Watanabe Tatsuro 渡邉達郎

Researcher Number	20595714
Other IDs
Affiliation (based on the past Project Information) *help	2021 – 2023: 佐賀大学, 医学部, 特任教授 2020 – 2021: 佐賀大学, 医学部, 特任准教授 2018: 佐賀大学, 医学部, 寄附講座准教授 2017: 佐賀大学, 医学部, 寄付講座准教授
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 50010:Tumor biology-related / Tumor therapeutics Except Principal Investigator Basic Section 52010:General internal medicine-related / Medium-sized Section 90:Biomedical engineering and related fields
Keywords	Principal Investigator DNAメチル化 / ATL / 薬剤耐性 / 診断 / 治療 / 腫瘍抑制因子 / 耐性化機構 / DNA脱メチル化剤 / メチオニン代謝 / 核酸代謝 … More / DNA demethylating agents / Methionine metabolism / Pyrimidine metabolism / Acquired resistance / DNA methylation / 創薬 / がん / エピジェネティクス / 脱メチル化剤 / メチル化 / DNA / 分子標的治療薬 / 分子標的薬 / がん予防 … More Except Principal Investigator シングルセル解析 / 内在性レトロウイルス / BCL-2 / DNAメチル化 / 急性骨髄性白血病 / がん / 硬さ / 形 / 細胞膜 / 細胞外小胞（EV） Less

成人T細胞白血病・リンパ腫におけるDNAメチル化異常を標的にした診断法と治療法の確立Principal Investigator
- Principal Investigator
  
  渡邉達郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Saga University
難治性白血病の内在性レトロウイルス活性化機序に基づく新規バイオマーカー開発
- Principal Investigator
  
  田部陽子
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Juntendo University
細胞外小胞の「形と硬さ」に基づくがん悪性化機序の定量解明
- Principal Investigator
  
  松崎賢寿
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Osaka University
Biological significance of DNA methylation abnormalities in ATL leukemogenesisPrincipal Investigator
- Principal Investigator
  
  Watanabe Tatsuro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Saga University
DNA demethylation therapy in ATLPrincipal Investigator
- Principal Investigator
  
  Watanabe Tatsuro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Tumor therapeutics
- Research Institution
  Saga University

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] Cancer progression by the okadaic acid class of tumor promoters and endogenous protein inhibitors of PP2A, SET and CIP2A2023
- Author(s)
  Fujiki Hirota、Sueoka Eisaburo、Watanabe Tatsuro、Komori Atsumasa、Suganuma Masami
- Journal Title
  
  Journal of Cancer Research and Clinical Oncology
  
  Volume: in press Issue: 11 Pages: 9425-9433
- DOI
  10.1007/s00432-023-04800-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07593
[Journal Article] Combination of a New Oral Demethylating Agent, OR2100, and Venetoclax for Treatment of Acute Myeloid Leukemia2023
- Author(s)
  Kamachi Kazuharu、Ureshino Hiroshi、Watanabe Tatsuro、Yoshida-Sakai Nao、Fukuda-Kurahashi Yuki、Kawasoe Kazunori、Hoshiko Toshimi、Yamamoto Yuta、Kurahashi Yuki、Kimura Shinya
- Journal Title
  
  Cancer Research Communications
  
  Volume: 3 Issue: 2 Pages: 297-308
- DOI
  10.1158/2767-9764.crc-22-0259
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07593, KAKENHI-PROJECT-21K16245
[Journal Article] Dual targeting of aberrant DNA and histone methylation synergistically suppresses tumor cell growth in ATL2023
- Author(s)
  Kurahashi Yuki、Watanabe Tatsuro、Yamamoto Yuta、Ureshino Hiroshi、Kamachi Kazuharu、Yoshida-Sakai Nao、Fukuda-Kurahashi Yuki、Yamashita Satoshi、Hattori Naoko、Nakamura Hideaki、Kawaguchi Atsushi、Ushijima Toshikazu、Sueoka Eisaburo、Kimura Shinya
- Journal Title
  
