Inagaki Tadakatsu 稲垣薫克

… Alternative Names

INAGAKI TADAKATSU 稲垣薫克

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Researcher Number	20638366
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員 2019 – 2023: 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員 2017 – 2018: 国立研究開発法人国立循環器病研究センター, 研究所, 研究員 2017: 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員 2016: 独立行政法人国立循環器病研究センター, 血管生理学部, 上級研究員 … More 2015: 国立研究開発法人国立循環器病研究センター, 研究所, 研究員 2015: 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員 2013 – 2014: 独立行政法人国立循環器病研究センター, 研究所, 流動研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine / Environmental physiology(including physical medicine and nutritional physiology) Except Principal Investigator Cardiovascular medicine / Basic Section 53020:Cardiology-related / Emergency medicine
Keywords	Principal Investigator 肺高血圧症 / Interleukin-6 / 肺動脈性肺高血圧症 / 右心不全 / 血管リモデリング / 炎症性サイトカイン / 炎症 / 肺血管リモデリング / 免疫細胞 / 炎症性サイトカイ … More / Interleukin-21 / ヘルパーT細胞 / interleukin-6 / 血管内皮機能障害 / 慢性低酸素 / 肺高血圧 / 血管内皮機能 / 血管造影 / Su5416 / 低酸素 / 冠動脈 / 右心肥大 … More Except Principal Investigator 循環器・高血圧 / インターロイキン-6 / サイトカイン / IL-6 / CD4 T細胞 / gp130 / 肺動脈性肺高血圧症 / 肺血管リモデリング / CD4陽性細胞 / interleukin-6 / 肺高血圧症 / 放射光Ｘ線回折法 / 心筋拡張機能障害 / 放射光X線回折法 / 心筋収縮タンパク質 / 心臓拡張機能障害 / 糖尿病 / ミオグロビン / 心虚血・再灌流 / モノアミンオキシダーゼ / マイクロダイアリシス法 / ヒドロキシラジカル / モノアミン / 虚血・再灌流 / 心臓 / 微小循環 / 肺交感神経活動 / 肺循環 / 間歇的低酸素 / 高血圧自然発症ラット / 延髄微小循環 / 心臓血管中枢 / 交感神経活動 / 高血圧 Less

獲得免疫系を介した肺高血圧症の病態形成機構の解明Principal Investigator
- Principal Investigator
  
  稲垣薫克
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
炎症シグナルによる肺動脈性肺高血圧症の発症機構解明に向けた基盤的研究Principal Investigator
- Principal Investigator
  
  稲垣薫克
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
Role of gp130-dependent cytokine signaling in pulmonary hypertension
- Principal Investigator
  
  Ishibashi Tomohiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
Fundamental research for the development of a new strategy for the treatment of severe pulmonary hypertension by IL-6 blockadePrincipal Investigator
- Principal Investigator
  
  Inagaki Tadakatsu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
Development of a treatment for pulmonary arterial hypertension focusing on inflammatory endothelial dysfunctionPrincipal Investigator
- Principal Investigator
  
  Inagaki Tadakatsu
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  National Cardiovascular Center Research Institute
Synchrotron radiation investigation of cardiac contractile protein dynamics at end diastole in a type 2 prediabetes model rat
- Principal Investigator
  
  SHIRAI Mikiyasu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular medicine
- Research Institution
  National Cardiovascular Center Research Institute
Role of microvascular dysfunction in the cardiovascular center for development of hypertension
- Principal Investigator
  
  Shirai Mikiyasu
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular medicine
- Research Institution
  National Cardiovascular Center Research Institute
Monoamine oxidae-induced hydroxyl radical production and cardiomyocyte injury during myocardial ischemia-reperfusion
- Principal Investigator
  
  AKIYAMA Tsuyoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  National Cardiovascular Center Research Institute
Elucidation of the transition mechanism of right ventricular hypertrophy to failure due to chronic hypoxiaPrincipal Investigator
- Principal Investigator
  
  Inagaki Tadakatsu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental physiology(including physical medicine and nutritional physiology)
- Research Institution
  National Cardiovascular Center Research Institute

All 2024 2023 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Patent

[Journal Article] IL-6/gp130 signaling in CD4+ T cells drives the pathogenesis of pulmonary hypertension.2024
- Author(s)
  Ishibashi T, Inagaki T, Okazawa M, Yamagishi A, Ohta-Ogo K, Asano R, Masaki T, Kotani Y, Ding X, Chikaishi-Kirino T, Maedera N, Shirai M, Hatakeyama K, Kubota Y, Kishimoto T, Nakaoka Y.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 121 Issue: 16
- DOI
  10.1073/pnas.2315123121
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08144, KAKENHI-PROJECT-21K08070, KAKENHI-PROJECT-23K27605
[Journal Article] Evaluation of right coronary vascular dysfunction in severe pulmonary hypertensive rats using synchrotron radiation microangiography2021
- Author(s)
  Inagaki Tadakatsu、Pearson James T.、Tsuchimochi Hirotsugu、Schwenke Daryl O.、Saito Shigeyoshi、Higuchi Takahiro、Masaki Takeshi、Umetani Keiji、Shirai Mikiyasu、Nakaoka Yoshikazu
- Journal Title
  
