Nakatsumi Hirokazu 中津海洋一

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NAKATSUMI Hirokazu 中津海洋一

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Researcher Number	20596837
Other IDs
Affiliation (Current)	2023: 名古屋市立大学, 医薬学総合研究院(薬学), 准教授
Affiliation (based on the past Project Information) *help	2019 – 2021: 名古屋市立大学, 医薬学総合研究院(薬学), 講師 2018: 名古屋市立大学, 大学院薬学研究科, 講師 2013 – 2015: 九州大学, 生体防御医学研究所, 研究員 2012 – 2013: 九州大学, 生体防御医学研究所, 学術研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 49010:Pathological biochemistry-related / Tumor biology / Functional biochemistry
Keywords	Principal Investigator mTORC1 / FOXK1 / CCL2 / シグナル伝達 / mTOR / 液ー液相分離 / 慢性炎症 / 肝疾患 / 生活習慣病 / 糖尿病 … More / 脂肪肝 / 炎症 / マクロファージ / がん / 腫瘍随伴マクロファージ / 血管新生 Less

mTORC1依存的液―液相分離制御によるがん促進機構の解明Principal Investigator
- Principal Investigator
  
  中津海洋一
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Nagoya City University
Analysis of mTORC1-FOXK1 axis in lifestyle-related diseasesPrincipal Investigator
- Principal Investigator
  
  NAKATSUMI Hirokazu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Nagoya City University
Mechanistic insights of tumor promotion via a novel mTOR signaling pwthwayPrincipal Investigator
- Principal Investigator
  
  Hirokazu Nakatsumi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kyushu University
Identification and functional analysis of mTOR downstream molecules using phospho-proteomic technologyPrincipal Investigator
- Principal Investigator
  
  NAKATSUMI Hirokazu
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kyushu University

All 2022 2020 2019 2018 2016 2015 2014 2013 2012

All Journal Article Presentation

[Journal Article] Senescence Connects Autophagy Deficiency to Inflammation and Tumor Progression in the Liver2022
- Author(s)
  Huda Nazmul、Khambu Bilon、Liu Gang、Nakatsumi Hirokazu、Yan Shengmin、Chen Xiaoyun、Ma Michelle、Dong Zheng、Nakayama Keiichi I.、Yin Xiao-Ming
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: - Issue: 2 Pages: 333-355
- DOI
  10.1016/j.jcmgh.2022.04.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07155
[Journal Article] Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium2022
- Author(s)
  Higa Tsunaki、Okita Yasutaka、Matsumoto Akinobu、Nakayama Shogo、Oka Takeru、Sugahara Osamu、Koga Daisuke、Takeishi Shoichiro、Nakatsumi Hirokazu、Hosen Naoki、Robine Sylvie、Taketo Makoto M.、Sato Toshiro、Nakayama Keiichi I.
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 1500-1500
- DOI
  10.1038/s41467-022-29165-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05215, KAKENHI-PROJECT-19J20466, KAKENHI-PROJECT-21K07155
[Journal Article] Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development.2020
- Author(s)
  Yamauchi, Y., Nita, A., Nishiyama, M., Muto, Y., Shimizu, H., Nakatsumi, H., Nakayama, K. I.
- Journal Title
  
  Genes Cells
  
  Volume: XX Issue: 6 Pages: 427-438
- DOI
  10.1111/gtc.12769
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02747, KAKENHI-PROJECT-18K19509, KAKENHI-PROJECT-20K21650, KAKENHI-PROJECT-18H05215, KAKENHI-PUBLICLY-20H05057, KAKENHI-PROJECT-18K06962
[Journal Article] Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation2020
- Author(s)
  Shirane Michiko、Wada Mariko、Morita Keiko、Hayashi Nahoki、Kunimatsu Reina、Matsumoto Yuki、Matsuzaki Fumiko、Nakatsumi Hirokazu、Ohta Keisuke、Tamura Yasushi、Nakayama Keiichi I.
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 4576-4576
- DOI
  10.1038/s41467-020-18413-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11733, KAKENHI-PROJECT-20K06730, KAKENHI-PROJECT-20K21413, KAKENHI-PROJECT-18H05215, KAKENHI-PUBLICLY-20H04907, KAKENHI-PROJECT-19H03174, KAKENHI-PROJECT-20H03255, KAKENHI-PROJECT-18K06962, KAKENHI-ORGANIZER-17H06413, KAKENHI-PROJECT-15H05705
[Journal Article] Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells2019
- Author(s)
  Shimizu Hideyuki、Takeishi Shoichiro、Nakatsumi Hirokazu、Nakayama Keiichi I.
- Journal Title
  
