Kasai Shuya 葛西秋宅

… Alternative Names

KASAI Shuya 葛西秋宅

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Researcher Number	20609664
Other IDs
Affiliation (Current)	2025: 弘前大学, 医学研究科, 助教
Affiliation (based on the past Project Information) *help	2018 – 2025: 弘前大学, 医学研究科, 助教 2014 – 2015: 東北大学, 生命科学研究科, 助教 2013: 岩手医科大学, 医学部, 研究員 2012: 岩手医科大学, 医学部, ポストドクター
Review Section/Research Field	Principal Investigator Basic Section 48040:Medical biochemistry-related / Human pathology / Experimental pathology Except Principal Investigator Basic Section 38030:Applied biochemistry-related / Human pathology
Keywords	Principal Investigator Gcn2 / Gcn1 / Parkinson's disease / dopaminergic neuron / disome / GCN1 / 翻訳 / パーキンソン病 / Disome / 翻訳停滞 … More / ATF4 / eIF2α / GCN2 / ミトコンドリアストレス / GCN1L1 / Amino acid starvation / Body weight loss / Cre/loxP / Tamoxifen / 体重減少 / タモキシフェン / 統合的ストレス応答 / アミノ酸飢餓応答 / Melanoma / Proliferation / IDP / NQO1 / 17-AAG / KEAP1 / NRF2 / メラノーマ / 腫瘍悪性化 / 腫瘍増殖 / 乳癌 / NACC1 … More Except Principal Investigator タンパク合成 / 翻訳 / YaeJ / リボソーム / 転移 / 大腸癌 / RhoGDI2 / 大腸癌の進展 Less

神経細胞における翻訳停滞センサーGcn1を介した翻訳ストレス応答機構の解明Principal Investigator
- Principal Investigator
  
  葛西秋宅
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Hirosaki University
Functional role of the translational regulator Gcn1 in a dopaminergic neuronPrincipal Investigator
- Principal Investigator
  
  葛西秋宅
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Hirosaki University
翻訳停滞解消因子YaeJの生理的役割と反応機構の解明
- Principal Investigator
  
  栗田大輔
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Hirosaki University
Functional analysis of GCN1L1 in mitochondrial stress responsePrincipal Investigator
- Principal Investigator
  
  Kasai Shuya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Hirosaki University
Melanoma chemotherapy targeting KEAP1-NRF2 pathwayPrincipal Investigator
- Principal Investigator
  
  Kasai Shuya
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  Tohoku University
Effect of RhoGDI2 expression on progression of colon cancer
- Principal Investigator
  
  Oikawa Hiroki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Iwate Medical University
Regulatory mechanism of tumor cell proliferation by pluripotency-associated transcriptional repressor NACC1Principal Investigator
- Principal Investigator
  
  KASAI Shuya
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Iwate Medical University

All 2024 2021 2020 2019 2018 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Emerging Role of GCN1 in Disease and Homeostasis2024
- Author(s)
  Yota Tatara, Shuya Kasai, Daichi Kokubu, Tadayuki Tsujita, Junsei Mimura, and Ken Itoh
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 5 Pages: 2998-2998
- DOI
  10.3390/ijms25052998
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06891, KAKENHI-PROJECT-23K24772
[Journal Article] Nrf2とATF4の相互作用を基盤にした未病気における疾患予防法の開発2021
- Author(s)
  葛西秋宅、多田羅洋太、三村純正、伊東健
- Journal Title
  
  BIO Clinica
  
  Volume: 36 Pages: 80-84
- Data Source
  KAKENHI-PROJECT-18K06910
[Journal Article] Ribosome binding protein GNC1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice2020
- Author(s)
  Yamazaki H,Kasai S,Mimura J,Ye P,Inose-Maruyama A,Tanji K,Wakabayashi K,Mizuno S,Sugiyama F,Takahashi S,Sato T,Ozaki T,Cavener DR,Yamamoto M,Itoh K
- Journal Title
  
  PloS Genet.
  
  Volume: 16 Issue: 4 Pages: e1008693-e1008693
- DOI
  10.1371/journal.pgen.1008693
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06910, KAKENHI-PROJECT-17K08616, KAKENHI-PROJECT-18H02533
[Journal Article] ストレス応答性転写因子Nrf2とATF4の相互作用を基盤にした疾患予防・アンチエイジング法の開発2020
- Author(s)
  葛西秋宅、清水直、多田羅洋太、三村純正、伊東健
- Journal Title
  
  BIO Clinica
  
  Volume: 35 Pages: 60-64
- Data Source
  KAKENHI-PROJECT-18K06910
[Journal Article] NAD(P)H:Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG.2016
- Author(s)
  Kasai S, Arakawa N, Okubo A, Shigeeda W, Yasuhira S, Masuda T, Akasaka T, Shibazaki M, Maesawa C.
- Journal Title
  
  PLoS One.
  