  American Journal of Physiology-Heart and Circulatory Physiology
  
  Volume: 320 Issue: 3 Pages: H1021-H1036
- DOI
  10.1152/ajpheart.00327.2020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08506
[Journal Article] Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension2021
- Author(s)
  Masaki T, Okazawa M, Asano R, Inagaki T, Ishibashi T, Yamagishi A, Umeki-Mizushima S, Nishimura M, Manabe Y, Ishibashi-Ueda H, Shirai M, Tsuchimochi H, Pearson JT, Kumanogoh A, Sakata Y, Ogo T, Kishimoto T, Nakaoka Y
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 118 Issue: 11
- DOI
  10.1073/pnas.2023899118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17622, KAKENHI-PROJECT-20K17137, KAKENHI-PROJECT-19K08506
[Journal Article] Pristane/Hypoxia (PriHx) Mouse as a Novel Model of Pulmonary Hypertension Reflecting Inflammation and Fibrosis2020
- Author(s)
  Mori Hiroyoshi、Ishibashi Tomohiko、Inagaki Tadakatsu、Okazawa Makoto、Masaki Takeshi、Asano Ryotaro、Manabe Yusuke、Ohta-Ogo Keiko、Narazaki Masashi、Ishibashi-Ueda Hatsue、Kumanogoh Atsushi、Nakaoka Yoshikazu
- Journal Title
  
  Circ J
  
  Volume: 84 Issue: 7 Pages: 1163-1172
- DOI
  10.1253/circj.CJ-19-1102
- NAID
  130007864283
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2020-06-25
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08506, KAKENHI-PROJECT-20K17137, KAKENHI-PROJECT-17K10002, KAKENHI-PROJECT-19K17622
[Journal Article] Angiotensin-converting enzyme 2 deficiency accelerates and angiotensin 1-7 restores age-related muscle weakness in mice.2018
- Author(s)
  Takeshita H, Yamamoto K, Nozato S, Takeda M, Fukada SI, Inagaki T, Tsuchimochi H, Shirai M, Nozato Y, Fujimoto T, Imaizumi Y, Yokoyama S, Nagasawa M, Hamano G, Hongyo K, Kawai T, Hanasaki-Yamamoto H, Takeda S, Takahashi T, Akasaka H, Itoh N, Takami Y, Takeya Y, Sugimoto K, Nakagami H, Rakugi H.
- Journal Title
  
  J Cachexia Sarcopenia Muscle.
  
  Volume: 9 Issue: 5 Pages: 975-986
- DOI
  10.1002/jcsm.12334
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H03262, KAKENHI-PROJECT-17H05080, KAKENHI-PROJECT-17K16033
[Journal Article] Ghrelin Preserves Ischemia-Induced Vasodilation of Male Rat Coronary Vessels Following β-Adrenergic Receptor Blockade2018
- Author(s)
  Pearson James T、Collie Nicola、Lamberts Regis R、Inagaki Tadakatsu、Yoshimoto Misa、Umetani Keiji、Davis Philip、Wilkins Gerard、Jones Pete P、Shirai Mikiyasu、Schwenke Daryl O
- Journal Title
  
  Endocrinology
  
  Volume: 159 Issue: 4 Pages: 1763-1773
- DOI
  10.1210/en.2017-03070
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16033
[Journal Article] Myocardial interstitial levels of serotonin and its major metabolite 5-hydroxyindole acetic acid during ischemia-reperfusion.2017
- Author(s)
  Du CK, Zhan DY, Akiyama T, Inagaki T, Shishido T, Shirai M, Pearson JT.
- Journal Title
  
  Am J Physiol Heart Circ Physiol.
  
  Volume: 312(1) Issue: 1 Pages: H60-H67
- DOI
  10.1152/ajpheart.00471.2016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-15F15119, KAKENHI-PROJECT-26462774, KAKENHI-PROJECT-16K08514, KAKENHI-PROJECT-16K15452
[Journal Article] Analysis of the microvascular morphology and hemodynamics of breast cancer in mice using SPring-8 synchrotron radiation microangiography.2017
- Author(s)
  Torii M, Fukui T, Inoue M, Kanao S, Umetani K, Shirai M, Inagaki T, Tsuchimochi H, Pearson JT, Toi M.
- Journal Title
  
