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Minegishi Yuriko  峯岸 ゆり子

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MINEGISHI Yuriko  峯岸 ゆり子

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Researcher Number 20621832
Affiliation (Current) 2025: 公益財団法人がん研究会, がんプレシジョン医療研究センター 分析生化学研究部, 特任研究員
Affiliation (based on the past Project Information) *help 2019 – 2023: 公益財団法人がん研究会, がんプレシジョン医療研究センター プロテオミクス解析グループ, 研究員
2017 – 2018: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 分子細胞生物学研究部, 研究員
2014: 独立行政法人国立病院機構(東京医療センター臨床研究センター), その他部局等, 研究員
2012 – 2013: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 分子細胞生物学研究部, 研究員
Review Section/Research Field
Principal Investigator
Ophthalmology / Basic Section 37030:Chemical biology-related
Except Principal Investigator
Basic Section 56060:Ophthalmology-related
Keywords
Principal Investigator
がん免疫 / イムノペプチドミクス / 質量分析 / ネオ抗原 / イムノペプチド / 遺伝性網膜疾患 / E50K変異 / 神経変性疾患 / 正常眼圧緑内障 / Optineurin … More / オプチニューリン / 遺伝子変異 / 抗原提示 / プロテアソーム分解 / KRAS / プロテオゲノミクス / ラベルフリー定量 / 抗原ペプチド / ドライバー変異 / HLA / 網膜発生 / シャペロン / Leber先天性黒内障 / ノックインマウス / LCA / Leber先天黒内障 / CCT / モデル動物 / ゲノム編集 / CRISPR-Cas9 / 複合ヘテロ接合変異 / 網膜変性 / Leber先天性黒内障(LCA) / 分子細胞生物学 / 緑内障変異 / 遺伝性疾患 / E50K / 家族性緑内障 / 緑内障 … More
Except Principal Investigator
網膜 / 動物モデル / プロテオーム解析 / 分子シャペロン / 疾患モデル動物 / 視細胞 / シャペロニン / 病態解析 / 疾患モデルマウス / ゲノム編集 / レーベル黒内障 / 遺伝性網膜疾患 Less
  • Research Projects

    (6 results)
  • Research Products

    (44 results)
  • Co-Researchers

    (2 People)
  •  Investigation of Target Protein Degradation and Its Effect on Enhancing Cancer-Specific Antigen Presentation by Quantitative Mass SpectrometryPrincipal Investigator

    • Principal Investigator
      峯岸 ゆり子
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 37030:Chemical biology-related
    • Research Institution
      Japanese Foundation for Cancer Research
  •  CCT2複合ヘテロ変異による網膜変性モデルマウスの病態と網羅的タンパク質定量解析

    • Principal Investigator
      岡本 晶子 (須賀)
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56060:Ophthalmology-related
    • Research Institution
      独立行政法人国立病院機構(東京医療センター臨床研究センター)
  •  Analysis of the rate-limiting factor for intracellular antigen processing of HLA class I antigen peptidesPrincipal Investigator

    • Principal Investigator
      MINEGISHI Yuriko
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 37030:Chemical biology-related
    • Research Institution
      Japanese Foundation for Cancer Research
  •  Analysis of retinal function of LCA-causing CCT2 and the generation of mouse model and therapeuticsPrincipal Investigator

    • Principal Investigator
      MINEGISHI Yuriko
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Japanese Foundation for Cancer Research
      独立行政法人国立病院機構(東京医療センター臨床研究センター)
  •  OPTN-E50K変異性正常眼圧緑内障の遺伝子治療に向けた検討Principal Investigator

    • Principal Investigator
      峯岸 ゆり子
    • Project Period (FY)
      2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Ophthalmology
    • Research Institution
      独立行政法人国立病院機構(東京医療センター臨床研究センター)
  •  Molecular analyses of glaucoma-associated mutations in OPTN gene and retinal blood flowPrincipal Investigator

    • Principal Investigator
      MINEGISHI Yuriko
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Ophthalmology
    • Research Institution
      独立行政法人国立病院機構(東京医療センター臨床研究センター)

