Zankov Dimitar Petrov ZANKOV DimitarP

… Alternative Names

Zankov Dimitar P. ZANKOV Dimitar P

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Researcher Number	20631295
Other IDs
Affiliation (based on the past Project Information) *help	2023: 国立研究開発法人国立循環器病研究センター, オープンイノベーションセンター, 室長 2019 – 2023: 国立研究開発法人国立循環器病研究センター, 研究所, 室長 2015 – 2018: 滋賀医科大学, 医学部, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator 不整脈 / Desmoglein 2 / Desmosome / Arrhythmia / Cardiomyopathy / Mouse model / DSG2 / knock-in mouse / dsg2 / ARVC … More / 遺伝子解析 / TMEM168 / TMEM168 gene / Brugada Syndrome / Ubiquitination / Sodium channel / Brugada syndrome / Inherited arrhythmia / イオンチャネル / 遺伝子変異 / 遺伝子異常 / ゲノム解析 … More Except Principal Investigator DNA構造多型 / DNA構造異常 / long read sequencer / ゲノム構造多型 / ゲノムDNA構造異常 / 遺伝性不整脈 Less

The elucidation of complicated genetic backgrounds and pathogenicity in patients with inherited primary arrhythmia syndromes caused by unknown etiology
- Principal Investigator
  
  大野聖子
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Cardiovascular Center Research Institute
Elucidation of the pathology in ARVC caused by Japanese-specific DSG2 mutations using knock-in mice models: searching for the therapeutic targetsPrincipal Investigator
- Principal Investigator
  
  Zankov Dimitar P
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
Identification of TMEM168 protein mutation in familial Brugada syndromePrincipal Investigator
- Principal Investigator
  
  Zankov Dimitar Petrov
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
  Shiga University of Medical Science
Genome-wide analysis to discover the gene mutation that relates to ventricular fibrillation and its molecular mechanismPrincipal Investigator
- Principal Investigator
  
  Zankov Dimitar P.
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Shiga University of Medical Science

All 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] RhoA rescues cardiac senescence by regulating Parkin-mediated mitophagy2023
- Author(s)
  Soh Joanne Ern Chi、Shimizu Akio、Molla Md Rasel、Zankov Dimitar P.、Nguyen Le Kim Chi、Khan Mahbubur Rahman、Tesega Wondwossen Wale、Chen Si、Tojo Misa、Ito Yoshito、Sato Akira、Hitosugi Masahito、Miyagawa Shigeru、Ogita Hisakazu
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 3 Pages: 102993-102993
- DOI
  10.1016/j.jbc.2023.102993
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06854, KAKENHI-PROJECT-20K08489, KAKENHI-PROJECT-21K08119, KAKENHI-PROJECT-21K09419, KAKENHI-PROJECT-22H04922
[Journal Article] Identification of transmembrane protein 168 mutation in familial Brugada syndrome.2020
- Author(s)
  Shimizu A, Zankov DP, Sato A, Komeno M, Toyoda F, Yamazaki S, Makita T, Noda T, Ikawa M, Asano Y, Miyashita Y, Takashima S, Morita H, Ishikawa T, Makita N, Hitosugi M, Matsuura H, Ohno S, Horie M, Ogita H.
- Journal Title
  
  FASEB Journal
  
  Volume: 34 Issue: 5 Pages: 6399-6417
- DOI
  10.1096/fj.201902991r
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08075, KAKENHI-PROJECT-18K19550, KAKENHI-PROJECT-18KK0245, KAKENHI-ORGANIZER-19H05749, KAKENHI-PROJECT-17F17418, KAKENHI-PROJECT-17K08536, KAKENHI-PROJECT-17K08627, KAKENHI-PROJECT-17K08657, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K09408, KAKENHI-PROJECT-20K08489, KAKENHI-PROJECT-18H02808, KAKENHI-PROJECT-18K15894, KAKENHI-PROJECT-18K07875, KAKENHI-PROJECT-18K08033, KAKENHI-PROJECT-19H03652, KAKENHI-PROJECT-18K19547, KAKENHI-PROJECT-21K08119
[Journal Article] Mutant KCNJ3 and KCNJ5 potassium channels as novel molecular targets in bradyarrhythmias and atrial fibrillation.2019
- Author(s)
  Yamada N, Asano Y, Fujita M, Yamazaki S, Inanobe A, Matsuura N, Kobayashi H, Ohno S, Ebana Y, Tsukamoto O, Ishino S, Takuwa A, Kioka H, Yamashita T, Hashimoto N, Zankov DP, Shimizu A, Asakura M, Asanuma H, Kato H, Nishida Y, Miyashita Y, Shinomiya H, Naiki N, Hayashi K, Makiyama T, Ogita H, et al.
- Journal Title
  
