Yokobayashi Shihori 横林しほり

Researcher Number	20615736
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 開拓研究本部, 理研ECL研究チームリーダー 2025: 京都大学, iPS細胞研究所, 特定拠点講師
Affiliation (based on the past Project Information) *help	2021 – 2023: 京都大学, iPS細胞研究所, 特定拠点講師 2016 – 2020: 京都大学, iPS細胞研究所, 特定拠点助教
Review Section/Research Field	Principal Investigator Biological Sciences / Basic Section 48040:Medical biochemistry-related / General medical chemistry
Keywords	Principal Investigator 生殖細胞 / ヒトiPS細胞 / リプログラミング / in vitro誘導系 / エピジェネティクス / エピゲノム / 多能性幹細胞 / 始原生殖細胞 / 哺乳類 / エピゲノム多様性 … More / クロマチン動態 / クロマチン高次構造 / クロマチン / ゲノム / 遺伝子 Less

Understanding the effects of heterogeneity in epigenomic reprogramming on germ cell differentiationPrincipal Investigator
- Principal Investigator
  
  横林しほり
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
エピゲノムリプログラミング過程のゆらぎに関わるクロマチン高次動態の解明Principal Investigator
- Principal Investigator
  
  横林しほり
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Chromatin dynamics during primordial germ cell development in mammalsPrincipal Investigator
- Principal Investigator
  
  Yokobayashi Shihori
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kyoto University
Chromatin dynamics involved in epigenetic reprogramming during mammalian germ cell developmentPrincipal Investigator
- Principal Investigator
  
  Yokobayashi Shihori
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Nucleome programming is required for the foundation of totipotency in mammalian germline development2022
- Author(s)
  Nagano Masahiro, Hu Bo, Yokobayashi Shihori et al.
- Journal Title
  
  The EMBO Journal
  
  Volume: 41 Issue: 13
- DOI
  10.15252/embj.2022110600
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02613, KAKENHI-PROJECT-19H03618, KAKENHI-PROJECT-20K21500, KAKENHI-PROJECT-21K20635, KAKENHI-PROJECT-23K23804, KAKENHI-PROJECT-21K20740, KAKENHI-PROJECT-17H06098
[Journal Article] Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells2021
- Author(s)
  Yokobayashi Shihori、Yabuta Yukihiro、Nakagawa Masato、Okita Keisuke、Hu Bo、Murase Yusuke、Nakamura Tomonori、Bourque Guillaume、Majewski Jacek、Yamamoto Takuya、Saitou Mitinori
- Journal Title
  
  Cell Reports
  
  Volume: 37 Issue: 5 Pages: 109909-109909
- DOI
  10.1016/j.celrep.2021.109909
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H05387, KAKENHI-PROJECT-18H02613
[Journal Article] Generation of human oogonia from induced pluripotent stem cells in culture2020
- Author(s)
  Yamashiro Chika、Sasaki Kotaro、Yokobayashi Shihori、Kojima Yoji、Saitou Mitinori
- Journal Title
  
  Nature Protocols
  
  Volume: 15 Issue: 4 Pages: 1560-1583
- DOI
  10.1038/s41596-020-0297-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02613, KAKENHI-PROJECT-17H06098
[Journal Article] Generation of human oogonia from induced pluripotent stem cells in vitro.2018
- Author(s)
  30.Yamashiro C, Sasaki K, Yabuta Y, Kojima Y, Nakamura T, Okamoto I, Yokobayashi S, Murase Y, Ishikura Y, Shirane K, Sasaki H, Yamamoto T, Saitou M.
- Journal Title
  
  Science
  
  Volume: 362(6412) Issue: 6412 Pages: 356-360
- DOI
  10.1126/science.aat1674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06030, KAKENHI-PROJECT-18H05214, KAKENHI-PROJECT-18H02613, KAKENHI-PROJECT-17H06802, KAKENHI-PROJECT-17H06098, KAKENHI-PROJECT-18K14714
[Journal Article] Reconstitution of Germ Cell Development In Vitro2018
- Author(s)
  Shihori Yokobayashi and Mitinori Saitou
- Journal Title
  
  Cell Biology of the Ovary
  
  Volume: 1 Pages: 1-19
- DOI
  10.1007/978-981-10-7941-2_1
- ISBN
  9789811079405, 9789811079412
- Data Source
  KAKENHI-PROJECT-18H02613
[Journal Article] Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells2017
- Author(s)
  Kojima Yoji、Sasaki Kotaro、Yokobayashi Shihori、Sakai Yoshitake、Nakamura Tomonori、Yabuta Yukihiro、Nakaki Fumio、Nagaoka So、Woltjen Knut、Hotta Akitsu、Yamamoto Takuya、Saitou Mitinori
- Journal Title
  
  Cell Stem Cell
  
  Volume: 21 Issue: 4 Pages: 517-532
- DOI
  10.1016/j.stem.2017.09.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08267, KAKENHI-PROJECT-16K21133, KAKENHI-PROJECT-17H06098
[Journal Article] Clonal variation of human induced pluripotent stem cells for induction into the germ cell fate†2017
- Author(s)
  Yokobayashi Shihori、Okita Keisuke、Nakagawa Masato、Nakamura Tomonori、Yabuta Yukihiro、Yamamoto Takuya、Saitou Mitinori
- Journal Title
  
