Nakatsumi Hirokazu 中津海洋一

… Alternative Names

NAKATSUMI Hirokazu 中津海洋一

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Researcher Number	20596837
Other IDs
Affiliation (Current)	2025: 名古屋市立大学, 医薬学総合研究院(薬学), 准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 名古屋市立大学, 医薬学総合研究院(薬学), 准教授 2019 – 2021: 名古屋市立大学, 医薬学総合研究院(薬学), 講師 2018: 名古屋市立大学, 大学院薬学研究科, 講師 2013 – 2015: 九州大学, 生体防御医学研究所, 研究員 2012 – 2013: 九州大学, 生体防御医学研究所, 学術研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 49010:Pathological biochemistry-related / Tumor biology / Functional biochemistry
Keywords	Principal Investigator mTORC1 / FOXK1 / CCL2 / シグナル伝達 / mTOR / 液ー液相分離 / Translation / P-body / 慢性炎症 / 肝疾患 … More / 生活習慣病 / 糖尿病 / 脂肪肝 / 炎症 / マクロファージ / がん / 腫瘍随伴マクロファージ / 血管新生 Less

Elucidation of Cancer-Promoting Mechanisms Through mTORC1-Dependent Regulation of Liquid-Liquid Phase SeparationPrincipal Investigator
- Principal Investigator
  
  Nakatsumi Hirokazu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Nagoya City University
Analysis of mTORC1-FOXK1 axis in lifestyle-related diseasesPrincipal Investigator
- Principal Investigator
  
  NAKATSUMI Hirokazu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Nagoya City University
Mechanistic insights of tumor promotion via a novel mTOR signaling pwthwayPrincipal Investigator
- Principal Investigator
  
  Hirokazu Nakatsumi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kyushu University
Identification and functional analysis of mTOR downstream molecules using phospho-proteomic technologyPrincipal Investigator
- Principal Investigator
  
  NAKATSUMI Hirokazu
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kyushu University

All 2023 2022 2020 2019 2018 2016 2015 2014 2013 2012

All Journal Article Presentation

[Journal Article] A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection2023
- Author(s)
  Funasaki Shintaro、Hatano Atsushi、Nakatsumi Hirokazu、Koga Daisuke、Sugahara Osamu、Yumimoto Kanae、Baba Masaya、Matsumoto Masaki、Nakayama Keiichi I.
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 9 Pages: 107552-107552
- DOI
  10.1016/j.isci.2023.107552
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19288, KAKENHI-PROJECT-21K07155, KAKENHI-PROJECT-21K19721, KAKENHI-PLANNED-20H05930, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-23K23870, KAKENHI-PROJECT-23K24474
[Journal Article] FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation.2023
- Author(s)
  Fujinuma S, Nakatsumi H, Shimizu H, Sugiyama S, Harada A, Goya T, Tanaka M, Kohjima M, Takahashi M, Izumi Y, Yagi M, Kang D, Kaneko M, Shigeta M, Bamba T, Ohkawa Y, Nakayama KI*.
- Journal Title
  
