KODAMA SUSUMU 児玉進

Researcher Number	20621460
Other IDs
Affiliation (Current)	2025: 岡山大学, 医歯薬学域, 准教授
Affiliation (based on the past Project Information) *help	2022: 岡山大学, 医歯薬学総合研究科, 准教授 2021 – 2022: 岡山大学, 医歯薬学域, 准教授 2017 – 2020: 岡山大学, 医歯薬学総合研究科, 准教授 2016: 東北大学, 薬学研究科, 助教 2012 – 2015: 東北大学, 薬学研究科(研究院), 助教 2012: 東北大学, 大学院・薬学研究科, 助教
Review Section/Research Field	Principal Investigator Medical pharmacy / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related Except Principal Investigator Medical pharmacy
Keywords	Principal Investigator 核内受容体 / シグナル伝達 / 炎症 / 異物応答 / 転写抑制 / 転写活性化 / ヘテロ２量体 / ヘテロ2量体 / 転写調節 / ヘテロ二量体 … More / 異物センサー / サイトカイン / 遺伝子発現調節 / 炎症性サイトカイン / 薬物動態 / 免疫応答 / 細胞シグナル / 免疫系 … More Except Principal Investigator トランスレーショナルリサーチ / 薬剤反応性 / ゲノム / HLA / 機序 / 副作用 / 発がん性試験 / PPARα / レポーターアッセイ / PXR / CAR / 核内受容体 / 細胞増殖 / 肝化学発がん Less

Understanding of the regulatory mechanisms of the xenoreceptors for chemical risk assessmentPrincipal Investigator
- Principal Investigator
  
  Kodama Susumu
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Okayama University
Understanding of the molecular mechanism for pharmacokinetic alteration caused by pro-inflammatory cytokinesPrincipal Investigator
- Principal Investigator
  
  Kodama Susumu
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Okayama University
  Tohoku University
Construction of novel MHC-class II based strategy and evaluation method for drug-induced myopathy.
- Principal Investigator
  
  Saito Yoshiro
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  National Institute of Health Sciences
Understanding of the molecular mechanism for the nuclear receptor PXR-mediated regulation of immune/inflammatory responsesPrincipal Investigator
- Principal Investigator
  
  Kodama Susumu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
化学物質のヒトでの安全性評価のための核内受容体CARを介した肝発がん機構の解明
- Principal Investigator
  
  山添康
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Regulation of the immune response by nuclear receptor PXRPrincipal Investigator
- Principal Investigator
  
  KODAMA SUSUMU
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University

All 2023 2020 2017 2015 2013 2012 Other

All Journal Article Presentation Other

[Journal Article] Structural characterization of 1,3-bis-tert-butyl monocyclic benzene derivatives with agonistic activity towards retinoid X receptor alpha2023
- Author(s)
  Kodama Susumu、Matsumoto Shuzo、Takamura Yuta、Fujihara Michiko、Watanabe Masaki、Ono Atsushi、Kakuta Hiroki
- Journal Title
  
  Toxicology Letters
  
  Volume: 373 Pages: 76-83
- DOI
  10.1016/j.toxlet.2022.11.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07044
[Journal Article] Pregnenolone 16α-carbonitrile ameliorates concanavalin A-induced liver injury in mice independent of the nuclear receptor PXR activation2017
- Author(s)
  Susumu Kodama, Takuto Shimura, Hideaki Kuribayashi, Taiki Abe, Kouichi Yoshinari
- Journal Title
  
  Toxicology Letters
  
  Volume: 271 Pages: 58-65
- DOI
  10.1016/j.toxlet.2017.02.018
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860095
[Journal Article] 臨床における重症薬疹とゲノムマーカー.2015
- Author(s)
  岡本（内田）好海, 児玉進, 中村亮介, 斎藤嘉朗
- Journal Title
  
  毒性質問箱
  
  Volume: 17 Pages: 18-23
- Data Source
  KAKENHI-PROJECT-15K15009
[Journal Article] Sulfotransferase genes: regulation by nuclear receptors in response to xeno/endo-biotics2013
- Author(s)
  Kodama S and Negishi M. Sulfotransferase genes
- Journal Title
  
  Drug Metabolism Reviews
  
  Volume: 45 Issue: 4 Pages: 441-449
- DOI
  10.3109/03602532.2013.835630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790142
[Journal Article] PXR cross-talks with internal and external signals in physiological and pathophysiological responses2013
- Author(s)
  Kodama S and Negishi M
- Journal Title
  