  Biology of Reproduction
  
  Volume: 96 Issue: 6 Pages: 1154-1166
- DOI
  10.1093/biolre/iox038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K21133, KAKENHI-PROJECT-17H06098
[Presentation] Understanding epigenome reprogramming in human germ cell fate using an in vitro reconstitution system2023
- Author(s)
  横林　しほり
- Organizer
  The 2nd International Symposium on Replication of Non Genome: Cutting Edge of Epigenetics
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04690
[Presentation] 試験管内再構成系を用いたヒト始原生殖細胞発生とエピゲノム機序の理解2023
- Author(s)
  横林　しほり
- Organizer
  第95回日本遺伝学会大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04690
[Presentation] Establishment of a robust system to reconstitute female human germ cell development in vitro2023
- Author(s)
  Shihori Yokobayashi
- Organizer
  CiRA Retreat 2022
- Data Source
  KAKENHI-PUBLICLY-22H04690
[Presentation] ヒトiPS細胞株におけるエピゲノム多様性の基底をなすゲノム特性の同定2022
- Author(s)
  横林しほり
- Organizer
  第74回日本細胞生物学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02613
[Presentation] ヒト生殖細胞分化系構築を目指した多能性幹細胞の多様性解析2022
- Author(s)
  横林しほり
- Organizer
  2022年度国立遺伝学研究所クロマチン研究会
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04690
[Presentation] ヒト生殖細胞分化系構築を目指した多能性幹細胞の多様性解析2022
- Author(s)
  横林しほり
- Organizer
  2022年度国立遺伝学研究所クロマチン研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02613
[Presentation] ヒトiPS細胞株におけるエピゲノム多様性の基底をなすゲノム特性の同定2022
- Author(s)
  横林しほり
- Organizer
  第74回日本細胞生物学会大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04690
[Presentation] Nucleome Programming for Mouse Germ Cell Development In Vitro.2021
- Author(s)
  Nagano M., Hu B., Yokobayashi S., Umemura F., Yamamura A., Ishikura Y., Yabuta Y., Ohta H., Saitou M.
- Organizer
  ASHBi Retreat 2021
- Data Source
  KAKENHI-PUBLICLY-20H05387
[Presentation] Inherent Genomic Properties Underlie the Epigenetic Heterogeneity of Human Induced Pluripotent Stem Cells.2021
- Author(s)
  Shihori Yokobayashi
- Organizer
  ASHBi Retreat 2021
- Data Source
  KAKENHI-PUBLICLY-20H05387
[Presentation] Inherent Genomic Properties Underlie the Epigenetic Heterogeneity of Human Induced Pluripotent Stem Cells.2021
- Author(s)
  Shihori Yokobayashi
- Organizer
  ASHBi Retreat 2021
- Data Source
  KAKENHI-PROJECT-18H02613
[Presentation] Nucleome Programming for Mouse Germ Cell Development In Vitro.2021
- Author(s)
  Nagano M., Hu B., Yokobayashi S., Umemura F., Yamamura A., Ishikura Y., Yabuta Y., Ohta H., Saitou M.
- Organizer
  ASHBi Retreat 2021
- Data Source
  KAKENHI-PROJECT-18H02613
[Presentation] Epigenetic variations of human induced pluripotent stem cells and their implications in their propensity for germ cell development.2020
- Author(s)
  Shihori Yokobayashi
- Organizer
  第43回日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02613
[Presentation] Epigenetic variations of human induced pluripotent stem cells and their implications in their propensity for germ cell development.2020
- Author(s)
  Shihori Yokobayashi
- Organizer
  第43回日本分子生物学会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05387
[Presentation] マウス始原生殖細胞発生過程におけるエピゲノム再編成に伴うクロマチン構造変化の解明2019
- Author(s)
  Masahiro Nagano, Bo Hu, Shihori Yokobayashi, Akitoshi Yamamura, Yukiko Ishikura, Yukihiro Yabuta, Hiroshi Ohta, Mitinori Saitou
- Organizer
  六甲医学研究会
- Data Source
  KAKENHI-PROJECT-18H02613
[Presentation] Clonal variation of human induced pluripotent stem cells for the induction into the germ cell fate2017
- Author(s)
  Shihori Yokobayashi and Mitinori Saitou
- Organizer
  六甲医学研究会
- Data Source
  KAKENHI-PROJECT-16K21133

1. 小島洋児

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 岡本郁弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yokobayashi Shihori 横林 しほり

Research Projects

Research Products

Co-Researchers

Understanding the effects of heterogeneity in epigenomic reprogramming on germ cell differentiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

エピゲノムリプログラミング過程のゆらぎに関わるクロマチン高次動態の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Chromatin dynamics during primordial germ cell development in mammalsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Chromatin dynamics involved in epigenetic reprogramming during mammalian germ cell developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Nucleome programming is required for the foundation of totipotency in mammalian germline development2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of human oogonia from induced pluripotent stem cells in culture2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of human oogonia from induced pluripotent stem cells in vitro.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reconstitution of Germ Cell Development In Vitro2018

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clonal variation of human induced pluripotent stem cells for induction into the germ cell fate†2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] Understanding epigenome reprogramming in human germ cell fate using an in vitro reconstitution system2023

Author(s)

Organizer

Data Source

[Presentation] 試験管内再構成系を用いたヒト始原生殖細胞発生とエピゲノム機序の理解2023

Author(s)

Organizer

Data Source

[Presentation] Establishment of a robust system to reconstitute female human germ cell development in vitro2023

Author(s)

Organizer

Data Source

[Presentation] ヒトiPS細胞株におけるエピゲノム多様性の基底をなすゲノム特性の同定2022

Author(s)

Organizer

Data Source

Yokobayashi Shihori 横林しほり