Hattori Hiroyoshi 服部浩佳

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HATTORI Hiroyoshi 服部浩佳

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Researcher Number	20624513
Affiliation (Current)	2025: 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, 室長
Affiliation (based on the past Project Information) *help	2016 – 2018: 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, 室長 2012 – 2015: 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, その他
Review Section/Research Field	Principal Investigator Pediatrics
Keywords	Principal Investigator gammaH2aX / DNA損傷 / etoposide / gammaH2AX / ＤＮＡ損傷 / RB1 / 遺伝学的検査 / 家族性腫瘍 / 遺伝カウンセリング / 網膜芽細胞腫 … More / 遺伝性腫瘍 / BCP-ALLモデル細胞 / 予後因子 / 抗がん剤感受性 / 小児急性リンパ性白血病 Less

An approach to establish pediatric hereditary cancer-related biomarkers applying DNA damage repair factorsPrincipal Investigator
- Principal Investigator
  
  Hattori Hiroyoshi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  National Hospital Organization Nagoya Medical Center
Exploration for therapeutic target using a novel prognostic factor IKZF1 targeting cells in childhood acute lymphoblastic leukemiaPrincipal Investigator
- Principal Investigator
  
  HATTORI Hiroyoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  National Hospital Organization Nagoya Medical Center

All 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Compound heterozygous TYK2 mutations underlie primary immunodeficiency with T-cell lymphopenia2018
- Author(s)
  Nemoto Michiko、Hattori Hiroyoshi、Maeda Naoko、Akita Nobuhiro、Muramatsu Hideki、Moritani Suzuko、Kawasaki Tomonori、Maejima Masami、Ode Hirotaka、Hachiya Atsuko、Sugiura Wataru、Yokomaku Yoshiyuki、Horibe Keizo、Iwatani Yasumasa
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 6956-6956
- DOI
  10.1038/s41598-018-25260-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04740, KAKENHI-PROJECT-16K08654, KAKENHI-PROJECT-17K08872, KAKENHI-PROJECT-18K05818, KAKENHI-PROJECT-15K09678
[Journal Article] Dynamic Modulation of Thymidylate Synthase Gene Expression and Fluorouracil Sensitivity in Human Colorectal Cancer Cells.2015
- Author(s)
  Wakasa K, Kawabata R, Nakao S, Hattori H, Taguchi K, Uchida J, Yamanaka T, Maehara Y, Fukushima M, Oda S.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 4 Pages: e0123076-e0123076
- DOI
  10.1371/journal.pone.0123076
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591568, KAKENHI-PROJECT-24592250, KAKENHI-PROJECT-15K09678
[Journal Article] NF-kB signaling mediates acquired resistance after PARP inhibition.2015
- Author(s)
  Nakagawa Y, Sedukhina AS, Okamoto N, Nagasawa S, Suzuki N, Ohta T, Hattori H, Roche-Molina M, Narváez AJ, Jeyasekharan AD, Bernal JA, Sato K.
- Journal Title
  
  Oncotarget
  
  Volume: 6 Pages: 3825-39
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591568
[Journal Article] p53 shapes genome-wide and cell type-specific changes in microRNA expression during the human DNA damage response.2014
- Author(s)
  Hattori H, Janky R, Nietfeld W, Aerts S, Babu MM, Venkitaraman AR.
- Journal Title
  
  Cell Cycle
  
  Volume: 13 Issue: 16 Pages: 2572-86
- DOI
  10.4161/15384101.2015.942209
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591568
[Journal Article] A-type lamins maintain the positional stability of DNA damage repair foci in mammalian nuclei.2013
- Author(s)
  Mahen R, Hattori H, Lee M, Sharma P, Jeyasekharan AD, Venkitaraman AR.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 5 Pages: e61893-e61893
- DOI
  10.1371/journal.pone.0061893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591568
[Journal Article] A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization.2013
- Author(s)
  Jeyasekharan AD, Liu Y, Hattori H, Pisupati V, Jonsdottir AB, Rajendra E, Lee M, Sundaramoorthy E, Schlachter S, Kaminski CF, Ofir-Rosenfeld Y, Sato K, Savill J, Ayoub N, Venkitaraman AR.
- Journal Title
  
  Nat Struct Mol Biol.
  
  Volume: 20 Issue: 10 Pages: 1191-8
- DOI
  10.1038/nsmb.2666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591568
[Journal Article] Nilotinib monotherapy induced complete remission in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to imatinib and dasatinib.2013
- Author(s)
  Sekimizu M, Yamashita Y, Ueki H, Akita N, Hattori H, Maeda N, Horibe K.
- Journal Title
  
  Leuk Lymphoma
  
  Volume: Epub ahead of print Pages: 1-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591568
[Journal Article] A DNA-Damage Selective Role for BRCA1 E3 Ligase in Claspin Ubiquitylation, CHK1 Activation, and DNA Repair2012
- Author(s)
  Sato K, Sundaramoorthy E, Rajendra E, Hattori H, Jeyasekharan AD, Ayoub N, Schiess R, Aebersold R, Nishikawa H, Sedukhina AS, Wada H, Ohta T, Venkitaraman AR
- Journal Title
  