  J Synchrotron Radiat
  
  Volume: 24 Issue: 5 Pages: 1039-1047
- DOI
  10.1107/s1600577517008372
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16033, KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-16K15452
[Journal Article] Widespread Coronary Dysfunction in the Absence of HDL Receptor SR-B1 in an Ischemic Cardiomyopathy Mouse Model.2017
- Author(s)
  Pearson JT, Yoshimoto M, Chen YC, Sultani R, Edgley AJ, Nakaoka H, Nishida M, Umetani K, Waddingham MT, Jin HL, Zhang Y, Kelly DJ, Schwenke DO, Inagaki T, Tsuchimochi H, Komuro I, Yamashita S, Shirai M.
- Journal Title
  
  Sci Rep
  
  Volume: Dec 22;7(1) Issue: 1 Pages: 18108-18108
- DOI
  10.1038/s41598-017-18485-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16033, KAKENHI-INTERNATIONAL-15K21716, KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-17H02100, KAKENHI-PROJECT-16K15452
[Journal Article] 2.Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice.2017
- Author(s)
  Takeshita H, Yamamoto K, Nozato S, Inagaki T, Tsuchimochi H, Shirai M, Yamamoto R, Imaizumi Y, Hongyo K, Yokoyama S, Takeda M, Oguro R, Takami Y, Itoh N, Takeya Y, Sugimoto K, Fukada SI, Rakugi H.
- Journal Title
  
  Scientific reports
  
  Volume: 7 Issue: 1 Pages: 42323-42323
- DOI
  10.1038/srep42323
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15273, KAKENHI-PROJECT-17K16033
[Journal Article] Chronic intermittent hypoxia accelerates coronary microcirculatory dysfunction in insulin-resistant Goto-Kakizaki rats.2016
- Author(s)
  Chen YC, Inagaki T, Fujii Y, Schwenke DO, Tsuchimochi H, Edgley AJ, Umetani K, Zhang Y, Kelly DJ, Yoshimoto M, Nagai H, Evans RG, Kuwahira I, Shirai M, Pearson JT.
- Journal Title
  
  Am J Physiol Regul Integr Comp Physiol.
  
  Volume: 311(2) Issue: 2 Pages: 426-439
- DOI
  10.1152/ajpregu.00112.2016
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-26860165, KAKENHI-PROJECT-16K15452, KAKENHI-PROJECT-15K21692
[Journal Article] Monoamine oxidase-induced hydroxyl radical production and cardiomyocyte injury during myocardial ischemia-reperfusion in rats2016
- Author(s)
  Tadakatsu Inagaki, Tsuyoshi Akiyama, Cheng-Kun Du, Dong-Yun Zhan, Misa Yoshimoto & Mikiyasu Shirai
- Journal Title
  
  Free Radical Research
  
  Volume: 50 Issue: 6 Pages: 645-653
- DOI
  10.3109/10715762.2016.1162300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15F15119, KAKENHI-PROJECT-26462774, KAKENHI-PROJECT-26860165, KAKENHI-PROJECT-16K08514
[Journal Article] Ghrelin promotes functional angiogenesis in a mouse model of critical limb ischemia through activation of pro-angiogenic microRNAs2016
- Author(s)
  Rajesh Katare, Shruti Rawal, Pujika E Munasinghe, Parul Dixit, Hirotsugu Tsuchimochi, Tadakatsu Inagaki, Yutaka Fujii, Keiji Umetani, Kenji Kangawa, Mikiyasu Shirai, Daryl Schwenke
- Journal Title
  
  Endocrinology
  
  Volume: 157 Issue: 2 Pages: 432-445
- DOI
  10.1210/en.2015-1799
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25350547, KAKENHI-PROJECT-25860184
[Journal Article] pH buffering of single rat skeletal muscle fibers in the in vivo environment.2016
- Author(s)
  Yoshinori Tanaka, Tadakatsu Inagaki, David C. Poole and Yutaka Kano.
- Journal Title
  
  American Journal of Physiology - Regulatory, Integrative and Comparative Physiology.
  
  Volume: in press Issue: 10 Pages: R926-R933
- DOI
  10.1152/ajpregu.00501.2015
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12665, KAKENHI-PROJECT-25860184, KAKENHI-PROJECT-16H03240
[Journal Article] Monoamine oxidase-induced hydroxyl radical production and cardiomyocyte injury during myocardial ischemia-reperfusion in rats.2016
- Author(s)
  Inagaki T, Akiyama T, Du CK, Zhan DY, Yoshimoto M, Shirai M.
- Journal Title
  
  Free Radic Res.
  
