INUI Masafumi 乾雅史

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Inui Masafumi 乾雅史

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Researcher Number	20643498
Other IDs	https://orcid.org/0000-0003-4720-007X
Affiliation (Current)	2024: 明治大学, 農学部, 専任准教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 明治大学, 農学部, 専任准教授 2019: 国立研究開発法人国立成育医療研究センター, システム発生・再生医学研究部, 室長 2017: 明治大学, 農学部, 専任講師 2017: 国立研究開発法人国立成育医療センター, システム発生/再生医学研究部, 室長 2015 – 2016: 国立研究開発法人国立成育医療研究センター, システム発生・再生医学研究部, 室長 2013 – 2014: 独立行政法人国立成育医療研究センター, システム発生・再生医学研究部, 室長
Review Section/Research Field	Principal Investigator Basic Section 44020:Developmental biology-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Developmental biology / Tumor biology Except Principal Investigator Sections That Are Subject to Joint Review: Basic Section90130:Medical systems-related , Basic Section90140:Medical technology assessment-related / Basic Section 90130:Medical systems-related / Basic Section 90140:Medical technology assessment-related / Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Human genetics / Orthopaedic surgery
Keywords	Principal Investigator 軟骨 / Scleraxis / 発生 / 腱 / 骨格筋 / Sox9 / SUMO化 / 骨代謝 / 形態形成 / 組織間相互作用 … More / iGONAD / 軟骨分化 / Ubiquitin化 / ゲノム編集 / 翻訳後修飾 / SOX9 / スクリーニング / TGFβ制御因子 / TGFb / クロストーク / TGFβ … More Except Principal Investigator 再生・移植医療 / 品質評価 / 非侵襲的評価 / 細胞・組織構築物 / 医療技術 / ハプロ不全優性遺伝病 / エピジェネティックなゆらぎ / エピゲノム編集 / DNAメチル化 / ハプロ不全 / エピジェネティクス / 染色体治療 / 遺伝子 / Cre-loxP / ゲノム編集 / CRISPR/Cas9 / 核型正常化 / ハプロタイプフェイジング / トリソミックレスキュー / 靱帯 / 腱 / 腱・靭帯 / GTF2IRD1 / 運動器 / 腱・靱帯 / Mkx Less

Sox9SUMO化を標的とした骨軟骨機能維持の試みPrincipal Investigator
- Principal Investigator
  
  乾雅史
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Meiji University
Non-invasive assessment of 3D tissue constructs for regenerative medicine and cell transplantation
- Principal Investigator
  
  宮本義孝
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90140:Medical technology assessment-related
  Basic Section 90130:Medical systems-related
  Sections That Are Subject to Joint Review: Basic Section90130:Medical systems-related , Basic Section90140:Medical technology assessment-related
- Research Institution
  National Center for Child Health and Development
The role of tendon cells in coordinating musculoskeletal morphogenesisPrincipal Investigator
- Principal Investigator
  
  乾雅史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  Meiji University
Epigenetic fluctuation associated with onset and severity of haploinsufficient dominant diseases
- Principal Investigator
  
  大鐘潤
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Meiji University
how skeletal muscles find correct tendons to connect during embryogenesisPrincipal Investigator
- Principal Investigator
  
  Inui Masafumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  Meiji University
The analysis of the role of SOX9 post-translational modification in vertebrate skeletal developmentPrincipal Investigator
- Principal Investigator
  
  Inui Masafumi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Developmental biology
- Research Institution
  Meiji University
  National Center for Child Health and Development
Trisomic rescue induction by allele-specific chromosome breakage using genome editing technique
- Principal Investigator
  
  Hara Mari
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Human genetics
- Research Institution
  Mie University
Elucidation of tendon and ligament regeneration and maintenance mechanism
- Principal Investigator
  
  ASAHARA Hiroshi
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical and Dental University
A screen for novel TGFb crosstalk modulatorPrincipal Investigator
- Principal Investigator
  