All 2024 2023 2022 2021 2020 2018 2017 2014 2013 2012 Other

All Journal Article Presentation Book

  • [Book] 医用工学ハンドブック2022

    • Author(s)
      峯岸ゆり子、植田 幸嗣
    • Total Pages
      475
    • Publisher
      エヌ・ティー・エス
    • ISBN
      4860437357
    • Data Source
      KAKENHI-PROJECT-20K05759
  • [Book] Retina Medicine2014

    • Author(s)
      峯岸ゆり子
    • Total Pages
      111
    • Publisher
      先端医学社
    • Data Source
      KAKENHI-PROJECT-24791885
  • [Book] Retina Medicine Vol3. No2.2014

    • Author(s)
      峯岸ゆり子
    • Total Pages
      98
    • Publisher
      先端医学社
    • Data Source
      KAKENHI-PROJECT-26861481
  • [Book] 日本人のヒット論文-本音で語る苦労話-第5回 オプチニューリン E50K 変異による遺伝性緑内障発症の機序『Retina Medicine』(中澤徹編)2014

    • Author(s)
      峯岸ゆり子
    • Publisher
      先端医学社
    • Data Source
      KAKENHI-PROJECT-24791885
  • [Book] 脳21 Vol.17 No.42014

    • Author(s)
      峯岸ゆり子、 岩田岳
    • Total Pages
      126
    • Publisher
      金芳堂
    • Data Source
      KAKENHI-PROJECT-26861481
  • [Journal Article] Emerging potential of immunopeptidomics by mass spectrometry in cancer immunotherapy2024

    • Author(s)
      MINEGISHI, Y., Haga, Y., Ueda, K。
    • Journal Title

      Cancer Science

      Volume: 115 Issue: 4 Pages: 1048-1059

    • DOI

      10.1111/cas.16118

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K04971
  • [Journal Article] Frontiers in mass spectrometry-based clinical proteomics for cancer diagnosis and treatment2023

    • Author(s)
      Yoshimi Haga, Yuriko Minegishi, Koji Ueda
    • Journal Title

      Cancer Science

      Volume: 114 Issue: 5 Pages: 1783-1791

    • DOI

      10.1111/cas.15731

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K05759, KAKENHI-PROJECT-23K05704, KAKENHI-PROJECT-23K21392
  • [Journal Article] Differential ion mobility mass spectrometry in immunopeptidomics identifies neoantigens carrying colorectal cancer driver mutations2022

    • Author(s)
      Yuriko Minegishi, Kazuma Kiyotani, Kensaku Nemoto, Yoshikage Inoue, Yoshimi Haga, Risa Fujii, Naomi Saichi, Satoshi Nagayama, Koji Ueda
    • Journal Title

      Communications Biology

      Volume: 5 Issue: 1 Pages: 831-831

    • DOI

      10.1038/s42003-022-03807-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K05759, KAKENHI-PROJECT-23K21392
  • [Journal Article] METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma2022

    • Author(s)
      Pan Yang、Suga Akiko、Kimura Itaru、Kimura Chojiro、Minegishi Yuriko、Nakayama Mao、Yoshitake Kazutoshi、Iejima Daisuke、Minematsu Naoko、Yamamoto Megumi、Mabuchi Fumihiko、Takamoto Mitsuko、Shiga Yukihiro、Araie Makoto、Kashiwagi Kenji、Aihara Makoto、Nakazawa Toru、Iwata Takeshi
    • Journal Title

      Journal of Clinical Investigation

      Volume: 132 Issue: 21

    • DOI

      10.1172/jci153589

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K09689, KAKENHI-PROJECT-22K09787, KAKENHI-PROJECT-20K09786, KAKENHI-PROJECT-20K18366
  • [Journal Article] Function of ERAP2 (endoplasmic reticulum aminopeptidase 2) in cancer immunity2021

    • Author(s)
      3.Hayashi, N., Ikeda, Y., Okamura, K., Tate, T., Nemoto, K., Nagayama, S., Minegishi, Y., Ueda, K., Kiyotani, K., Nakamura, Y. and Kei Kawana
    • Journal Title

      Journal of Reproductive Immunology

      Volume: 148 Pages: 103410-103410

    • DOI

      10.1016/j.jri.2021.103410

    • Data Source
      KAKENHI-PROJECT-20K05759
  • [Journal Article] Differential immunopeptidome analysis revealed cancer specific amino acid usage of HLA class-I antigens and novel neoantigens of colorectal cancer2021