  Blood Advances
  
  Volume: 7 Issue: 8 Pages: 1545-1559
- DOI
  10.1182/bloodadvances.2022008362
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16245, KAKENHI-PROJECT-20K07593, KAKENHI-PROJECT-20K08756
[Journal Article] Diffuse Large B-cell Lymphoma Involving an Abundant Infiltration of T Follicular Helper Cells2023
- Author(s)
  Ishii Keitaro、Kamachi Kazuharu、Okamoto Sho、Katsuya Hiroo、Fujita Mai、Nagaie Toshiaki、Nishioka Atsujiro、Yoshimura Mariko、Ureshino Hiroshi、Kubota Yasushi、Ando Toshihiko、Watanabe Tatsuro、Takeuchi Mai、Kai Keita、Ohshima Koichi、Kimura Shinya
- Journal Title
  
  Intern. Med.
  
  Volume: 62 Issue: 9 Pages: 1335-1340
- DOI
  10.2169/internalmedicine.0521-22
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2023-05-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07593
[Journal Article] Targeting DNMT1 by demethylating agent OR-2100 increases tyrosine kinase inhibitors-sensitivity and depletes leukemic stem cells in chronic myeloid leukemia2022
- Author(s)
  Kamachi Kazuharu、Ureshino Hiroshi、Watanabe Tatsuro、Yoshida Nao、Yamamoto Yuta、Kurahashi Yuki、Fukuda-Kurahashi Yuki、Hayashi Yoshihiro、Hirai Hideyo、Yamashita Satoshi、Ushijima Toshikazu、Okada Seiji、Kimura Shinya
- Journal Title
  
  Cancer Letters
  
  Volume: 526 Pages: 273-283
- DOI
  10.1016/j.canlet.2021.11.032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07593, KAKENHI-PROJECT-21K16245, KAKENHI-PROJECT-20K08756, KAKENHI-PROJECT-21H02956
[Journal Article] 経口脱メチル化薬によるATLの標的治療2021
- Author(s)
  渡邉達郎
- Journal Title
  
  血液内科
  
  Volume: 82 Pages: 561-567
- NAID
  40022562703
- Data Source
  KAKENHI-PROJECT-20K07593
[Journal Article] Adult T‐cell leukemia‐lymphoma acquires resistance to <scp>DNA</scp> demethylating agents through dysregulation of enzymes involved in pyrimidine metabolism2021
- Author(s)
  Yoshida‐Sakai Nao、Watanabe Tatsuro、Yamamoto Yuta、Ureshino Hiroshi、Kamachi Kazuharu、Kurahashi Yuki、Fukuda‐Kurahashi Yuki、Kimura Shinya
- Journal Title
  
  International Journal of Cancer
  
  Volume: 150 Issue: 7 Pages: 1184-1197
- DOI
  10.1002/ijc.33901
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07593, KAKENHI-PROJECT-20K08756, KAKENHI-PROJECT-21K16245
[Journal Article] Silylation of Deoxynucleotide Analog Yields an Orally Available Drug with Antileukemia Effects2021
- Author(s)
  Ureshino Hiroshi、Kurahashi Yuki、Watanabe Tatsuro、Yamashita Satoshi、Kamachi Kazuharu、Yamamoto Yuta、Fukuda-Kurahashi Yuki、Yoshida-Sakai Nao、Hattori Naoko、Hayashi Yoshihiro、Kawaguchi Atsushi、Tohyama Kaoru、Okada Seiji、Harada Hironori、Ushijima Toshikazu、Kimura Shinya
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 20 Issue: 8 Pages: 1412-1421
- DOI
  10.1158/1535-7163.mct-20-1125
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08824, KAKENHI-PROJECT-20K07593, KAKENHI-PROJECT-20K08756, KAKENHI-PROJECT-21K16245, KAKENHI-PROJECT-19H04355
[Journal Article] Role of TNF-α-Inducing Protein Secreted by Helicobacter pylori as a Tumor Promoter in Gastric Cancer and Emerging Preventive Strategies2021
- Author(s)
  Suganuma Masami、Watanabe Tatsuro、Sueoka Eisaburo、Lim In Kyoung、Fujiki Hirota
- Journal Title
  
