility to the extracellular juxtamembrane stalk region of membrane protein for substrate recognition by viral ubiquitin ligase K52022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The BcsD subunit of type I bacterial cellulose synthase interacts dynamically with the BcsAB catalytic core complex2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dynamic Control of Microbial Movement by Photoswitchable ATP Antagonists2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Substrate specificity of glycoside hydrolase family 1 β-glucosidase AtBGlu42 from Arabidopsis thaliana and its molecular mechanism2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Characterization of measles virus V protein by NMR spectroscopy2023

Author(s)

Organizer

Data Source

[Presentation] Introduction of viral protein study in Hokkaido2023

Author(s)

Organizer

Data Source

[Presentation] OneDep: Unified System for Deposition, Biocuration, and Validation of Macromolecular Structures2022

Author(s)

Organizer

Data Source

[Presentation] Mechanistic analysis of type I interferon pathway inhibition by Measles virus V protein2022

Author(s)

Organizer

Data Source

[Presentation] Characterization of the minimum region of measles virus V protein to interact with STAT22022

Author(s)

Organizer

Data Source

[Presentation] Prediction of ligand-protein binding site2022

Author(s)

Organizer

Data Source

[Presentation] 狂犬病ウイルスのP蛋白質が宿主のJAK-STAT経路を阻害する分子機構の解明2022

Author(s)

Organizer

Data Source

[Presentation] Characterization of the minimum region of measles virus V protein for the interaction with STAT22022

Author(s)

Organizer

Data Source

[Presentation] Interaction and functional analysis between Breast tumor kinase and an adaptor protein2022

Author(s)

Yu Jian 于健

[Presentation] native SADの利用　Vincent Olieric（PSI）について2021