  Drug Metabolism Reviews
  
  Volume: 45 Issue: 3 Pages: 300-310
- DOI
  10.3109/03602532.2013.795585
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790142
[Presentation] IL-6刺激に応答した薬物代謝酵素CYP1A2遺伝子の転写抑制メカニズムの解明2020
- Author(s)
  柳田翔太、吉井奈穂、森彩美、小野敦、児玉進
- Organizer
  日本薬学会第140年会（京都）
- Data Source
  KAKENHI-PROJECT-16K08390
[Presentation] Pregnenolone 16α-carbonitrileは核内受容体PXRの活性化を介さずにコンカナバリンＡ誘導肝障害を軽減する2015
- Author(s)
  児玉進、志村匠斗、栗林秀明、吉成浩一
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-11-13
- Data Source
  KAKENHI-PROJECT-26860095
[Presentation] 核内受容体PXR活性化による四塩化炭素誘発性肝障害の軽減作用2015
- Author(s)
  倉冨雅、阿部太紀、児玉進、吉成浩一
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  石川県立音楽堂（金沢）
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-26860095
[Presentation] 核内受容体PXRによる免疫反応調節の機序解明2013
- Author(s)
  志村匠斗、児玉進、栗林秀明、宮田昌明、山添康、吉成浩一
- Organizer
  第52回日本薬学会東北支部大会
- Place of Presentation
  仙台
- Year and Date
  2013-10-20
- Data Source
  KAKENHI-PROJECT-24790142
[Presentation] 核内受容体PXRによる免疫反応調節の機序解明2013
- Author(s)
  志村匠斗、児玉進、栗林秀明、宮田昌明、山添康、吉成浩一
- Organizer
  第40回日本毒性学会学術年会
- Place of Presentation
  千葉
- Year and Date
  2013-06-17
- Data Source
  KAKENHI-PROJECT-24790142
[Presentation] 核内受容体PXRによる免疫反応調節の機序解明2013
- Author(s)
  志村匠斗、児玉進、栗林秀明、宮田昌明、山添康、吉成浩一
- Organizer
  第40回　日本毒性学会学術年会
- Place of Presentation
  タワーホール船堀（東京都）
- Data Source
  KAKENHI-PROJECT-24790142
[Presentation] 核内受容体PXRはコンカナバリンA投与により誘導されるT細胞依存性肝炎を抑制する2012
- Author(s)
  児玉進、志村匠斗、栗林秀明、吉成浩一、山添康
- Organizer
  日本薬物動態学会第27回年会
- Place of Presentation
  東京
- Year and Date
  2012-11-22
- Data Source
  KAKENHI-PROJECT-24790142
[Presentation] 核内受容体PXRはコンカナバリンA投与により誘導されるT細胞依存性肝炎を抑制する2012
- Author(s)
  児玉進、志村匠斗、栗林秀明、吉成浩一、山添康
- Organizer
  日本薬物動態学会　第27回年会
- Place of Presentation
  タワーホール船堀（東京都）
- Data Source
  KAKENHI-PROJECT-24790142
[Presentation] 核内受容体PXRによる免疫反応調節の機序解明
- Author(s)
  志村匠斗、児玉進、栗林秀明、宮田昌明、山添康、吉成浩一
- Organizer
  第52回　日本薬学会東北支部大会
- Place of Presentation
  東北大学川内北キャンパス（仙台）
- Data Source
  KAKENHI-PROJECT-24790142
[]

1. Saito Yoshiro (50215571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 山添康 (00112699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 吉成浩一 (60343399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 宮田昌明 (90239418)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 中村亮介 (50333357)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

KODAMA SUSUMU 児玉 進

Research Projects

Research Products

Co-Researchers

Understanding of the regulatory mechanisms of the xenoreceptors for chemical risk assessmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding of the molecular mechanism for pharmacokinetic alteration caused by pro-inflammatory cytokinesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Construction of novel MHC-class II based strategy and evaluation method for drug-induced myopathy.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Understanding of the molecular mechanism for the nuclear receptor PXR-mediated regulation of immune/inflammatory responsesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

化学物質のヒトでの安全性評価のための核内受容体CARを介した肝発がん機構の解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of the immune response by nuclear receptor PXRPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Structural characterization of 1,3-bis-tert-butyl monocyclic benzene derivatives with agonistic activity towards retinoid X receptor alpha2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pregnenolone 16α-carbonitrile ameliorates concanavalin A-induced liver injury in mice independent of the nuclear receptor PXR activation2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 臨床における重症薬疹とゲノムマーカー.2015

Author(s)

Journal Title

Data Source

[Journal Article] Sulfotransferase genes: regulation by nuclear receptors in response to xeno/endo-biotics2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PXR cross-talks with internal and external signals in physiological and pathophysiological responses2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] IL-6刺激に応答した薬物代謝酵素CYP1A2遺伝子の転写抑制メカニズムの解明2020

Author(s)

Organizer

Data Source

[Presentation] Pregnenolone 16α-carbonitrileは核内受容体PXRの活性化を介さずにコンカナバリンＡ誘導肝障害を軽減する2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 核内受容体PXR活性化による四塩化炭素誘発性肝障害の軽減作用2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

KODAMA SUSUMU 児玉進