HOSOYAMA TOHRU 細山徹

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HOSOYAMA Tohru 細山徹

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Researcher Number	20638803
Other IDs	https://orcid.org/0000-0002-1825-6923
Affiliation (Current)	2025: 国立研究開発法人国立長寿医療研究センター, 研究所ジェロサイエンス研究センター, 副部長
Affiliation (based on the past Project Information) *help	2022 – 2024: 国立研究開発法人国立長寿医療研究センター, 研究所ジェロサイエンス研究センター, 副部長 2021: 国立研究開発法人国立長寿医療研究センター, ジェロサイエンス研究センター, 副部長 2018 – 2020: 国立研究開発法人国立長寿医療研究センター, 再生再建医学研究部, 室長 2017: 山口大学, 大学院医学系研究科, 助教 2013 – 2017: 山口大学, 医学(系)研究科(研究院), 助教 2015: 山口大学, 大学院医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Cardiovascular surgery Except Principal Investigator Cardiovascular surgery / Basic Section 52010:General internal medicine-related / Medium-sized Section 58:Society medicine, nursing, and related fields / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Keywords	Principal Investigator 成熟骨格筋 / 遺伝子組換えマウス / 高齢者 / VDR / 骨格筋 / 筋線維 / 間葉系前駆細胞 / 骨格筋内脂肪蓄積 / 筋力低下 / ビタミンD … More / サルコペニア / 変異挿入 / Creドライバーマウス / トランスポゾン / 骨格筋老化 / マウスiPS細胞 / スリーピングビューティーシステム / 幹細胞老化 / 骨格筋幹細胞 / 血管新生療法 / 重度末梢血管障害 / 血管成熟化 / 血管新生 / 末梢血単核球 / 細胞移植療法 / 末梢血管障害 / アペリン / 低酸素プレコンディショニング / 下肢虚血 / 細胞移植治療 / ヒトiPS細胞 / 骨格筋前駆細胞 / 心筋前駆細胞 / ヒト多能性幹細胞 … More Except Principal Investigator 低酸素プレコンディショニング / 細胞老化 / 幹細胞老化 / 細胞シート / 心筋幹細胞 / 再生医療 / 細胞移植療法 / 末梢血単核球 / 細胞移植治療 / 感覚器能力 / 心理的能力 / バイタリティ / 移動能力 / 認知能力 / 転倒リスクスコア / 基本チェックリスト / ICOPEハンドブック / 簡易評価 / Intrinsic capacity / 高齢者診療 / 簡易評価票 / Intrinsic Capacity / 睡眠 / 身体活動 / 加速度計 / デジタルバイオマーカー / フレイル / 運動 / 呼吸器 / マイオカイン / COPD / 運動モデル / 中型動物モデル / 低酸素刺激 / 難治性潰瘍 / 難治性皮膚潰瘍 / 加齢 / 心不全 / 虚血性心疾患 / 細胞移植 / 血管新生 / 末梢血管障害 / 低酸素プレコンディショニング法 / アペリン / 下肢虚血 / 虚血耐性 / CD34陽性骨髄細胞 / 虚血プレコンディショニング法 / 脊髄虚血保護 / 虚血プレコンディショニング / 重症下肢虚血 / 前臨床試験 Less

デジタルバイオマーカーによるフレイル評価のための学術的基盤構築と包括的妥当性検証
- Principal Investigator
  
  大須賀洋祐
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  National Center for Geriatrics and Gerontology
運動による老化細胞除去機構の解明ー慢性呼吸器疾患治療モデルへの展開
- Principal Investigator
  
  杉本昌隆
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
高齢者における内在能力の簡易評価票の開発のためのコホート研究
- Principal Investigator
  
  佐竹昭介
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  National Center for Geriatrics and Gerontology
Elucidation of vitamin D signaling on muscle homeostasis and sarcopenia pathophysiologyPrincipal Investigator
- Principal Investigator
  
