NAGAI JUN 永井潤

Researcher Number	20608369
Affiliation (based on the past Project Information) *help	2014 – 2016: 長崎大学, 医歯薬学総合研究科(薬学系), 助教 2013: 長崎大学, 医歯(薬)学総合研究科, 助教 2012: 長崎大学, 医歯(薬)学総合研究科, 技術補佐員
Review Section/Research Field	Principal Investigator Pain science / General pharmacology Except Principal Investigator Anesthesiology
Keywords	Principal Investigator 神経障害性疼痛 / リゾホスファチジン酸 / LC-MS/MS / FAAH / MAGL / 相互作用 / CB受容体 / 2-AG / 炎症性疼痛 / カンナビノイド … More / エピジェネティクス / マイクログリア / 質量分析定量 / iPLA2 / cPLA2 / オピオイド受容体 / プレガバリン / 質量分析 / オピオイド / エピゲノム / 下降性抑制 / 慢性疼痛 / TOF-MS / リゾリン脂質 / 線維筋痛症 … More Except Principal Investigator 創薬スクリーニング / プライミング / iPS細胞 / リゾホスファチジン酸 / 慢性疼痛 / 断続的くり返し精神的ストレス / 脱髄 / NFκBアセチル化 / KCC2 / iPS / LPAプライミング / アストロサイト / ミクログリア / in vio再構成 / フィードフォワード機構 / 線維筋痛症 / 神経障害性疼痛 / LPA受容体 / 脂質メディエーター Less

アレルギー疾患における即時型から遅延型への移行過程の脂質制御機構解明と創薬Principal Investigator
- Principal Investigator
  
  永井潤
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Nagasaki University
Reproduction of chronic pain model through a reconstitution of neuronal circuit components including LPA priming and iPS cells, and its application for drug discovery
- Principal Investigator
  
  UEDA Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Anesthesiology
- Research Institution
  Nagasaki University
Differential regulation of lipid mediators in acute and chronic pain and drug discoveryPrincipal Investigator
- Principal Investigator
  
  NAGAI Jun
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pain science
- Research Institution
  Nagasaki University
Lipids and epigenetic silencing machinery in an experimental mouse modei of fibromyalgiaPrincipal Investigator
- Principal Investigator
  
  NAGAI JUN
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pain science
- Research Institution
  Nagasaki University

All 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Book

[Book] 痛み診療キーポイント2014
- Author(s)
  植田弘師, 永井潤
- Total Pages
  2
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-26860383
[Journal Article] Lys39-Lysophosphatidate Carbonyl Oxygen Interaction Locks LPA1 N-terminal Cap to the Orthosteric Site and partners Arg124 During Receptor Activation．2015
- Author(s)
  Omotuyi OI, Nagai J ,Ueda H
- Journal Title
  
  Scientific Reports
  
  Volume: 5(13343) Issue: 1 Pages: 13343-13343
- DOI
  10.1038/srep13343
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26253077, KAKENHI-PROJECT-26860383
[Journal Article] リゾホスファチジン酸2014
- Author(s)
  植田弘師、永井潤
- Journal Title
  
  痛み診療キーポイント
  
  Volume: 5 Pages: 36-37
- Data Source
  KAKENHI-PROJECT-26253077
[Journal Article] Lysophosphatidic acid and its receptors LPA1 and LPA3 mediate paclitaxel-induced neuropathic pain in mice.2014
- Author(s)
  Uchida H, Nagai J, Ueda H
- Journal Title
  
  Mol Pain
  
  Volume: 10:71 Pages: 1-7
- DOI
  10.1186/1744-8069-10-71
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26253077, KAKENHI-PROJECT-26830048, KAKENHI-PROJECT-26860383
[Journal Article] リゾホスファチジン酸2014
- Author(s)
  植田弘師,永井潤
- Journal Title
  
  痛みの診療シリーズ
  
  Pages: 36-37
- Data Source
  KAKENHI-PROJECT-24790576
[Journal Article] 慢性疼痛創薬標的としてのリゾホスファチジン酸、遺伝子2013
- Author(s)
  植田弘師,永井潤
- Journal Title
  
  医学MOOK 24(メディカルドゥ) ISSN
  
  Pages: 1349-2527
- Data Source
  KAKENHI-PROJECT-24790576
[Journal Article] Interleukin-1β Plays Key Roles in LPA-Induced Amplification of LPA Production in Neuropathic Pain Model2013
- Author(s)
  Yano R
- Journal Title
  
  Cell Mol Neurobiol
  
  Volume: 33 Issue: 8 Pages: 1033-1041
- DOI
  10.1007/s10571-013-9970-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790576
[Journal Article] An LPA species (18 : 1 LPA) plays key roles in the self-amplification of spinal LPA production in the peripheral neuropathic pain model2013
- Author(s)
  Ma L, Nagai J, Chun J,. Ueda H
- Journal Title
  