  JCI Insight
  
  Volume: 4 Issue: 4
- DOI
  10.1172/jci.insight.125138
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06962, KAKENHI-PROJECT-18H05215, KAKENHI-PROJECT-16H06276
[Journal Article] Nuclear-cytoplasmic shuttling protein PP2AB56 contributes to mTORC1-dependent dephosphorylation of FOXK12018
- Author(s)
  Nakatsumi Hirokazu、Oka Takeru、Higa Tsunaki、Shirane Michiko、Nakayama Keiichi I.
- Journal Title
  
  Genes to Cells
  
  Volume: 23 Issue: 7 Pages: 599-605
- DOI
  10.1111/gtc.12597
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06962, KAKENHI-PROJECT-18H05215, KAKENHI-PROJECT-16H06276
[Journal Article] 次世代プロテオミクスが拓く生命科学研究の新地平：ウエスタンブロッティングはもう要らない?!2012
- Author(s)
  中津海洋一、松本雅記、中山敬一
- Journal Title
  
  生化学
  
  Volume: 84 Pages: 53-57
- NAID
  10030346257
- Data Source
  KAKENHI-PROJECT-24770129
[Journal Article] Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation2012
- Author(s)
  Kanie T, et al
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 32 Issue: 3 Pages: 590-605
- DOI
  10.1128/mcb.06570-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J00843, KAKENHI-PROJECT-22710186, KAKENHI-PROJECT-24770129
[Journal Article] 次世代プロテオミクスが拓く生命科学研究の新地平 : ウエスタンブロッティングはもう要らない?!2012
- Author(s)
  中津海洋一、松本雅記、中山敬一
- Journal Title
  
  生化学
  
  Volume: 84 Pages: 53-57
- NAID
  10030346257
- Data Source
  KAKENHI-PROJECT-24770129
[Journal Article] mTORターゲットのリン酸化プロテオミクス2012
- Author(s)
  中津海洋一、松本雅記、中山敬一
- Journal Title
  
  細胞工学
  
  Volume: 31 Pages: 1360-1367
- Data Source
  KAKENHI-PROJECT-24770129
[Journal Article] mTORターゲットのリン酸化プロテオミクス2012
- Author(s)
  中津海洋一、松本雅記、中山敬一
- Journal Title
  