  Toxins
  
  Volume: 13 Issue: 3 Pages: 181-181
- DOI
  10.3390/toxins13030181
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07593
[Journal Article] Targeting aberrant DNA hypermethylation as a driver of ATL leukemogenesis by using the new oral demethylating agent OR-21002020
- Author(s)
  Watanabe Tatsuro、Yamashita Satoshi、Ureshino Hiroshi、Kamachi Kazuharu、Kurahashi Yuki、Fukuda-Kurahashi Yuki、Yoshida Nao、Hattori Naoko、Nakamura Hideaki、Sato Akemi、Kawaguchi Atsushi、Sueoka-Aragane Naoko、Kojima Kensuke、Okada Seiji、Ushijima Toshikazu、Kimura Shinya、Sueoka Eisaburo
- Journal Title
  
  Blood
  
  Volume: 136 Issue: 7 Pages: 871-884
- DOI
  10.1182/blood.2019003084
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07593, KAKENHI-PROJECT-20K07700, KAKENHI-PROJECT-20K08756, KAKENHI-PROJECT-17K09928, KAKENHI-PROJECT-19K17860
[Journal Article] 成人T細胞白血病・リンパ腫におけるエピジェネティクス異常を標的にした創薬2019
- Author(s)
  渡邉達郎、木村晋也
- Journal Title
  
  血液内科
  
  Volume: 78 Pages: 117-121
- NAID
  40021792490
- Data Source
  KAKENHI-PROJECT-17H06956
[Journal Article] Inhibition of TNFα-interacting protein α (Tipα)-associated gastric carcinogenesis by BTG2/TIS21 via downregulating cytoplasmic nucleolin expression.2018
- Author(s)
  Devanand Preethi, Oya Yukiko, Sundaramoorthy Santhoshkumar, Song Kye Yong, Watanabe Tatsuro, Kobayashi Yasuhito, Shimizu Yoshihiko, Hong Soon Auck , Suganuma Masami, Lim In kyoung
- Journal Title
  
  Experimental & Molecular Medicine volume
  
  Volume: 50 Issue: 2 Pages: e449-e449
- DOI
  10.1038/emm.2017.281
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06956
[Journal Article] Cancer Prevention with Green Tea and Its Principal Constituent, EGCG: from Early Investigations to Current Focus on Human Cancer Stem Cells2018
- Author(s)
  Fujiki Hirota, Watanabe Tatsuro, Sueoka Eisaburo, Rawangkan Anchalee, Suganuma Masami
- Journal Title
  
  Molecules and cells
  
  Volume: 41 Pages: 73-82
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06956
[Journal Article] Down-regulation of histone deacetylase 4, -5 and -6 as a mechanism of synergistic enhancement of apoptosis in human lung cancer cells treated with the combination of a synthetic retinoid, Am80 and green tea catechin2017
- Author(s)
  Oya Yukiko、Mondal Anupom、Rawangkan Anchalee、Umsumarng Sonthaya、Iida Keisuke、Watanabe Tatsuro、Kanno Miki、Suzuki Kaori、Li Zhenghao、Kagechika Hiroyuki、Shudo Koichi、Fujiki Hirota、Suganuma Masami
- Journal Title
  
  Journal of Nutritional Biochemistry
  
  Volume: 42 Pages: 7-16
- DOI
  10.1016/j.jnutbio.2016.12.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H06956, KAKENHI-PROJECT-16K18908
[Journal Article] Functional analysis of Discoidin domain receptor 2 mutation and expression in squamous cell lung cancer2017
- Author(s)
  Kobayashi-Watanabe Naomi、Sato Akemi、Watanabe Tatsuro、Abe Tomonori、Nakashima Chiho、Sueoka Eisaburo、Kimura Shinya、Sueoka-Aragane Naoko
- Journal Title
  