  Hosoyama Tohru
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  National Center for Geriatrics and Gerontology
Elucidation of Muscle Aging using Random MutagenesisPrincipal Investigator
- Principal Investigator
  
  Hosoyama Tohru
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  National Center for Geriatrics and Gerontology
Activated cardiosphere-derived cell sheet therapy improves left ventricular function of old infarcted heart
- Principal Investigator
  
  MIKAMO Akihito
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular surgery
- Research Institution
  Yamaguchi University
Novel cell-based therapeutic strategies focusing on vessel maturation for severe peripheral vascular diseasesPrincipal Investigator
- Principal Investigator
  
  HOSOYAMA Tohru
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular surgery
- Research Institution
  Yamaguchi University
Challenges to rejuvenate aged-cardiac stem cells by genome editing to develop next generation therapeutic strategies for heart failure.
- Principal Investigator
  
  HAMANO Kimikazu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular surgery
- Research Institution
  Yamaguchi University
Development of transplantation therapy using hypoxically preconditioned cell sheets for lower limb ischemic ulcers
- Principal Investigator
  
  HAMANO Kimikazu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular surgery
- Research Institution
  Yamaguchi University
Clinical study on the protective effect of ischemic preconditioning against spinal cord injury
- Principal Investigator
  
  TAKAHASHI Masaya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular surgery
- Research Institution
  Yamaguchi University
Synergistic effects of hypoxic preconditioning with apelin administration on cell-based therapy.
- Principal Investigator
  
  SUEHIRO Kotaro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular surgery
- Research Institution
  Yamaguchi University
Therapeutic angiogenesis with preconditioned stem cells for clinical settings
- Principal Investigator
  
  KATSURA Shunsaku
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular surgery
- Research Institution
  Yamaguchi University
Challenges for derivation of cardiac progenitors with microRNA regulationPrincipal Investigator
- Principal Investigator
  
  HOSOYAMA Tohru
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular surgery
- Research Institution
  Yamaguchi University

All 2024 2023 2022 2021 2020 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Patent

[Journal Article] Lack of vitamin D signalling in mesenchymal progenitors causes fatty infiltration in muscle2024
- Author(s)
  Hosoyama Tohru、Kawai‐Takaishi Minako、Iida Hiroki、Yamamoto Yoko、Nakamichi Yuko、Watanabe Tsuyoshi、Takemura Marie、Kato Shigeaki、Uezumi Akiyoshi、Matsui Yasumoto
- Journal Title
  
  Journal of Cachexia, Sarcopenia and Muscle
  
  Volume: 印刷中 Issue: 3 Pages: 13448-13448
- DOI
  10.1002/jcsm.13448
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18368, KAKENHI-PROJECT-19KK0234, KAKENHI-PROJECT-21K09289, KAKENHI-PROJECT-19H04063, KAKENHI-PROJECT-20H03872
[Journal Article] Influence of vitamin D on sarcopenia pathophysiology: A longitudinal study in humans and basic research in knockout mice2022
- Author(s)
  Mizuno Takafumi、Hosoyama Tohru、Tomida Makiko、Yamamoto Yoko、Nakamichi Yuko、Kato Shigeaki、Kawai‐Takaishi Minako、Ishizuka Shinya、Nishita Yukiko、Tange Chikako、Shimokata Hiroshi、Imagama Shiro、Otsuka Rei
- Journal Title
  
  Journal of Cachexia, Sarcopenia and Muscle
  
  Volume: 13 Issue: 6 Pages: 2961-2973
- DOI
  10.1002/jcsm.13102
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09289, KAKENHI-PROJECT-19KK0234, KAKENHI-PROJECT-20H03872, KAKENHI-PROJECT-20H04114, KAKENHI-PROJECT-19K22728
[Journal Article] 細胞老化とフレイル2022
- Author(s)
  津島博道、細山　徹、杉本昌隆
- Journal Title
  