  細胞工学
  
  Volume: 31 Pages: 1360-1367
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] 定量的リン酸化プロテオミクスによるmTOR下流の大規模シグナル解析2020
- Author(s)
  中津海洋一
- Organizer
  第1回シロリムス新作用研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06962
[Presentation] PP2AB56 は核内転写因子FOXK1 のmTORC1 依存的脱リン酸化に寄与する2019
- Author(s)
  中津海洋一・白根道子・中山敬一
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-18K06962
[Presentation] 定量的大規模リン酸化プロテオミクスによるmTORC1下流のシグナル解析2019
- Author(s)
  中津海洋一
- Organizer
  基礎生物学研究所部門公開セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18K06962
[Presentation] 定量的リン酸化プロテオミクスによるmTORC1下流の新規がん促進シグナルの解析2019
- Author(s)
  中津海洋一・松本雅記・白根道子・中山敬一
- Organizer
  日本プロテオーム学会2019年大会
- Data Source
  KAKENHI-PROJECT-18K06962
[Presentation] mTORC1依存的な転写因子の脱リン酸化メカニズムとその生物学的意義2018
- Author(s)
  中津海　洋一
- Organizer
  第91回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06962
[Presentation] Noncanonical Pathway for Regulation of CCL2 Expression by an mTORC1-FOXK1 Axis Promotes Recruitment of Tumor-Associated Macrophages.2018
- Author(s)
  中津海　洋一
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06962
[Presentation] mTORC1の活性化はFOXK1経路を介して炎症を誘導する2016
- Author(s)
  中津海洋一
- Organizer
  「冬の若手ワークショップ2016」（転写研究会・転写サイクル・転写代謝システム共催）
- Place of Presentation
  山梨県南都留郡
- Year and Date
  2016-02-04
- Data Source
  KAKENHI-PROJECT-26830078
[Presentation] mTORC1の活性化はFOXK1経路を介して炎症を誘導する2015
- Author(s)
  中津海洋一, 松本雅記, 中山敬一
- Organizer
  BMB2015 第38回日本分子生物学会第88回日本生化学会合同大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26830078
[Presentation] mTORC1の活性化はFOXK1経路を介して炎症を誘導する2015
- Author(s)
  中津海洋一
- Organizer
  新学術領域「転写代謝システム」領域班会議
- Place of Presentation
  熊本県熊本市
- Year and Date
  2015-06-14
- Data Source
  KAKENHI-PROJECT-26830078
[Presentation] リン酸化プロテオミクス解析から明らかになったmTORC1による癌微小環境の制御2014
- Author(s)
  中津海洋一
- Organizer
  大阪大学蛋白研究所セミナーキナーゼ・シグナリング研究の進展
- Place of Presentation
  大阪大学
- Invited
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] mTORC1と炎症性ケモカインをつなぐ新規分子の発見とがん促進作用2013
- Author(s)
  中津海洋一、松本雅記、中山敬一
- Organizer
  第36回分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] 栄養シグナルと炎症の接点!? : mTORC1と炎症性ケモカインをつなぐ新規分子の発見とがん促進作用2013
- Author(s)
  中津海洋一、松本雅記、中山敬一
- Organizer
  第25回高遠・分子細胞生物学シンポジウム
- Place of Presentation
  (ポスター発表)
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] FOXK1 mediates mTORC1-dependent chemokine production and promotes cancer progression2013
- Author(s)
  Nakatsumi H., Matsumoto M., Nakayama K. I.
- Organizer
  The 23^<th> Hot Spring Harbor Symposium
- Place of Presentation
  Japan (Poster presentation)
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] mTORC1と炎症性ケモカインをつなぐ新規分子の発見とがん促進作用2013
- Author(s)
  中津海洋一、松本雅記、中山敬一
- Organizer
  第36回分子生物学会
- Place of Presentation
  (ポスター発表)
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] Identification of a novel mTOR target linking to transcriptional regulation and cancer progression.2013
- Author(s)
  Nakatsumi H., Matsumoto M., Nakayama K. I.
- Organizer
  The 8th International Symposium of the Institute Network
- Place of Presentation
  Japan
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] リン酸化プロテオミクス解析から明らかになったmTORC1による癌微小環境の制御2013
- Author(s)
  中津海洋一
- Organizer
  大阪大学蛋白研究所セミナーキナーゼ・シグナリング研究の進展
- Invited
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] Identification of a novel mTOR target linking to transcriptional regulation and cancer progression2013
- Author(s)
  Nakatsumi H., Matsumoto M., Nakayama K. I.
- Organizer
  The 8^<th> International Symposium of the Institute Network
- Place of Presentation
  Japan (Poster presentation)
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] 栄養シグナルと炎症の接点！？：mTORC1と炎症性ケモカインをつなぐ新規分子の発見とがん促進作用2013
- Author(s)
  中津海洋一、松本雅記、中山敬一
- Organizer
  第25回高遠・分子細胞生物学シンポジウム
- Place of Presentation
  滋賀県高野山
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] FOXK1 mediates mTORC1-dependent chemokine production and promotes cancer progression.2013
- Author(s)
  Nakatsumi H., Matsumoto M., Nakayama K. I.
- Organizer
  The 23th Hot Spring Harbor Symposium
- Place of Presentation
  Japan
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] mTORと転写をつなぐ新規分子FOXK1の発見と癌進展における促進作用2012
- Author(s)
  中津海洋一、松本雅記、中山敬一
- Organizer
  第35回分子生物学会
- Place of Presentation
  (ワークショップ)
- Invited
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] mTORと転写をつなぐ新規分子FOXK1の発見とがん進展における促進作用2012
- Author(s)
  中津海洋一, 松本雅記, 小山田浩二, 中山敬一
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-24770129

1. 西山正章

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# of Collaborated Products: 1 results
2. 中山啓子

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# of Collaborated Products: 1 results
3. 中山敬一

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# of Collaborated Products: 1 results

Nakatsumi Hirokazu 中津海 洋一

NAKATSUMI Hirokazu 中津海 洋一

Research Projects

Research Products

Co-Researchers

mTORC1依存的液―液相分離制御によるがん促進機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of mTORC1-FOXK1 axis in lifestyle-related diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanistic insights of tumor promotion via a novel mTOR signaling pwthwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and functional analysis of mTOR downstream molecules using phospho-proteomic technologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Senescence Connects Autophagy Deficiency to Inflammation and Tumor Progression in the Liver2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nuclear-cytoplasmic shuttling protein PP2AB56 contributes to mTORC1-dependent dephosphorylation of FOXK12018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 次世代プロテオミクスが拓く生命科学研究 の新地平：ウエスタンブロッティングはもう要らない?!2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 次世代プロテオミクスが拓く生命科学研究の新地平 : ウエスタンブロッティングはもう要らない?!2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] mTORターゲットのリン酸化プロテオミクス2012

Author(s)

Journal Title

Data Source

[Journal Article] mTORターゲットのリン酸化プロテオミ クス2012

Author(s)

Nakatsumi Hirokazu 中津海洋一

NAKATSUMI Hirokazu 中津海洋一

[Journal Article] 次世代プロテオミクスが拓く生命科学研究の新地平：ウエスタンブロッティングはもう要らない?!2012

[Journal Article] mTORターゲットのリン酸化プロテオミクス2012