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Inoue Miyuki  井上 みゆき

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井上 みゆき  イノウエ ミユキ

INOUE MIYUKI  井上 みゆき

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Researcher Number 20631766
Other IDs
Affiliation (Current) 2025: 熊本大学, 大学院生命科学研究部(医), 特定研究員
Affiliation (based on the past Project Information) *help 2022 – 2023: 熊本大学, 大学院生命科学研究部(医), 医学教育部研究員
2021: 熊本大学, 大学院生命科学研究部(医), 研究員
2016 – 2017: 熊本大学, 大学院生命科学研究部(医), 特任助教
2015: 熊本大学, 生命科学研究部, 特任助教
2014: 熊本大学, 大学院生命科学研究部(医), 特任助教
2013: 熊本大学, 生命科学研究部, 特任助教
Review Section/Research Field
Principal Investigator
Ophthalmology / Basic Section 56060:Ophthalmology-related
Except Principal Investigator
Basic Section 56060:Ophthalmology-related
Keywords
Principal Investigator
TGF-β2 / 線維柱帯細胞 / 緑内障 / 線維化 / 結膜線維芽細胞 / TGF-β / STAT3 / 可溶性IL-6レセプター / soluble IL-6 receptor / IL-6 / サイトカイン … More
Except Principal Investigator
… More ファイブロサイト / 線維化 / エピゲノム / 創傷治癒 / 緑内障 Less
  • Research Projects

    (4 results)
  • Research Products

    (35 results)
  • Co-Researchers

    (11 People)
  •  Analysis of epigenetic change and gene regulation mechanisms involved in intracellular metabolism in glaucoma pathogenesis.Principal Investigator

    • Principal Investigator
      井上 みゆき
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56060:Ophthalmology-related
    • Research Institution
      Kumamoto University
  •  Study on epigenetic changes and memory effects in wound healing after glaucoma surgery

    • Principal Investigator
      Inoue Toshihiro
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56060:Ophthalmology-related
    • Research Institution
      Kumamoto University
  •  Investigation of glaucoma pathogenesis based on molecular signalings of TGF-beta and IL-6-medicated trans-signalingPrincipal Investigator

    • Principal Investigator
      Inoue Miyuki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Kumamoto University
  •  Investigation of regulatory mechanisms of aqueous outflow based on molecular signalings of TGF-beta and proinflammatory cytokines.Principal Investigator

    • Principal Investigator
      INOUE MIYUKI
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Ophthalmology
    • Research Institution
      Kumamoto University

All 2024 2023 2022 2021 2018 2017 2016 2014 2013 Other

All Journal Article Presentation

  • [Journal Article] Disease-Modifying Drugs Extend Survival in Hereditary Transthyretin Amyloid Polyneuropathy2024

    • Author(s)
      Ueda M, Misumi Y, Nomura T, Tasaki M, Yamakawa S, Obayashi K, Yamashita T, Ando Y.
    • Journal Title

      Ann Neurol

      Volume: 95 Pages: 230-236

    • DOI

      10.1016/j.bbrc.2023.149397

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07528, KAKENHI-PROJECT-23K09062, KAKENHI-PROJECT-21K09703, KAKENHI-PROJECT-23K24245
  • [Journal Article] Predicting the Extent of Damage in the Humphrey Field Analyzer 24-2 Visual Fields Using 10-2 Test Results in Patients With Advanced Glaucoma2024

    • Author(s)
      Asaoka Ryo、Sugisaki Kenji、Inoue Toshihiro、Yoshikawa Keiji、Kanamori Akiyasu、Yamazaki Yoshio、Ishikawa Shinichiro、Uchida Kenichi、Iwase Aiko、Araie Makoto、for Advanced Glaucoma Study Members in Japan Glaucoma Society
    • Journal Title

      Translational Vision Science & Technology

      Volume: 13 Issue: 2 Pages: 2-2

    • DOI

      10.1167/tvst.13.2.2

    • Data Source
      KAKENHI-PROJECT-21K09703
  • [Journal Article] Risk factors for Baerveldt glaucoma drainage implantation for uveitic glaucoma2023

