Udagawa Tsuyoshi 宇田川剛

Researcher Number	20644199
Other IDs
Affiliation (Current)	2025: 名古屋市立大学, 医薬学総合研究院(薬学), 准教授
Affiliation (based on the past Project Information) *help	2022: 名古屋市立大学, 医薬学総合研究院(薬学), 准教授 2020 – 2021: 東北大学, 薬学研究科, 助教 2016 – 2018: 東北大学, 薬学研究科, 助教 2014 – 2015: 東北大学, 薬学研究科(研究院), 助教 2013: 名古屋大学, 医学(系)研究科(研究院), 特任助教
Review Section/Research Field	Principal Investigator Basic Section 44010:Cell biology-related / Molecular biology / Neurology
Keywords	Principal Investigator 品質管理 / 翻訳 / 細胞死 / 神経変性 / タンパク質分解 / タンパク質凝集体 / リボソーム / 脳・神経 / mRNA品質管理 / 脳機能制御 … More / 転写後遺伝子発現調節 / ALS・FTLD / mRNA代謝 / RNA結合タンパク質 / シナプス / ALS/FTLD Less

Mechanism of cell death induction by the failure of ribosome-associated quality control pathwayPrincipal Investigator
- Principal Investigator
  
  Udagawa Tsuyoshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Nagoya City University
  Tohoku University
Role of Ribosome-associated quality control in mammalian neuronsPrincipal Investigator
- Principal Investigator
  
  Udagawa Tsuyoshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Tohoku University
Involvement of TDP-43 and FUS on translational and synaptic control and its relevance to ALS/FTLDPrincipal Investigator
- Principal Investigator
  
  Udagawa Tsuyoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
  Nagoya University

All 2022 2021 2019 2018 2017 2016 2015 2013 Other

All Journal Article Presentation

[Journal Article] Failure to Degrade CAT-Tailed Proteins Disrupts Neuronal Morphogenesis and Cell Survival2021
- Author(s)
  Udagawa Tsuyoshi、Seki Moeka、Okuyama Taku、Adachi Shungo、Natsume Tohru、Noguchi Takuya、Matsuzawa Atsushi、Inada Toshifumi
- Journal Title
  
  Cell Reports
  
  Volume: 34 Issue: 1 Pages: 108599-108599
- DOI
  10.1016/j.celrep.2020.108599
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06615, KAKENHI-PUBLICLY-19H05282, KAKENHI-PROJECT-18H03977, KAKENHI-PROJECT-18H02567, KAKENHI-PROJECT-19K22481
[Journal Article] Optimized protocol for tRNA identification in the ribosomal complexes from human cell lines2021
- Author(s)
  Tsuyoshi Udagawa, Moeka Seki, Toshifumi Inada
- Journal Title
  
  STAR Protocols
  
  Volume: 2(3) Issue: 3 Pages: 100615-100615
- DOI
  10.1016/j.xpro.2021.100615
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06615
[Journal Article] Ubiquitination of stalled ribosome triggers ribosome-associated quality control2017
- Author(s)
  Matsuo Y, Ikeuchi K, Saeki Y, Iwasaki S, Schmidt C, Udagawa T, Sato F, Tsuchiya H, Becker T, Tanaka K, Ingolia NT, Beckmann R, Inada T
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 159-159
- DOI
  10.1038/s41467-017-00188-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07243, KAKENHI-PROJECT-26293018, KAKENHI-PLANNED-26116003, KAKENHI-PROJECT-16K18486, KAKENHI-PROJECT-26000014, KAKENHI-PUBLICLY-17H05679, KAKENHI-PROJECT-17H04998
[Journal Article] FUSの最近の話題2016
- Author(s)
  宇田川剛
- Journal Title
  
  最新医学　3月増刊号　特集　認知症
  
  Volume: 71 Pages: 538-543
- Data Source
  KAKENHI-PROJECT-25860708
[Journal Article] FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization.2015
- Author(s)
  Udagawa, T., Fujioka, Y., Tanaka, M., Honda, D., Yokoi, S., Riku, Y., Ibi, D., Nagai, T., Yamada, K., Watanabe, H., Katsuno, M., Inada, T., Ohno, K., Sokabe, M., Okado, H., Ishigaki S*., and Sobue, G.
- Journal Title
  
  Nat Commun
  
  Volume: 6 Issue: 1 Pages: 7098-7098
- DOI
  10.1038/ncomms8098
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09310, KAKENHI-PUBLICLY-25118508, KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-26116003, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-24247028, KAKENHI-PROJECT-15H06719, KAKENHI-PROJECT-25460093, KAKENHI-PROJECT-15K15337, KAKENHI-PROJECT-26670439, KAKENHI-PROJECT-25860708, KAKENHI-PROJECT-26293206, KAKENHI-PLANNED-26117002, KAKENHI-ORGANIZER-26117001
[Journal Article] The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons2013
- Author(s)
  Honda D, Ishigaki S, Iguchi Y, Fujioka Y, Udagawa T, Masuda A, Ohno K, Katsuno M, Sobue G.
- Journal Title
  
  FEBS Open Bio.
  