  Volume: 11 Issue: 4 Pages: e0153181-e0153181
- DOI
  10.1371/journal.pone.0153181
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08353, KAKENHI-PROJECT-25460421, KAKENHI-PROJECT-25460462, KAKENHI-PROJECT-26860243
[Journal Article] Tatemichi Y, Shibazaki M, Yasuhira S, Kasai S, Tada H, Oikawa H, Suzuki Y, Takikawa Y, Masuda T, Maesawa C.2015
- Author(s)
  Nucleus accumbens associated 1 is recruited within the promyelocytic leukemia nuclear body through SUMO modification.
- Journal Title
  
  Cancer Sci.
  
  Volume: 106 Issue: 7 Pages: 848-56
- DOI
  10.1111/cas.12680
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08353, KAKENHI-PROJECT-25460421, KAKENHI-PROJECT-25460462
[Journal Article] Immunohistochemistry for histone h3 lysine 9 methyltransferase and demethylase proteins in human melanomas.2014
- Author(s)
  Miura S, Maesawa C, Shibazaki M, Yasuhira S, Kasai S, Tsunoda K, Maeda F, Takahashi K, Akasaka T, Masuda T. Immunohistochemistry for histone h3 lysine 9 methyltransferase and demethylase proteins in human melanomas.
- Journal Title
  
  Am J Dermatopathol
  
  Volume: 36(3) Issue: 3 Pages: 211-216
- DOI
  10.1097/dad.0b013e3182964e02
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590431, KAKENHI-PROJECT-24590489, KAKENHI-PROJECT-24659283, KAKENHI-PROJECT-24791171, KAKENHI-PROJECT-25460421, KAKENHI-PROJECT-25460462, KAKENHI-PROJECT-25860964, KAKENHI-PROJECT-26860891
[Journal Article] beta-catenin signaling induces CYP1A1 expression by disrupting adherens junctions in Caco-2 human colon carcinoma cells.2013
- Author(s)
  Shuya Kasaia, Takanori Ishigaki, Ryo Takumi, Tohoru Kamimura, Hideaki Kikuchi,
- Journal Title
  
  Biochim. Biophys. Acta,
  
  Volume: 1830 Issue: 3 Pages: 2509-2516
- DOI
  10.1016/j.bbagen.2012.11.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510081, KAKENHI-PROJECT-24790391
[Journal Article] Transcriptional and post-transcriptional regulation of βIII-tubulin protein expression in relation with cell cycle-dependent regulation of tumor cells2012
- Author(s)
  Shibazaki M, Maesawa C, Akasaka K, Kasai S, Yasuhira S, Kanno K, Nakayama I, Sugiyama T, Wakabayasi G, Masuda T, Mori N
- Journal Title
  
  Int.J.Oncol.
  