  Volume: Apr 24 Pages: 1-9
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25860184
[Journal Article] Pulmonary Macrophages Attenuate Hypoxic Pulmonary Vasoconstriction via β3AR/iNOS Pathway in Rats Exposed to Chronic Intermittent Hypoxia2015
- Author(s)
  Hisashi Nagai, Ichiro Kuwahira, Daryl O. Schwenke, Hirotsugu Tsuchimochi, Akina Nara, Sayoko Ogura, Takashi Sonobe, Tadakatsu Inagaki, Yutaka Fujii, Rutsuko Yamaguchi, Lisa Wingenfeld, Keiji Umetani, Tatsuo Shimosawa, Kenichi Yoshida, Koichi Uemura, James T. Pearson, Mikiyasu Shirai
- Journal Title
  
  PLoS ONE
  
  Volume: 10 Issue: 7 Pages: 1-20
- DOI
  10.1371/journal.pone.0131923
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25350547, KAKENHI-PROJECT-26670413, KAKENHI-PROJECT-25860184, KAKENHI-PROJECT-26461262
[Journal Article] Microvascular oxygen partial pressure during hyperbaric oxygen in diabetic rat skeletal muscle.2015
- Author(s)
  Kohei Yamakoshi, Kazuyoshi Yagishita, Hirotsugu Tsuchimochi, Tadakatsu Inagaki, Mikiyasu Shirai,
- Journal Title
  
  Am. J. Physiol. Regul. Integr. Comp. Physiol
  
  Volume: 309(12) Issue: 12 Pages: 1512-1520
- DOI
  10.1152/ajpregu.00380.2015
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10433, KAKENHI-PROJECT-25860184
[Journal Article] Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension2015
- Author(s)
  Hashimoto-Kataoka T, Hosen N, Sonobe T, Arita Y, Yasui T, Masaki T, Minami M, Inagaki T, Miyagawa S, Sawa Y, Murakami M, Kumanogoh A, Yamauchi-Takihara K, Okumura M, Kishimoto T, Komuro I, Shirai M, Sakata Y, and Nakaoka Y
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: Early Edition Issue: 20 Pages: 1-10
- DOI
  10.1073/pnas.1424774112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25860184, KAKENHI-PROJECT-15K01712, KAKENHI-PROJECT-15K15309, KAKENHI-PROJECT-26670413, KAKENHI-PROJECT-25293183
[Journal Article] Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing myosin cross-bridge extension.2015
- Author(s)
  Waddingham MT, Edgley AJ, Astolfo A, Inagaki T, Fujii Y, Du CK, Zhan DY, Tsuchimochi H, Yagi N, Kelly DJ, Shirai M, Pearson JT.
- Journal Title
  
  Cardiovasc Diabetol
  
  Volume: 14 Issue: 1 Pages: 92-105
- DOI
  10.1186/s12933-015-0256-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21692, KAKENHI-PROJECT-15F15119, KAKENHI-PROJECT-26670413, KAKENHI-PROJECT-25860184
[Journal Article] Myocardial interstitial levels of serotonin and its major metabolite, 5-hydroxyindole acetic acid, in in vivo rat heart2014
- Author(s)
  Cheng-Kun Du, Dong-Yun Zhan, Tsuyoshi Akiyama, Takashi Sonobe, Tadakatsu Inagaki, Mikiyasu Shirai
- Journal Title
  
  Life Sciences
  
  Volume: １１７ Issue: 1 Pages: 33-39
- DOI
  10.1016/j.lfs.2014.09.019
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24790791, KAKENHI-PROJECT-25860184, KAKENHI-PROJECT-25871236, KAKENHI-PROJECT-26462774
[Journal Article] Beta2-adrenergic receptor-dependent attenuation of hypoxic pulmonary vasoconstriction prevents progression of pulmonary arterial hypertension in intermittent hypoxic rats2014
- Author(s)
  Hisashi Nagai, Ichiro Kuwahira, Daryl O. Schwenke, Hirotsugu Tsuchimochi, Akina Nara, Tadakatsu Inagaki, Sayoko Ogura, Yutaka Fujii, Keiji Umetani, Tatsuo Shimosawa, Kenichi Yoshida, James T. Pearson, Koichi Uemura, Mikiyasu Shirai
- Journal Title
  
  PLOS ONE
  
  Volume: 10 Issue: 10 Pages: 1-10
- DOI
  10.1371/journal.pone.0110693
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25350547, KAKENHI-PROJECT-25860184, KAKENHI-PROJECT-26461262, KAKENHI-PROJECT-26670413
[Journal Article] Pulmonary vascular tone is dependent on the central modulation of sympathetic nerve　activity following chronic intermittent hypoxia2014
- Author(s)
  Mikiyasu Shirai, Hirotsugu Tsuchimochi, Hisashi Nagai, Emily Gray, James Todd Pearson, Takashi Sonobe, Misa Yoshimoto, Tadakatsu Inagaki, Yutaka Fujii, Keiji Umetani, Ichiro Kuwahira, Daryl Schwenke
- Journal Title
  