  日本サルコペニア・フレイル学会誌
  
  Volume: 6 Pages: 5-9
- Data Source
  KAKENHI-PROJECT-22K19743
[Journal Article] Possible Application of Muscle Specific Conditional Mouse-Derived Induced Pluripotent Stem Cells for Muscle Research2020
- Author(s)
  Tohru Hosoyama
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 21 Pages: 100744-100744
- DOI
  10.1016/j.bbrep.2020.100744
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09089
[Journal Article] Age-related increase in Wnt inhibitor causes a senescence-like phenotype in human cardiac stem cells.2017
- Author(s)
  Nakamura T, Hosoyama T, Murakami J, Samura M, Ueno K, Kurazumi H, Suzuki R, Mikamo A, Hamano K.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K10218
[Journal Article] Hypoxic preconditioning of human cardiosphere-derived cell sheets enhances cellular functions via activation of the PI3K/Akt/mTOR/HIF-1α pathway.2017
- Author(s)
  Tanaka Y, Hosoyama T, Mikamo A, Kurazumi H, Nishimoto A, Ueno K, Shirasawa B, Hamano K.
- Journal Title
  
  American Journal of Translational Research
  
  Volume: 9 Pages: 664-673
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K10218
[Journal Article] Therapeutic strategies for cell-based neovascularization in critical limb ischemia.2017
- Author(s)
  Samura M, Hosoyama T, Takeuchi Y, Ueno K, Morikage N, Hamano K.
- Journal Title
  
  Journal of Translational Medicine
  
  Volume: 15 Pages: 49-49
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K10244
[Journal Article] Ulcer healing effect of autologous mixed sheets consisting of fibroblasts and peripheral blood mononuclear cells in rabbit ischemic hind limb.2017
- Author(s)
  Takeuchi Y, Ueno K, Mizoguchi T, Samura M, Harada T, Oga A, Murata T, Hosoyama T, Morikage N, Hamano K
- Journal Title
  
  Am J Transl Res
  
  Volume: 15 Pages: 2340-2351
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04939
[Journal Article] Age-related increase in Wnt inhibitor causes a senescence-like phenotype in human cardiac stem cells.2017
- Author(s)
  Nakamura T, Hosoyama T, Murakami J, Samura M, Ueno K, Kurazumi H, Suzuki R, Mikamo A, Hamano K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 487 Issue: 3 Pages: 653-659
- DOI
  10.1016/j.bbrc.2017.04.110
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10218, KAKENHI-PROJECT-17K16594
[Journal Article] Age-related increase in Wnt inhibitor causes a senescence-like phenotype in human cardiac stem cells.2017
- Author(s)
  Nakamura T, Hosoyama T, Murakami J, Samura M, Ueno K, Kurazumi H, Suzuki R, Mikamo A, Hamano K.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15508
[Journal Article] Influence of aging on the quantity and quality of human cardiac stem cells.2016
- Author(s)
  Nakamura T, Hosoyama T, Kawamura D, Takeuchi Y, Tanaka Y, Samura M, Ueno K, Nishimoto A, Kurazumi H, Suzuki R, Ito H, Sakata K, Mikamo A, Li TS, Hamano K.
- Journal Title
  
  Scientific Reports
  
  Volume: ６ Issue: 1 Pages: 22781-22781
- DOI
  10.1038/srep22781
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15508, KAKENHI-PROJECT-15K15509, KAKENHI-PROJECT-15K19922
[Journal Article] Combinatorial Treatment with Apelin-13 Enhances the Therapeutic Efficacy of a Preconditioned Cell-Based Therapy for Peripheral Ischemia.2016
- Author(s)
  Samura M, Morikage N, Suehiro K, Tanaka Y, Nakamura T, Nishimoto A, Ueno K, Hosoyama T, Hamano K.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 19379-19379
- DOI
  10.1038/srep19379
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K10244, KAKENHI-PROJECT-26462111
[Journal Article] Treatment of refractory cutaneous ulcers with mixed sheets consisting of peripheral blood mononuclear cells and fibroblasts2016
- Author(s)
  Ueno K, Takeuchi Y, Samura M, Tanaka Y, Nakamura T, Nishimoto A, Murata T, Hosoyama T, Hamano K
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 28538-28538
- DOI
  10.1038/srep36758
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04939, KAKENHI-PROJECT-26462110, KAKENHI-PROJECT-15K19921
[Journal Article] Cardiosphere-derived cell sheet primed with hypoxia improves left ventricular function of chronically infarcted heart.2015
- Author(s)
  Hosoyama T, Samura M, Kudo T, Nishimoto A, Ueno K, Murata T, Ohama T, Sato K, Mikamo A, Yoshimura K, Li TS, Hamano K.
- Journal Title
  
