Hashita Tadahiro 坡下真大

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HASHITA Tadahiro 坡下真大

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Researcher Number	20613384
Other IDs
Affiliation (Current)	2025: 名古屋市立大学, 医薬学総合研究院(薬学), 准教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 名古屋市立大学, 医薬学総合研究院(薬学), 講師 2016 – 2018: 名古屋市立大学, 大学院薬学研究科, 講師 2015: 名古屋市立大学, 薬学研究科(研究院), 講師 2014: 群馬大学, 大学院医学系研究科, 助教 2013 – 2014: 群馬大学, 医学(系)研究科(研究院), 助教 2012: 群馬大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Medical pharmacy / Basic Section 09070:Educational technology-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Natural medicines
Keywords	Principal Investigator 血液脳関門 / iPS細胞 / iPS / タイトジャンクション / 脳毛細血管内皮細胞 / iPS細胞由来血管内皮前駆細胞 / トランスポーターの局在 / 薬物透過性試験 / iPS細胞由来ミクログリア / 筋萎縮性側索硬化症（ALS） … More / ALS患者iPS細胞由来ミクログリア / iPS細胞由来BBB構成細胞 / リアルタイム培養細胞解析装置 / 巨核球 / 分子標的治療薬 / 血小板減少 … More Except Principal Investigator 多職種連携 / プロフェッショナリズム / 薬学教育 / 看護教育 / 医学教育 / iPSC / 病態モデル / 新興感染症 / 炎症 / ヒトiPS細胞 / long COVID-19 / 新型コロナウイルス / バリアー機能 / 後遺症 / Wnt / 血液脳関門 / 脳毛細血管内皮細胞 / SARS-CoV-2 / COVID-19 / iPS細胞 / ＰＫ－ＰＤ解析 / 薬物輸送担体 / PK-PD解析 / 細胞中薬物濃度 / 血中薬物濃度 / 薬力学 / 細胞内薬物動態 / 細胞内薬物濃度 / 薬動力学 / 薬剤抵抗性 / オピオイド / 和漢薬 / 疫学研究 / 処方調査 / ガスモチン / 大腸がん / 胃がん / カルテ調査 / モサプリドクエン酸塩 / 大建中湯 / 漢方薬の臨床薬理 / 副作用予防 / 有効性・安全性 / 西洋医薬品 / 漢方薬 / 東西医薬品の併用 / ＴＤＭ / 微量定量法 / 血球移行 / 薬物治療モニタリング / 超微量分析 / 高感度定量法 / 高感度微量定量法 / 薬物濃度モニタリング Less

初年次多職種連携教育の評価によるアンプロフェッショナル行動の予測
- Principal Investigator
  
  柿崎真沙子
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 09070:Educational technology-related
- Research Institution
  Nagoya City University
Development of novel therapeutics against emerging infectious diseases by targeting blood–brain barrier
- Principal Investigator
  
  Kanda Yasunari
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  National Institute of Health Sciences
Development of a BBB evaluation system mimicking inflammatory response using ALS patient iPS cell-derived microgliaPrincipal Investigator
- Principal Investigator
  
  Tadahiro Hashita
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Nagoya City University
The construction of a blood-brain barrier model using novel human iPS cell-derived endothelial progenitor cellsPrincipal Investigator
- Principal Investigator
  
  Hashita Tadahiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nagoya City University
Drug resistance caused by intracellular pharmacokinetics
- Principal Investigator
  
  YAMAMOTO KOUJIROU
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Gunma University
Clinical pharmacological study for proper use in combination with Japanese traditional medicine and Western medicine
- Principal Investigator
  
  Nakamura Tomonori
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Natural medicines
- Research Institution
  Keio University
Development of non-invasive therapeutic drug monitoring method for pediatric patients
- Principal Investigator
  
