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Takahashi Hirokazu  高橋 宏和

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Hirokazu Takahashi  高橋 宏和

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Researcher Number 20607783
Other IDs
Affiliation (Current) 2025: 佐賀大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2024: 佐賀大学, 医学部附属病院, 特任教授
2020 – 2024: 佐賀大学, 医学部, 特任教授
2016 – 2019: 佐賀大学, 医学部, 講師
2017: 佐賀大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 53010:Gastroenterology-related / Gastroenterology
Except Principal Investigator
Basic Section 57030:Conservative dentistry-related / Basic Section 58060:Clinical nursing-related / Basic Section 59020:Sports sciences-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Basic Section 54030:Infectious disease medicine-related / Periodontology
Keywords
Principal Investigator
ヘパトカイン / 運動 / NASH / 運動療法 / 非アルコール性脂肪性肝疾患 / 脂肪肝 / サルコペニア / 網羅解析 / バイオマーカー / 肝線維化 … More / NAFLD / 肝臓病学 / 医学 / 非アルコール性脂肪肝炎 / トランスレーショナルリサーチ / 消化器病学 / アディポカイン / 糖尿病 / 肥満 … More
Except Principal Investigator
糖尿病 / 歯周病 / 運動 / 腸内細菌叢 / 妊娠 / 多職種協働 / 慢性疾患看護 / 重度肝硬変 / 多職種連携 / 肝硬変 / 海馬 / 臓器連関 / うつ・不安 / エピジェネティクス / 運動トレーニング / 口腔内細菌叢 / 脳 / 脂肪組織 / プラセントカイン / SOD3 / 母子間情報伝達 / エクサカイン / 肥満 / 胎盤 / 筋肉 / 代謝異常 / 糖代謝 / 骨格筋 / 発症制御機構 / チロシンキナーゼ / 遺伝子 / 感受性 / 2型糖尿病 / 1型糖尿病 / エンテロウイルス / コクサッキーBウイルス / エンテロウイルス受容体 / インターフェロン / Stat2 / チロシンキナーゼ2 / 膵島 / 脳心筋炎ウイルス / 膵島細胞 / stat / Tyrosine kinase 2 / インスリン / 膵島炎 / Stat / Tyrosine kinase 2 (Tyk2) / 感受性遺伝子 / ウイルス / 低体重児出産 Less
  • Research Projects

    (10 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (21 People)
  •  The effects of oral dysbiosis on brain -cross talk among organs-

    • Principal Investigator
      片桐 さやか
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57030:Conservative dentistry-related
    • Research Institution
      Tokyo Medical and Dental University
  •  Identification and functional analysis of exercise-induced hepatokine in NAFLDPrincipal Investigator

    • Principal Investigator
      高橋 宏和
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Saga University
  •  Mechanisms of long-term maintenance of brain function enhanced by exercise

    • Principal Investigator
      冨賀 裕貴
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59020:Sports sciences-related
    • Research Institution
      Fukuoka University
  •  多職種協働を促進する重度肝硬変患者に対する看護支援ガイドの開発

    • Principal Investigator
      川久保 愛
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 58060:Clinical nursing-related
    • Research Institution
      Saga University
  •  Monitoring regullation of maternal organ function involving the transmission of exersei effects on offspring

    • Principal Investigator
      楠山 譲二
    • Project Period (FY)
      2022 – 2026
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
    • Research Institution
      Tokyo Medical and Dental University
  •  The effect of periodontitis on metabolism in skeletal muscles

    • Principal Investigator
      Katagiri Sayaka
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57030:Conservative dentistry-related
    • Research Institution
      Tokyo Medical and Dental University
  •  The significance and the mechanisms of virus-induced diabetes susceptibility genes

    • Principal Investigator
      Nagafuchi Seiho
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54030:Infectious disease medicine-related
    • Research Institution
      Saga University
  •  Identification of exercise induced hepatokine for treatment of NAFLDPrincipal Investigator

    • Principal Investigator
      Takahashi Hirokauzu
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Saga University
  •  Maternal periodontal disease induce fetal failure and postnatal glucose intolerance

    • Principal Investigator
      Katagiri Sayaka
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Periodontology
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of therapeutic strategy with exercise-induced adipokine for nonalcoholic fatty liver diseasePrincipal Investigator

    • Principal Investigator
      Hirokazu Takahashi
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Gastroenterology
    • Research Institution
      Saga University