  American Journal of Translational Research
  
  Volume: 7 Pages: 2738-2738
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K10218
[Journal Article] Hypoxic preconditioning reinforces cellular functions of autologous peripheral blood-derived cells in rabbit hindlimb ischemia model.2014
- Author(s)
  Kudo T, Hosoyama T, Samura M, Katsura S, Nishimoto A, Kugimiya N, Fujii Y, Li TS, Hamano K.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 444 Issue: 3 Pages: 370-375
- DOI
  10.1016/j.bbrc.2014.01.054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390336, KAKENHI-PROJECT-25462162
[Patent] 低酸素処理により機能賦活化した細胞シートの製造方法2015
- Inventor(s)
  濱野公一、細山　徹、上野耕司
- Industrial Property Rights Holder
  山口大学
- Industrial Property Rights Type
  特許
- Filing Date
  2015-09-16
- Overseas
- Data Source
  KAKENHI-PROJECT-15K10218
[Patent] 末梢血単核球又は末梢血単核球より分泌される因子を伴う線維芽細胞を含む細胞シート2015
- Inventor(s)
  濱野公一、上野耕司、細山　徹
- Industrial Property Rights Holder
  山口大学
- Industrial Property Rights Type
  特許
- Filing Date
  2015-10-28
- Overseas
- Data Source
  KAKENHI-PROJECT-15H04939
[Presentation] ビタミンD欠乏とサルコペニア・フレイルリスク2024
- Author(s)
  細山　徹
- Organizer
  第26回健康栄養シンポジウム
- Data Source
  KAKENHI-PROJECT-21K09289
[Presentation] Impact of cell-cell communications and environmental changes surrounding muscle on IMAT formation2023
- Author(s)
  Tohru Hosoyama
- Organizer
  IAGG-AOR2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09289
[Presentation] ビタミンDシグナル阻害やビタミンD欠乏は骨格筋内脂肪浸潤を導く2023
- Author(s)
  細山　徹, 飯田浩貴, 高石美奈子, 上住聡芳, 渡邉　剛, 竹村真里枝, 松井康素
- Organizer
  第10回日本サルコペニア・フレイル学会大会
- Data Source
  KAKENHI-PROJECT-21K09289
[Presentation] 筋由来Seno-suppressorの機能および運動モデルにおける動態解析2023
- Author(s)
  津島博道、浅井あずさ、細山　徹、多田敬典、杉本昌隆
- Organizer
  第23回日本抗加齢医学会
- Data Source
  KAKENHI-PROJECT-22K19743
[Presentation] ビタミンDとサルコペニア―骨格筋に対するビタミンDの多様な作用と疾患との関わり―2023
- Author(s)
  細山　徹
- Organizer
  第71回日本職業・災害医学会学術大会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21K09289
[Presentation] Role of Vitamin D in Muscle Homeostasis.2023
- Author(s)
  Tohru Hosoyama
- Organizer
  NCGG-ICAH-TMIG Joint Symposium 2023 IAGG-AOR Satellite
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09289
[Presentation] マウス骨格筋由来抗細胞老化因子（seno-suppressor）の解析2023
- Author(s)
  津島博道、浅井あづさ、細山　徹、多田敬典、杉本昌隆
- Organizer
  第33回日本老年学会
- Data Source
  KAKENHI-PROJECT-22K19743
[Presentation] サルコペニアの病態にビタミンDが及ぼす影響－ヒトにおける縦断的研究およびノックアウトマウスを用いた基礎研究―2023
- Author(s)
  水野隆文, 細山　徹, 富田真紀子, 石塚真哉, 西田裕紀子, 丹下智香子, 下方浩史, 今釜史郎, 大塚礼
- Organizer
  第23回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-21K09289
[Presentation] Vitamin D signaling plays an inhibitory role in formation of intramuscular adipose tissue.2023
- Author(s)
  Tohru Hosoyama, Hiroki Iida, Minako Kawai-Takaishi, Akiyoshi Uezumi, Ken Watanabe.
- Organizer
  IAGG-AOR2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09289
[Presentation] サルコペニア・フレイルのバイオマーカー探索の試み2022
- Author(s)
  細山　徹
- Organizer
