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Kasai Shuya  葛西 秋宅

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KASAI Shuya  葛西 秋宅

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Researcher Number 20609664
Other IDs
Affiliation (Current) 2025: 弘前大学, 医学研究科, 助教
Affiliation (based on the past Project Information) *help 2018 – 2025: 弘前大学, 医学研究科, 助教
2014 – 2015: 東北大学, 生命科学研究科, 助教
2013: 岩手医科大学, 医学部, 研究員
2012: 岩手医科大学, 医学部, ポストドクター
Review Section/Research Field
Principal Investigator
Basic Section 48040:Medical biochemistry-related / Human pathology / Experimental pathology
Except Principal Investigator
Basic Section 38030:Applied biochemistry-related / Human pathology
Keywords
Principal Investigator
Gcn2 / Gcn1 / Parkinson's disease / dopaminergic neuron / disome / GCN1 / 翻訳 / パーキンソン病 / Disome / 翻訳停滞 … More / ATF4 / eIF2α / GCN2 / ミトコンドリアストレス / GCN1L1 / Amino acid starvation / Body weight loss / Cre/loxP / Tamoxifen / 体重減少 / タモキシフェン / 統合的ストレス応答 / アミノ酸飢餓応答 / Melanoma / Proliferation / IDP / NQO1 / 17-AAG / KEAP1 / NRF2 / メラノーマ / 腫瘍悪性化 / 腫瘍増殖 / 乳癌 / NACC1 … More
Except Principal Investigator
タンパク合成 / 翻訳 / YaeJ / リボソーム / 転移 / 大腸癌 / RhoGDI2 / 大腸癌の進展 Less
  • Research Projects

    (7 results)
  • Research Products

    (21 results)
  • Co-Researchers

    (12 People)
  •  神経細胞における翻訳停滞センサーGcn1を介した翻訳ストレス応答機構の解明Principal Investigator

    • Principal Investigator
      葛西 秋宅
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      Hirosaki University
  •  Functional role of the translational regulator Gcn1 in a dopaminergic neuronPrincipal Investigator

    • Principal Investigator
      葛西 秋宅
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      Hirosaki University
  •  翻訳停滞解消因子YaeJの生理的役割と反応機構の解明

    • Principal Investigator
      栗田 大輔
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 38030:Applied biochemistry-related
    • Research Institution
      Hirosaki University
  •  Functional analysis of GCN1L1 in mitochondrial stress responsePrincipal Investigator

    • Principal Investigator
      Kasai Shuya
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      Hirosaki University
  •  Melanoma chemotherapy targeting KEAP1-NRF2 pathwayPrincipal Investigator

    • Principal Investigator
      Kasai Shuya
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Human pathology
    • Research Institution
      Tohoku University
  •  Effect of RhoGDI2 expression on progression of colon cancer

    • Principal Investigator
      Oikawa Hiroki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Iwate Medical University
  •  Regulatory mechanism of tumor cell proliferation by pluripotency-associated transcriptional repressor NACC1Principal Investigator

    • Principal Investigator
      KASAI Shuya
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Iwate Medical University

All 2024 2021 2020 2019 2018 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

  • [Journal Article] Emerging Role of GCN1 in Disease and Homeostasis2024

    • Author(s)
      Yota Tatara, Shuya Kasai, Daichi Kokubu, Tadayuki Tsujita, Junsei Mimura, and Ken Itoh
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 25 Issue: 5 Pages: 2998-2998

    • DOI

      10.3390/ijms25052998

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06891, KAKENHI-PROJECT-23K24772
  • [Journal Article] Nrf2とATF4の相互作用を基盤にした未病気における疾患予防法の開発2021

    • Author(s)
      葛西秋宅、多田羅洋太、三村純正、伊東健
    • Journal Title

      BIO Clinica

      Volume: 36 Pages: 80-84

    • Data Source
      KAKENHI-PROJECT-18K06910
  • [Journal Article] Ribosome binding protein GNC1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice2020

    • Author(s)
      Yamazaki H,Kasai S,Mimura J,Ye P,Inose-Maruyama A,Tanji K,Wakabayashi K,Mizuno S,Sugiyama F,Takahashi S,Sato T,Ozaki T,Cavener DR,Yamamoto M,Itoh K
    • Journal Title

      PloS Genet.