  Cell Reports
  
  Volume: 42(5) Issue: 5 Pages: 112530-112530
- DOI
  10.1016/j.celrep.2023.112530
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18924, KAKENHI-PROJECT-21K07155, KAKENHI-PROJECT-22K19275, KAKENHI-PUBLICLY-22H04676, KAKENHI-PLANNED-21H05292, KAKENHI-PLANNED-22H05185, KAKENHI-PROJECT-23H00372, KAKENHI-PROJECT-23K27087
[Journal Article] Phosphorylation of PBX2, a novel downstream target of mTORC1, is determined by GSK3 and PP12022
- Author(s)
  Wada Reona、Fujinuma Shun、Nakatsumi Hirokazu、Matsumoto Masaki、Nakayama Keiichi I
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 173 Issue: 2 Pages: 129-138
- DOI
  10.1093/jb/mvac094
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07155, KAKENHI-PROJECT-22K19288, KAKENHI-PROJECT-20K21386, KAKENHI-PLANNED-20H05930, KAKENHI-PROJECT-23K23870, KAKENHI-PROJECT-18H05215
[Journal Article] Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium2022
- Author(s)
  Higa Tsunaki、Okita Yasutaka、Matsumoto Akinobu、Nakayama Shogo、Oka Takeru、Sugahara Osamu、Koga Daisuke、Takeishi Shoichiro、Nakatsumi Hirokazu、Hosen Naoki、Robine Sylvie、Taketo Makoto M.、Sato Toshiro、Nakayama Keiichi I.
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 1500-1500
- DOI
  10.1038/s41467-022-29165-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05215, KAKENHI-PROJECT-19J20466, KAKENHI-PROJECT-21K07155
[Journal Article] Senescence Connects Autophagy Deficiency to Inflammation and Tumor Progression in the Liver2022
- Author(s)
  Huda Nazmul、Khambu Bilon、Liu Gang、Nakatsumi Hirokazu、Yan Shengmin、Chen Xiaoyun、Ma Michelle、Dong Zheng、Nakayama Keiichi I.、Yin Xiao-Ming
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 14 Issue: 2 Pages: 333-355
- DOI
  10.1016/j.jcmgh.2022.04.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07155, KAKENHI-PROJECT-18H05215
[Journal Article] Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development.2020
- Author(s)
  Yamauchi, Y., Nita, A., Nishiyama, M., Muto, Y., Shimizu, H., Nakatsumi, H., Nakayama, K. I.
- Journal Title
  
  Genes Cells
  
  Volume: XX Issue: 6 Pages: 427-438
- DOI
  10.1111/gtc.12769
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02747, KAKENHI-PROJECT-18K19509, KAKENHI-PROJECT-20K21650, KAKENHI-PROJECT-18H05215, KAKENHI-PUBLICLY-20H05057, KAKENHI-PROJECT-18K06962
[Journal Article] Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation2020
- Author(s)
  Shirane Michiko、Wada Mariko、Morita Keiko、Hayashi Nahoki、Kunimatsu Reina、Matsumoto Yuki、Matsuzaki Fumiko、Nakatsumi Hirokazu、Ohta Keisuke、Tamura Yasushi、Nakayama Keiichi I.
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 4576-4576
- DOI
  10.1038/s41467-020-18413-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11733, KAKENHI-PROJECT-20K06730, KAKENHI-PROJECT-20K21413, KAKENHI-PROJECT-18H05215, KAKENHI-PUBLICLY-20H04907, KAKENHI-PROJECT-19H03174, KAKENHI-PROJECT-20H03255, KAKENHI-PROJECT-18K06962, KAKENHI-ORGANIZER-17H06413, KAKENHI-PROJECT-15H05705
[Journal Article] Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells2019
- Author(s)
  Shimizu Hideyuki、Takeishi Shoichiro、Nakatsumi Hirokazu、Nakayama Keiichi I.
- Journal Title
  
  JCI Insight
  
  Volume: 4 Issue: 4
- DOI
  10.1172/jci.insight.125138
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06962, KAKENHI-PROJECT-18H05215, KAKENHI-PROJECT-16H06276
[Journal Article] Nuclear-cytoplasmic shuttling protein PP2AB56 contributes to mTORC1-dependent dephosphorylation of FOXK12018
- Author(s)
  Nakatsumi Hirokazu、Oka Takeru、Higa Tsunaki、Shirane Michiko、Nakayama Keiichi I.
- Journal Title
  
  Genes to Cells
  
  Volume: 23 Issue: 7 Pages: 599-605
- DOI
  10.1111/gtc.12597
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06962, KAKENHI-PROJECT-18H05215, KAKENHI-PROJECT-16H06276
[Journal Article] 次世代プロテオミクスが拓く生命科学研究の新地平：ウエスタンブロッティングはもう要らない?!2012
- Author(s)
  中津海洋一、松本雅記、中山敬一
- Journal Title
  
  生化学
  
  Volume: 84 Pages: 53-57
- NAID
  10030346257
- Data Source
  KAKENHI-PROJECT-24770129
[Journal Article] Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation2012
- Author(s)
  Kanie T, et al
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 32 Issue: 3 Pages: 590-605
- DOI
  10.1128/mcb.06570-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J00843, KAKENHI-PROJECT-22710186, KAKENHI-PROJECT-24770129
[Journal Article] 次世代プロテオミクスが拓く生命科学研究の新地平 : ウエスタンブロッティングはもう要らない?!2012
- Author(s)
  中津海洋一、松本雅記、中山敬一
- Journal Title
  
