MIYAMOTO Hirotaka 宮元敬天

Researcher Number	20619481
Other IDs
External Links
Affiliation (Current)	2025: 長崎大学, 医歯薬学総合研究科(薬学系), 助教
Affiliation (based on the past Project Information) *help	2025: 長崎大学, 医歯薬学総合研究科(薬学系), 助教 2014 – 2023: 長崎大学, 医歯薬学総合研究科(薬学系), 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy Except Principal Investigator Medium-sized Section 58:Society medicine, nursing, and related fields
Keywords	Principal Investigator 低体温療法 / バンコマイシン / タンパク結合 / PK/PD / 組織分布 / 組織中濃度 / テジゾリド / 抗MRSA薬 / 薬物分布 / タンパク結合率 … More / 虚血再灌流 / 組織移行性 / 組織移行 / CYP3A2 … More Except Principal Investigator バイオマーカー / 精神疾患 / 視える化 Less

人工冬眠の医療応用へ向けた低体温時の抗菌薬投与最適化Principal Investigator
- Principal Investigator
  
  宮元敬天
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Nagasaki University
Challenge to "visualize mental illness" to realize a symbiotic society with illness
- Principal Investigator
  
  大山要
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Nagasaki University
Analysis of pharmacokinetic variables for optimization of anti-MRSA drug administration during hypothermia therapyPrincipal Investigator
- Principal Investigator
  
  MIYAMOTO Hirotaka
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Nagasaki University
Evaluation for factors affectiong on tissue distribution of drugs under hypothermiaPrincipal Investigator
- Principal Investigator
  
  MIYAMOTO Hirotaka
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nagasaki University
Evaluation for change in drug distribution under hypothermia for optimization of medicationPrincipal Investigator
- Principal Investigator
  
  MIYAMOTO Hirotaka
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nagasaki University

All 2022 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Influence of Liver Intoxication by Carbon Tetrachloride or D-Galactosamine on Absorption of Fluorescein Isothiocyanate-Dextran-10 and Other Marker Compounds with Different Molecular Weights from the Rat Liver Surface2020
- Author(s)
  Miyamoto H, Tsuda K, Honda T, Tokunaga A, Fumoto S, Nishida K
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 43 Issue: 2 Pages: 319-324
- DOI
  10.1248/bpb.b19-00686
- NAID
  130007793710
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2020-02-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06598, KAKENHI-PROJECT-19K07223
[Journal Article] Evaluation of mRNA expression of drug-metabolizing enzymes in acetaminophen-induced hepatotoxicity using a three-dimensional hepatocyte culture system2019
- Author(s)
  Taniguchi Mariko、Miyamoto Hirotaka、Tokunaga Ayako、Fumoto Shintaro、Tanaka Takashi、Nishida Koyo
- Journal Title
  
  Xenobiotica
  
  Volume: - Issue: 6 Pages: 1-9
- DOI
  10.1080/00498254.2019.1683258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07223
[Journal Article] Effect of renal ischaemia/reperfusion‐induced acute kidney injury on pharmacokinetics of midazolam in rats2019
- Author(s)
  Tokunaga Ayako、Miyamoto Hirotaka、Fumoto Shintaro、Nishida Koyo
- Journal Title
  
  Journal of Pharmacy and Pharmacology
  
  Volume: 71 Issue: 12 Pages: 1792-1799
- DOI
  10.1111/jphp.13167
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07223
[Journal Article] Edaravone, a cytoprotective drug, enhances transgene expression mediated by lipoplexes in HepG2 cells and mice2018
- Author(s)
  Wang S, Fumoto S, Miyamoto H, Tanaka M, Nishida K
- Journal Title
  
  Int J Pharm
  
  Volume: 548 Issue: 1 Pages: 173-181
- DOI
  10.1016/j.ijpharm.2018.06.068
- NAID
  120006988001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06598, KAKENHI-PROJECT-16K18947
[Journal Article] The Insertion Timing of PEGylated Lipids to Galactosylated Lipoplexes is Important for Liver-Selective Transfection in Mice2016
- Author(s)
  Fumoto S, Taniguchi N, Ikai Y, Yoshikawa N, Miyamoto H, Sasaki H, Hashida M, Kawakami S, Nishida K
- Journal Title
  
