Takaishi Shigeo 高石繁生

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TAKAISHI Shigeo 高石繁生

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Researcher Number	20596829
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 特定准教授
Affiliation (based on the past Project Information) *help	2017 – 2021: 京都大学, 医学研究科, 特定准教授 2014: 九州大学, 学内共同利用施設等, 准教授 2012 – 2014: 九州大学, 先端医療イノベーションセンター, 准教授 2011: 九州大学, 先端医療イノベーションセンター, 学術研究員(特任准教授)
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 内科 / 癌 / 膵癌発症複合遺伝子変異マウス / ヒト膵癌培養細胞 / COX-2遺伝子 / COX-1遺伝子 / ヒト膵癌培養細胞株 / 膵癌自然発症マウス / SNAIL2(=SLUG)遺伝子 / 上皮間葉転換関連転写因子(EMT-TFs) … More / CAGE法遺伝子解析 / ヒト及びマウス膵癌培養細胞 / 膵癌自然発症マウス(KPC) / SNAIL2(別称SLUG) / 上皮間葉転換(EMT) / 膵癌幹細胞 / CAGE法 / COX-1, -2遺伝子 / ヒト膵癌オルガノイド / ヒト及びマウス膵癌培養細胞株 / 膵癌発症マウス / 国際情報交流、アメリカ合衆国 / 「国際情報交流、アメリカ合衆国」 / 国際情報交換、アメリカ合衆国 / 国際情報交換（アメリカ合衆国） / ガストリン/CCK2受容体 / CCK２受容体阻害薬YF476 / 発癌物質メチルニトロソウレア / ヘリコバクター菌感染 / プロガストリン / ガストリン/CCK２受容体 / Lgr5陽性細胞 / 胃前庭部上皮幹細胞 / 胃発癌マウス Less

ヒト膵癌オルガノイドを用いた腫瘍微小環境の構造解析と浸潤・転移マウスモデルの確立Principal Investigator
- Principal Investigator
  
  高石繁生
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto University
Investigation of the roles of bone marrow-derived fibroblasts/myofibroblasts and their molecular mechanism in the carcinogenesis of mouse models of pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  Takaishi Shigeo
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto University
The role of bone marrow-derived cells and interleukin-17 in the mouse model of Helicobacter-infected gastric cancerPrincipal Investigator
- Principal Investigator
  
  TAKAISHI Shigeo
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyushu University

All 2021 2020 2019 2018 2015 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] G.I. Research 第20巻1号　総説「胃癌・大腸癌幹細胞」2012
- Author(s)
  高石繁生
- Total Pages
  6
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-23590919
[Book] 最新内科学、６章　内科疾患と腫瘍学、２　癌幹細胞2012
- Author(s)
  高石繁生、赤司浩一
- Publisher
  西村書店
- Data Source
  KAKENHI-PROJECT-23590919
[Journal Article] SNAIL regulates gastric carcinogenesis through CCN3 and NEFL.2021
- Author(s)
  Ru Chen, Kenji Masuo, Akitada Yogo, Shoko Yokoyama, Aiko Sugiyama, Hiroshi Seno, Akihiko Yoshizawa, Shigeo Takaishi
- Journal Title
  
  Carcinogenesis
  
  Volume: 42 (2) Issue: 2 Pages: 190-201
- DOI
  10.1093/carcin/bgaa133
- NAID
  120006979787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09460
[Journal Article] Promoter-level transcriptome identifies stemness associated with relatively high proliferation in pancreatic cancer cells.2020
- Author(s)
  Ru Chen, Aiko Sugiyama, Naoyuki Kataoka, Masahiro Sugimoto, Shoko Yokoyama, Akihisa Fukuda, Shigeo Takaishi, Hiroshi Seno
- Journal Title
  
  Frontiers in Oncology,
  
  Volume: 10 Pages: 1-14
- DOI
  10.3389/fonc.2020.00316
- NAID
  120006826695
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09460, KAKENHI-PROJECT-17K00416, KAKENHI-PLANNED-20H05743
[Journal Article] Arid1a is essential for intestinal stem cells through Sox9 regulation.2019
- Author(s)
  Hiramatsu Y, Fukuda A, Ogawa S, Goto N, Ikuta K, Tsuda M, Matsumoto Y, Kimura Y, Yoshioka T, Takada Y, Maruno T, Hanyu Y, Tsuruyama T, Wang Z, Akiyama H, Takaishi S, Miyoshi H, Taketo MM, Chiba T, Seno H.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 116 (5) Issue: 5 Pages: 1704-1713
- DOI
  10.1073/pnas.1804858116
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09460, KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-17H04059, KAKENHI-PROJECT-17H04157
[Journal Article] E-cadherin regulates proliferation of colorectal cancer stem cells through NANOG.2018
- Author(s)
  Tamura S, Isobe T, Ariyama H, Nakano M, Kikushige Y, Takaishi S, Kusaba H, Takenaka K, Ueki T, Nakamura M, Akashi K, Baba E.
- Journal Title
  