  Basic Research in Cardiology
  
  Volume: 109 Issue: 5 Pages: 432-432
- DOI
  10.1007/s00395-014-0432-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25350547, KAKENHI-PROJECT-25860184, KAKENHI-PROJECT-26670413
[Patent] 肺高血圧症の予防および／または治療用医薬2023
- Inventor(s)
  中岡良和、稲垣　薫克
- Industrial Property Rights Holder
  中岡良和、稲垣　薫克
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-22K08144
[Presentation] IL-6/gp130 signaling in CD4+ T cells drives the pathogenesis of pulmonary hypertension.2024
- Author(s)
  Tadakatsu Inagaki, Tomohiko Ishibashi, Makoto Okazawa, Ryotaro Asano, Yoshikazu Nakaoka
- Organizer
  第88回日本循環器学会
- Data Source
  KAKENHI-PROJECT-21K08070
[Presentation] IL-6/gp130 signaling in CD4+ T cells drives the pathogenesis of pulmonary hypertension.2024
- Author(s)
  Tadakatsu Inagaki, Tomohiko Ishibashi, Makoto Okazawa, Ryotaro Asano, Yoshikazu Nakaoka
- Organizer
  第88回日本循環器学会
- Data Source
  KAKENHI-PROJECT-22K08144
[Presentation] Interleukin-6欠損による肺高血圧症病態形成の抑制2023
- Author(s)
  稲垣薫克、石橋知彦、山岸亜希子、丁欣、岡澤慎、中岡良和
- Organizer
  第8回日本肺高血圧・肺循環学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08070
[Presentation] CD4陽性細胞のIL-6シグナルを介した肺高血圧症病態形成2023
- Author(s)
  稲垣薫克、石橋知彦、岡澤慎、浅野遼太郎、中岡良和
- Organizer
  第31回日本血管生物医学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08070
[Presentation] CD4陽性細胞のIL-6シグナルを介した肺高血圧症病態形成2023
- Author(s)
  稲垣薫克、石橋知彦、岡澤慎、浅野遼太郎、中岡良和
- Organizer
  第31回日本血管生物医学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08144
[Presentation] Interleukin-6欠損による肺高血圧症病態形成の抑制2023
- Author(s)
  稲垣薫克、石橋知彦、山岸亜希子、丁欣、岡澤慎、中岡良和
- Organizer
  第8回日本肺高血圧・肺循環学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08144
[Presentation] Anti-interleukin-21 aptamer treatment improves pathology in a rodent models of pulmonary hypertension.2021
- Author(s)
  Tadakatsu Inagaki, Ryotaro Asano, Marie Mitsui, Tomohiko Ishibashi, Makoto Okazawa, Takeshi Ogo, Yoshikazu Nakaoka
- Organizer
  The 5th JCS Council Forum on Basic Cardio Vascular Research
- Data Source
  KAKENHI-PROJECT-19K08506
[Presentation] 肺高血圧症における IL-6 の重要性:遺伝子改変ラットを用いた検討2021
- Author(s)
  稲垣薫克, 石橋知彦, 岡澤慎, 正木豪, 真鍋侑資, 浅野遼太郎, 中岡良和
- Organizer
  第29回日本血管生物医学会学術集会 (CVMW2021)
- Data Source
  KAKENHI-PROJECT-21K08070
[Presentation] 芳香族炭化水素受容体を介した肺動脈性肺高血圧症の病態形成メカニズム2021
- Author(s)
  岡澤慎, 正木豪, 浅野遼太郎, 稲垣薫克, 石橋知彦, 山岸亜紀子, 真鍋侑資, 大郷剛, 中岡良和
- Organizer
  第29回日本血管生物医学会学術集会 (CVMW2021)
- Data Source
  KAKENHI-PROJECT-21K08070
[Presentation] The role of gp130-mediated IL-6 signaling in the CD4+ lymphocytes for the pathogenesis of pulmonary arterial hypertension2021
- Author(s)
  Ishibashi T, Masaki T, Inagaki T, Chikaishi-Kirino T, Okazawa M, Nakaoka Y
- Organizer
  第5回日本循環器学会基礎研究フォーラム (BCVR)
- Data Source
  KAKENHI-PROJECT-21K08070
[Presentation] Anti-interleukin-21 aptamer treatment improves pathology in a rodent models of pulmonary hypertension2021
- Author(s)
  Inagaki T, Asano R, Mitsui M, Ishibashi T, Okazawa M, Ogo T, Nakaoka Y
- Organizer
  第5回日本循環器学会基礎研究フォーラム (BCVR)
- Data Source
  KAKENHI-PROJECT-21K08070
[Presentation] 肺高血圧症におけるIL-6の重要性：遺伝子改変ラットを用いた検討2021
- Author(s)
  稲垣薫克、石橋知彦、岡澤慎、正木豪、真鍋侑資、浅野遼太郎、大郷剛、中岡良和
- Organizer
  第29回日本血管生物医学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08506
[Presentation] Interleukin-21阻害による肺動脈性肺高血圧症の新規治療法開発2020
- Author(s)
  稲垣薫克,浅野遼太郎,石橋知彦,岡澤慎,正木豪,三井麻利江,青木一晃,大郷剛,中岡良和
- Organizer
  第5回日本肺高血圧・肺循環学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08506
[Presentation] Critical Roles of Interleukin-21 Signaling in the Pathogenesis of Pulmonary Arterial Hypertension2020
- Author(s)
  Tadakatsu Inagaki, Tomohiko Ishibashi, Makoto Okazawa, Takeshi Masaki, Marie Mitsui, Kazuteru Aoki, Ryotaro Asano, Takeshi Ogo, Yoshikazu Nakaoka
- Organizer
  The 21st International Vascular Biology Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08506
[Presentation] gp130 Signaling in CD4 Cells Is Important for the Pathogenesis of Pulmonary Arterial Hypertension2020
- Author(s)
  Tomohiko Ishibashi, Takeshi Masaki, Tadakatsu Inagaki, Makoto Okazawa, Yoshikazu Nakaoka
- Organizer
  The 21st International Vascular Biology Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08506