  Lung Cancer
  
  Volume: 110 Pages: 35-41
- DOI
  10.1016/j.lungcan.2017.05.017
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09850, KAKENHI-PROJECT-17H06956
[Journal Article] Deep sequencing of the T cell receptor visualizes reconstitution of T cell immunity in mogamulizumab-treated adult T cell leukemia. Oncoimmunology2017
- Author(s)
  3.Shindo T, Kitaura K, Ureshino H, Kamachi K, Miyahara M, Doi K, Watanabe T, Sueoka E, Shin-I T, Suzuki R, Kimura S
- Journal Title
  
  Oncoimmunology
  
  Volume: 7 Issue: 3 Pages: e1405204-e1405204
- DOI
  10.1080/2162402x.2017.1405204
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09850, KAKENHI-PROJECT-17H06956
[Patent] 成人T細胞白血病/リンパ腫の検出方法2020
- Inventor(s)
  渡邉達郎、末岡榮三朗、木村晋也、嬉野博志
- Industrial Property Rights Holder
  渡邉達郎、末岡榮三朗、木村晋也、嬉野博志
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20K07593
[Patent] 血液がんの診断および治療方法2020
- Inventor(s)
  木村晋也、渡邉達郎、山本雄太、倉橋祐樹、酒向孫市、脇田弘臣
- Industrial Property Rights Holder
  木村晋也、渡邉達郎、山本雄太、倉橋祐樹、酒向孫市、脇田弘臣
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-102904
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20K07593
[Patent] 成人T細胞白血病/リンパ腫の検出方法2019
- Inventor(s)
  渡邉達郎、末岡榮三朗、木村晋也、嬉野博志
- Industrial Property Rights Holder
  渡邉達郎、末岡榮三朗、木村晋也、嬉野博志
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17H06956
[Presentation] Targets of Metabolic Alteration in Venetoclax / Decitabine Resistant Acute Myeloid Leukemia.2023
- Author(s)
  Kotoko Yamatani, Tatsuro Watanabe, Kaori Saito, Abhishek Maiti, Satoshi Yamashita, Abdullah Khasawneh, Faith Jessica Paran, Kala Hayes, Gautam Borthakur, Joe R Harman, Shinya Kimura, Courtney DiNardo, Thomas Milne, Michael Andreeff, Yoko Tabe, Marina Konopleva
- Organizer
  .65th American Society of Hematology Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24235
[Presentation] Biological significance of pyrimidine metabolism enzyme UCK2 in adult T-cell leukemia/lymphoma2022
- Author(s)
  渡邉達郎、吉田奈央、山本雄大、蒲池和晴倉橋祐樹、倉橋佑紀川副和紀、嬉野博志中村秀明、末岡榮三朗、木村晋也
- Organizer
  84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07593
[Presentation] ATL 発がんにおけるピリミジンヌクレオチド代謝酵素 UCK2 の関与2022
- Author(s)
  渡邉達郎、吉田‐坂井奈央、山本雄大、嬉野博志、蒲池和晴、倉橋祐樹、川副和紀、倉橋佑紀、中村秀明、岡田誠治、末岡榮三朗、木村晋也
- Organizer
  第8回日本TLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07593
[Presentation] エピジェネティクス治療薬に耐性を獲得した成人T細胞白血病／リンパ腫細胞株に対する治療2022
- Author(s)
  倉橋祐樹、嬉野博志、蒲池和晴、山本雄大、渡邉達郎、木村晋也
- Organizer
  第26回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07593
[Presentation] 成人T細胞白血病/リンパ腫におけるメチオニン代謝を介したエピゲノム調節機構の治療標的としての可能性2022
- Author(s)
  渡邉達郎、倉橋祐樹、蒲池和晴、山本雄大、川副和紀、嬉野博志、末岡榮三朗、木村晋也
- Organizer
  第26回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07593
[Presentation] Biological significance of UCK2 in HTLV-1-infected cells in ATL leukemogenesis and acquired resistance to azacitidine2022
- Author(s)
  Tatsuro Watanabe, Yuta Yamamoto, Kazuharu Kamachi, Yuki Kurahashi, Nao Yoshida-Saka, Hiroshi Ureshino, Yuki Fukuda-Kurahashi, Hideaki Nakamura, Eisaburo Sueoka, Shinya Kimura
- Organizer
  EHA 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07593
[Presentation] 成人 T 細胞白血病/リンパ腫の発がんにおけるピリミジン代謝酵素 UCK2 の重要2022