  Gene and Cell Therapy
  
  Volume: 1 Pages: 1-11
- NAID
  120006987274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18947
[Journal Article] Evaluation for Peritoneal Injury at an Early Stage Using Dual Macromolecular Markers2016
- Author(s)
  Hirata H, Fumoto S, Miyamoto H, Nakashima M, Nakayama M, Nishida K
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 39 Issue: 10 Pages: 1581-1587
- DOI
  10.1248/bpb.b15-01042
- NAID
  130005598443
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18947
[Journal Article] Effect of Metabolic Inhibitors on the Hepatic Disposition of 5-Fluorouracil after Application to the Rat Liver Surface2016
- Author(s)
  Kenta Shimokawa, Kazumi Wakasugi, Rei Tomonaga, Ken Utsunomiya, Hirotaka Miyamoto, Shintaro Fumoto, Koyo Nishida
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 39 Issue: 3 Pages: 361-367
- DOI
  10.1248/bpb.b15-00757
- NAID
  130005132312
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07891, KAKENHI-PROJECT-26860108, KAKENHI-PROJECT-16K18947
[Presentation] Comparison of pharmacokinetic variability of vancomycin and tedizolid during hypothermia2022
- Author(s)
  宮元　敬天、作田里奈、徳留　千江、麓　伸太郎、西田　孝洋
- Organizer
  日本薬物動態学会第37年会
- Data Source
  KAKENHI-PROJECT-19K07223
[Presentation] バンコマイシンの薬物動態に及ぼす低体温の影響評価2021
- Author(s)
  宮元　敬天、徳留　千江、徳永　彩子、長岡　希歩、麓　伸太郎、西田　孝洋
- Organizer
  日本薬物動態学会第３６回年会
- Data Source
  KAKENHI-PROJECT-19K07223
[Presentation] 各種腎障害時における肝代謝型薬物の体内動態変化とその要因解析2021
- Author(s)
  中原　美南海、宮元敬天、徳永彩子、麓伸太郎、西田孝洋
- Organizer
  第2回長崎県薬剤師学術大会
- Data Source
  KAKENHI-PROJECT-19K07223
[Presentation] バンコマイシンと抗菌薬併用による腎障害発症リスク変化の副作用データベースに基づく評価2021
- Author(s)
  宮元敬天、徳留千江、中原美南海、麓伸太郎、西田孝洋
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K07223
[Presentation] 低体温モデルラットにおけるバンコマイシンの体内動態評価2019
- Author(s)
  宮元敬天徳永彩子、長岡希歩、麓伸太郎、西田孝洋
- Organizer
  日本薬物動態学会第34年会
- Data Source
  KAKENHI-PROJECT-19K07223
[Presentation] グリセロール誘発性急性腎障害モデルラットにおけるミダゾラムの体内動態評価2018
- Author(s)
  徳永彩子、宮元敬天、井手陶子、麓伸太郎、西田孝洋
- Organizer
  第35回日本薬学会九州支部大会
- Data Source
  KAKENHI-PROJECT-16K18947
[Presentation] Effect of hypothermia on drug disposition of FITC-dextran and vancomycin in rats2018
- Author(s)
  Hirotaka Miyamoto, Ayako Tokunaga, Akihiro Moritsuka, Shintaro Fumoto, Koyo Nishida
- Organizer
  2018 International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18947
[Presentation] LPS/D-Gal 誘発急性肝炎モデルラットにおけるミダゾラムの体内動態評価及び組織分布に着目した変動要因解析2018
- Author(s)
  谷口麻里子、西畑　智世、宮元　敬天、徳永　彩子、麓　伸太郎、西田　孝洋
- Organizer
  医療薬学フォーラム2018/第26回クリニカルファーマシーシンポジウム
- Data Source
  KAKENHI-PROJECT-16K18947
[Presentation] 腎虚血・再灌流誘発性急性腎障害モデルラットにおけるミダゾラムの組織移行変化の要因解明2018
- Author(s)
  徳永彩子, 宮元敬天, 麓伸太郎, 西田孝洋
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K18947
[Presentation] 腎虚血再灌流に伴う急性腎障害モデルラットにおけるミダゾラムの体内動態変化2018
- Author(s)
  徳永彩子、宮元敬天、麓伸太郎、西田孝洋
- Organizer
  第12回次世代を担う若手医療薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-16K18947
[Presentation] 腎虚血・再灌流モデルラットにおけるミダゾラム動態評価および変動要因の解析2017
- Author(s)
  徳永彩子, 宮元敬天, 麓伸太郎, 西田孝洋
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-16K18947
[Presentation] 低体温療法時におけるバンコマイシン投与最適化に向けた組織移行性変化の要因解明2017
- Author(s)
  宮元敬天
- Organizer
  メディカルサイエンスセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-16K18947
[Presentation] 腹腔内投与したバンコマイシンの吸収性に与える腹膜障害の影響評価とその予測2017
- Author(s)
  宮元敬天, 高橋由紀奈, 森塚暁裕, 麓伸太郎, 西田孝洋
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-16K18947