    • Author(s)
      Manako Kiyofumi、Takahashi Eri、Saruwatari Junji、Matsumura Tomoyo、Kojima Sachi、Inoue Toshihiro
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 4473-4473

    • DOI

      10.1038/s41598-023-29244-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K16899, KAKENHI-PROJECT-20K07134, KAKENHI-PROJECT-21K09703
  • [Journal Article] A case of melanoma complicated with uveitis induced by two types of BRAF/MEK inhibitors and nivolumab treatment2023

    • Author(s)
      Obaru Chiaki、Kimura Toshihiro、Yamamura Manami、Kuriyama Haruka、Kashiwada‐Nakamura Kayo、Mizuhashi Satoru、Matsumura Tomoyo、Watanabe Takahiro、Inoue Toshihiro、Fukushima Satoshi
    • Journal Title

      The Journal of Dermatology

      Volume: 51 Issue: 4

    • DOI

      10.1111/1346-8138.17015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K16285, KAKENHI-PROJECT-23K15271, KAKENHI-PROJECT-21K08351, KAKENHI-PROJECT-21K09703
  • [Journal Article] A ROCK inhibitor suppresses the transforming growth factor-beta-2-induced endothelial-mesenchymal transition in Schlemm’s canal endothelial cells2023

    • Author(s)
      Fujimoto Tomokazu、Inoue-Mochita Miyuki、Inoue Toshihiro
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 149397-149397

    • DOI

      10.1038/s41598-023-36808-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K09768, KAKENHI-PROJECT-22K09794, KAKENHI-PROJECT-21K09703
  • [Journal Article] Ipilimumab-related uveitis and refractory hypotony with a flat chamber in a trabeculectomized eye with exfoliation glaucoma: A case report2023

    • Author(s)
      Funagura Naofumi、Fukushima Satoshi、Inoue Toshihiro
    • Journal Title

      American Journal of Ophthalmology Case Reports

      Volume: 29 Pages: 101807-101807

    • DOI

      10.1016/j.ajoc.2023.101807

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08351, KAKENHI-PROJECT-21K09703
  • [Journal Article] Tissue Reactivity to, and Stability of, Glaucoma Drainage Device Materials Placed Under Rabbit Conjunctiva2022

    • Author(s)
      Kenichi Nakamura, Tomokazu Fujimoto, Miho Okada, Kentaro Maki, Atsushi Shimazaki, Masatomo Kato, Toshihiro Inoue
    • Journal Title

      Translational Vision Science and Technology

      Volume: 11 Issue: 4 Pages: 9-9

    • DOI

      10.1167/tvst.11.4.9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09703
  • [Journal Article] Elevated soluble vascular endothelial growth factor receptor levels in aqueous humor from patients with different types of glaucoma.2022

    • Author(s)
      Kenichi Nakamura, Sachi Kojima, Miyuki Inoue-Mochita, Hidenobu Tanihara, Toshihiro Inoue
    • Journal Title

      Experimental Eye Research

      Volume: 223 Pages: 109204-109204

    • DOI

      10.1016/j.exer.2022.109204

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K09703, KAKENHI-PROJECT-21K16899
  • [Journal Article] Intraocular Pressure-Lowering Effects of Trabeculectomy Versus MicroShunt Insertion in Rabbit Eyes2021

    • Author(s)
      Fujimoto Tomokazu、Nakashima Kei-Ichi、Watanabe-Kitamura Fumika、Watanabe Takahiro、Nakamura Kenichi、Maki Kentaro、Shimazaki Atsushi、Kato Masatomo、Tanihara Hidenobu、Inoue Toshihiro
    • Journal Title

      Translational Vision Science & Technology

      Volume: 10 Issue: 9 Pages: 9-9

    • DOI

      10.1167/tvst.10.9.9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K09703
  • [Journal Article] Potential roles of the IL-6 family in conjunctival fibrosis2021