  YAMAMOTO Koujirou
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Gunma University
Analysis of thrombocytopenia of molecular target drug by realtime culture cells analysis device with iPS cellsPrincipal Investigator
- Principal Investigator
  
  HASHITA Tadahiro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Gunma University

All 2024 2023 2022 2021 2020 2019 2018 2017 Other

All Journal Article Presentation Patent

[Journal Article] SARS-CoV-2 causes dysfunction in human iPSC-derived brain?microvascular endothelial cells potentially by modulating the Wnt signaling pathway2024
- Author(s)
  Yamada Shigeru、Hashita Tadahiro、Yanagida Shota、Sato Hiroyuki、Yasuhiko Yukuto、Okabe Kaori、Noda Takamasa、Nishida Motohiro、Matsunaga Tamihide、Kanda Yasunari
- Journal Title
  
  Fluids and Barriers of the CNS
  
  Volume: 21 Issue: 1 Pages: 32-32
- DOI
  10.1186/s12987-024-00533-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KJ1620, KAKENHI-PROJECT-22K19394, KAKENHI-PROJECT-22K19395, KAKENHI-PLANNED-21H05269, KAKENHI-PROJECT-21H02634, KAKENHI-PROJECT-23K24035
[Journal Article] Generation of Brain Microvascular Endothelial-like Cells from Human iPS Cell-Derived Endothelial Progenitor Cells Using TGF-β Receptor Inhibitor, Laminin 511 Fragment, and Neuronal Cell Culture Supplements2022
- Author(s)
  Aoki Hiromasa、Yamashita Misaki、Hashita Tadahiro、Iwao Takahiro、Aoyama Mineyoshi、Matsunaga Tamihide
- Journal Title
  
  Pharmaceutics
  
  Volume: 14 Issue: 12 Pages: 2697-2697
- DOI
  10.3390/pharmaceutics14122697
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08211, KAKENHI-PROJECT-21H04865, KAKENHI-PROJECT-21K16403, KAKENHI-PROJECT-20K07160
[Journal Article] Efficient differentiation and purification of human induced pluripotent stem cell-derived endothelial progenitor cells and expansion with the use of inhibitors of ROCK, TGF-β, and GSK3β2020
- Author(s)
  Aoki Hiromasa、Yamashita Misaki、Hashita Tadahiro、Ogami Koichi、Hoshino Shinichi、Iwao Takahiro、Matsunaga Tamihide
- Journal Title
  
  Heliyon
  
  Volume: 6 Issue: 3 Pages: e03493-e03493
- DOI
  10.1016/j.heliyon.2020.e03493
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H01811, KAKENHI-PROJECT-17H03635, KAKENHI-PROJECT-18K14630, KAKENHI-PROJECT-17K08422
[Journal Article] Laminin 221 fragment is suitable for the differentiation of human induced pluripotent stem cells into brain microvascular endothelial-like cells with robust barrier integrity2020
- Author(s)
  Aoki Hiromasa、Yamashita Misaki、Hashita Tadahiro、Iwao Takahiro、Matsunaga Tamihide
- Journal Title
  