  Volume: 40(3) Pages: 695-702
- DOI
  10.3892/ijo.2011.1291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300121, KAKENHI-PROJECT-22390071, KAKENHI-PROJECT-24590489, KAKENHI-PROJECT-24790391, KAKENHI-PROJECT-24791171
[Presentation] Ribosome binding protein Gcn1 knockout mice exhibit embryonic lethality with growth retardation2020
- Author(s)
  葛西秋宅、劉君、山嵜博未、三村純正、伊東健
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K06910
[Presentation] Ribosome binding protein GCN1L1 knockout mice exhibit embryonic lethality with growth retardation and reduced cell proliferation2019
- Author(s)
  Shuya Kasai, Hiromi Yamazaki, Junsei Mimura, Peng Ye, Atsushi Inose-Maruyama, Ken Itoh
- Organizer
  9th Biennial Meeting for the Society for Free Radical Research Asia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06910
[Presentation] Body weight loss in postnatal GCN1L1 knockout mice2019
- Author(s)
  Jun Liu, Shuya Kasai, Hiromi Yamazaki, Junsei Mimura, Ken Itoh
- Organizer
  第1回弘前メディカルサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-18K06910
[Presentation] Involvement of GCN1L1-GCN2 in mitochondrial dysfunction-induced ATF4 activation2019
- Author(s)
  Shuya Kasai, Ken Itoh
- Organizer
  Keystone symposia, Mitochondrial Biology in Heart and Skeletal Muscle
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06910
[Presentation] ATF4を介したミトコンドリアストレス応答経路におけるGCN1L1-GCN2経路の関与2018
- Author(s)
  葛西秋宅、山嵜博未、三村純正、伊東健
- Organizer
  第71回日本酸化ストレス学会、第18回日本NO学会合同学術集会
- Data Source
  KAKENHI-PROJECT-18K06910
[Presentation] ミトコンドリアストレスによるATF4活性化とGCN1L1-GCN2経路の関与2018
- Author(s)
  葛西秋宅、山嵜博未、三村純正、伊東健
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K06910
[Presentation] 悪性黒色腫細胞株の網羅的エクソーム解析による新規関連遺伝子の検索2012
- Author(s)
  柴崎晶彦,三浦慎平,安平進士,葛西秋宅,赤坂俊英,増田友之,前沢千早
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24790391
[Presentation] 多能性維持関連因子NACC1(nucleus accumbens-associated protein 1)の細胞周期特異的リン酸化の制御2012
- Author(s)
  葛西秋宅、加茂政晴、柴崎晶彦、安平進士、前沢千早
- Organizer
  代35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24790391
[Presentation] 多能性維持関連因子NACC1(nucleus accumbens-associated protein 1)の細胞周期特異的リン酸化の制御2012
- Author(s)
  葛西秋宅,加茂政晴,柴崎晶彦,安平進士,前沢千早
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24790391
[Presentation] 肝細胞癌培養細胞株におけるHGF/METシグナルに与える細胞質内ヒストン脱アセチル化酸素　HDAC6発現の影響2012
- Author(s)
  菅野公徳,前沢千早,柴崎晶彦,安平進士,葛西秋宅,石川雄一,及川浩樹,増田友之
- Organizer
  第101回日本病理学会
- Place of Presentation
  東京都新宿区
- Data Source
  KAKENHI-PROJECT-24790391
[Presentation] 悪性黒色腫における抗チューブリン剤耐性はBCL2とBCL-XLによって規定される2012
- Author(s)
  渡辺彩乃,安平進士,葛西秋宅,柴崎晶彦,赤坂俊英,増田友之,前沢千早
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24790391
[Presentation] 悪性黒色腫におけるNRF2/NQO1高発現とHSP90阻害剤17-AAG感受性
- Author(s)
  葛西秋宅、柴崎晶彦、三浦慎平、安平進士、前沢千早
- Organizer
  第３７回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26860243

1. Oikawa Hiroki (50285582)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. Masuda Tomoyuki (10199698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. Maesawa Chihaya (10326647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. Shibazaki Akihiko (20445109)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. Otsuka Koki (50316387)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Yasuhira Shinji (90311729)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 二階堂義和 (50613478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 岩崎信太郎 (80611441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 栗田大輔 (60552651)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 行木信一 (80302959)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 森望

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 菊池英明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kasai Shuya 葛西 秋宅

KASAI Shuya 葛西 秋宅

Research Projects

Research Products

Co-Researchers

神経細胞における翻訳停滞センサーGcn1を介した翻訳ストレス応答機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional role of the translational regulator Gcn1 in a dopaminergic neuronPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

翻訳停滞解消因子YaeJの生理的役割と反応機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of GCN1L1 in mitochondrial stress responsePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Melanoma chemotherapy targeting KEAP1-NRF2 pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of RhoGDI2 expression on progression of colon cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulatory mechanism of tumor cell proliferation by pluripotency-associated transcriptional repressor NACC1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Emerging Role of GCN1 in Disease and Homeostasis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nrf2とATF4の相互作用を基盤にした未病気における疾患予防法の開発2021

Author(s)

Journal Title

Data Source

[Journal Article] Ribosome binding protein GNC1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ストレス応答性転写因子Nrf2とATF4の相互作用を基盤にした疾患予防・アンチエイジング法の開発2020

Author(s)

Journal Title

Data Source

[Journal Article] NAD(P)H:Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tatemichi Y, Shibazaki M, Yasuhira S, Kasai S, Tada H, Oikawa H, Suzuki Y, Takikawa Y, Masuda T, Maesawa C.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunohistochemistry for histone h3 lysine 9 methyltransferase and demethylase proteins in human melanomas.2014

Author(s)

Journal Title

DOI

Data Source

Kasai Shuya 葛西秋宅

KASAI Shuya 葛西秋宅

[Presentation] 肝細胞癌培養細胞株におけるHGF/METシグナルに与える細胞質内ヒストン脱アセチル化酸素　HDAC6発現の影響2012