    • Author(s)
      Watanabe-Kitamura Fumika、Ogawa Akiko、Fujimoto Tomokazu、Iraha Satoshi、Inoue-Mochita Miyuki、Watanabe Takahiro、Takahashi Eri、Tanihara Hidenobu、Inoue Toshihiro
    • Journal Title

      Experimental Eye Research

      Volume: 210 Pages: 108708-108708

    • DOI

      10.1016/j.exer.2021.108708

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K18371, KAKENHI-PROJECT-21K09703
  • [Journal Article] Stimulation of the adenosine A3 receptor, not the A1 or A2 receptors, promote neurite outgrowth of retinal ganglion cells2018

    • Author(s)
      Nakashima Kei-Ichi、Iwao Keiichiro、Inoue Toshihiro、Haga Akira、Tsutsumi Takayuki、Mochita Miyuki Inoue、Fujimoto Tomokazu、Tanihara Hidenobu
    • Journal Title

      Experimental Eye Research

      Volume: 170 Pages: 160-168

    • DOI

      10.1016/j.exer.2018.02.019

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11458, KAKENHI-PROJECT-17K11485, KAKENHI-PROJECT-15K10872, KAKENHI-PROJECT-17H04351
  • [Journal Article] YAP/TAZ are essential for TGF-β2-mediated conjunctival fibrosis2018

    • Author(s)
      Futakuchi A, Inoue T, Wei FY, Inoue M, Fujimoto T, Tomizawa K, and Tanihara H
    • Journal Title

      Investigative Ophthalmology & visual science

      Volume: 印刷中

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10872
  • [Journal Article] Decreased MCP-1/CCR2 axis-mediated chemotactic effect of conjunctival fibroblasts after transdifferentiation into myofibroblasts.2018

    • Author(s)
      Tsutsumi-Kuroda U, Inoue T, Futakuchi A, Shobayashi K, Takahashi E, Kojima S, Inoue-Mochita M, Fujimoto T, Tanihara H.
    • Journal Title

      Exp Eye Res.

      Volume: 170 Pages: 76-80

    • DOI

      10.1016/j.exer.2018.02.008

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11485, KAKENHI-PROJECT-15K10872, KAKENHI-PROJECT-17K11458, KAKENHI-PROJECT-18K16929, KAKENHI-PROJECT-17H04351
  • [Journal Article] Inhibition of Rho Kinase Induces Antioxidative Molecules and Suppresses Reactive Oxidative Species in Trabecular Meshwork Cells.2017

    • Author(s)
      Fujimoto T, Inoue T, Ohira S, Awai-Kasaoka N, Kameda T, Inoue-Mochita M, Tanihara H.
    • Journal Title

      Journal of Ophthalmology

      Volume: 2017 Pages: 7598140-7598140

    • DOI

      10.1155/2017/7598140

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K11289, KAKENHI-PROJECT-17K11458, KAKENHI-PROJECT-17K19729, KAKENHI-PROJECT-17H04351, KAKENHI-PROJECT-15K10872
  • [Journal Article] Molecular mechanisms underlying the filtration bleb-maintaining effects of suberoylanilide hydroxamic acid (SAHA).2017

    • Author(s)
      Futakuchi A, Inoue T, Fujimoto T, Kuroda U, Inoue-Mochita M, Takahashi E, Ohira S, Tanihara H.
    • Journal Title

      Investigative Ophthalmology & Visual Sciences

      Volume: 58 Issue: 4 Pages: 2421-2429

    • DOI

      10.1167/iovs.16-21403

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26293375, KAKENHI-PROJECT-26462693, KAKENHI-PROJECT-15K15636, KAKENHI-PROJECT-15K10872, KAKENHI-PROJECT-17K11458, KAKENHI-PROJECT-17H04351
  • [Journal Article] Live cell imaging of actin dynamics in dexamethasone-treated porcine trabecular meshwork cells2016

    • Author(s)
      Tomokazu Fujimoto, Toshihiro Inoue, Miyuki Inoue-Mochita, Hidenobu Tanihara
    • Journal Title