  第77回日本体力医学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K09289
[Presentation] Vitamin D, a potential role for tissue homeostasis and sarcopenia.2022
- Author(s)
  Tohru Hosoyama
- Organizer
  The 8th Asian Conference for Frailty and Sarcopenia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09289
[Presentation] Vitamin D as a biomarker candidate for sarcopenia and dynapenia; from basic and epidemiological studies.2022
- Author(s)
  Tohru Hosoyama
- Organizer
  The 8th Asian Conference for Frailty and Sarcopenia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09289
[Presentation] サルコペニア・フレイルのバイオマーカー探索の試み2022
- Author(s)
  細山　徹
- Organizer
  第77回日本体力医学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24238
[Presentation] マウス筋細胞由来抗細胞老化因子の探索2022
- Author(s)
  津島博道、浅井あづさ、細山　徹、多田敬典、杉本昌隆
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K19743
[Presentation] Lack of vitamin D signaling accelerates muscle atrophy in cachexia.2022
- Author(s)
  Tohru Hosoyama, Yoshihiro Miyagawa, Minako Takaishi-Kawai, Ken Watanabe.
- Organizer
  The 8th Asian Conference for Frailty and Sarcopenia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09289
[Presentation] 成熟筋線維におけるビタミンDシグナルの役割2021
- Author(s)
  細山徹、高石美菜子、飯田浩貴、渡邉剛、松井康素、渡邉研
- Organizer
  骨格筋生物学研究会
- Data Source
  KAKENHI-PROJECT-21K09289
[Presentation] ビタミンD低下がサルコペニア病態生理に与える影響について2021
- Author(s)
  水野隆文、細山徹、飯田浩貴、石塚真哉、渡辺剛、平岩秀樹、松井康素、今釜史郎
- Organizer
  第36回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-21K09289
[Presentation] Possible applications of muscle specific conditional mouse-derived iPS cells for muscle research2018
- Author(s)
  Tohru Hosoyama, Minako Kawai
- Organizer
  第6回若手による骨格筋細胞研究会
- Data Source
  KAKENHI-PROJECT-18K09089
[Presentation] 虚血プレコンディショニングによる脊髄障害予防の機序解析2017
- Author(s)
  溝口高弘、上野耕司, 竹内由利子，佐村誠, 細山徹, 森景則保, 美甘章仁, 濱野公一
- Organizer
  第47回日本心臓血管外科学会
- Place of Presentation
  東京　グランドニッコー東京台場
- Year and Date
  2017-02-27
- Data Source
  KAKENHI-PROJECT-26462110
[Presentation] Possible contribution of Wnt antagonist to human cardiac stem/progenitor cell aging2017
- Author(s)
  Tohru Hosoyama, Tamami Nakamura ,Koji Ueno, Akihito Mikamo, Kimikazu Hamano
- Organizer
  KEYSTONE SYMPOSIA
- Data Source
  KAKENHI-PROJECT-15K10218
[Presentation] 難治性皮膚潰瘍に対する積層化細胞シートの基礎的検討2017
- Author(s)
  溝口高弘、上野耕司、竹内由利子、佐村誠、西本新、細山徹、森景則保、美甘章仁、濱野公一
- Organizer
  第16回日本再生医療学会総会
- Place of Presentation
  宮城県仙台市　仙台国際センター
- Year and Date
  2017-03-07
- Data Source
  KAKENHI-PROJECT-15H04939
[Presentation] マウス難治性皮膚潰瘍モデルにおける細胞混合シートの効果2017
- Author(s)
  竹内由利子、上野耕司、溝口髙弘、細山徹、濱野公一
- Organizer
  第16回日本再生医療学会総会
- Place of Presentation
  宮城県仙台市　仙台国際センター
- Year and Date
  2017-03-07
- Data Source
  KAKENHI-PROJECT-15H04939
[Presentation] 難治性皮膚潰瘍に対する線維芽細胞シートのCollagen IIIを活性化させる因子の基礎的検討2017
- Author(s)
  上野耕司、竹内由利子、溝口高弘、佐村誠、細山徹、濱野公一
- Organizer
  第16回日本再生医療学会総会
- Place of Presentation
  宮城県仙台市　仙台国際センター
- Year and Date
  2017-03-07
- Data Source