  Circulation
  
  Volume: In press Issue: 18 Pages: 2157-2169
- DOI
  10.1161/circulationaha.118.036761
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08627, KAKENHI-PROJECT-17K08657, KAKENHI-PROJECT-17K09577, KAKENHI-PROJECT-17K09578, KAKENHI-PROJECT-18K07875, KAKENHI-PROJECT-18K08100, KAKENHI-PROJECT-17F17418, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-15KK0302, KAKENHI-PROJECT-17K07251, KAKENHI-PROJECT-18K08033, KAKENHI-PROJECT-19K08538, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H01560, KAKENHI-PROJECT-17K09495, KAKENHI-PROJECT-17H04018, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18H04074, KAKENHI-PROJECT-18H02803, KAKENHI-PROJECT-18H02808, KAKENHI-PROJECT-18K19547, KAKENHI-PROJECT-19H03652
[Journal Article] Protective effects of intercalated disk protein afadin on chronic pressure overload-induced myocardial damage.2017
- Author(s)
  Zankov DP, Shimizu A, Tanaka-Okamoto M, Miyoshi J, Ogita H.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 39335-39335
- DOI
  10.1038/srep39335
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460389, KAKENHI-PROJECT-15K09136
[Journal Article] Differential Effects of Myocardial Afadin on Pressure Overload-Induced Compensated Cardiac Hypertrophy2017
- Author(s)
  Zankov, D.P., Sato, A., Shimizu, A., and Ogita, H.
- Journal Title
  
  Circ J
  
  Volume: 81 Issue: 12 Pages: 1862-1870
- DOI
  10.1253/circj.CJ-17-0394
- NAID
  130006219260
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08623, KAKENHI-PROJECT-17K08627, KAKENHI-PROJECT-17K08657, KAKENHI-PROJECT-17F17418, KAKENHI-PROJECT-15K09136
[Journal Article] Novel therapeutic role for dipeptidyl peptidase III in the treatment of hypertension.2016
- Author(s)
  Pang X, Shimizu A, Kurita S, Zankov DP, Takeuchi K, Yasuda-Yamahara M, Kume S, Ishida T, Ogita H.
- Journal Title
  
  Hypertension
  
  Volume: 68 Issue: 3 Pages: 630-641
- DOI
  10.1161/hypertensionaha.116.07357
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460389, KAKENHI-PROJECT-15K09136
[Journal Article] Significance of serum Zn-α2-glycoprotein for the regulation of blood pressure.2015
- Author(s)
  Kurita S, Takeuchi K, Hayashi Y, Ueyama H, Zankov DP, Pang X, Otsuka T, Ohkubo I, Ogikubo O, Ogita H
- Journal Title
  