  Oncology Reports
  
  Volume: 40 (2) Pages: 693-703
- DOI
  10.3892/or.2018.6464
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09460, KAKENHI-PROJECT-18H02840, KAKENHI-PROJECT-16H06250
[Journal Article] Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice.2018
- Author(s)
  Ikuta K, Fukuda A, Ogawa S, Masuo K, Goto N, Hiramatsu Y, Tsuda M, Kimura Y, Matsumoto Y, Kimura Y, Maruno T, Kanda K, Nishi K, Takaori K, Uemoto S, Takaishi S, Chiba T, Nishi E, Seno H.
- Journal Title
  
  Gut
  
  Volume: 印刷中 Issue: 5 Pages: 882-892
- DOI
  10.1136/gutjnl-2017-315425
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09460, KAKENHI-PUBLICLY-18H04694, KAKENHI-PROJECT-17H04048, KAKENHI-PROJECT-17H06804, KAKENHI-PROJECT-16K09394, KAKENHI-PROJECT-16K15613
[Journal Article] CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis.2015
- Author(s)
  Hayakawa Y, Jin G, Wang H, Chen X, Westphalen CB, Asfaha S, Renz BW, Ariyama H, Dubeykovskaya ZA, Takemoto Y, Lee Y, Muley A, Tailor Y, Chen D, Muthupalani S, Fox JG, Shulkes A, Worthley DL, Takaishi S, Wang TC.
- Journal Title
  
  Gut
  
  Volume: 64(4) Issue: 4 Pages: 544-553
- DOI
  10.1136/gutjnl-2014-307190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590919
[Journal Article] Progastrin Promotes Antral Carcinogenesis and Gastric Stem Cell Function2013
- Author(s)
  Yoku Hayakawa, Shigeo Takaishi, Guangchun Jin, Hiroshi Ariyama, Christoph B. Westphalen, Samuel Asfaha, Yagnesh H. Tailor, Wataru Shibata, Xiangdong Yang, Duan Chen, Mark T. Whary, Sureshkumar Muthupalani, James G. Fox, Arthur Shulkes, Timothy C. Wang
- Journal Title
  
  Gastroenterology
  
  Volume: Vol. 144, Issue 5, Suppl. 1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590919
[Journal Article] The unfolded protein response is activated in Helicobacter-induced gastric carcinogenesis in a non-cell autonomous manner2013
- Author(s)
  Baird M, Woon Ang P, Clark I, Bishop D, Oshima M, Cook MC, Hemmings C, Takaishi S, Worthley D, Boussioutas A, Wang TC, Taupin D.
- Journal Title
  
  Laboratory Investigation
  
  Volume: 93(1) Issue: 1 Pages: 112-122
- DOI
  10.1038/labinvest.2012.131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590919
[Journal Article] P53 gene mutation increases progastrin dependent colonic proliferation and colon cancer formation in mice2012
- Author(s)
  Ramanathan V, Jin G, Westphalen CB, Whelan A, Dubeykovskiy A, Takaishi S, Wang TC.
- Journal Title
  
  Cancer Investigation
  
  Volume: 30(4) Issue: 4 Pages: 275-286
- DOI
  10.3109/07357907.2012.657814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590919
[Journal Article] Inhibition of gastric carcinogenesis by the hormone, gastrin, is mediated by suppression of TFF1 epigenetic silencing.2011
- Author(s)
  Tomita H, Kawakami K, Minamoto T, et al
- Journal Title
  
  Gastroenterology
  
  Volume: 140 (3) Issue: 3 Pages: 879-91
- DOI
  10.1053/j.gastro.2010.11.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249051, KAKENHI-PROJECT-23590919, KAKENHI-PROJECT-23659643
[Journal Article] Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth.2011
- Author(s)
  Quante M, Tu SP, Tomita H, Gonda T, Wang SS, Takaishi S, Baik GH, Shibata W, Diprete B, Betz KS, Friedman R, Varro A, Tycko B, Wang TC.
- Journal Title
  
  Cancer Cell
  
  Volume: 19(2) Issue: 2 Pages: 257-272
- DOI
  10.1016/j.ccr.2011.01.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590919
[Journal Article] In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice.2011
- Author(s)
  Takaishi S, Shibata W, Tomita H, Jin G, Yang X, Ericksen R, Dubeykovskaya Z, Asfaha S, Quante M, Betz KS, Shulkes A, Wang TC.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol
  