[Presentation] Critical Roles of Interleukin－6／Interleukin－21－Signaling Axis in the Pathogenesis of Pulmonary　Arterial Hypertension2019
- Author(s)
  Inagaki T, Ogo T, Nakaoka Y
- Organizer
  第83回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16033
[Presentation] CD4陽性細胞におけるgp130シグナルは肺高血圧症の病態形成に重要である2019
- Author(s)
  石橋知彦、正木豪、稲垣薫克、森啓悦、浅野遼太郎、岡澤慎、中岡良和
- Organizer
  第27回日本血管生物医学会
- Data Source
  KAKENHI-PROJECT-19K08506
[Presentation] 炎症性サイトカインシグナル阻害によるPAHの新規治療法開発2019
- Author(s)
  稲垣薫克、大郷剛、中岡良和
- Organizer
  第4回日本肺高血圧・肺循環学会
- Data Source
  KAKENHI-PROJECT-19K08506
[Presentation] Macitentan reverses impaired coronary vasodilator function in severe pulmonary hypertensive rats2018
- Author(s)
  Inagaki T,Nakaoka Y
- Organizer
  the23rd Annual Scientific Meeting of International Society of Cardiovascular Pharmacotherapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16033
[Presentation] Cre-mediated recombination in hematopoietic lineage cells of smooth muscle cell-specific targeted Cre mice2018
- Author(s)
  Ishibashi T, Inagaki T, Mori H, Masaki T, Asano R, Okazawa M, Nakaoka Y.
- Organizer
  The16 Korea－Japan Joint Symposium on Vasucular Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16033
[Presentation] Cre expression in hematopoietic cells of smooth muscle cell-targeted Cre recombination mice2018
- Author(s)
  Ishibashi T, Inagaki T, Mori H, Masaki T, Asano R, Okazawa M, Nakaoka Y
- Organizer
  第2回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-17K16033
[Presentation] Macitentan treatment ameliorate impaired right coronary vasodilative functio n in SuHx rat model of severe pulmonary arterial hypertension2018
- Author(s)
  Tadakatsu Inagaki, Hirotsugu Tsuchimochi, James Pearson, Hiroyoshi Mori, Daryl Schwenke, Keiji Umetani, Mikiyasu Shirai, Yoshikazu Nakaoka.
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-17K16033
[Presentation] Macitentan reverses impaired right coronary vasodilative function in SuHx rat model of severe pulmonary arterial hypertension.2018
- Author(s)
  Tadakatsu Inagaki, Hirotsugu Tsuchimochi, James Pearson, Hiroyoshi Mori, Daryl Schwenke, Keiji Umetani, Mikiyasu Shirai, Yoshikazu Nakaoka.
- Organizer
  The 82nd Annual Scientific Meeting of the Japanese Circulation Society
- Data Source
  KAKENHI-PROJECT-17K16033
[Presentation] Macitentan reverses impaired right coronary vasodilative function in SuHx rat2018
- Author(s)
  Tadakatsu Inagaki, Hirotsugu Tsuchimochi, James Pearson, Hiroyoshi Mori, Daryl Schwenke, Keiji Umetani, Mikiyasu Shirai, Yoshikazu Nakaoka.
- Organizer
  The 1st JCS Council Forum on Basic CardioVascular Research
- Data Source
  KAKENHI-PROJECT-17K16033
[Presentation] TrkB might have a role for right ventricular homeostasis under chronic hypoxia-induced pulmonary hypertension2018
- Author(s)
  Okazawa M, Inagaki T, Ishibashi T, Masaki T, Mori H, Asano R, Nakaoka Y
- Organizer
  第2回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-17K16033
[Presentation] A novel mouse model of PAH reflecting inflammation and fibrosis.2018
- Author(s)
  森啓悦、稲垣薫克、石橋知彦、岡澤慎、正木豪、浅野遼太郎、熊ノ郷淳、中岡良和
- Organizer
  第23回日本血管病理研究会
- Data Source
  KAKENHI-PROJECT-17K16033
[Presentation] 炎症性サイトカインの肺高血圧症病態における役割2018
- Author(s)
  中岡　良和、稲垣　薫克
- Organizer
  第3回日本肺高血圧・肺循環学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16033
[Presentation] 肺高血圧症での冠動脈内皮機能障害はマシテンタンで改善される2018
- Author(s)
  稲垣　薫克、森　啓悦、中岡　良和
- Organizer
  第3回日本肺高血圧・肺循環学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16033
[Presentation] Pristane might be useful for creating a novel model of CTD-PAH in mice2018
- Author(s)
  Mori H, Inagaki T, Ishibashi T, Okazawa M, Masaki T, Asano R, Nakaoka Y
- Organizer
  第2回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-17K16033
[Presentation] プリスタンを用いた新しい膠原病性肺高血圧症モデル作製の試み2018
- Author(s)
  森　啓悦、稲垣　薫克、石橋　知彦、岡澤　慎、正木　豪、中岡　良和
- Organizer
  第3回日本肺高血圧・肺循環学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16033
[Presentation] Beta-blockade prevents coronary microvascular endothelial dysfunction in non-obese salt-sensitive insulin resistant rats on a high salt diet2017
- Author(s)
  H Tsuchimochi, H Thambyah, AJ Edgley, T Inagaki, MT Waddingham, YC Chen, CK Du, DY Zhan, V Sukumaran, T Sonobe, K Umetani, M Shirai, JT Pearson