[Presentation] アセトアミノフェン肝障害時および治療後における薬物代謝酵素mRNA発現変化のin vitro実験による評価2016
- Author(s)
  谷口麻里子、宮元敬天、徳永彩子、麓伸太郎、西田孝洋
- Organizer
  第33回日本薬学会九州支部大会
- Place of Presentation
  鹿児島大学（鹿児島県鹿児島市）
- Year and Date
  2016-12-03
- Data Source
  KAKENHI-PROJECT-16K18947
[Presentation] Evaluation for Effect of Hypothermia on Midazolam Disposition in Rats2016
- Author(s)
  Hirotaka Miyamoto, Ayako Tokunaga, Akihiro Moritsuka, Mariko Taniguchi, Shintaro Fumoto and Koyo Nishida
- Organizer
  The 1st Workshop for Japan-Korea Young Scientists on Pharmaceutics
- Place of Presentation
  京都教育文化センター(京都府京都市)
- Year and Date
  2016-06-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18947
[Presentation] Preparation of the Excel template for estimation of ka and illustration the plasma concentration time curve after repeated oral administration of drugs2016
- Author(s)
  Hirotaka Miyamoto, Ayako Tokunaga, Shi Nanzi, Hisashi Hamasaki, Shintaro, Fumoto and Koyo Nishida
- Organizer
  日本薬物動態学会第31年会
- Place of Presentation
  キッセイ文化ホール（長野県松本市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K18947
[Presentation] Development of two-layer sheet formulation containing 5-FU and its pharmacokinetic consideration after application to rat liver surface2015
- Author(s)
  Koyo Nishida, Yosuke Kariya, Ken Utsunomiya Yoshimi Tsurusaki, Kenta Shimokawa, Hirotaka Miyamoto, Shintaro Fumoto
- Organizer
  日本薬物動態学会第30年会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-26860108
[Presentation] 生理学的薬物速度論による低体温時のラットにおけるミダゾラム体内動態の予測2015
- Author(s)
  宮元敬天、森塚暁裕、谷口麻里子、麓伸太郎、西田孝洋
- Organizer
  第18回日本脳低温療法学会
- Place of Presentation
  香川県民ホール（香川県高松市）
- Year and Date
  2015-07-10
- Data Source
  KAKENHI-PROJECT-26860108
[Presentation] Establishment of the method for estimation the absorbed rate constant from the pharmacokinetic parameters obtained by package insert2015
- Author(s)
  Hirotaka Miyamoto, Takenori Tsukinuki, Mariko Taniguchi, Eriko Kinoshita, Shintaro Fumoto, and Koyo Nishida
- Organizer
  日本薬物動態学会第30年会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-26860108
[Presentation] 急性肝炎モデルラットにおけるmidaaolzmの体内動態および変動要因の解析2015
- Author(s)
  谷口麻里子、宮元敬天、平田春奈、麓伸太郎、西田孝洋
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26860108
[Presentation] 肝クリアランスの予測に基づく低体温時におけるミダゾラム定速注入時の投与速度最適化
- Author(s)
  宮元敬天、松枝慧、森塚暁裕、堀友理香、麓伸太郎、西田孝洋
- Organizer
  第17回日本脳低温療法学会
- Place of Presentation
  プラザヴェルデ（静岡県沼津市）
- Year and Date
  2014-08-01 – 2014-08-02
- Data Source
  KAKENHI-PROJECT-26860108
[Presentation] EVALUATION FOR CHANGE IN THE DISPOSITION OF MIDAZOLAM UNDER HYPOTHERMIA IN RATS BY IN VITRO METABOLISM AND PROTEIN BINDING STUDY
- Author(s)
  Hirotaka Miyamoto, Mariko Taniguchi, Haruna Hirata, Shintaro Fumoto and Koyo Nishida
- Organizer
  29th JSSX Meeting and 19th North American ISSX Meeting
- Place of Presentation
  Hilton San Francisco Union Square（アメリカ）
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-26860108
[Presentation] 添付文書記載の薬物動態パラメータを用いたExcel VBAによる吸収速度定数の推定
- Author(s)
  西田孝洋、突貫雄紀、平田春奈、下川研太、宮元敬天
- Organizer
  医療薬学フォーラム
- Place of Presentation
  ビッグサイトTFTホール（東京都江東区）
- Year and Date
  2014-06-28 – 2014-06-29
- Data Source
  KAKENHI-PROJECT-26860108
[Presentation] HepG2細胞における活発なエンドサイトーシス経路と細胞周期の関連
- Author(s)
  宇根隆通、麓伸太郎、宮元敬天、西田孝洋
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  慶應義塾大学　薬学部　芝共立キャンパス（東京都港区）
- Year and Date
  2014-07-30 – 2014-07-31
- Data Source
  KAKENHI-PROJECT-26860108