All 2024 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

  • [Journal Article] 過去の運動習慣が将来のうつ・不安を予防するメカニズムの解明2024

    • Author(s)
      冨賀裕貴、檜垣靖樹、高橋宏和
    • Journal Title

      デサントスポーツ科学

      Volume: 45 Pages: 134-141

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K27962
  • [Journal Article] Porphyromonas gingivalis Administration Induces Gestational Obesity, Alters Gene Expression in the Liver and Brown Adipose Tissue in Pregnant Mice, and Causes Underweight in Fetuses2022

    • Author(s)
      Yoshida S、Hatasa M、Ohsugi Y、Tsuchiya Y、Liu A、Niimi H、Morita K、Shimohira T、Sasaki N、Maekawa S、Shiba T、Hirota T、Okano T、Hirose A、Ibi R、Noritake K、Tomiga Y、Nitta H、Suzuki T、Takahashi H、Miyasaka N、Iwata T、Katagiri S
    • Journal Title

      Frontiers in Cellular and Infection Microbiology

      Volume: 11 Pages: 1-15

    • DOI

      10.3389/fcimb.2021.745117

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K18501, KAKENHI-PROJECT-20K23020, KAKENHI-PROJECT-19KK0217, KAKENHI-PROJECT-20H03863, KAKENHI-PROJECT-19H03467, KAKENHI-PROJECT-21J00572, KAKENHI-PROJECT-20K21670, KAKENHI-PROJECT-21K19590, KAKENHI-PROJECT-20K18527, KAKENHI-PROJECT-21K16984, KAKENHI-PROJECT-22KJ1198
  • [Journal Article] Relationship between NAFLD and Periodontal Disease from the View of Clinical and Basic Research, and Immunological Response2021

    • Author(s)
      Hatasa Masahiro、Yoshida Sumiko、Takahashi Hirokazu、Tanaka Kenichi、Kubotsu Yoshihito、Ohsugi Yujin、Katagiri Takaharu、Iwata Takanori、Katagiri Sayaka
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 7 Pages: 3728-3728

    • DOI

      10.3390/ijms22073728

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K18501, KAKENHI-PROJECT-20H03863, KAKENHI-PROJECT-21K19590
  • [Journal Article] TYK2 Promoter Variant Is Associated with Impaired Insulin Secretion and Lower Insulin Resistance in Japanese Type 2 Diabetes Patients.2021

    • Author(s)
      Mori H, Takahashi H, Mine K, Higashimoto K, Inoue K, Kojima M, Kuroki S, Eguchi T, Ono Y, Inuzuka S, Soejima H, Nagafuchi S, Anzai K.
    • Journal Title

      Genes (Basel).

      Volume: 12 Issue: 3 Pages: 400-400

    • DOI

      10.3390/genes12030400

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08183, KAKENHI-PROJECT-18H02853, KAKENHI-PROJECT-20H03643, KAKENHI-PROJECT-21K19451
  • [Journal Article] Genetic Susceptibility of the Host in Virus-Induced Diabetes.2020

    • Author(s)
      Mine K, Yoshikai Y, Takahashi H, Mori H, Anzai K, Nagafuchi S.
    • Journal Title

      Microorganisms

      Volume: 8 Issue: 8 Pages: 1133-1133

    • DOI

      10.3390/microorganisms8081133

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02853, KAKENHI-PLANNED-16H06496
  • [Journal Article] Impaired upregulation of Stat2 gene restrictive to pancreatic β-cells is responsible for virus-induced diabetes in DBA/2 mice.2020

    • Author(s)
      Mine, K.; Nagafuchi, S.; Hatano, S.; Tanaka, K.; Mori, H.; Takahashi, H.; Anzai, K.; Yoshikai, Y.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 521 Issue: 4 Pages: 853-860

    • DOI

      10.1016/j.bbrc.2019.10.193

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02853, KAKENHI-PROJECT-17J03060, KAKENHI-PLANNED-16H06496
  • [Journal Article] Therapeutic Approaches to Nonalcoholic Fatty Liver Disease: Exercise Intervention and Related Mechanisms.2019

    • Author(s)
      Takahashi H, Kotani K, Tanaka K, Egucih Y, Anzai K.
    • Journal Title

      Front Endocrinol

      Volume: 9 Pages: 588-588

    • DOI

      10.3389/fendo.2018.00588

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15754
  • [Journal Article] Viruses with masked pathogenicity and genetically susceptible hosts -How to discover potentially pathogenic viruses.2019