      Experimental Eye Research

      Volume: 145 Pages: 393-400

    • DOI

      10.1016/j.exer.2016.02.007

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10872, KAKENHI-PROJECT-15K15636, KAKENHI-PROJECT-26293375, KAKENHI-PROJECT-26462664
  • [Journal Article] The effects of ripasudil (K-115), a Rho kinase inhibitor, on activation of human conjunctival fibroblasts.2016

    • Author(s)
      Futakuchi A, Inoue T, Fujimoto T, Inoue-Mochita M, Kawai M, Tanihara H.
    • Journal Title

      Experimental Eye Research

      Volume: 149 Pages: 107-115

    • DOI

      10.1016/j.exer.2016.07.001

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26293375, KAKENHI-PROJECT-26462664, KAKENHI-PROJECT-26462693, KAKENHI-PROJECT-15K15636, KAKENHI-PROJECT-15K10857, KAKENHI-PROJECT-15K10872
  • [Journal Article] Vascular Endothelial Growth Factor-A Increases the Aqueous Humor Outflow Facility.2016

    • Author(s)
      Fujimoto T, Inoue T, Maki K, Inoue-Mochita M, Tanihara H.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 9 Pages: e0161332-e0161332

    • DOI

      10.1371/journal.pone.0161332

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26293375, KAKENHI-PROJECT-26462664, KAKENHI-PROJECT-15K10872, KAKENHI-PROJECT-16K11289
  • [Journal Article] p38 MAP Kinase Inhibitor Suppresses Transforming Growth Factor-β2-Induced Type 1 Collagen Production in Trabecular Meshwork Cells.2014

    • Author(s)
      Inoue-Mochita M, Inoue T, Fujimoto T, Kameda T, Awai-Kasaoka N, Ohtsu N, Kimoto K, Tanihara H.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 3 Pages: 1-13

    • DOI

      10.1371/journal.pone.0120774

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25670735, KAKENHI-PROJECT-25861640, KAKENHI-PROJECT-26293375, KAKENHI-PROJECT-26462693, KAKENHI-PROJECT-26462664
  • [Journal Article] Oxidative stress response siganling pathways in trabecular meshwork cells and their effects on cell viability2013

    • Author(s)
      Awai-Kasaoka N, Inoue T, Kameda T, Fujimoto T, Inoue-Mochita M, Tanihara H
    • Journal Title

      Molecular Vision

      Volume: 19 Pages: 1332-1340

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25861640
  • [Presentation] 結膜線維芽細胞におけるせりンーグリシン代謝酵素に対するLSD1阻害剤の効果2024

    • Author(s)
      井上みゆき、船蔵直史、古賀友紹、藤本智和、中尾光善、井上俊洋
    • Organizer
      第128回 日本眼科学会総会
    • Data Source
      KAKENHI-PROJECT-22K09768
  • [Presentation] マイトマイシンCはヒト結膜線維芽細胞に細胞老化を誘導する2023

    • Author(s)
      木村 顕俊, 藤本 智和, 伊良波 諭, 井上 俊洋
    • Organizer
      第127回日本眼科学会総会
    • Data Source
      KAKENHI-PROJECT-21K09703
  • [Presentation] ぶどう膜炎続発緑内障に対するバルベルトインプラント挿入術の成績と危険因子2023

    • Author(s)
      松村 智世, 眞名子 聖史, 高橋 枝里, 小島 祥, 瀧原 祐史, 井上 俊洋
    • Organizer
      第127回日本眼科学会総会
    • Data Source
      KAKENHI-PROJECT-21K09703
  • [Presentation] リジン特異的脱メチル化酵素Kdm7aはM1/M2マクロファージ均衡を制御する2023

    • Author(s)
      船藏直史, 古賀友紹, 洪 性賢, 衛藤 貫, 井上俊洋, 中尾光善
    • Organizer
      第46回日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-21K09703
  • [Presentation] 新しい濾過手術用デバイスの可能性.2022