  生化学
  
  Volume: 84 Pages: 53-57
- NAID
  10030346257
- Data Source
  KAKENHI-PROJECT-24770129
[Journal Article] mTORターゲットのリン酸化プロテオミクス2012
- Author(s)
  中津海洋一、松本雅記、中山敬一
- Journal Title
  
  細胞工学
  
  Volume: 31 Pages: 1360-1367
- Data Source
  KAKENHI-PROJECT-24770129
[Journal Article] mTORターゲットのリン酸化プロテオミクス2012
- Author(s)
  中津海洋一、松本雅記、中山敬一
- Journal Title
  
  細胞工学
  
  Volume: 31 Pages: 1360-1367
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] mTOR-dependent Regulation of Liquid-Liquid Phase Separation and Translation2023
- Author(s)
  Hirokazu Nakatsumi
- Organizer
  日本生物物理学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07155
[Presentation] mTORC1はP-bodyに局在するmRNAの翻訳を制御する2023
- Author(s)
  中津海洋一
- Organizer
  日本プロテオーム学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07155
[Presentation] mTOR-dependent Regulation of Liquid-Liquid Phase Separation and Translation2023
- Author(s)
  Hirokazu Nakatsumi
- Organizer
  日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07155
[Presentation] 定量的リン酸化プロテオミクスによるmTOR下流の大規模シグナル解析2020
- Author(s)
  中津海洋一
- Organizer
  第1回シロリムス新作用研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06962
[Presentation] PP2AB56 は核内転写因子FOXK1 のmTORC1 依存的脱リン酸化に寄与する2019
- Author(s)
  中津海洋一・白根道子・中山敬一
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-18K06962
[Presentation] 定量的大規模リン酸化プロテオミクスによるmTORC1下流のシグナル解析2019
- Author(s)
  中津海洋一
- Organizer
  基礎生物学研究所部門公開セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18K06962
[Presentation] 定量的リン酸化プロテオミクスによるmTORC1下流の新規がん促進シグナルの解析2019
- Author(s)
  中津海洋一・松本雅記・白根道子・中山敬一
- Organizer
  日本プロテオーム学会2019年大会
- Data Source
  KAKENHI-PROJECT-18K06962
[Presentation] mTORC1依存的な転写因子の脱リン酸化メカニズムとその生物学的意義2018
- Author(s)
  中津海　洋一
- Organizer
  第91回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06962
[Presentation] Noncanonical Pathway for Regulation of CCL2 Expression by an mTORC1-FOXK1 Axis Promotes Recruitment of Tumor-Associated Macrophages.2018
- Author(s)
  中津海　洋一
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06962
[Presentation] mTORC1の活性化はFOXK1経路を介して炎症を誘導する2016
- Author(s)
  中津海洋一
- Organizer
  「冬の若手ワークショップ2016」（転写研究会・転写サイクル・転写代謝システム共催）
- Place of Presentation
  山梨県南都留郡
- Year and Date
  2016-02-04
- Data Source
  KAKENHI-PROJECT-26830078
[Presentation] mTORC1の活性化はFOXK1経路を介して炎症を誘導する2015
- Author(s)
  中津海洋一, 松本雅記, 中山敬一
- Organizer
  BMB2015 第38回日本分子生物学会第88回日本生化学会合同大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26830078
[Presentation] mTORC1の活性化はFOXK1経路を介して炎症を誘導する2015
- Author(s)
  中津海洋一
- Organizer
  新学術領域「転写代謝システム」領域班会議
- Place of Presentation
  熊本県熊本市
- Year and Date
  2015-06-14
- Data Source
  KAKENHI-PROJECT-26830078
[Presentation] リン酸化プロテオミクス解析から明らかになったmTORC1による癌微小環境の制御2014
- Author(s)
  中津海洋一
- Organizer
  大阪大学蛋白研究所セミナーキナーゼ・シグナリング研究の進展
- Place of Presentation
  大阪大学
- Invited
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] mTORC1と炎症性ケモカインをつなぐ新規分子の発見とがん促進作用2013
- Author(s)
  中津海洋一、松本雅記、中山敬一
- Organizer
  第36回分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] 栄養シグナルと炎症の接点!? : mTORC1と炎症性ケモカインをつなぐ新規分子の発見とがん促進作用2013
- Author(s)
  中津海洋一、松本雅記、中山敬一
- Organizer
  第25回高遠・分子細胞生物学シンポジウム
- Place of Presentation
  (ポスター発表)
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] FOXK1 mediates mTORC1-dependent chemokine production and promotes cancer progression2013
- Author(s)
  Nakatsumi H., Matsumoto M., Nakayama K. I.
- Organizer
  The 23^<th> Hot Spring Harbor Symposium
- Place of Presentation
  Japan (Poster presentation)
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] mTORC1と炎症性ケモカインをつなぐ新規分子の発見とがん促進作用2013
- Author(s)
  中津海洋一、松本雅記、中山敬一
- Organizer
  第36回分子生物学会
- Place of Presentation
  (ポスター発表)
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] Identification of a novel mTOR target linking to transcriptional regulation and cancer progression.2013
- Author(s)
  Nakatsumi H., Matsumoto M., Nakayama K. I.
- Organizer
  The 8th International Symposium of the Institute Network
- Place of Presentation
  Japan
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] リン酸化プロテオミクス解析から明らかになったmTORC1による癌微小環境の制御2013
- Author(s)
  中津海洋一
- Organizer
  大阪大学蛋白研究所セミナーキナーゼ・シグナリング研究の進展
- Invited
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] Identification of a novel mTOR target linking to transcriptional regulation and cancer progression2013
- Author(s)
  Nakatsumi H., Matsumoto M., Nakayama K. I.
- Organizer
  The 8^<th> International Symposium of the Institute Network
- Place of Presentation
  Japan (Poster presentation)
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] 栄養シグナルと炎症の接点！？：mTORC1と炎症性ケモカインをつなぐ新規分子の発見とがん促進作用2013
- Author(s)
  中津海洋一、松本雅記、中山敬一
- Organizer
  第25回高遠・分子細胞生物学シンポジウム
- Place of Presentation
  滋賀県高野山
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] FOXK1 mediates mTORC1-dependent chemokine production and promotes cancer progression.2013
- Author(s)
  Nakatsumi H., Matsumoto M., Nakayama K. I.
- Organizer
  The 23th Hot Spring Harbor Symposium
- Place of Presentation
  Japan
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] mTORと転写をつなぐ新規分子FOXK1の発見と癌進展における促進作用2012
- Author(s)
  中津海洋一、松本雅記、中山敬一
- Organizer
  第35回分子生物学会
- Place of Presentation
  (ワークショップ)
- Invited
- Data Source
  KAKENHI-PROJECT-24770129
[Presentation] mTORと転写をつなぐ新規分子FOXK1の発見とがん進展における促進作用2012
- Author(s)
  中津海洋一, 松本雅記, 小山田浩二, 中山敬一
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-24770129