- Organizer
  ESC Congress 2017（Barcelona)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15452
[Presentation] Impaired right coronary vasodilative function in pulmonary hypertensive rat assessed by　in vivo synchrotron microangiography.2017
- Author(s)
  Tadakatsu Inagaki, Hirotsugu Tsuchimochi, James T. Pearson, Daryl O. Schwenke, Keiji Umetani, Mikiyasu Shirai, Yoshikazu Nakaoka.
- Organizer
  The 8th TAKAO International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16033
[Presentation] Fluorescence imaging guided identification of autonomic nerve fibers and the measurement of their activities in vivo by using Thy1-YFP transgenic mice.2016
- Author(s)
  Tsuchimochi H, Inagaki T, Shirai M.
- Organizer
  The 93rd Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  Sapporo
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-26670413
[Presentation] Exercise training attenuates the development of diabetic cardiomyopathy through modulating inflammation and oxidative stress2016
- Author(s)
  Sukumaran V, Inagaki T, Tsuchimochi H, Shirai M.
- Organizer
  The 93rd Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  Sapporo
- Year and Date
  2016-03-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670413
[Presentation] Chronic intermittent hypoxia accelerates coronary microcirculatory dysfunction in young insulin resistant Goto-Kakizaki rats.2016
- Author(s)
  Perason J, Chen Y, Inagaki T, Fujii, Y, Schwenke D, Edgley A, Umetani K, Zhan Y, Yoshimoto M, Tsuchimochi H, Nagai H, Kuwahira I, Evans R, Shirai M.
- Organizer
  The 93rd Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  Sapporo
- Year and Date
  2016-03-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670413
[Presentation] 肺高血圧ラットの右冠動脈では血管拡張機能が低下する：放射光微小血管造影による評価2016
- Author(s)
  稲垣　薫克,　土持　裕胤,　藤井　豊,　ピアソン　ジェームズ,　シュウェンキ　ダリル,　梅谷　啓二,　白井　幹康
- Organizer
  第93回日本生理学会大会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-25860184
[Presentation] 放射光微小血管造影法による肺高血圧モデルラットの冠血管機能評価2016
- Author(s)
  稲垣薫克
- Organizer
  第6回Basic and Clinical PH Conference
- Place of Presentation
  リーガロイヤルホテル大阪
- Year and Date
  2016-02-04
- Invited
- Data Source
  KAKENHI-PROJECT-25860184
[Presentation] 心臓間質におけるヒドロキシルラジカル測定法の開発2015
- Author(s)
  稲垣薫克、秋山剛、白井幹康
- Organizer
  第70回日本体力医学会大会
- Place of Presentation
  和歌山県民文化会館
- Year and Date
  2015-09-18
- Data Source
  KAKENHI-PROJECT-25860184
[Presentation] Importance of body temperature regulation for evaluation of cardiac function in anesthetised mice
- Author(s)
  Hirotugu Tsuchimochi, Tadakatsu Inagaki, Mikiyasu Shirai
- Organizer
  日本生理学会
- Place of Presentation
  神戸
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-25860184
[Presentation] モノアミンオキシダーゼによる心筋虚血再灌流時のヒドロキシラジカル産生
- Author(s)
  稲垣薫克、秋山　剛、戦　冬雲、杜　成坤、白井幹康
- Organizer
  第92回日本生理学会大会
- Place of Presentation
  神戸市
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-26462774
[Presentation] 動的運動時の心拍数調節におけるTRPV1チャネルおよびカプサイシン感受性神経の役割
- Author(s)
  土持裕胤、稲垣薫克、白井幹康
- Organizer
  日本体力医学会
- Place of Presentation
  長崎
- Year and Date
  2014-09-19 – 2014-09-21
- Data Source
  KAKENHI-PROJECT-25860184
[Presentation] Aerobic tredmill training prevents the obesity caused by gene disruption of Ca2+-sensor protein mice
- Author(s)
  Shigeo Wakabayashi,Shu Nakao, Tadakatsu Inagaki, Hirotsugu Tsuchimochi, Tomoe Nakamura-Nishitani, Mikiyasu Shirai
- Organizer
  日本生理学会
- Place of Presentation
  神戸
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-25860184
[Presentation] 高気圧高酸素に対する糖尿病の循環調節機構
- Author(s)
  山越康平、柳下和慶、土持裕胤、稲垣薫克、白井幹康、狩野豊
- Organizer
  日本体力医学会
- Place of Presentation
  長崎
- Year and Date
  2014-09-19 – 2014-09-21
- Data Source
  KAKENHI-PROJECT-25860184
[Presentation] 慢性低酸素により生じる右心室肥大におけるNCS-1の働き
- Author(s)
  稲垣　薫克
- Organizer
  第27回呼吸研究会
- Place of Presentation
  電気通信大学（東京）
- Data Source
  KAKENHI-PROJECT-25860184
[Presentation] Role of monoamine oxidase on hydroxyl radical production during ischemia/reperfusion in anesthetized rats
- Author(s)
  Tadakatsu Inagaki, Tsuyoshi Akiyama, Dong-Yun Zhan, Ceng-Kun Du, Mikiyasu Shirai
- Organizer
  日本生理学会
- Place of Presentation
  神戸
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-25860184