- Author(s)
  渡邉達郎、嬉野博志、中村秀明、末岡榮三朗、木村晋也
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07593
[Presentation] 成人 T 細胞白血病／リンパ腫に対する DNA 脱メチル化剤と HDAC 阻害剤の併用効果2022
- Author(s)
  倉橋祐樹、嬉野博志、蒲池和晴、城戸口啓介、川副和紀、倉橋佑紀、山本雄大、渡邉達郎、木村晋也
- Organizer
  第8回日本TLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07593
[Presentation] Biomarkers of clinical resistance to Decitabine and Venetoclax therapy inferred by transcriptome and methylation analyses2022
- Author(s)
  Kotoko Yamatani, Abhishek Maiti, Tatsuro Watanabe, Kaori Saitoh, Kala Hayes, Kanako Kinjo, Kazuho Ikeo, Takashi Miida, Shinya Kimura,Courtney D. DiNardo, Su Xiaoping, Yoko Tabe, Marina Konopleva
- Organizer
  64th American Society of Hematology Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24235
[Presentation] メチオニン代謝を介した HTLV-1 感染細胞のエピゲノム調節2021
- Author(s)
  渡邉達郎, 吉田奈央, 山本雄大, 嬉野博志, 蒲池和晴, 倉橋祐樹, 倉橋佑紀, 中村秀明, 服部奈緒子, 山下聡, 岡田誠治, 牛島俊和, 末岡榮三朗, 木村晋也
- Organizer
  第7回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07593
[Presentation] Aberrant epigenetic regulation through reprogramming of methionine metabolism in ATL leukemogenesis2021
- Author(s)
  渡邉達郎, 吉田奈央, 蒲池和晴, 倉橋祐樹, 倉橋佑紀, 嬉野博志, 中村秀明, 末岡榮三朗, 木村信也
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07593
[Presentation] Aberrant epigenetic regulation through metabolic reprogramming in ATL leukemogenesis2021
- Author(s)
  Watanabe T, Yamamoto Y, Kamachi K, Kurahashi Y, Yoshida N, Ureshino H, Fukuda-Kurahashi Y, Nakamura H, Sueoka E, Kimura S
- Organizer
  EHA2021 Virtual Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07593
[Presentation] 成人T細胞白血病/リンパ腫の発がん及びアザシチジン耐性獲得におけるUCK2の役割2021
- Author(s)
  渡邉達郎, 吉田奈央, 倉橋祐樹, 蒲池和晴, 山本雄大, 嬉野博志, 末岡榮三朗, 木村晋也
- Organizer
  第25回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07593
[Presentation] Molecular Mechanism of Acquired Resistance to DNA Demethylating Agents in Adult T-cell Leukemia/ Lymphoma2021
- Author(s)
  Watanabe T, Yoshida N, Yamamoto Y, Ureshino H, Kamachi K, Kurahashi Y, Fukuda-Kurahashi Y, Kimura S
- Organizer
  The 12th JSH International Symposium 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07593
[Presentation] 成人T細胞白血病/リンパ腫におけるメチオニンを介したエピジェネティクス制御2021
- Author(s)
  渡邉達郎, 嬉野博志, 中村秀明, 末岡榮三朗, 木村晋也
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07593
[Presentation] 成人T細胞白血病/リンパ腫におけるT細胞受容体シグナル制御分子のDNAメチル化異常の細胞生物学的意義2020
- Author(s)
  渡邉達郎、吉田奈央、嬉野博志、蒲池和晴、倉橋祐樹、山本雄大、山下聡、岡田誠治、牛島俊和、末岡榮三朗、木村晋也
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07593
[Presentation] ATLL細胞株におけるDNA脱メチル化剤耐性獲得機序の解明2020
- Author(s)
  吉田奈央、渡邉達郎、倉橋祐樹、嬉野博志、蒲池和晴、末岡榮三朗、木村晋也
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07593
[Presentation] 成人T細胞白血病/リンパ腫におけるT細胞受容体シグナル制御分子THEMISのDNAメチル化異常2020
- Author(s)
  渡邉達郎、嬉野博志、山下聡、牛島俊和、岡田誠治、末岡榮三朗、木村晋也
- Organizer
  第79回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07593
[Presentation] 成人T細胞白血病/リンパ腫におけるDNAメチル化異常によるT細胞受容体シグナル制御の破綻2020
- Author(s)
  渡邉達郎、嬉野博志、倉橋祐樹、蒲池和晴、吉田奈央、山本雄大、末岡榮三朗、木村晋也
- Organizer
  第24回日本がん分子治療学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07593
[Presentation] ATLL細胞株におけるDNA脱メチル化剤耐性獲得機序の解明2020
- Author(s)
  吉田奈央、渡邉達郎、嬉野博志、倉橋祐樹、蒲池和晴、末岡榮三朗、木村晋也