    • Author(s)
      Yuriko Minegishi, Kazuma Kiyotani, Kensaku Nemoto, Yoshikage Inoue, Yoshimi Haga, Risa Fujii, Naomi Saichi, Satoshi Nagayama, Koji Ueda
    • Journal Title

      bioRxiv

      Volume: 10.1101 Pages: 439118-439118

    • DOI

      10.1101/2021.04.09.439118

    • Data Source
      KAKENHI-PROJECT-20K05759
  • [Journal Article] Mutation in the Zebrafish cct2 Gene Leads to Abnormalities of Cell Cycle and Cell Death in the Retina: A Model of CCT2-Related Leber Congenital Amaurosis2018

    • Author(s)
      Minegishi Yuriko、Nakaya Naoki、Tomarev Stanislav I.
    • Journal Title

      Investigative Opthalmology & Visual Science

      Volume: 59 Issue: 2 Pages: 995-1004

    • DOI

      10.1167/iovs.17-22919

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11472
  • [Journal Article] Enhanced Optineurin E50 K-TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma.2013

    • Author(s)
      Minegishi Y, Seki T, Yuasa S, Fukuda K, Iwata T, et al
    • Journal Title

      Hum Mol Genet.

      Volume: 22 Issue: 17 Pages: 3559-3367

    • DOI

      10.1093/hmg/ddt210

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J30002, KAKENHI-PUBLICLY-24117716, KAKENHI-PROJECT-24791885
  • [Presentation] イムノペプチドーム解析によるがん特異的HLA Class I提示抗原ペプチドの探索2024

    • Author(s)
      峯岸ゆり子
    • Organizer
      2024年がん関連三学会Rising Starネットワーキング
    • Data Source
      KAKENHI-PROJECT-23K04971
  • [Presentation] Identification of naturally presented oncogenic KRAS neoepitope species by mass spectrometry2024

    • Author(s)
      1.Minegishi, Y., Ueda, K.
    • Organizer
      The 1st International Symposium on Cancer Immunology and Immunotherapy (JACI2024)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K04971
  • [Presentation] Detection of KRAS G12D/G12V neoepitopes expressed by cancer cell lines using LC-MS/MS2023

    • Author(s)
      Iwamoto, N., Minegishi, Y., Ueda, K., Koguchi, Y., Redmond, W., Piening, B., Fox, B.A, Tran, E., Shimada, T.
    • Organizer
      The 38th annual Meeting of Society for Immunotherapy of Cancer (SITC2023)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K04971
  • [Presentation] Potential of mass spectrometry in antigen discovery for cancer immunotherapy2023

    • Author(s)
      峯岸ゆり子、芳賀淑美、箱崎勇治、清谷一馬、長山聡、植田幸嗣
    • Organizer
      第82回日本癌学会学術総会シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K04971
  • [Presentation] Simultaneous identification of KRAS mutation-carrying multiple neoepitopes by differential ion mobility-assisted targeted-mass spectrometry.2023

    • Author(s)
      Minegishi, Y., Iwamoto, N., Shimada, T., Kiyotani, K., Nagayama, S., Tran, E., Koguchi, Y., Redmond, W., Piening, B., Fox, B.A., Ueda, K.
    • Organizer
      The 38th annual Meeting of Society for Immunotherapy of Cancer (SITC2023)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K04971
  • [Presentation] 微分型イオン移動度質量分析によるがん免疫医療のためのイムノペプチドームの探索2023

    • Author(s)
      長山聡、峯岸ゆり子、植田幸嗣
    • Organizer
      第109回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-23K04971
  • [Presentation] Explore the immunopeptidome for shared neoantigen by differential ion mobility-mass spectrometry2022

    • Author(s)
      峯岸ゆり子、芳賀淑美、清谷一馬、長山聡、植田幸嗣
    • Organizer
      第81回日本癌学会学術総会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K05759
  • [Presentation] An effort to catalog the cancer driver mutation-carrying neoantigens for the frontier of immunotherapy2022

    • Author(s)
      Minegishi, Y., Kiyotani, K., K, Nemoto, K., Nagayama, S., Ueda, K.
    • Organizer
      Human Proteome Organization World Congress (HUPO2022)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K05759
  • [Presentation] 微分型イオン移動度質量分析によるがん免疫医療のためのイムノペプチドームの探索2022