      Volume: 16 Issue: 4 Pages: e1008693-e1008693

    • DOI

      10.1371/journal.pgen.1008693

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06910, KAKENHI-PROJECT-17K08616, KAKENHI-PROJECT-18H02533
  • [Journal Article] ストレス応答性転写因子Nrf2とATF4の相互作用を基盤にした疾患予防・アンチエイジング法の開発2020

    • Author(s)
      葛西秋宅、清水直、多田羅洋太、三村純正、伊東健
    • Journal Title

      BIO Clinica

      Volume: 35 Pages: 60-64

    • Data Source
      KAKENHI-PROJECT-18K06910
  • [Journal Article] NAD(P)H:Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG.2016

    • Author(s)
      Kasai S, Arakawa N, Okubo A, Shigeeda W, Yasuhira S, Masuda T, Akasaka T, Shibazaki M, Maesawa C.
    • Journal Title

      PLoS One.

      Volume: 11 Issue: 4 Pages: e0153181-e0153181

    • DOI

      10.1371/journal.pone.0153181

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08353, KAKENHI-PROJECT-25460421, KAKENHI-PROJECT-25460462, KAKENHI-PROJECT-26860243
  • [Journal Article] Tatemichi Y, Shibazaki M, Yasuhira S, Kasai S, Tada H, Oikawa H, Suzuki Y, Takikawa Y, Masuda T, Maesawa C.2015

    • Author(s)
      Nucleus accumbens associated 1 is recruited within the promyelocytic leukemia nuclear body through SUMO modification.
    • Journal Title

      Cancer Sci.

      Volume: 106 Issue: 7 Pages: 848-56

    • DOI

      10.1111/cas.12680

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08353, KAKENHI-PROJECT-25460421, KAKENHI-PROJECT-25460462
  • [Journal Article] Immunohistochemistry for histone h3 lysine 9 methyltransferase and demethylase proteins in human melanomas.2014

    • Author(s)
      Miura S, Maesawa C, Shibazaki M, Yasuhira S, Kasai S, Tsunoda K, Maeda F, Takahashi K, Akasaka T, Masuda T. Immunohistochemistry for histone h3 lysine 9 methyltransferase and demethylase proteins in human melanomas.
    • Journal Title

      Am J Dermatopathol

      Volume: 36(3) Issue: 3 Pages: 211-216

    • DOI

      10.1097/dad.0b013e3182964e02

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23590431, KAKENHI-PROJECT-24590489, KAKENHI-PROJECT-24659283, KAKENHI-PROJECT-24791171, KAKENHI-PROJECT-25460421, KAKENHI-PROJECT-25460462, KAKENHI-PROJECT-25860964, KAKENHI-PROJECT-26860891
  • [Journal Article] beta-catenin signaling induces CYP1A1 expression by disrupting adherens junctions in Caco-2 human colon carcinoma cells.2013

    • Author(s)
      Shuya Kasaia, Takanori Ishigaki, Ryo Takumi, Tohoru Kamimura, Hideaki Kikuchi,
    • Journal Title

      Biochim. Biophys. Acta,

      Volume: 1830 Issue: 3 Pages: 2509-2516

    • DOI

      10.1016/j.bbagen.2012.11.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24510081, KAKENHI-PROJECT-24790391
  • [Journal Article] Transcriptional and post-transcriptional regulation of βIII-tubulin protein expression in relation with cell cycle-dependent regulation of tumor cells2012

    • Author(s)
      Shibazaki M, Maesawa C, Akasaka K, Kasai S, Yasuhira S, Kanno K, Nakayama I, Sugiyama T, Wakabayasi G, Masuda T, Mori N
    • Journal Title

      Int.J.Oncol.