  Hypertens　Res
  
  Volume: 38 Issue: 4 Pages: 244-251
- DOI
  10.1038/hr.2014.165
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462711, KAKENHI-PROJECT-26460389, KAKENHI-PROJECT-15K09136, KAKENHI-PROJECT-25462712
[Presentation] Gain-of-Function KCND3 Variants Identified in Young Patients with Refractory Epilepsy might be a Cause of Sudden Unexpected Death in Epilepsy.2023
- Author(s)
  Byambajav Tserenlkham, Koichiro Takayama, Dimitar Zankov, Minoru Horie, Seiko Ohno
- Organizer
  Heart Rhythm Soceity Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08119
[Presentation] Desmoglein 2 mutant mice reproduce arrhythmogenic right ventricular2022
- Author(s)
  Zankov D, Ohno S.
- Organizer
  ESC Congress 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02888
[Presentation] Human-specific desmoglein 2 mutations in mice models of arrhythmogenic right ventricular cardiomyopathy reproduce patients' phenotype2021
- Author(s)
  Zankov Dimitar
- Organizer
  Europeean Heart Rhythm Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08119
[Presentation] Human-specific desmoglein 2 mutations in mice models of arrythmogenic right ventricular cardiomyopathy reproduce patients' phenotype2021
- Author(s)
  Zankov DP, Ohno S
- Organizer
  European Heart Rhythm Association Meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02888
[Presentation] Human-specific desmoglein 2 mutations in mice models of arrythmogenic right ventricular cardiomyopathy reproduce patients' phenotype2021
- Author(s)
  D.P. Zankov & S. Ohno.
- Organizer
  European heart rhythm association congress, April 23-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08033
[Presentation] A Novel TMEM168 Gene Mutation in Familial Brugada Syndrome Attenuates Na+ channel Function by Modulating Nav1.5 Expression2019
- Author(s)
  Dimitar Petrov Zankov
- Organizer
  Japanese Circulation Society Meeting
- Data Source
  KAKENHI-PROJECT-18K08033
[Presentation] Essential role of myocardial afadin in cardiac protecting during chronic pressure overload.2018
- Author(s)
  Dimitar P. Zankov、扇田久和
- Organizer
  日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-15K09136
[Presentation] Differential effects of myocardial afadin on pressure overload-induced compensated cardiac hypertrophy.2018
- Author(s)
  Dimitar P. Zankov
- Organizer
  日本循環器学会（Circulation Journal Award受賞講演）
- Invited
- Data Source
  KAKENHI-PROJECT-15K09136
[Presentation] Exome-wide analysis links nuclear membrane protein TMEM168 to the arrhythmogenesis in a family with inherited Brugada syndrome.2018
- Author(s)
  Dimitar P. Zankov、扇田久和
- Organizer
  先端モデル動物支援プラットフォーム成果発表会
- Data Source
  KAKENHI-PROJECT-15K09136
[Presentation] Intercalated disk protein afadin prevents pressure overload-induced cardiac dysfunction in a stimulus-dependent manner.2018
- Author(s)
  Dimitar P. Zankov、扇田久和
- Organizer
  日本循環器学会
- Data Source
  KAKENHI-PROJECT-15K09136
[Presentation] Deciphering signaling pathway of a novel cancer pro-invasive and -metastatic molecule, epithelial membrane protein 1.2017
- Author(s)
  Mohammad Khusni B. Ahamad Amin、清水昭男、Dimitar P. Zankov、佐藤朗、扇田久和
- Organizer
  生命科学系学会合同年次集会
- Data Source
  KAKENHI-PROJECT-15K09136
[Presentation] Critical role of myocardial afadin in cardiac protection during chronic mechanical overload.2017
- Author(s)
  Dimitar P. Zankov、清水昭男、佐藤朗、扇田久和
- Organizer
  日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-15K09136
[Presentation] Myocardial afadin is essential for maintaining cardiac function against mechanical stress-induced, but not pharmacological stimulation-mediated, pressure overload.2017
- Author(s)
  Hisakazu Ogita, Dimitar P. Zankov
- Organizer
  American Heart Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09136
[Presentation] Myocardial afadin critically oppose myocardial injury during chronic pressure overload in mice.2016
- Author(s)
  Dimitar P. Zankov, Akio Shimizu, Hisakazu Ogita.
- Organizer
  日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県・仙台市）
- Year and Date
  2016-09-27
- Data Source
  KAKENHI-PROJECT-15K09136
[Presentation] Myocardial afadin attenuates chronic pressure overload-induced cardiac damage via transforming growth factor β receptor-mediated signaling.2016
- Author(s)
  Hisakazu Ogita, Dimitar P. Zankov.
- Organizer
  American Heart Association
- Place of Presentation
  New Orleans（アメリカ合衆国）
- Year and Date
  2016-11-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09136
[Presentation] Myocardial afadin is a critical regulator for cardiac function in response to chronic pressure overload.2015
- Author(s)
  Dimitar P. Zankov, Hisakazu Ogita.
- Organizer
  日本循環器学会
- Place of Presentation
  大阪市
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-15K09136

1. OGITA Hisakazu (50379236)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
2. 大野聖子 (20610025)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. 牧山武 (30528302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 相庭武司 (40574348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 福山恵 (60625771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 加藤浩一 (70736983)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 園田桂子 (90824417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 高山幸一郎 (20816988)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Wang Qi (70756767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 上山久雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 清水昭男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 森田宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Zankov Dimitar Petrov ZANKOV DimitarP

Zankov Dimitar P. ZANKOV Dimitar P

Research Projects

Research Products

Co-Researchers

The elucidation of complicated genetic backgrounds and pathogenicity in patients with inherited primary arrhythmia syndromes caused by unknown etiology

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the pathology in ARVC caused by Japanese-specific DSG2 mutations using knock-in mice models: searching for the therapeutic targetsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of TMEM168 protein mutation in familial Brugada syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Genome-wide analysis to discover the gene mutation that relates to ventricular fibrillation and its molecular mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] RhoA rescues cardiac senescence by regulating Parkin-mediated mitophagy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of transmembrane protein 168 mutation in familial Brugada syndrome.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutant KCNJ3 and KCNJ5 potassium channels as novel molecular targets in bradyarrhythmias and atrial fibrillation.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protective effects of intercalated disk protein afadin on chronic pressure overload-induced myocardial damage.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differential Effects of Myocardial Afadin on Pressure Overload-Induced Compensated Cardiac Hypertrophy2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Novel therapeutic role for dipeptidyl peptidase III in the treatment of hypertension.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Significance of serum Zn-α2-glycoprotein for the regulation of blood pressure.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] Gain-of-Function KCND3 Variants Identified in Young Patients with Refractory Epilepsy might be a Cause of Sudden Unexpected Death in Epilepsy.2023

Author(s)

Organizer

Data Source

[Presentation] Desmoglein 2 mutant mice reproduce arrhythmogenic right ventricular2022

Author(s)

Organizer

Data Source

[Presentation] Human-specific desmoglein 2 mutations in mice models of arrhythmogenic right ventricular cardiomyopathy reproduce patients' phenotype2021

Author(s)

Organizer

Data Source

[Presentation] Human-specific desmoglein 2 mutations in mice models of arrythmogenic right ventricular cardiomyopathy reproduce patients' phenotype2021