    • Author(s)
      峯岸ゆり子、清谷一馬、長山聡、植田幸嗣
    • Organizer
      日本プロテオーム学会
    • Data Source
      KAKENHI-PROJECT-20K05759
  • [Presentation] Function of ERAP2 (endoplasmic reticulum aminopeptidase 2) in cancer immunity2021

    • Author(s)
      3.Hayashi, N., Ikeda, Y., Okamura, K., Tate, T., Nemoto, K., Nagayama, S., Minegishi, Y., Ueda, K., Kiyotani, K., Nakamura, Y. and Kei Kawana
    • Organizer
      The 36th Annual Meeting Japanese Society for Immunology of Reproduction
    • Data Source
      KAKENHI-PROJECT-20K05759
  • [Presentation] がん免疫個別化医療の実現に向けた高深度・高感度イムノペプチドミクス2021

    • Author(s)
      峯岸ゆり子、植田幸嗣
    • Organizer
      日本薬学会第142年会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K05759
  • [Presentation] Global immunopeptidomics by differential ion mobility mass spectrometry for identification of patient specific HLA-presented antigens directly from clinical tissues.2021

    • Author(s)
      Minegishi, Y., Kiyotani, K., K, Nemoto, K., Nagayama, S., Ueda, K
    • Organizer
      Human Proteome Organization World Congress (HUPO2021)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K05759
  • [Presentation] プロテオゲノミクス解析による大腸癌組織上HLA提示抗原ペプチドの網羅的同定2020

    • Author(s)
      峯岸ゆり子
    • Organizer
      第79回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K05759
  • [Presentation] Mutation in Leber’s congenital amaurosis-causing gene cct2 evokes retinal hypoplasia in zebrafish2018

    • Author(s)
      Yuriko MINEGISHI
    • Organizer
      The Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11472
  • [Presentation] Mutation in Leber’s congenital amaurosis causing gene, cct2, evokes retinal hypoplasia in zebrafish2018

    • Author(s)
      Minegishi, Y., Nakaya, N,m Iwata, T. and Tomarev, S.
    • Organizer
      Human Genome Meeting 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11472
  • [Presentation] ゼブラフィッシュを用いたCct2遺伝子変異による網膜病態についての検討2017

    • Author(s)
      峯岸ゆり子
    • Organizer
      第10回Retinal Research Meeting
    • Data Source
      KAKENHI-PROJECT-17K11472
  • [Presentation] オプチニューリンのアミノ酸E50K変異による遺伝性緑内障の発症機序2014

    • Author(s)
      峯岸ゆり子
    • Organizer
      第19回東北眼疾患病態研究会
    • Place of Presentation
      仙台
    • Year and Date
      2014-05-19
    • Invited
    • Data Source
      KAKENHI-PROJECT-26861481
  • [Presentation] オプチニューリンのアミノ酸 E50K 変異による遺伝性緑内障の発症機序2014

    • Author(s)
      峯岸ゆり子, 岩田岳
    • Organizer
      第19回東北眼疾患病態研究会
    • Place of Presentation
      仙台
    • Year and Date
      2014-05-19
    • Invited
    • Data Source
      KAKENHI-PROJECT-24791885
  • [Presentation] 緑内障原因遺伝子オプチニューリンとE50K 変異によるタンパクの不溶化と病態発症との関連2013

    • Author(s)
      峯岸ゆり子, 家島大輔, 小林宏明, 池在龍, 川瀬和秀, 山本哲也, 関倫久, 湯浅慎介, 福田恵一, 岩田岳
    • Organizer
      第17回眼科分子生物学研究会
    • Place of Presentation
      静岡
    • Year and Date
      2013-02-24
    • Data Source
      KAKENHI-PROJECT-24791885
  • [Presentation] Etiologic dynamics of optineurin E50K mutant in iPSC from open angle glaucoma patient2013

    • Author(s)
      Minegishi, Y., Iwata, T
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2013-11-13
    • Data Source
      KAKENHI-PROJECT-24791885
  • [Presentation] Distinct protein complex formation evokes insolubility of OPTN and mislocalization in iPSC-derived neural cells from E50K-POAG patients2013