  Mol Pain
  
  Volume: 17(9) Pages: 1-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790576
[Journal Article] Necessity of Lysophosphatidic Acid Receptor 1 for Development of Arthritis2013
- Author(s)
  Miyabe Y, Miyabe C, Iwai Y, Takayasu A, Fukuda S, Yokoyama W, Nagai J, Jona M, Tokuhara Y, Ohkawa R, Albers HM, Ovaa H, Aoki J, Chun J, Yatomi Y, Ueda H, Miyasaka M, Miyasaka N, Nanki T
- Journal Title
  
  Arthritis Rheum
  
  Volume: 65 Issue: 8 Pages: 2037-2047
- DOI
  10.1002/art.37991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591435, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111005, KAKENHI-PROJECT-24790576
[Journal Article] Chemical signature of neuropathic pain2013
- Author(s)
  Ueda H, Matsunaga H, Olaposi OI, Nagai J
- Journal Title
  
  Biochimica et Biophysica Acta
  
  Volume: 1831(1) Issue: 1 Pages: 61-73
- DOI
  10.1016/j.bbalip.2012.08.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790576, KAKENHI-PUBLICLY-23116513
[Journal Article] 神経障害性疼痛における生理活性脂質LPAの生合成機構および病態機能2012
- Author(s)
  植田弘師、永井潤
- Journal Title
  