  Volume: 300(2) Issue: 2 Pages: G334-G344
- DOI
  10.1152/ajpgi.00134.2010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590919
[Journal Article] IFN-γ inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis.2011
- Author(s)
  Tu SP, Quante M, Bhagat G, Takaishi S, Cui G, Yang XD, Muthuplani S, Shibata W, Fox JG, Pritchard DM, Wang TC.
- Journal Title
  
  Cancer Research
  
  Volume: 71(12) Issue: 12 Pages: 4247-4259
- DOI
  10.1158/0008-5472.can-10-4009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590919
[Presentation] 胆道癌におけるドーパミンの自己分泌作用は癌幹細胞の微小環境に寄与する2020
- Author(s)
  余語覚匡、高石繁生、増尾謙志、陳如、増井俊彦、妹尾浩
- Organizer
  第78回日本癌学会学術総会(ポスター発表)
- Data Source
  KAKENHI-PROJECT-17K09460
[Presentation] SNAIL2は膵癌の幹細胞性維持において重要である2020
- Author(s)
  増尾謙志、高石繁生、余語覚匡、陳如、福田晃久、増井俊彦、妹尾浩
- Organizer
  第78回日本癌学会学術総会(ポスター発表)
- Data Source
  KAKENHI-PROJECT-17K09460
[Presentation] SNAIL regulates gastric carcinogenesis through CCN3 and NEFL.2020
- Author(s)
  陳如、高石繁生、増尾謙志、余語覚匡、杉山愛子、妹尾浩
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K09460
[Presentation] Progastrin Promotes Antral Carcinogenesis and Gastric Stem Cell Function2013
- Author(s)
  Hayakawa Y, Takaishi S, Jin G, Ariyama H, Westphalen CB, Asfaha S, Tailor Y, Shibata W, Yang X, Chen D, Whary MT, Muthupalani S, Fox JG, Shulkes A, Wang TC
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  アメリカ合衆国、フロリダ
- Data Source
  KAKENHI-PROJECT-23590919
[Presentation] Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche2011
- Author(s)
  Takaishi S
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-23590919
[Presentation] Progastrin Promotes Antral Carcinogenesis and Gastric Stem Cell Function
- Author(s)
  Yoku Hayakawa, Shigeo Takaishi, Guangchun Jin, Hiroshi Ariyama, Christoph B. Westphalen, Samuel Asfaha, Yagnesh H. Tailor, Wataru Shibata, Xiangdong Yang, Duan Chen, Mark T. Whary, Sureshkumar Muthupalani, James G. Fox, Arthur Shulkes, Timothy C. Wang
- Organizer
  Digestive Disease Week,
- Place of Presentation
  Orange County Convention Center, FL, USA
- Data Source
  KAKENHI-PROJECT-23590919

1. 増井俊彦 (20452352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. HAYAKAWA Yoku

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. WANG Timothy C.

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
4. 源利成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 川上和之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takaishi Shigeo 高石 繁生

TAKAISHI Shigeo 高石 繁生

Research Projects

Research Products

Co-Researchers

ヒト膵癌オルガノイドを用いた腫瘍微小環境の構造解析と浸潤・転移マウスモデルの確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the roles of bone marrow-derived fibroblasts/myofibroblasts and their molecular mechanism in the carcinogenesis of mouse models of pancreatic cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of bone marrow-derived cells and interleukin-17 in the mouse model of Helicobacter-infected gastric cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] G.I. Research 第20巻1号 総説「胃癌・大腸癌幹細胞」2012

Author(s)

Total Pages

Publisher

Data Source

[Book] 最新内科学、６章 内科疾患と腫瘍学、２ 癌幹細胞2012

Author(s)

Publisher

Data Source

[Journal Article] SNAIL regulates gastric carcinogenesis through CCN3 and NEFL.2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Promoter-level transcriptome identifies stemness associated with relatively high proliferation in pancreatic cancer cells.2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Arid1a is essential for intestinal stem cells through Sox9 regulation.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] E-cadherin regulates proliferation of colorectal cancer stem cells through NANOG.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Progastrin Promotes Antral Carcinogenesis and Gastric Stem Cell Function2013

Author(s)

Journal Title

Data Source

[Journal Article] The unfolded protein response is activated in Helicobacter-induced gastric carcinogenesis in a non-cell autonomous manner2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] P53 gene mutation increases progastrin dependent colonic proliferation and colon cancer formation in mice2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of gastric carcinogenesis by the hormone, gastrin, is mediated by suppression of TFF1 epigenetic silencing.2011

Author(s)

Takaishi Shigeo 高石繁生

TAKAISHI Shigeo 高石繁生

[Book] G.I. Research 第20巻1号　総説「胃癌・大腸癌幹細胞」2012

[Book] 最新内科学、６章　内科疾患と腫瘍学、２　癌幹細胞2012