    • Author(s)
      Minegishi, Y., Iejima, D., Kobayashi, H., Chi., ZL., Kawase, K., Yamamoto, T., Seki, T., Yuasa, S., Fukuda, K., Iwata, T
    • Organizer
      ARVO2013
    • Place of Presentation
      Seattle, WA, USA
    • Year and Date
      2013-05-05
    • Data Source
      KAKENHI-PROJECT-24791885
  • [Presentation] Aberrant accumulation of glaucoma-associated OPTN E50K mutant protein potentiates the glaucomatous retinal vulnerability2012

    • Author(s)
      Minegishi, Y., Iwata, T
    • Organizer
      XX Biennial Meeting of the International Society for Eye Research
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2012-07-23
    • Data Source
      KAKENHI-PROJECT-24791885
  • [Presentation] オプチニューリン E50K 変異体による正常眼圧緑内障の病態機序の解明2012

    • Author(s)
      峯岸ゆり子, 小林宏明, 家島大輔, 岩田岳
    • Organizer
      第5回 Retinal Research Meeting
    • Place of Presentation
      東京
    • Year and Date
      2012-12-08
    • Data Source
      KAKENHI-PROJECT-24791885
  • [Presentation] Comparative functional analysis of optineurin and its glaucoma-related mutant E50K by mammalian cell-based LC-MS/MS proteomics2012

    • Author(s)
      Minegishi, Y., Kobayashi, H., Iwata, T
    • Organizer
      XX Biennial Meeting of the International Society for Eye Research
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2012-07-25
    • Data Source
      KAKENHI-PROJECT-24791885
  • [Presentation] オプチニューリンのアミノ酸E50K変異による遺伝性緑内障の発症機序

    • Author(s)
      峯岸ゆり子、 岩田岳
    • Organizer
      第19回東北眼疾患病態研究会
    • Place of Presentation
      仙台、 日本。
    • Invited
    • Data Source
      KAKENHI-PROJECT-24791885
  • [Presentation] Comperative functional analysis of optineurin and its glaucoma-related mutant E50K by mammalian cell-based LC-MS/MS proteomics

    • Author(s)
      Minegishi, Y., Kobayashi, H., Iwata
    • Organizer
      XX Biennial Meeting of the International Society for Eye Research
    • Place of Presentation
      ベルリン、ドイツ
    • Data Source
      KAKENHI-PROJECT-24791885
  • [Presentation] Aberrant accumulation of glaucoma-associated OPTN E50K mutant protein potentiates the glaucomatous retinal vulnerability

    • Author(s)
      Minegishi, Y., Iwata
    • Organizer
      XX Biennial Meeting of the International Society for Eye Research
    • Place of Presentation
      ベルリン、ドイツ
    • Data Source
      KAKENHI-PROJECT-24791885
  • [Presentation] オプチニューリンE50K変異体による正常眼圧緑内障の病態機序の解明

    • Author(s)
      峯岸ゆり子、小林宏明、家島大輔、岩田岳
    • Organizer
      The 5th Retinal Research Meeting
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24791885
  • [Presentation] 緑内障原因遺伝子オプチニューリンとE50K変異によるタンパクの不溶化と病態発症との関連

    • Author(s)
      峯岸ゆり子、家島大輔、小林宏明、池在龍、川瀬和秀、山本哲也、関倫久、湯浅慎介、福田恵一、岩田岳
    • Organizer
      第17回眼科分子生物学研究会
    • Place of Presentation
      静岡
    • Data Source
      KAKENHI-PROJECT-24791885
  • [Presentation] Distinct protein complex formation evokes insolubility of OPTN and mislocalization in iPSC-derived neural cells from E50K-POAG patients

    • Author(s)
      Minegishi, Y., Iejima, D., Kobayashi, H., Chi1., ZL., Kawase, K., Yamamoto, T., Seki, T., Yuasa, S., Fukuda, K., Iwata, T
    • Organizer
      ARVO2013 Annual Meeting
    • Place of Presentation
      シアトル、アメリカ
    • Data Source
      KAKENHI-PROJECT-24791885
  • [Presentation] Etiologic dynamics of optineurin E50K mutant in iPSC from open angle glaucoma patient.

    • Author(s)
      Minegishi, Y., Iwata, T.
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      サンディエゴ、 アメリカ。
    • Data Source
      KAKENHI-PROJECT-24791885
  • 1.  岡本 晶子 (70450400)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  SUGA Akiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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