1. 西山正章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 松本雅記

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# of Collaborated Products: 1 results
3. 和泉自泰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 中山啓子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 中山敬一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakatsumi Hirokazu 中津海 洋一

NAKATSUMI Hirokazu 中津海 洋一

Research Projects

Research Products

Co-Researchers

Elucidation of Cancer-Promoting Mechanisms Through mTORC1-Dependent Regulation of Liquid-Liquid Phase SeparationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of mTORC1-FOXK1 axis in lifestyle-related diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanistic insights of tumor promotion via a novel mTOR signaling pwthwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and functional analysis of mTOR downstream molecules using phospho-proteomic technologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphorylation of PBX2, a novel downstream target of mTORC1, is determined by GSK3 and PP12022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Senescence Connects Autophagy Deficiency to Inflammation and Tumor Progression in the Liver2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nuclear-cytoplasmic shuttling protein PP2AB56 contributes to mTORC1-dependent dephosphorylation of FOXK12018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 次世代プロテオミクスが拓く生命科学研究 の新地平：ウエスタンブロッティングはもう要らない?!2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation2012

Nakatsumi Hirokazu 中津海洋一

NAKATSUMI Hirokazu 中津海洋一

[Journal Article] 次世代プロテオミクスが拓く生命科学研究の新地平：ウエスタンブロッティングはもう要らない?!2012

[Journal Article] mTORターゲットのリン酸化プロテオミクス2012