- Organizer
  第24回日本がん分子治療学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07593
[Presentation] 成人T細胞白血病／リンパ腫に対するDNA脱メチル化剤とEZH阻害剤の併用効果と標的因子DUSP52020
- Author(s)
  倉橋祐樹、吉田奈央、嬉野博志、蒲池和晴、山本雄大、渡邉達郎、木村晋也
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07593
[Presentation] 成人T細胞白血病／リンパ腫に対するDNA脱メチル化剤とEZH2阻害剤の併用療法2020
- Author(s)
  倉橋祐樹、渡邉達郎、嬉野博志、蒲池和晴、吉田奈央、山本雄大、木村晋也
- Organizer
  第24回日本がん分子治療学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07593
[Presentation] Therapeutic impact of (-)-epigallocatechin gallate on human cancer stem cells, and synergistic anticancer effects with the combination of green tea catechins and anticancer drugs2018
- Author(s)
  Watanabe Tatsuro, Suganuma Masami, Fujiki Hirota
- Organizer
  Innovation of Functional Foods in Asia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06956
[Presentation] DNAメチル化異常を標的とした成人T細胞白血病/リンパ腫の新規治療法の可能性2018
- Author(s)
  渡邉達郎、嬉野博志、倉橋祐樹、山下聡、牛島俊和、末岡榮三朗、木村晋也
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H06956
[Presentation] 成人T細胞白血病/リンパ腫における転写開始点近傍の異常なDNAメチル化亢進は治療標的になり得る2018
- Author(s)
  渡邉達郎、嬉野博志、山下聡、牛島俊和、末岡榮三朗、木村晋也
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H06956
[Presentation] 成人T細胞白血病/リンパ腫におけるDNAメチル化異常と脱メチル化剤による抗腫瘍効果2018
- Author(s)
  渡邉達郎、嬉野博志、倉橋祐樹、末岡榮三朗、木村晋也
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17H06956
[Presentation] Abnormal DNA Methylation Patterns in Adult T-cell Leukemia-Lymphoma Reflected Disease Status as a Therapeutic Target2018
- Author(s)
  Tatsuro Watanabe, Hiroshi Ureshino, Yuki Kurahashi, Satoshi Yamashita, Toshikazu Ushijima, Eisaburo Sueoka, Shinya Kimura
- Organizer
  The 9th JSH International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06956
[Presentation] Aberrant Regional DNA Hypermethylation as a Preventive and Therapeutic Target for Adult T-cell Leukemia-Lymphoma2018
- Author(s)
  Tatsuro Watanabe, Hiroshi Ureshino, Yuki Kurahashi, Yuki Fukuda-Kurahashi, Satoshi Yamashita, Toshikazu Ushijima, Seiji Okada, Eisaburo Sueoka, Shinya Kimura
- Organizer
  60th ASH Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06956
[Presentation] HTLV-1感染者の臨床経過モニタリングにおけるHAS-Flow法の有用性の検討2017
- Author(s)
  中村秀明、佐藤明美、渡邉達郎、板村英和、末岡榮三朗
- Organizer
  第4回　日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-17H06956
[Presentation] TCR Repertoire, Effector Regulatory T-cells and KIR Genotyping Uncover Immunological Dynamics in Mogamulizumab-treated ATL2017
- Author(s)
  Shindo T, Kusunoki Y, Kitamura K, Nishikawa H, Watanabe N, Ureshino H, Miyahara M, Watanabe T, Sueoka E, Espinoza L, Takami A, Ichinohe T Suzuki R, Tanaka H, Saji H, Kimura S
- Organizer
  The 18th International Conference on Human Retrovirology: HTLV and Related Viruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06956
[Presentation] Epigenetic Regulation of the Genes in Indolent Types of Adult T-cell leukemia/Lymphoma Analyzed by Comprehensive DNA Methylation Array2017
- Author(s)
  Nakamura H, Watanabe T, Sato A, Yamashita S, Ushijima T, Sueoka E
- Organizer
  The 18th International Conference on Human Retrovirology: HTLV and Related Viruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06956