  INUI Masafumi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  National Research Institute for Child Health and Development

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Epigenome editing revealed the role of DNA methylation of T-DMR/CpG island shore on Runx2 transcription.2024
- Author(s)
  Yutaro Kawa, Miyuki Shindo, Jun Ohgane, Masafumi Inui
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04755
[Journal Article] Scleraxis-lineage cells are required for correct muscle patterning.2023
- Author(s)
  Yudai Ono , Saundra Schlesinger , Kanako Fukunaga , Shinsei Yambe , Tempei Sato , Takako Sasaki , Chisa Shukunami , Hiroshi Asahara , Masafumi Inui
- Journal Title
  
  Development
  
  Volume: 150 Issue: 10 Pages: 1-12
- DOI
  10.1242/dev.201101
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03107, KAKENHI-PROJECT-23K23899
[Journal Article] Digoxigenin‐labeled <scp>RNA</scp> probes for untranslated regions enable the isoform‐specific gene expression analysis of myosin heavy chains in whole‐mount in situ hybridization2022
- Author(s)
  Tanji Masafumi、Wada Keitaro、Sakamoto Keita、Ono Yudai、Inui Masafumi
- Journal Title
  
  Development, Growth & Differentiation
  
  Volume: 65 Issue: 1 Pages: 48-55
- DOI
  10.1111/dgd.12832
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K23899
[Journal Article] Protocadherin-1 is expressed in the notochord of mouse embryo but is dispensable for its formation2021
- Author(s)
  Fukunaga Kanako、Tanji Masafumi、Hanzawa Nana、Kuroda Hiroki、Inui Masafumi
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 27 Pages: 101047-101047
- DOI
  10.1016/j.bbrep.2021.101047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06697
[Journal Article] Wwp2 maintains cartilage homeostasis through regulation of Adamts52019
- Author(s)
  Mokuda Sho、Nakamichi Ryo、Matsuzaki Tokio、Ito Yoshiaki、Sato Tempei、Miyata Kohei、Inui Masafumi、Olmer Merissa、Sugiyama Eiji、Lotz Martin、Asahara Hiroshi
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 2429-2429
- DOI
  10.1038/s41467-019-10177-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19603, KAKENHI-PROJECT-15H02560
[Journal Article] Comparative analysis demonstrates cell type-specific conservation of SOX9 targets between mouse and chicken.2019
- Author(s)
  Yamashita S, Kataoka K, Yamamoto H, Kato T, Hara S, Yamaguchi K, Renard-Guillet C, Katou Y, Shirahige K, Ochi H, Ogino H, Uchida T, Inui M, Takada S, Shigenobu S, and Asahara H
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 12560-12560
- DOI
  10.1038/s41598-019-48979-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06631, KAKENHI-PROJECT-19K06672, KAKENHI-PROJECT-19K06689, KAKENHI-PROJECT-15H02560, KAKENHI-PROJECT-16H04794
[Journal Article] Dissecting the roles of miR-140 and its host gene2018
- Author(s)
  Inui M, Mokuda S, Sato T, Tamano M, Takada S, Asahara H.
- Journal Title
  
  Nature Cell Biology
  
  Volume: 20 Pages: 516-518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18558
[Journal Article] Dissecting the roles of miR-140 and its host gene2018
- Author(s)
  Inui Masafumi、Mokuda Sho、Sato Tempei、Tamano Moe、Takada Shuji、Asahara Hiroshi
- Journal Title
  
  Nature Cell Biology
  
  Volume: 20 Issue: 5 Pages: 516-518
- DOI
  10.1038/s41556-018-0077-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15544, KAKENHI-PROJECT-18K19603, KAKENHI-ORGANIZER-26113001, KAKENHI-PLANNED-26113008, KAKENHI-PROJECT-15H02560
[Journal Article] Tendons and Ligaments: Connecting Developmental Biology to Musculoskeletal Disease Pathogenesis2017
- Author(s)
  Asahara Hiroshi、Inui Masafumi、Lotz Martin K
- Journal Title
  