    • Author(s)
      井上俊洋
    • Organizer
      第33回日本緑内障学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K09703
  • [Presentation] シュレム管内皮細胞におけるTGF-β2誘発EndMT様変化に対するROCK阻害剤の影響2022

    • Author(s)
      藤本智和, 井上みゆき, 井上俊洋
    • Organizer
      第126回日本眼科学会総会
    • Data Source
      KAKENHI-PROJECT-21K09703
  • [Presentation] TGF-β-induced activation of conjunctival fibroblasts is modulated by FGF-2 and substratum stiffness.2021

    • Author(s)
      Matsumura T, Fujimoto T, Iraha S, Futakuchi A, Takihara Y, Watanabe-Kitamura F, Takahashi E, Inoue-Mochita M, Inoue T.
    • Organizer
      9th World Glaucoma E-Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K09703
  • [Presentation] Transcriptomics in rabbit bleb after trabeculectomy or Microshunt insertion2021

    • Author(s)
      Fujimoto T, Watanabe-Kitamura F, Maki K, Shimazaki A, Kato M, Tanihara H, Inoue T.
    • Organizer
      9th World Glaucoma E-Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K09703
  • [Presentation] The effects of materials of glaucoma drainage devices on rabbit's ocular tissue.2021

    • Author(s)
      Nakamura K, Fujimoto T, Maki K, Shimazaki A, Kato M, Tanihara H, Inoue T.
    • Organizer
      9th World Glaucoma E-Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K09703
  • [Presentation] Pseudoexfoliation-latest update, Challenges of glaucoma surgery2021

    • Author(s)
      Inoue T
    • Organizer
      9th World Glaucoma E-Congress
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K09703
  • [Presentation] ヒト線維柱帯細胞の線維化に対するインターロイキン6シグナルの役割2016

    • Author(s)
      井上みゆき、井上俊洋、二口亜希子、藤本智和、小島祥、谷原秀信
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15K10872
  • [Presentation] Visualization of actin filament using time-lapse fluorescent microscopy in trabecular meshwork cells2013

    • Author(s)
      Fujimoto T, Inoue T, Inoue-Mochita M, Kasaoka N, Shobayashi K, Tanihara H
    • Organizer
      World Glaucoma Congress 2013
    • Place of Presentation
      Vancouver, Canada
    • Data Source
      KAKENHI-PROJECT-25861640
  • [Presentation] Identification of TGF-β2-induced proinflammatory cytokines secreted from cultured trabecular meshwork cells2013

    • Author(s)
      Inoue-Mochita M, Inoue T, Fujimoto T, Awai-Kasaoka N, Tanihara H
    • Organizer
      The Annual Meeting of the Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Seattle, Washington, USA
    • Data Source
      KAKENHI-PROJECT-25861640
  • [Presentation] 線維柱帯細胞内TGF-β2シグナルに対するROCK阻害剤およびp38阻害剤の影響

    • Author(s)
      井上 みゆき
    • Organizer
      日本眼科学会
    • Place of Presentation
      帝国ホテル(東京)
    • Year and Date
      2014-04-02 – 2014-04-06
    • Data Source
      KAKENHI-PROJECT-25861640
  • [Presentation] Effects of p38 inhibitor on TGF-β2 signal in trabecular meshwork cells

    • Author(s)
      Miyuki Inoue-Mochita, Toshihiro Inoue, Tomokazu Fujimoto, Nanako Awai-Kasaoka, Hidenobu Tanihara
    • Organizer
      ARVO (The association for research in Vision and Ophthalmology)2014
    • Place of Presentation
      Orland, FL, U.S.A
    • Year and Date
      2014-05-04 – 2014-05-08
    • Data Source
      KAKENHI-PROJECT-25861640
  • 1.  Inoue Toshihiro (00317025)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 24 results
  • 2.  谷原 秀信 (60217148)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 3.  藤本 智和 (50756426)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 4.  UEDA Mitsuharu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  FUKUSHIMA Satoshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  小島 祥
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  安東 由喜雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  田崎 雅義
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  木村 俊寛
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  小川 亜希子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  高橋 枝里
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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