1. 末岡榮三朗 (00270603)

# of Collaborated Projects: 3 results

# of Collaborated Products: 29 results
2. 服部奈緒子 (30611090)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. 木村晋也 (80359794)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
4. 松崎賢寿 (50830527)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 竹見祥大 (70871440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 田部陽子 (70306968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 藍智彦 (00570128)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 岡崎康司 (80280733)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 里史明 (10468580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. HARADA Yuka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 末岡尚子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 嬉野博志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 原田浩徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Watanabe Tatsuro 渡邉 達郎

Research Projects

Research Products

Co-Researchers

成人T細胞白血病・リンパ腫におけるDNAメチル化異常を標的にした診断法と治療法の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

難治性白血病の内在性レトロウイルス活性化機序に基づく新規バイオマーカー開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞外小胞の「形と硬さ」に基づくがん悪性化機序の定量解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Biological significance of DNA methylation abnormalities in ATL leukemogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

DNA demethylation therapy in ATLPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Cancer progression by the okadaic acid class of tumor promoters and endogenous protein inhibitors of PP2A, SET and CIP2A2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combination of a New Oral Demethylating Agent, OR2100, and Venetoclax for Treatment of Acute Myeloid Leukemia2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dual targeting of aberrant DNA and histone methylation synergistically suppresses tumor cell growth in ATL2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Diffuse Large B-cell Lymphoma Involving an Abundant Infiltration of T Follicular Helper Cells2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Targeting DNMT1 by demethylating agent OR-2100 increases tyrosine kinase inhibitors-sensitivity and depletes leukemic stem cells in chronic myeloid leukemia2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 経口脱メチル化薬によるATLの標的治療2021

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Adult T‐cell leukemia‐lymphoma acquires resistance to <scp>DNA</scp> demethylating agents through dysregulation of enzymes involved in pyrimidine metabolism2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Silylation of Deoxynucleotide Analog Yields an Orally Available Drug with Antileukemia Effects2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of TNF-α-Inducing Protein Secreted by Helicobacter pylori as a Tumor Promoter in Gastric Cancer and Emerging Preventive Strategies2021

Author(s)

Journal Title

Watanabe Tatsuro 渡邉達郎