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Udagawa Tsuyoshi  宇田川 剛

ORCIDConnect your ORCID iD *help
Researcher Number 20644199
Other IDs
Affiliation (Current) 2025: 名古屋市立大学, 医薬学総合研究院(薬学), 准教授
Affiliation (based on the past Project Information) *help 2022: 名古屋市立大学, 医薬学総合研究院(薬学), 准教授
2020 – 2021: 東北大学, 薬学研究科, 助教
2016 – 2018: 東北大学, 薬学研究科, 助教
2014 – 2015: 東北大学, 薬学研究科(研究院), 助教
2013: 名古屋大学, 医学(系)研究科(研究院), 特任助教
Review Section/Research Field
Principal Investigator
Basic Section 44010:Cell biology-related / Molecular biology / Neurology
Keywords
Principal Investigator
品質管理 / 翻訳 / 細胞死 / 神経変性 / タンパク質分解 / タンパク質凝集体 / リボソーム / 脳・神経 / mRNA品質管理 / 脳機能制御 … More / 転写後遺伝子発現調節 / ALS・FTLD / mRNA代謝 / RNA結合タンパク質 / シナプス / ALS/FTLD Less
  • Research Projects

    (3 results)
  • Research Products

    (17 results)
  • Co-Researchers

    (4 People)
  •  Mechanism of cell death induction by the failure of ribosome-associated quality control pathwayPrincipal Investigator

    • Principal Investigator
      Udagawa Tsuyoshi
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 44010:Cell biology-related
    • Research Institution
      Nagoya City University
      Tohoku University
  •  Role of Ribosome-associated quality control in mammalian neuronsPrincipal Investigator

    • Principal Investigator
      Udagawa Tsuyoshi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Molecular biology
    • Research Institution
      Tohoku University
  •  Involvement of TDP-43 and FUS on translational and synaptic control and its relevance to ALS/FTLDPrincipal Investigator

    • Principal Investigator
      Udagawa Tsuyoshi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurology
    • Research Institution
      Tohoku University
      Nagoya University

All 2022 2021 2019 2018 2017 2016 2015 2013 Other

All Journal Article Presentation

  • [Journal Article] Failure to Degrade CAT-Tailed Proteins Disrupts Neuronal Morphogenesis and Cell Survival2021

    • Author(s)
      Udagawa Tsuyoshi、Seki Moeka、Okuyama Taku、Adachi Shungo、Natsume Tohru、Noguchi Takuya、Matsuzawa Atsushi、Inada Toshifumi
    • Journal Title

      Cell Reports

      Volume: 34 Issue: 1 Pages: 108599-108599

    • DOI

      10.1016/j.celrep.2020.108599

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K06615, KAKENHI-PUBLICLY-19H05282, KAKENHI-PROJECT-18H03977, KAKENHI-PROJECT-18H02567, KAKENHI-PROJECT-19K22481
  • [Journal Article] Optimized protocol for tRNA identification in the ribosomal complexes from human cell lines2021

    • Author(s)
      Tsuyoshi Udagawa, Moeka Seki, Toshifumi Inada
    • Journal Title

      STAR Protocols

      Volume: 2(3) Issue: 3 Pages: 100615-100615

    • DOI

      10.1016/j.xpro.2021.100615

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K06615
  • [Journal Article] Ubiquitination of stalled ribosome triggers ribosome-associated quality control2017

    • Author(s)
      Matsuo Y, Ikeuchi K, Saeki Y, Iwasaki S, Schmidt C, Udagawa T, Sato F, Tsuchiya H, Becker T, Tanaka K, Ingolia NT, Beckmann R, Inada T
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 159-159

    • DOI

      10.1038/s41467-017-00188-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07243, KAKENHI-PROJECT-26293018, KAKENHI-PLANNED-26116003, KAKENHI-PROJECT-16K18486, KAKENHI-PROJECT-26000014, KAKENHI-PUBLICLY-17H05679, KAKENHI-PROJECT-17H04998
  • [Journal Article] FUSの最近の話題2016

    • Author(s)
      宇田川剛
    • Journal Title

      最新医学 3月増刊号 特集 認知症

      Volume: 71 Pages: 538-543

    • Data Source
      KAKENHI-PROJECT-25860708
  • [Journal Article] FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization.2015

    • Author(s)
      Udagawa, T., Fujioka, Y., Tanaka, M., Honda, D., Yokoi, S., Riku, Y., Ibi, D., Nagai, T., Yamada, K., Watanabe, H., Katsuno, M., Inada, T., Ohno, K., Sokabe, M., Okado, H., Ishigaki S*., and Sobue, G.
    • Journal Title

      Nat Commun

      Volume: 6 Issue: 1 Pages: 7098-7098

    • DOI

      10.1038/ncomms8098

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09310, KAKENHI-PUBLICLY-25118508, KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-26116003, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-24247028, KAKENHI-PROJECT-15H06719, KAKENHI-PROJECT-25460093, KAKENHI-PROJECT-15K15337, KAKENHI-PROJECT-26670439, KAKENHI-PROJECT-25860708, KAKENHI-PROJECT-26293206, KAKENHI-PLANNED-26117002, KAKENHI-ORGANIZER-26117001
  • [Journal Article] The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons2013

    • Author(s)
      Honda D, Ishigaki S, Iguchi Y, Fujioka Y, Udagawa T, Masuda A, Ohno K, Katsuno M, Sobue G.
    • Journal Title

      FEBS Open Bio.