  Journal of Bone and Mineral Research
  
  Volume: 32 Issue: 9 Pages: 1773-1782
- DOI
  10.1002/jbmr.3199
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26113008, KAKENHI-PROJECT-15H02560, KAKENHI-PROJECT-15K15544
[Journal Article] CRISPR/Cas9-mediated simultaneous knockout of Dmrt1 and Dmrt3 does not recapitulate the 46,XY gonadal dysgenesis observed in 9p24.3 deletion patients2017
- Author(s)
  Masafumi Inui, Moe Tamano, Tomoko Kato, Shuji Takada
- Journal Title
  
  BB Reports
  
  Volume: 9 Pages: 238-244
- DOI
  10.1016/j.bbrep.2017.01.001
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K18558, KAKENHI-PROJECT-16K21664
[Journal Article] Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs.2016
- Author(s)
  Rho Nakamichi, Nakamichi R, Ito Y, Inui M, Onizuka N, Kayama T, Kataoka K, Suzuki H, Mori M, Inagawa M, Ichinose S, Lotz M, Sakai D, Masuda K, Ozaki T, Asahara H.
- Journal Title
  
  Nature Communications
  
  Volume: 7 Issue: 1 Pages: 12503-12503
- DOI
  10.1038/ncomms12503
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01486, KAKENHI-PLANNED-26113008, KAKENHI-PROJECT-15K15387, KAKENHI-PROJECT-15K15544, KAKENHI-INTERNATIONAL-15K21720, KAKENHI-PROJECT-15H02560, KAKENHI-PROJECT-16H05456
[Journal Article] Transcription factor Mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo.2015
- Author(s)
  Otabe K, Nakahara H, Hasegawa A, Matsukawa T, Ayabe F, Onizuka N, Inui M, Takada S, Ito Y, Sekiya I, Muneta T, Lotz M, Asahara H.
- Journal Title
  
  J Orthop Res.
  
  Volume: 33 Issue: 1 Pages: 1-8
- DOI
  10.1002/jor.22750
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293317, KAKENHI-PROJECT-25293386, KAKENHI-PLANNED-26113008, KAKENHI-PROJECT-15H02560
[Journal Article] Rapid generation of mouse models with defined point mutations by the CRISPR/Cas9 system2014
- Author(s)
  Inui M, Miyado M, Igarashi M, Tamano M, Kubo A, Yamashita S, Asahara H, Fukami M, Takada S.
- Journal Title
  