  Curr Biol
  
  Volume: 22 Issue: 18 Pages: 1659-66
- DOI
  10.1016/j.cub.2012.07.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300358, KAKENHI-PROJECT-24591568, KAKENHI-PLANNED-24112005
[Presentation] RB1遺伝学的検査による片眼性網膜芽細胞腫のリスク層別化2018
- Author(s)
  服部浩佳、森川真紀、久保田敏信、秋田直洋、関水匡大、市川瑞穂、前田尚子、堀部敬三.
- Organizer
  第24回日本家族性腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09678
[Presentation] がんゲノム医療における遺伝カウンセリングの重要性2018
- Author(s)
  服部浩佳.
- Organizer
  第72回国立病院総合医学会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09678
[Presentation] 網膜芽細胞腫に続発した二次性骨肉腫の2例2018
- Author(s)
  加藤結子、服部浩佳、秋田直洋、関水匡大、市川瑞穂、前田尚子、久保田敏信、小野学、二村昌樹、後藤雅彦、堀部敬三.
- Organizer
  第273回日本小児科学会東海地方会
- Data Source
  KAKENHI-PROJECT-15K09678
[Presentation] Risk Stratification of Unilateral Retinoblastoma Patients with the RB1 Genetic Testing.2018
- Author(s)
  Hattori H、Morikawa M、Taguchi I、Kubota T 、Akita N 、Sekimizu M 、Ichikawa M 、Maeda N、Horibe K.
- Organizer
  The 50th Congress of the International Society of Paediatric Oncology (SIOP)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09678
[Presentation] X;13均衡型相互転座を伴いRB1遺伝子に切断点がない網膜芽細胞腫患者の分子遺伝学的解析2018
- Author(s)
  堤真紀子、服部浩佳、秋田直洋、前田尚子、藤田尚子、河合美紀、倉橋浩樹.
- Organizer
  日本人類遺伝学会第63回大会
- Data Source
  KAKENHI-PROJECT-15K09678
[Presentation] 遺伝学的検査を行った小児家族性腫瘍の6例2017
- Author(s)
  服部浩佳
- Organizer
  第23回日本家族性腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09678
[Presentation] The implications of RB1 genetic testing for the patients with unilateral retinoblastoma （片眼性網膜芽細胞腫に対するRB1遺伝学的検査の意義）2017
- Author(s)
  服部浩佳
- Organizer
  第59回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09678
[Presentation] Integration of Genetic Testing for Unilateral Retinoblastoma in Clinical Practice - A Single Institutes Experience in Japan -2017
- Author(s)
  Hattori H et al.
- Organizer
  The 12th Meeting of The UK Eye Genetics Group & the 20th Meeting of The International Society for Genetic Eye Diseases & Retinoblastoma
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09678
[Presentation] ①当院の小児固形腫瘍患者における家族性腫瘍症候群とその対応について2016
- Author(s)
  服部浩佳
- Organizer
  第22回日本家族性腫瘍学会学術集会
- Place of Presentation
  愛媛
- Year and Date
  2016-06-03
- Data Source
  KAKENHI-PROJECT-15K09678
[Presentation] Clinical Issues for the Treatment of Adolescents and Young Adults with Hematologic Malignancy and Bone and Soft Tissue Sarcoma in Japan – A Single Institute’s Experience
- Author(s)
  Hattori Hiroyoshi
- Organizer
  9th St. Jude-VIVA Forum in Pediatric Oncology
- Place of Presentation
  Singapore
- Year and Date
  2015-03-28 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24591568

1. HORIBE Keizo (30209308)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. SAITO Yuko

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. YAMASHITA Yuka

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. Taguchi Iku

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. Tsutsumi Makiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. Kubota Toshinobu

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. Maeda Naoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. Morikawa Maki

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. Sato Ko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. IWATANI Yasumasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 太田智彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hattori Hiroyoshi 服部 浩佳

HATTORI Hiroyoshi 服部 浩佳

Research Projects

Research Products

Co-Researchers

An approach to establish pediatric hereditary cancer-related biomarkers applying DNA damage repair factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploration for therapeutic target using a novel prognostic factor IKZF1 targeting cells in childhood acute lymphoblastic leukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Compound heterozygous TYK2 mutations underlie primary immunodeficiency with T-cell lymphopenia2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dynamic Modulation of Thymidylate Synthase Gene Expression and Fluorouracil Sensitivity in Human Colorectal Cancer Cells.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NF-kB signaling mediates acquired resistance after PARP inhibition.2015

Author(s)

Journal Title

Data Source

[Journal Article] p53 shapes genome-wide and cell type-specific changes in microRNA expression during the human DNA damage response.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A-type lamins maintain the positional stability of DNA damage repair foci in mammalian nuclei.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nilotinib monotherapy induced complete remission in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to imatinib and dasatinib.2013

Author(s)

Journal Title

Data Source

[Journal Article] A DNA-Damage Selective Role for BRCA1 E3 Ligase in Claspin Ubiquitylation, CHK1 Activation, and DNA Repair2012

Author(s)

Journal Title

DOI

Data Source

[Presentation] RB1遺伝学的検査による片眼性網膜芽細胞腫のリスク層別化2018

Author(s)

Organizer

Data Source

[Presentation] がんゲノム医療における遺伝カウンセリングの重要性2018

Author(s)

Organizer

Data Source

[Presentation] 網膜芽細胞腫に続発した二次性骨肉腫の2例2018

Author(s)

Organizer

Data Source

[Presentation] Risk Stratification of Unilateral Retinoblastoma Patients with the RB1 Genetic Testing.2018

Author(s)

Organizer

Data Source

[Presentation] X;13均衡型相互転座を伴いRB1遺伝子に切断点がない網膜芽細胞腫患者の分子遺伝学的解析2018

Author(s)

Organizer

Data Source

[Presentation] 遺伝学的検査を行った小児家族性腫瘍の6例2017

Author(s)

Organizer

Data Source

[Presentation] The implications of RB1 genetic testing for the patients with unilateral retinoblastoma （片眼性網膜芽細胞腫に対するRB1遺伝学的検査の意義）2017

Hattori Hiroyoshi 服部浩佳

HATTORI Hiroyoshi 服部浩佳