  ペインクリニック
  
  Volume: 33(11) Pages: 1575-1583
- Data Source
  KAKENHI-PROJECT-24790576
[Journal Article] Single Application of A2 NTX, a Botulinum Toxin A2 Subunit, Prevents Chronic Pain Over Long Periods in Both Diabetic and Spinal Cord Injury–Induced Neuropathic Pain Models2012
- Author(s)
  Ma, L., Nagai J, J., Sekino, Y., Goto, Y., Nakahira, L., Ueda, H.
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 119 Issue: 3 Pages: 282-286
- DOI
  10.1254/jphs.12080SC
- NAID
  10030987065
- ISSN
  1347-8613, 1347-8648
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790576, KAKENHI-PUBLICLY-23116513
[Presentation] 中枢性神経障害性疼痛時の脳におけるLPA産生2017
- Author(s)
  見山知穂、原大斗、塚原涼子、永井潤、ハルダーセボック、鑓水大介、佐々木恵太、植田弘師
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Data Source
  KAKENHI-PROJECT-26253077
[Presentation] 神経障害性疼痛の維持機構におけるLPA1受容体を介するアストロサイト活性化の役割2017
- Author(s)
  根山広行、永井潤、塚原完、塚原涼子、河本綜一郎、森下祐樹、植田弘師
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Data Source
  KAKENHI-PROJECT-26253077
[Presentation] LPA1 receptor signaling as a therapeutic　target for fibromyalgia in ICS model mice2016
- Author(s)
  Mukae　T,Nagai J, Ueda　H
- Organizer
  16th World Congress on Pain　（IASP)
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253077
[Presentation] 慢性疼痛維持期におけるリゾホスファチジン酸（LPA）産生におけるグリア細胞の役割2016
- Author(s)
  見山知穂、永井潤、迎武紘、居塚詔子、植田弘師
- Organizer
  第59回神経化学会大会
- Place of Presentation
  マリンメッセ（福岡国際会議場）(福岡県福岡市）
- Data Source
  KAKENHI-PROJECT-26253077
[Presentation] Interaction between lysophosphatidic acid and endocannabinoid system in inflammatory and neuropathic pain2015
- Author(s)
  永井潤、迎武紘、植田弘師
- Organizer
  FASEB　SCIENCE　RESEARCH　CONFERENCE
- Place of Presentation
  Banff,Canada
- Year and Date
  2015-08-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860383
[Presentation] Mutual inhibition between endogenous cannabinoids and LPA in inflammatory and neuropathic pain2015
- Author(s)
  Nagai J, Ueda H
- Organizer
  FASEB2015
- Place of Presentation
  Banff conference centre （カナダ、バンフ）
- Year and Date
  2015-08-26
- Data Source
  KAKENHI-PROJECT-26253077
[Presentation] 質量顕微鏡とLC-MS/MS解析による神経障害時の脊髄におけるリゾホスファチジン酸合成機構の解析2015
- Author(s)
  永井潤、植田弘師
- Organizer
  第36回　日本疼痛学会
- Place of Presentation
  熊本市民会館（熊本県熊本市）
- Year and Date
  2015-07-04
- Data Source
  KAKENHI-PROJECT-26253077
[Presentation] 質量顕微鏡とLC-MS/MS解析による神経障害時の脊髄におけるリゾホスファチジン酸合成機構の解析2015
- Author(s)
  永井潤、杉浦悠毅、植田弘師
- Organizer
  第37回日本疼痛学会
- Place of Presentation
  熊本、市民会館崇城大学ホール
- Year and Date
  2015-07-04
- Data Source
  KAKENHI-PROJECT-26860383
[Presentation] パクリタキセル誘発性神経障害性疼痛におけるLPA合成と脱髄機構2014
- Author(s)
  永井潤、植田弘師
- Organizer
  第36回日本疼痛学会
- Place of Presentation
  大阪
- Year and Date
  2014-06-20
- Data Source
  KAKENHI-PROJECT-24790576
[Presentation] パクリタキセル誘発性神経障害性疼痛における LPA合成と脱髄機構2014
- Author(s)
  永井潤、早田信正、河野浩之、迎武紘、植田弘師
- Organizer
  第36回日本疼痛学会
- Place of Presentation
  KKRホテル大阪（大阪府大阪市）
- Year and Date
  2014-06-20
- Data Source
  KAKENHI-PROJECT-26860383
[Presentation] 慢性疼痛病態時のリゾホスファチジン酸生合成のフィードフォワード合成機構2014
- Author(s)
  植田弘師, 永井潤
- Organizer
  第56回日本脂質生化学会
- Place of Presentation
  近畿大学東大阪キャンパス（大阪府東大阪市）
- Year and Date
  2014-06-07
- Invited
- Data Source
  KAKENHI-PROJECT-26860383
[Presentation] パクリタキセル誘発性神経障害性疼痛におけるLPA合成と脱髄機構2014
- Author(s)
  永井　潤
- Organizer
  日本疼痛学会
- Place of Presentation
  KKRホテル大阪（大阪府大阪市)
- Data Source
  KAKENHI-PROJECT-24790576
[Presentation] 慢性疼痛とリゾホスファチジン酸について2013
- Author(s)
  永井潤、植田弘師
- Organizer
  第4回長崎疼痛フォーラム
- Place of Presentation
  長崎
- Year and Date
  2013-02-14
- Data Source
  KAKENHI-PROJECT-24790576
[Presentation] 慢性疼痛とリゾホスファチジン酸について2013
- Author(s)
  永井潤
- Organizer
  第４回　長崎疼痛フォーラム
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-24790576
[Presentation] 質量分析計を用いた神経障害性疼痛におけるグリア介在性リゾホスファチジン酸合成の定量2013
- Author(s)
  永井潤、植田弘師
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Year and Date
  2013-03-22
- Data Source
  KAKENHI-PROJECT-24790576
[Presentation] 質量分析計を用いた神経障害性疼痛におけるグリア介在性リゾホスファチジン酸合成の定量2013
- Author(s)
  永井潤
- Organizer
  第86回　日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24790576
[Presentation] JNK/c-jun シグナル伝達を介するリゾホスファチジン酸誘発性脱髄機構2012
- Author(s)
  永井潤
- Organizer
  第５４回日本脂質生化学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24790576
[Presentation] JNK/c-junシグナル伝達を介するリゾホスファチジン酸誘発性脱髄機構2012
- Author(s)
  永井潤、植田弘師
- Organizer
  第54回日本脂質生化学会
- Place of Presentation
  福岡
- Year and Date
  2012-06-08
- Data Source
  KAKENHI-PROJECT-24790576
[Presentation] パクリタキセル誘発性神経障害性疼痛におけるLPA合成と脱髄機構慢性疼痛病
- Author(s)
  永井潤、迎武紘、河野浩之、早田信正、植田弘師
- Organizer
  第36回　日本疼痛学会
- Place of Presentation
  KKR大阪（大阪府大阪市）
- Year and Date
  2014-06-20 – 2014-06-21
- Data Source
  KAKENHI-PROJECT-26253077
[Presentation] LPAを介する神経障害性疼痛の分子基盤に基づいた薬理学的治療研究
- Author(s)
  迎　武紘、永井潤、植田弘師
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-26253077
[Presentation] Pharmacotherapeutic studies on molecular machineries determining the levels of LPA production in various neuropathic pain models.
- Author(s)
  Mukae T, Nagai J, Ueda H
- Organizer
  6th international conference on Phospholipase A2 and Lipid Mediators
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-02-10 – 2015-02-12
- Data Source
  KAKENHI-PROJECT-26253077
[Presentation] Interaction between lysophosphatidic acid and endocannabinoid system in inflammatory and neuropathic pain
- Author(s)
  永井潤, 迎武紘, 植田弘師
- Organizer
  第88回　日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-26860383
[Presentation] LC-MS/MS解析による神経障害性疼痛誘発因子リゾホスファチジン酸合成機構の解析
- Author(s)
  塚原完、永井潤、植田弘師
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-26253077
[Presentation] 慢性疼痛病態時のリゾホスフアチジン酸生合成のフィードフォワード制御
- Author(s)
  永井潤、松下洋輔、植田弘師
- Organizer
  第56回日本脂質生化学会大会
- Place of Presentation
  近畿大学（大阪府東大阪市）
- Year and Date
  2014-06-06 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-26253077
[Presentation] Molecular machineries determining the levels of LPA production in various neuropathic pain models - LC-MS/MS analysis.
- Author(s)
  Nagai J, Mukae T, Ueda H
- Organizer
  6th international conference on Phospholipase A2 and Lipid Mediators
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-02-10 – 2015-02-12
- Data Source
  KAKENHI-PROJECT-26253077
[Presentation] Molecular machineries determining the levels of LPA production in various neuropathic pain models - LC-MS/MS analysis
- Author(s)
  永井潤, 迎武紘, 植田弘師
- Organizer
  6th international conference on Phospholipase A2 and Lipid Mediators
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-02-10 – 2015-02-12
- Data Source
  KAKENHI-PROJECT-26860383
[Presentation] 神経障害性疼痛および炎症性疼痛を制御するリゾホスファチジン酸—カンナビノイド合成機構の相互作用解析
- Author(s)
  永井潤、迎　武紘、植田弘師
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-26253077
[Presentation] Differential regulation of endocannabinoids and LPA production in inflammatory and neuropathic pain.
- Author(s)
  Ueda H, Nagai J Mukae T
- Organizer
  6th international conference on Phospholipase A2 and Lipid Mediators
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-02-10 – 2015-02-12
- Invited
- Data Source
  KAKENHI-PROJECT-26253077