      Volume: 40(3) Pages: 695-702

    • DOI

      10.3892/ijo.2011.1291

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22300121, KAKENHI-PROJECT-22390071, KAKENHI-PROJECT-24590489, KAKENHI-PROJECT-24790391, KAKENHI-PROJECT-24791171
  • [Presentation] Ribosome binding protein Gcn1 knockout mice exhibit embryonic lethality with growth retardation2020

    • Author(s)
      葛西 秋宅、劉 君、山嵜 博未、三村 純正、伊東 健
    • Organizer
      第93回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-18K06910
  • [Presentation] Ribosome binding protein GCN1L1 knockout mice exhibit embryonic lethality with growth retardation and reduced cell proliferation2019

    • Author(s)
      Shuya Kasai, Hiromi Yamazaki, Junsei Mimura, Peng Ye, Atsushi Inose-Maruyama, Ken Itoh
    • Organizer
      9th Biennial Meeting for the Society for Free Radical Research Asia
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06910
  • [Presentation] Body weight loss in postnatal GCN1L1 knockout mice2019

    • Author(s)
      Jun Liu, Shuya Kasai, Hiromi Yamazaki, Junsei Mimura, Ken Itoh
    • Organizer
      第1回弘前メディカルサイエンスフォーラム
    • Data Source
      KAKENHI-PROJECT-18K06910
  • [Presentation] Involvement of GCN1L1-GCN2 in mitochondrial dysfunction-induced ATF4 activation2019

    • Author(s)
      Shuya Kasai, Ken Itoh
    • Organizer
      Keystone symposia, Mitochondrial Biology in Heart and Skeletal Muscle
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06910
  • [Presentation] ATF4を介したミトコンドリアストレス応答経路におけるGCN1L1-GCN2経路の関与2018

    • Author(s)
      葛西秋宅、山嵜博未、三村純正、伊東健
    • Organizer
      第71回日本酸化ストレス学会、第18回日本NO学会 合同学術集会
    • Data Source
      KAKENHI-PROJECT-18K06910
  • [Presentation] ミトコンドリアストレスによるATF4活性化とGCN1L1-GCN2経路の関与2018

    • Author(s)
      葛西秋宅、山嵜博未、三村純正、伊東健
    • Organizer
      第92回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-18K06910
  • [Presentation] 悪性黒色腫細胞株の網羅的エクソーム解析による新規関連遺伝子の検索2012

    • Author(s)
      柴崎晶彦,三浦慎平,安平進士,葛西秋宅,赤坂俊英,増田友之,前沢千早
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24790391
  • [Presentation] 多能性維持関連因子NACC1(nucleus accumbens-associated protein 1)の細胞周期特異的リン酸化の制御2012

    • Author(s)
      葛西秋宅、加茂政晴、柴崎晶彦、安平進士、前沢千早
    • Organizer
      代35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24790391
  • [Presentation] 多能性維持関連因子NACC1(nucleus accumbens-associated protein 1)の細胞周期特異的リン酸化の制御2012

    • Author(s)
      葛西秋宅,加茂政晴,柴崎晶彦,安平進士,前沢千早
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24790391
  • [Presentation] 肝細胞癌培養細胞株におけるHGF/METシグナルに与える細胞質内ヒストン脱アセチル化酸素 HDAC6発現の影響2012

    • Author(s)
      菅野公徳,前沢千早,柴崎晶彦,安平進士,葛西秋宅,石川雄一,及川浩樹,増田友之
    • Organizer
      第101回日本病理学会
    • Place of Presentation
      東京都新宿区
    • Data Source
      KAKENHI-PROJECT-24790391
  • [Presentation] 悪性黒色腫における抗チューブリン剤耐性はBCL2とBCL-XLによって規定される2012

    • Author(s)
      渡辺彩乃,安平進士,葛西秋宅,柴崎晶彦,赤坂俊英,増田友之,前沢千早
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24790391
  • [Presentation] 悪性黒色腫におけるNRF2/NQO1高発現とHSP90阻害剤17-AAG感受性

    • Author(s)
      葛西秋宅、柴崎晶彦、三浦慎平、安平進士、前沢千早
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-26860243
  • 1.  Oikawa Hiroki (50285582)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  Masuda Tomoyuki (10199698)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  Maesawa Chihaya (10326647)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 4.  Shibazaki Akihiko (20445109)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 5.  Otsuka Koki (50316387)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  Yasuhira Shinji (90311729)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  二階堂 義和 (50613478)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  岩崎 信太郎 (80611441)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  栗田 大輔 (60552651)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  行木 信一 (80302959)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  森 望
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  菊池 英明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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