1. Ishibashi Tomohiko (30722285)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
2. Shirai Mikiyasu (70162758)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. TSUCHIMOCHI HIROTSUGU (60379948)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. AKIYAMA Tsuyoshi (70202554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. SHIMIZU Shuji (80443498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TO Seikon (90590646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. KIN Mika (40746773)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SEN Toun (30616941)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. Pearson James (30261390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. 中岡良和 (90393214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
11. Masaki Takeshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
12. Mori Hiroyoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
13. Fukushima Yasue

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YAGI Naoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. UMETANI Keiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
16. NOZATO Satoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. TAKESHITA Hikari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. FUJII Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 深田宗一朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 柳下和慶

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. ZHAN DONGYUN

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
22. 狩野豊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 山本浩一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Inagaki Tadakatsu 稲垣 薫克

INAGAKI TADAKATSU 稲垣 薫克

Research Projects

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Co-Researchers

獲得免疫系を介した肺高血圧症の病態形成機構の解明Principal Investigator

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炎症シグナルによる肺動脈性肺高血圧症の発症機構解明に向けた基盤的研究Principal Investigator

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Role of gp130-dependent cytokine signaling in pulmonary hypertension

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Fundamental research for the development of a new strategy for the treatment of severe pulmonary hypertension by IL-6 blockadePrincipal Investigator

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Development of a treatment for pulmonary arterial hypertension focusing on inflammatory endothelial dysfunctionPrincipal Investigator

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Synchrotron radiation investigation of cardiac contractile protein dynamics at end diastole in a type 2 prediabetes model rat

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Role of microvascular dysfunction in the cardiovascular center for development of hypertension

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Monoamine oxidae-induced hydroxyl radical production and cardiomyocyte injury during myocardial ischemia-reperfusion

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Elucidation of the transition mechanism of right ventricular hypertrophy to failure due to chronic hypoxiaPrincipal Investigator

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[Journal Article] IL-6/gp130 signaling in CD4+ T cells drives the pathogenesis of pulmonary hypertension.2024

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[Journal Article] Evaluation of right coronary vascular dysfunction in severe pulmonary hypertensive rats using synchrotron radiation microangiography2021

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[Journal Article] Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension2021

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[Journal Article] Pristane/Hypoxia (PriHx) Mouse as a Novel Model of Pulmonary Hypertension Reflecting Inflammation and Fibrosis2020

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Inagaki Tadakatsu 稲垣薫克

INAGAKI TADAKATSU 稲垣薫克