  KAKENHI-PROJECT-15H04939
[Presentation] 末梢血単核球と線維芽細胞からなる細胞混合シートを用いた難治性皮膚潰瘍治療の臨床応用に向けて2017
- Author(s)
  竹内由利子、上野耕司、溝口高弘、西本新、細山徹、森景則保、濱野公一
- Organizer
  第47回日本心臓血管外科学会総会
- Place of Presentation
  東京　グランドニッコウー東京台場
- Year and Date
  2017-02-27
- Data Source
  KAKENHI-PROJECT-15H04939
[Presentation] Influence of Aging on Cardiac Stem/Progenitor Cells2016
- Author(s)
  Tohru Hosoyama
- Organizer
  BIT's 7th World Gene Convention-2016
- Place of Presentation
  中国　上海市
- Year and Date
  2016-11-03
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15508
[Presentation] 磁石埋込全層欠損による難治性皮膚潰瘍モデルの開発2016
- Author(s)
  竹内由利子、田中裕也、中村玉美、佐村　誠、上野耕司、西本　新、細山　徹、濱野公一
- Organizer
  第15回日本再生医療学会総会
- Place of Presentation
  大阪府大阪市　大阪国際会議場
- Year and Date
  2016-03-17
- Data Source
  KAKENHI-PROJECT-15H04939
[Presentation] 加齢や心機能低下がヒト心筋幹細胞(cardiosphere-derived cells)の量と質に与える影響2016
- Author(s)
  中村玉美、細山　徹、竹内由利子、田中裕也、佐村　誠、上野耕司、美甘章仁、李　桃生、濱野公一
- Organizer
  第15回日本再生医療学会総会
- Place of Presentation
  大阪府大阪市・大阪国際会議場
- Year and Date
  2016-03-17
- Data Source
  KAKENHI-PROJECT-15K15508
[Presentation] アロ細胞混合シートを用いた難治性皮膚潰瘍治療の検討と移植された細胞シートの残存有無の検証2016
- Author(s)
  上野耕司、竹内由利子、佐村　誠、田中裕也、中村玉美、西本　新、細山　徹、濱野公一
- Organizer
  第15回日本再生医療学会総会
- Place of Presentation
  大阪府大阪市　大阪国際会議場
- Year and Date
  2016-03-17
- Data Source
  KAKENHI-PROJECT-15H04939
[Presentation] 末梢血単核球と線維芽細胞の細胞混合シートを用いた難治性皮膚潰瘍治療の基礎的検討2016
- Author(s)
  竹内由利子、上野耕司、田中裕也、中村玉美、佐村　誠、西本　新、細山　徹、森景則保、美甘章仁、濱野公一
- Organizer
  第46回日本心臓血管外科学会学術総会
- Place of Presentation
  愛知県名古屋市　名古屋国際会議場
- Year and Date
  2016-02-15
- Data Source
  KAKENHI-PROJECT-15H04939
[Presentation] Therapeutic application of cell sheet primed with hypoxia for myocardial infarction2015
- Author(s)
  Tohru Hosoyama, Makoto Samura, Tomoaki Kudo, Koji Ueno, Yuya Tanaka, Tamami Nakamura ,Akihito Mikamo, Kimikazu Hamano
- Organizer
  Keystone Symposia
- Place of Presentation
  アイルランド・ダブリン市
- Year and Date
  2015-05-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10218
[Presentation] マウス下肢虚血モデルにおける末梢血単核球移植とApelin同時投与による治療効果の検証2015
- Author(s)
  佐村　誠、細山　徹、田中裕也、中村玉美、工藤智明、釘宮成二、上野耕司、西本　新、森景則保、美甘章仁、濱野公一
- Organizer
  第１１５回日本外科学会定期学術集会
- Place of Presentation
  愛知県名古屋市・名古屋国際会議場
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-15K10244
[Presentation] Derivation of Multipotent Spheres from Human Pluripotent Stem Cells for Cell-based Therapy in Heart and Skeletal Muscle Diseases2014
- Author(s)
  Tohru Hosoyama, Makoto Samura, Tomoaki Kudo, Masatoshi Suzuki, Kimikazu Hamano
- Organizer
  Keystone Symposia, Growth and Wasting in Heart and Skeletal Muscle
- Place of Presentation
  Santa Fe, New Mexico, USA
- Data Source
  KAKENHI-PROJECT-25670595
[Presentation] 骨格筋前駆EZスフィアの多分化能と心不全治療への応用の可能性
- Author(s)
  細山徹、佐村誠、工藤智明、鈴木正寿、濱野公一
- Organizer
  精神・神経疾患研究開発費　武田班平成26年度班会議
- Place of Presentation
  JA共済ビルカンファレンスホール（東京都千代田区）
- Year and Date
  2014-12-03 – 2014-12-04
- Invited
- Data Source
  KAKENHI-PROJECT-25670595