      Volume: 20 Issue: 1 Pages: 1-10

    • DOI

      10.1016/j.fob.2013.11.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24500469, KAKENHI-PROJECT-24659429, KAKENHI-PROJECT-25860708
  • [Presentation] 異常翻訳の品質管理因子による認知機能制御2022

    • Author(s)
      宇田川剛、奥山卓、関萌香、稲田利文
    • Organizer
      第95回日本生化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K06615
  • [Presentation] Failure to Degrade CAT-Tailed Proteins Disrupts Neuronal Morphogenesis and Cell Survival2021

    • Author(s)
      Tsuyoshi Udagawa, Moeka Seki, Taku Okuyama, Shungo Adachi, Tohru Natsume, Takuya Noguchi, Atsushi Matsuzawa, Toshifumi Inada
    • Organizer
      第22回日本RNA学会年会
    • Data Source
      KAKENHI-PROJECT-20K06615
  • [Presentation] 異常翻訳に対する品質管理機構RQCによる不良新生タンパク質のクリアランスは神経細胞生存に重要である2021

    • Author(s)
      Tsuyoshi Udagawa, Moeka Seki, Taku Okuyama, Shungo Adachi, Tohru Natsume, Takuya Noguchi, Atsushi Matsuzawa, Toshifumi Inada
    • Organizer
      第44回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K06615
  • [Presentation] Clearance of translation arrest products by ribosome-associated quality control is critical for neuron morphogenesis and survival2019

    • Author(s)
      Tsuyoshi Udagawa
    • Organizer
      第20回武田科学振興財団科学シンポジウム
    • Data Source
      KAKENHI-PROJECT-16K07243
  • [Presentation] Ribosome-associated quality control (RQC)因子 は神経突起伸長と認知機能を特異的に制御する2018

    • Author(s)
      宇田川剛、奥山卓、関萌香、稲田利文
    • Organizer
      第20回日本RNA学会年会
    • Data Source
      KAKENHI-PROJECT-16K07243
  • [Presentation] mRNA代謝・翻訳異常に起因する 精神神経疾患の発症機構解明を目指して2017

    • Author(s)
      宇田川剛
    • Organizer
      日本薬学会東北支部  第16回生物化学若手研究者セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K07243
  • [Presentation] 哺乳類細胞におけるRQC trigger (RQT)因子の機能解析2016

    • Author(s)
      宇田川剛、杉山誉人、佐藤光紗希、信田理沙、稲田利文
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-16K07243
  • [Presentation] FUSはGluA1 mRNA安定性の調節を介してシナプス機能及びFTLD/ALS様行動を制御する2015

    • Author(s)
      宇田川剛
    • Organizer
      第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Invited
    • Data Source
      KAKENHI-PROJECT-25860708
  • [Presentation] FUS depletion in adult causes behavioral abnormalities that mimic FTLD through post-transcriptional regulation of synaptic protein expression.2013

    • Author(s)
      Tsuyoshi Udagawa, Yusuke Fujioka, Daiyu Honda, Daisuke Ibi, Taku Nagai, Satoshi Yokoi, Masahisa Katsuno, Hayuo Okado, Shinsuke Ishigaki, Gen Sobue
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Data Source
      KAKENHI-PROJECT-25860708
  • [Presentation] FUS regulates AMPA receptor function and ALS/FTLD-associated behaviors via GluR1 mRNA stabilization

    • Author(s)
      Tsuyoshi Udagawa, Yusuke Fujioka, Motoki Tanaka, Daiyu Honda, Satoshi Yokoi, Taku Nagai, Kiyofumi Yamada, Masahisa Katsuno, Masahiro Sokabe, Haruo Okado, Shinsuke Ishigaki, Gen Sobue
    • Organizer
      CSHL meeting 'Translational Control'
    • Place of Presentation
      Cold Spring Harbor
    • Year and Date
      2014-09-02 – 2014-09-06
    • Data Source
      KAKENHI-PROJECT-25860708
  • [Presentation] FUS はGluR1 mRNA の安定化を介してAMPA 受容体機能、及び ALS/FTLD 関連行動を制御する

    • Author(s)
      宇田川剛、藤岡祐介、田中基樹、本田祐、横井聡、衣斐大祐、永井拓、山田清文、勝野雅央、曽我部正博、岡戸晴生、石垣診佑、祖父江元
    • Organizer
      第16回日本RNA学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-07-23 – 2014-07-25
    • Data Source
      KAKENHI-PROJECT-25860708
  • 1.  WATANABE Hirohisa
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 2.  石垣 診祐
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  祖父江 元
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  増田 章男
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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