  Fluids and Barriers of the CNS
  
  Volume: 17 Issue: 1 Pages: 25-25
- DOI
  10.1186/s12987-020-00186-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H01811, KAKENHI-PROJECT-17K08422
[Journal Article] Isolation of induced pluripotent stem cell-derived endothelial progenitor cells from sac-like structures2019
- Author(s)
  Aoki Hiromasa、Yamashita Misaki、Hashita Tadahiro、Nakayama Mizuki、Yagi Mayuko、Iwao Takahiro、Matsunaga Tamihide
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 515 Issue: 4 Pages: 672-678
- DOI
  10.1016/j.bbrc.2019.05.179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H01811, KAKENHI-PROJECT-17K08422
[Patent] 多能性幹細胞から脳毛細血管内皮細胞への分化誘導方法2019
- Inventor(s)
  松永民秀、坡下真大、山下美紗季
- Industrial Property Rights Holder
  松永民秀、坡下真大、山下美紗季
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-17K08422
[Patent] 高純度ヒトiPS細胞由来血管内皮前駆細胞の作製法および拡大培養法の確立2019
- Inventor(s)
  松永民秀、坡下真大、青木啓将
- Industrial Property Rights Holder
  松永民秀、坡下真大、青木啓将
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-040117
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17K08422
[Presentation] ヒトiPS細胞由来脳微小血管内皮様細胞のバリア機能に対するSARS-CoV-2感染の影響2023
- Author(s)
  柳田翔太、山田茂、坡下真大、佐藤寛之、安彦行人、岡部馨、野田隆正、西田基宏、松永民秀、諫田泰成
- Organizer
  フォーラム2023 衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-22K19394
[Presentation] SARS-CoV-2感染によるヒト血液脳関門のバリア機能低下2023
- Author(s)
  山田茂、坡下真大、柳田翔太、佐藤寛之、安彦行人、岡部馨、野田隆政、西田基宏、松永民秀、諫田泰成
- Organizer
  日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-22K19394
[Presentation] 創薬応用を目指したiPS細胞由来血液脳関門モデルの開発2022
- Author(s)
  坡下　真大
- Organizer
  日本実験動物代替法学会第35回大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07160
[Presentation] 創薬応用を目指したiPS細胞由来血液脳関門モデルの開発2022
- Author(s)
  坡下　真大
- Organizer
  日本薬物動態学会第37回年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07160
[Presentation] iPS細胞用いた血液脳関門モデルの作製とその機能評価2022
- Author(s)
  佐藤寛之，山下美紗季，坡下真大，岩尾岳洋，松永民秀
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-20K07160
[Presentation] ハンチントン病iPS細胞由来ミクログリア・内皮細胞を用いたin vitroヒトBBB病態モデルの開発2022
- Author(s)
  山下美紗季, 佐藤寛之, 坡下真大, 岩尾岳洋, 松永民秀
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K07160
[Presentation] ヒトiPS細胞由来脳ペリサイトの分化誘導法の確立2021
- Author(s)
  西　萌奈，山下美紗季，坡下真大，岩尾岳洋，松永民秀
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-20K07160
[Presentation] 病態解明研究に応用可能なヒトiPS細胞由来脳毛細血管内皮細胞の作製2021
- Author(s)
  山下美紗季，青木啓将，青山峰芳，坡下真大，松永民秀
- Organizer
  第31回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-20K07160
[Presentation] Differentiation of human iPS cell-derived endothelial progenitor cells into brain microvascular endothelial cells.2019
- Author(s)
  Aoki H, Yamashita M, Hashita T, Iwao T, Matsunaga T.
- Organizer
  EUROTOX 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08422
[Presentation] Differentiation and freeze, thawing of human iPS cell-derived brain microvascular endothelial cells.2019
- Author(s)
  Yamashita M, Aoki H, Hashita T, Iwao T, Matsunaga T.
- Organizer
  EUROTOX 2019
- Data Source
  KAKENHI-PROJECT-17K08422
[Presentation] Effect of compounds Y on the barrier function of human iPSCs derived brain microvascular endothelial cells.2018
- Author(s)
  Misaki Yamashita, Hiromasa Aoki, Tadahiro Hashita, Takahiro Iwao, Tamihide Matsunaga
- Organizer
  The 54th Congress of the European Societies of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08422
[Presentation] Development of a novel blood brain barrier model derived from human iPSCs.2018
- Author(s)
  Misaki Yamashita, Hiromasa Aoki, Tadahiro Hashita, Takahiro Iwao, Tamihide Matsunaga
- Organizer
  2018 International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08422
[Presentation] 異種由来不含条件下におけるiPS細胞由来血管内皮前駆細胞の作出2018
- Author(s)
  青木啓将, 山下美紗季, 坡下真大, 松永民秀
- Organizer
  再生医療学会
- Data Source
  KAKENHI-PROJECT-17K08422
[Presentation] Generation of endothelial progenitor cells and brain microvascular endothelial cells from human iPSCs.2017
- Author(s)
  青木啓将, 山下美紗季, 坡下真大, 松永民秀
- Organizer
  薬物動態学会
- Data Source
  KAKENHI-PROJECT-17K08422
[Presentation] Compounds Y improve the barrier function of brain microvascular endothelial cells derived from human iPSCs.2017
- Author(s)
  山下美紗季, 青木啓将, 坡下真大, 松永民秀
- Organizer
  薬物動態学会
- Data Source
  KAKENHI-PROJECT-17K08422
[Presentation] 和漢薬と西洋薬の併用の適正性に関する疫学的研究
- Author(s)
  葛西良佳, 青森達, 坡下真大, 鈴木小夜, 小林典子, 中島綾, 荒木拓也, 山本康次郎, 中村智徳
- Organizer
  日本薬学会135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25460116