1. HAMANO Kimikazu (60263787)

# of Collaborated Projects: 6 results

# of Collaborated Products: 22 results
2. LI Tao-sheng (50379997)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
3. 森景則保 (50335741)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. 松井康素 (50501623)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 木下かほり (60896306)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. KATSURA Shunsaku (40457304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TAKAHASHI Masaya (60634730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SUEHIRO Kotaro (10569312)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MIKAMO Akihito (30372709)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
10. 藏澄宏之 (50645116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 上野耕司 (30736070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
12. 杉本昌隆 (50426491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. 村上太郎 (10252305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 多田敬典 (20464993)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. 渡邉淳 (90321843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 大須賀洋祐 (10741986)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 大寺祥佑 (20751720)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 早坂太一 (50314092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 笹井浩行 (60733681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 斎藤民 (80323608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 佐竹昭介 (50508116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 重水大智 (70617464)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 前田圭介 (50775179)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 荒木厚 (60539196)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 田村嘉章 (50842142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 中道裕子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HOSOYAMA TOHRU 細山 徹

HOSOYAMA Tohru 細山 徹

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Elucidation of vitamin D signaling on muscle homeostasis and sarcopenia pathophysiologyPrincipal Investigator

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Elucidation of Muscle Aging using Random MutagenesisPrincipal Investigator

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Novel cell-based therapeutic strategies focusing on vessel maturation for severe peripheral vascular diseasesPrincipal Investigator

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Challenges for derivation of cardiac progenitors with microRNA regulationPrincipal Investigator

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[Journal Article] Lack of vitamin D signalling in mesenchymal progenitors causes fatty infiltration in muscle2024

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[Journal Article] Influence of vitamin D on sarcopenia pathophysiology: A longitudinal study in humans and basic research in knockout mice2022

HOSOYAMA TOHRU 細山徹

HOSOYAMA Tohru 細山徹