    • Author(s)
      Nagafuchi S, Mine K, Takahashi H, Anzai K, and Yoshikai Y.
    • Journal Title

      J Med Virol

      Volume: 印刷中 Issue: 8 Pages: 1365-1367

    • DOI

      10.1002/jmv.25472

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-16H06496, KAKENHI-PROJECT-17J03060, KAKENHI-PROJECT-18H02853
  • [Journal Article] Viruses with masked pathogenicity and genetically susceptible hosts―How to discover potentially pathogenic viruses.2019

    • Author(s)
      Nagafuchi, S.; Mine, K.; Takahashi, H.; Anzai, K.; Yoshikai, Y.
    • Journal Title

      J. Med. Virol.

      Volume: 91 Pages: 1365-1467

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18H02853
  • [Journal Article] Model Animal Mimicking Human Virus-induced Diabetes2018

    • Author(s)
      Mine Keiichiro、Takahashi Hirokazu、Nagafuchi Seiho
    • Journal Title

      EBioMedicine

      Volume: 32 Pages: 8-8

    • DOI

      10.1016/j.ebiom.2018.05.018

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17J03060, KAKENHI-PROJECT-18H02853
  • [Journal Article] Author Correction: Periodontal pathogenic bacteria, Aggregatibacter actinomycetemcomitans affect non-alcoholic fatty liver disease by altering gut microbiota and glucose metabolism.2018

    • Author(s)
      Komazaki R, Katagiri S, Takahashi H, Maekawa S, Shiba T, Takeuchi Y, Kitajima Y, Ohtsu A, Udagawa S, Sasaki N, Watanabe K, Sato N, Miyasaka N, Eguchi Y, Anzai K, Izumi Y.
    • Journal Title

      Sci Rep.

      Volume: 12;8(1) Issue: 1 Pages: 4620-4620

    • DOI

      10.1038/s41598-018-23000-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11982
  • [Presentation] NOD マウスにおけるTyk2 遺伝子の意義の解明2020

    • Author(s)
      三根敬一朗、吉開泰信、森仁恵、高橋宏和、安西慶三、永淵正法
    • Organizer
      第58回日本糖尿病学会九州地方会
    • Data Source
      KAKENHI-PROJECT-18H02853
  • [Presentation] EMC-Dウイルス誘発糖尿病におけるメスの感受性に関する検討2020

    • Author(s)
      三根敬一朗、森仁恵、高橋宏和、吉開泰信、安西慶三、永淵正法
    • Organizer
      第63回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-18H02853
  • [Presentation] Exercise induced hepatic HSC70 as a biomarker of exercise effect and its potential therapeutic effect on NAFLD2019

    • Author(s)
      Hirokazu Takahashi, Kenichi Tanaka, Yoichiro Kitajima, Keizo Anzai and Yuichiro Eguchi
    • Organizer
      AASLD Liver Meeting 2019 Parallel Session
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15754
  • [Presentation] A Promoter Variant of TYK2,a Putative Virus-Induced Susceptibility Gene,Is Associated with Impaired Insulin Secretion and Nonobese Type2 Diabetes.2019

    • Author(s)
      Mori H, Takahashi H, Mine M, Inoue K, Kojima M, Kuroki S, Ono Y, Inuzuka S, Nagafuchi S, Anzai K.
    • Organizer
      Food Security Heart & Diabetes
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02853
  • [Presentation] 新規ウイルス糖尿病感受性遺伝子の同定と発症メカニズムの解析2019

    • Author(s)
      三根敬一朗、森仁恵、高橋宏和、吉開泰信、安西慶三、永淵正法
    • Organizer
      第62回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-18H02853
  • [Presentation] Pancreatic beta cell specific reduced Stat2 gene expression isresponsible for serving susceptibility to virus-induced diabetes in DBA/2 mice2019

    • Author(s)
      Mine K, Nagafuchi S, Mori, H, Takahashi K, Yoshikai Y, Anzai K.
    • Organizer
      55th ANNUAL MEETING EASD
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02853
  • [Presentation] ヒトウイルス糖尿病感受性遺伝子多型 TYK2 promoter variant(TYK2PV)の同定とその意義2018

    • Author(s)
      永淵正法,小島夫美子,藤本秀士,栗崎宏憲,吉開泰信,安西慶三,三根敬一朗,高橋宏和
    • Organizer
      第92回日本感染症学会学術講演会
    • Data Source
      KAKENHI-PROJECT-18H02853
  • [Presentation] TYK2 遺伝子多型,IgE,抗GAD 抗体から考えられた日本人T1D 患者の特徴2018