  Volume: 20 Issue: 1 Pages: 1-10
- DOI
  10.1016/j.fob.2013.11.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500469, KAKENHI-PROJECT-24659429, KAKENHI-PROJECT-25860708
[Presentation] 異常翻訳の品質管理因子による認知機能制御2022
- Author(s)
  宇田川剛、奥山卓、関萌香、稲田利文
- Organizer
  第95回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K06615
[Presentation] Failure to Degrade CAT-Tailed Proteins Disrupts Neuronal Morphogenesis and Cell Survival2021
- Author(s)
  Tsuyoshi Udagawa, Moeka Seki, Taku Okuyama, Shungo Adachi, Tohru Natsume, Takuya Noguchi, Atsushi Matsuzawa, Toshifumi Inada
- Organizer
  第22回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-20K06615
[Presentation] 異常翻訳に対する品質管理機構RQCによる不良新生タンパク質のクリアランスは神経細胞生存に重要である2021
- Author(s)
  Tsuyoshi Udagawa, Moeka Seki, Taku Okuyama, Shungo Adachi, Tohru Natsume, Takuya Noguchi, Atsushi Matsuzawa, Toshifumi Inada
- Organizer
  第44回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K06615
[Presentation] Clearance of translation arrest products by ribosome-associated quality control is critical for neuron morphogenesis and survival2019
- Author(s)
  Tsuyoshi Udagawa
- Organizer
  第20回武田科学振興財団科学シンポジウム
- Data Source
  KAKENHI-PROJECT-16K07243
[Presentation] Ribosome-associated quality control (RQC)因子は神経突起伸長と認知機能を特異的に制御する2018
- Author(s)
  宇田川剛、奥山卓、関萌香、稲田利文
- Organizer
  第20回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-16K07243
[Presentation] mRNA代謝・翻訳異常に起因する精神神経疾患の発症機構解明を目指して2017
- Author(s)
  宇田川剛
- Organizer
  日本薬学会東北支部　第16回生物化学若手研究者セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-16K07243
[Presentation] 哺乳類細胞におけるRQC trigger (RQT)因子の機能解析2016
- Author(s)
  宇田川剛、杉山誉人、佐藤光紗希、信田理沙、稲田利文
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K07243
[Presentation] FUSはGluA1 mRNA安定性の調節を介してシナプス機能及びFTLD/ALS様行動を制御する2015
- Author(s)
  宇田川剛
- Organizer
  第38回日本分子生物学会年会　第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-25860708
[Presentation] FUS depletion in adult causes behavioral abnormalities that mimic FTLD through post-transcriptional regulation of synaptic protein expression.2013
- Author(s)
  Tsuyoshi Udagawa, Yusuke Fujioka, Daiyu Honda, Daisuke Ibi, Taku Nagai, Satoshi Yokoi, Masahisa Katsuno, Hayuo Okado, Shinsuke Ishigaki, Gen Sobue
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（神戸市）
- Data Source
  KAKENHI-PROJECT-25860708
[Presentation] FUS regulates AMPA receptor function and ALS/FTLD-associated behaviors via GluR1 mRNA stabilization
- Author(s)
  Tsuyoshi Udagawa, Yusuke Fujioka, Motoki Tanaka, Daiyu Honda, Satoshi Yokoi, Taku Nagai, Kiyofumi Yamada, Masahisa Katsuno, Masahiro Sokabe, Haruo Okado, Shinsuke Ishigaki, Gen Sobue
- Organizer
  CSHL meeting 'Translational Control'
- Place of Presentation
  Cold Spring Harbor
- Year and Date
  2014-09-02 – 2014-09-06
- Data Source
  KAKENHI-PROJECT-25860708
[Presentation] FUS はGluR1 mRNA の安定化を介してAMPA 受容体機能、及び ALS/FTLD 関連行動を制御する
- Author(s)
  宇田川剛、藤岡祐介、田中基樹、本田祐、横井聡、衣斐大祐、永井拓、山田清文、勝野雅央、曽我部正博、岡戸晴生、石垣診佑、祖父江元
- Organizer
  第16回日本RNA学会年会
- Place of Presentation
  名古屋
- Year and Date
  2014-07-23 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-25860708

1. WATANABE Hirohisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 石垣診祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 祖父江元

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 増田章男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Udagawa Tsuyoshi 宇田川 剛

Research Projects

Research Products

Co-Researchers

Mechanism of cell death induction by the failure of ribosome-associated quality control pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of Ribosome-associated quality control in mammalian neuronsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of TDP-43 and FUS on translational and synaptic control and its relevance to ALS/FTLDPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Failure to Degrade CAT-Tailed Proteins Disrupts Neuronal Morphogenesis and Cell Survival2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Optimized protocol for tRNA identification in the ribosomal complexes from human cell lines2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ubiquitination of stalled ribosome triggers ribosome-associated quality control2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] FUSの最近の話題2016

Author(s)

Journal Title

Data Source

[Journal Article] FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] 異常翻訳の品質管理因子による認知機能制御2022

Author(s)

Organizer

Data Source

[Presentation] Failure to Degrade CAT-Tailed Proteins Disrupts Neuronal Morphogenesis and Cell Survival2021

Author(s)

Organizer

Data Source

[Presentation] 異常翻訳に対する品質管理機構RQCによる不良新生タンパク質のクリアランスは神経細胞生存に重要である2021

Author(s)

Organizer

Data Source

[Presentation] Clearance of translation arrest products by ribosome-associated quality control is critical for neuron morphogenesis and survival2019

Author(s)

Organizer

Data Source

[Presentation] Ribosome-associated quality control (RQC)因子 は神経突起伸長と認知機能を特異的に制御する2018

Author(s)

Organizer

Data Source

[Presentation] mRNA代謝・翻訳異常に起因する 精神神経疾患の発症機構解明を目指して2017

Author(s)

Organizer

Data Source

[Presentation] 哺乳類細胞におけるRQC trigger (RQT)因子の機能解析2016

Author(s)

Organizer

Place of Presentation

Year and Date

Udagawa Tsuyoshi 宇田川剛

[Presentation] Ribosome-associated quality control (RQC)因子は神経突起伸長と認知機能を特異的に制御する2018

[Presentation] mRNA代謝・翻訳異常に起因する精神神経疾患の発症機構解明を目指して2017