1. 大山要 (50437860)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 中嶋幹郎 (00260737)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 竹林実 (60304440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 相原希美 (60908557)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 山口拓 (80325563)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 小川さやか (80629171)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NISHIDA Koyo

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
8. FUMOTO Shintaro

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
9. TOKUNAGA Ayako

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results

MIYAMOTO Hirotaka 宮元 敬天

Research Projects

Research Products

Co-Researchers

人工冬眠の医療応用へ向けた低体温時の抗菌薬投与最適化Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Challenge to "visualize mental illness" to realize a symbiotic society with illness

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of pharmacokinetic variables for optimization of anti-MRSA drug administration during hypothermia therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation for factors affectiong on tissue distribution of drugs under hypothermiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation for change in drug distribution under hypothermia for optimization of medicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Influence of Liver Intoxication by Carbon Tetrachloride or D-Galactosamine on Absorption of Fluorescein Isothiocyanate-Dextran-10 and Other Marker Compounds with Different Molecular Weights from the Rat Liver Surface2020

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Evaluation of mRNA expression of drug-metabolizing enzymes in acetaminophen-induced hepatotoxicity using a three-dimensional hepatocyte culture system2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of renal ischaemia/reperfusion‐induced acute kidney injury on pharmacokinetics of midazolam in rats2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Edaravone, a cytoprotective drug, enhances transgene expression mediated by lipoplexes in HepG2 cells and mice2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] The Insertion Timing of PEGylated Lipids to Galactosylated Lipoplexes is Important for Liver-Selective Transfection in Mice2016

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Evaluation for Peritoneal Injury at an Early Stage Using Dual Macromolecular Markers2016

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Effect of Metabolic Inhibitors on the Hepatic Disposition of 5-Fluorouracil after Application to the Rat Liver Surface2016

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

MIYAMOTO Hirotaka 宮元敬天