    • Author(s)
      三根敬一朗,永淵正法,南昌江,岡田朗,近藤しおり,平川可南子,日比生由美,小島夫美子,栗崎宏憲,藤本秀士,筒信隆,横川泰,吉開泰信,森仁恵,松田やよい,高橋宏和,安西慶三
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-18H02853
  • [Presentation] EMC-D virus-induced diabetes in DBA/2 mice2018

    • Author(s)
      Keiichiro Mine, Seiho Nagafuchi, Hirokazu Takahashi, Yasunobu Yoshikai, Hitoe Mori, Yayoi Matsuda, Keizo Anzai
    • Organizer
      54th Annual Meeting of the European Association for the Study of Diabetes
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02853
  • [Presentation] ウイルス感染による糖尿病発症の遺伝的基盤2018

    • Author(s)
      永淵正法,小島夫美子,藤本秀士,栗崎宏憲,吉開泰信,安西慶三,三根敬一朗,高橋宏和
    • Organizer
      第56回糖尿病学会九州地方会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18H02853
  • [Presentation] 2 型糖尿病のインスリン分泌能にTKY2 遺伝子多型が与える影響2018

    • Author(s)
      森仁恵,高橋宏和,三根敬一朗,井上佳奈子,松田やよい,小野恭祐,永淵正法,安西慶三
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-18H02853
  • [Presentation] DBA/2 マウスにおけるウイルス性1 型糖尿病感受性遺伝子の探索2018

    • Author(s)
      三根敬一朗,森仁恵,田中賢一,畑野晋也,高橋宏和,吉開泰信,安西慶三,永淵正法
    • Organizer
      第56回糖尿病学会九州地方会
    • Data Source
      KAKENHI-PROJECT-18H02853
  • [Presentation] Aggregatibacter actinomycetemcomitans affect non-alcoholic fatty liver disease by altering gut microbiota and glucose metabolis.2017

    • Author(s)
      Katagiri S, Komazaki R, Takahashi H, Maekawa S, Shiba T, Takeuchi Y, Kitajima Y, Ohtsu A, Udagawa S, Sasaki N, Watanabe K, Sato N, Miyasaka N, Eguchi Y, Anzai K, Izumi Y.
    • Organizer
      The 103rd Annual Meeting of American Academy of Periodontology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11982
  • [Presentation] 運動惹起性アディポカインの探索2017

    • Author(s)
      高橋宏和,江口有一郎,Goodyear Laurie,安西慶三
    • Organizer
      第60回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-16H07070
  • [Presentation] 脂肪組織における運動効果と運動惹起性アディポカインの探索2017

    • Author(s)
      高橋宏和,江口有一郎,Goodyear Laurie,安西慶三
    • Organizer
      第37回 日本肥満学会
    • Data Source
      KAKENHI-PROJECT-16H07070
  • [Presentation] 運動惹起性アディポカインの探索2017

    • Author(s)
      高橋宏和
    • Organizer
      第9回分子骨格筋代謝研究会
    • Data Source
      KAKENHI-PROJECT-16H07070
  • [Presentation] 脂肪組織における運動効果と運動惹起性アディポカインの探索2016

    • Author(s)
      高橋宏和、江口有一郎、Laurie J Goodyear、 安西慶三
    • Organizer
      第37回 日本肥満学会
    • Place of Presentation
      東京ファッションタウン
    • Year and Date
      2016-10-07
    • Data Source
      KAKENHI-PROJECT-16H07070
  • 1.  Katagiri Sayaka (60510352)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 2.  廣田 朝光 (50435674)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  冨賀 裕貴 (50826394)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 4.  Nagafuchi Seiho (00150441)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 14 results
  • 5.  安西 慶三 (60258556)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 14 results
  • 6.  鈴木 敏彦 (10292848)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  服部 淳彦 (70183910)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  楠山 譲二 (70596105)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  杉原 玄一 (70402261)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  上阪 直史 (70597624)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  檜垣 靖樹 (10228702)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  川久保 愛 (90710252)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  清水 安子 (50252705)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  江口 有一郎 (80343341)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  TANAKA Kenichi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  Goodyear Laurie J
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 17.  Xue Ruidan
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  吉開 康信
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  大杉 勇人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 20.  東元 健
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  桧垣 靖樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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