  Scientific Reports
  
  Volume: 4 Issue: 1 Pages: 5396-5396
- DOI
  10.1038/srep05396
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25132713, KAKENHI-PROJECT-25871177, KAKENHI-PROJECT-26860837, KAKENHI-PROJECT-26870887, KAKENHI-PROJECT-26870891
[Presentation] Scleraxis-lineage cells are required for correct muscle patterning2023
- Author(s)
  Yudai Ono, Saundra Schlesinger, Kanako Fukunaga, Shinsei Yambe, Tempei Sato, Takako Sasaki, Chisa Shukunami, Hiroshi Asahara, Masafumi Inui
- Organizer
  第56回日本発生生物学会
- Data Source
  KAKENHI-PROJECT-23K23899
[Presentation] マウス筋腱相互作用と形態形成2023
- Author(s)
  乾雅史
- Organizer
  第9回日本筋学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K23899
[Presentation] ScxCre-L;Lmx1b flox／floxマウスの骨格筋形態の解析2023
- Author(s)
  和田啓太郎、乾雅史
- Organizer
  第9回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-23K23899
[Presentation] 腱組織の再構築から機能評価と応用に向けて2023
- Author(s)
  宮本義孝、宮戸健二、寺本直純、田山千春、中林一彦、梅澤明弘、乾雅史
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-23K23899
[Presentation] 腱・間葉細胞との相互作用による骨格筋パターニング2022
- Author(s)
  乾雅史
- Organizer
  第8回日本筋学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K23899
[Presentation] エピゲノム編集による Runx2 転写調節機構の解析2022
- Author(s)
  加和優多郎、大鐘潤、乾雅史
- Organizer
  第45回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21H04755
[Presentation] PYモチーフを欠損したSmad2の骨格筋への影響の解析2022
- Author(s)
  坂本渓太、乾雅史
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K23899
[Presentation] Scleraxis-lineage cells are required for correct muscle patterning2021
- Author(s)
  乾雅史
- Organizer
  第54回日本発生生物学会
- Data Source
  KAKENHI-PROJECT-19K06697
[Presentation] 腱細胞による骨格筋の正確な配向の制御2020
- Author(s)
  乾雅史
- Organizer
  第43回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K06697
[Presentation] 腱細胞から分泌される筋配向制御因子の探索2020
- Author(s)
  尾野雄大、乾雅史
- Organizer
  第7回日本筋学会
- Data Source
  KAKENHI-PROJECT-19K06697
[Presentation] 腱細胞から分泌される筋配向制御因子の探索2019
- Author(s)
  尾野雄大、乾雅史
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K06697
[Presentation] Scx positive tendon cells are required for correct muscle patterning in mammalian embryo2019
- Author(s)
  Yudai Ono, Tempei Sato, Hiroshi Asahara, Masafumi Inui
- Organizer
  Society of Muscle Biology, Frontiers in Myogenesis meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06697
[Presentation] CRISPR/Cas9 mediated amino acid substitution revealed the role of SOX9 post-translational modification in skeletal development2017
- Author(s)
  乾雅史
- Organizer
  2017年度生命科学系学会合同年次大会（CONBIO2017）
- Data Source
  KAKENHI-PROJECT-16K18558
[Presentation] ゲノム編集による疾患モデルマウスの作製と解析2017
- Author(s)
  乾雅史
- Organizer
  第69回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-16K18558

1. ASAHARA Hiroshi (70294460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. Hara Mari (30176383)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Hashizume Ryotaro (50456662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Ichishi Masako (80632372)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Miyagawa yoshitaka (90415604)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 森雅樹 (10602625)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 脇田幸子 (20782981)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 大鐘潤 (50313078)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 長嶋比呂志 (50318664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 宮本義孝 (20425705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 池内真志 (90377820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 河野菜摘子 (00451691)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 中林一彦 (10415557)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SEKIYA Ichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. TAKADA Shuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 宗田大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 加藤朋子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 宿南知佐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

INUI Masafumi 乾 雅史

Inui Masafumi 乾 雅史

Research Projects

Research Products

Co-Researchers

Sox9SUMO化を標的とした骨軟骨機能維持の試みPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Non-invasive assessment of 3D tissue constructs for regenerative medicine and cell transplantation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of tendon cells in coordinating musculoskeletal morphogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Epigenetic fluctuation associated with onset and severity of haploinsufficient dominant diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

how skeletal muscles find correct tendons to connect during embryogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The analysis of the role of SOX9 post-translational modification in vertebrate skeletal developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Trisomic rescue induction by allele-specific chromosome breakage using genome editing technique

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of tendon and ligament regeneration and maintenance mechanism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A screen for novel TGFb crosstalk modulatorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Epigenome editing revealed the role of DNA methylation of T-DMR/CpG island shore on Runx2 transcription.2024

Author(s)

Journal Title

Data Source

[Journal Article] Scleraxis-lineage cells are required for correct muscle patterning.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Digoxigenin‐labeled <scp>RNA</scp> probes for untranslated regions enable the isoform‐specific gene expression analysis of myosin heavy chains in whole‐mount in situ hybridization2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protocadherin-1 is expressed in the notochord of mouse embryo but is dispensable for its formation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Wwp2 maintains cartilage homeostasis through regulation of Adamts52019

Author(s)

INUI Masafumi 乾雅史

Inui Masafumi 乾雅史