1. UEDA Hiroshi (00145674)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
2. 塚原涼子 (60724490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 松永隼人 (20437833)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 水田賢志 (50717618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 田中義正 (90280700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 水谷龍明 (50701843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 内田仁司 (30549621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 南木敏宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 宮坂信之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAGAI JUN 永井 潤

Research Projects

Research Products

Co-Researchers

アレルギー疾患における即時型から遅延型への移行過程の脂質制御機構解明と創薬Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Reproduction of chronic pain model through a reconstitution of neuronal circuit components including LPA priming and iPS cells, and its application for drug discovery

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Differential regulation of lipid mediators in acute and chronic pain and drug discoveryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Lipids and epigenetic silencing machinery in an experimental mouse modei of fibromyalgiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 痛み診療キーポイント2014

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Lys39-Lysophosphatidate Carbonyl Oxygen Interaction Locks LPA1 N-terminal Cap to the Orthosteric Site and partners Arg124 During Receptor Activation．2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] リゾホスファチジン酸2014

Author(s)

Journal Title

Data Source

[Journal Article] Lysophosphatidic acid and its receptors LPA1 and LPA3 mediate paclitaxel-induced neuropathic pain in mice.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] リゾホスファチジン酸2014

Author(s)

Journal Title

Data Source

[Journal Article] 慢性疼痛創薬標的としてのリゾホスファチジン酸、遺伝子2013

Author(s)

Journal Title

Data Source

[Journal Article] Interleukin-1β Plays Key Roles in LPA-Induced Amplification of LPA Production in Neuropathic Pain Model2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An LPA species (18 : 1 LPA) plays key roles in the self-amplification of spinal LPA production in the peripheral neuropathic pain model2013

Author(s)

Journal Title

Data Source

[Journal Article] Necessity of Lysophosphatidic Acid Receptor 1 for Development of Arthritis2013

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[Journal Article] Chemical signature of neuropathic pain2013

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[Journal Article] 神経障害性疼痛における生理活性脂質LPAの生合成機構および病態機能2012

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[Journal Article] Single Application of A2 NTX, a Botulinum Toxin A2 Subunit, Prevents Chronic Pain Over Long Periods in Both Diabetic and Spinal Cord Injury&ndash;Induced Neuropathic Pain Models2012

Author(s)

NAGAI JUN 永井潤

[Journal Article] Single Application of A2 NTX, a Botulinum Toxin A2 Subunit, Prevents Chronic Pain Over Long Periods in Both Diabetic and Spinal Cord Injury–Induced Neuropathic Pain Models2012

[Presentation] LPA1 receptor signaling as a therapeutic　target for fibromyalgia in ICS model mice2016

[Presentation] 質量顕微鏡とLC-MS/MS解析による神経障害時の脊髄におけるリゾホスファチジン酸合成機構の解析2015