1. YAMAMOTO Koujirou (70174787)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. AOMORI Tohru (40620802)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. Kanda Yasunari (70510387)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 松永民秀 (40209581)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
5. Nakamura Tomonori (30251151)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 佐藤浩子 (50396652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 手塚淑人 (00433649)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 鈴木小夜 (90424134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 小林典子 (90245449)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 地引綾 (00746224)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 荒木拓也 (00568248)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 永野大輔 (90738387)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 降幡知巳 (80401008)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 柿崎真沙子 (20580872)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 高桑修 (10647332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 恒川幸司 (70556646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 川出義浩 (20738439)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 舘知也 (80618447)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 齊藤将之 (40797023)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 堀英生 (90903526)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 鏡裕行 (00347824)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 澤田美和 (80938548)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 山口琴美 (40432314)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 中西仁恵 (81002194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 岩尾岳洋 (50581740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 青山峰芳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hashita Tadahiro 坡下 真大

HASHITA Tadahiro 坡下 真大

Research Projects

Research Products

Co-Researchers

初年次多職種連携教育の評価によるアンプロフェッショナル行動の予測

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel therapeutics against emerging infectious diseases by targeting blood&#8211;brain barrier

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a BBB evaluation system mimicking inflammatory response using ALS patient iPS cell-derived microgliaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The construction of a blood-brain barrier model using novel human iPS cell-derived endothelial progenitor cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Drug resistance caused by intracellular pharmacokinetics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clinical pharmacological study for proper use in combination with Japanese traditional medicine and Western medicine

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of non-invasive therapeutic drug monitoring method for pediatric patients

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of thrombocytopenia of molecular target drug by realtime culture cells analysis device with iPS cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] SARS-CoV-2 causes dysfunction in human iPSC-derived brain?microvascular endothelial cells potentially by modulating the Wnt signaling pathway2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of Brain Microvascular Endothelial-like Cells from Human iPS Cell-Derived Endothelial Progenitor Cells Using TGF-β Receptor Inhibitor, Laminin 511 Fragment, and Neuronal Cell Culture Supplements2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficient differentiation and purification of human induced pluripotent stem cell-derived endothelial progenitor cells and expansion with the use of inhibitors of ROCK, TGF-β, and GSK3β2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Laminin 221 fragment is suitable for the differentiation of human induced pluripotent stem cells into brain microvascular endothelial-like cells with robust barrier integrity2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Isolation of induced pluripotent stem cell-derived endothelial progenitor cells from sac-like structures2019

Author(s)

Journal Title

DOI

Data Source

[Patent] 多能性幹細胞から脳毛細血管内皮細胞への分化誘導方法2019

Inventor(s)

Hashita Tadahiro 坡下真大

HASHITA Tadahiro 坡下真大

Development of novel therapeutics against emerging infectious diseases by targeting blood–brain barrier