IKEBUCHI Yuki 池淵祐樹

Researcher Number	20645725
Other IDs
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2014 – 2024: 東京大学, 医学部附属病院, 助教 2013: 東京大学, 医学部附属病院, 特任助教 2012: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 56020:Orthopedics-related Except Principal Investigator Basic Section 47040:Pharmacology-related / Basic Section 56020:Orthopedics-related / Medium-sized Section 90:Biomedical engineering and related fields / Drug development chemistry
Keywords	Principal Investigator 骨細胞 / 骨代謝 / 細胞老化 / 細胞外膜小胞 / 抗体創薬 / 細胞内シグナル / 細胞分化制御 / Wntシグナル / 骨リモデリング / 酸化ストレス … More / 破骨細胞 / アポトーシス小体 / 軟骨細胞 / W9ペプチド / Wペプチド / 軟骨代謝 / 細胞間ネットワーク / RANK-RANKL相互作用 / 細胞内シグナル伝達 / 骨・軟骨代謝 / 関節リウマチ / RANKL / 骨カップリング / 骨代謝カップリング … More Except Principal Investigator 炎症 / 自己免疫疾患 / RANKL逆シグナル / シグナル伝達 / 膜小胞 / 生活動作 / 骨リモデリング / 骨代謝 / RANKL / 骨細胞 / 破骨細胞 / 骨芽細胞 / 小胞 / 投与量設計 / 治療最適化 / in silico解析 / キナーゼ阻害剤 / 副作用 / 分子標的薬 / がん / 抗がん剤 / システム薬理学 / 機械学習 / 細胞毒性 / 医療・福祉 / 臨床 / 薬剤反応性 / 蛋白質 / トランスレーショナルリサーチ / 療・福祉 / 炎症性サイトカイン / 薬剤性肝障害 / 医薬品化学 Less

Analysis of the roles of RANKL reverse signaling in the autoimmune disease development
- Principal Investigator
  
  本間雅
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  The University of Tokyo
Development of novel signal modifying molecules based on comprehensive decoding of Wnt signalingPrincipal Investigator
- Principal Investigator
  
  池淵祐樹
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  The University of Tokyo
Analysis on the regulatory mechanism of bone remodeling based on cellular senescence in osteocytesPrincipal Investigator
- Principal Investigator
  
  Ikebuchi Yuki
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  The University of Tokyo
Functional analysis of osteocytic membrane vesicles in osteoclast activation under daily activities
- Principal Investigator
  
  苅谷嘉顕
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  The University of Tokyo
Analysis on the physiological role of osteocytic small extracellular vesicles in the bone remodelingPrincipal Investigator
- Principal Investigator
  
  Ikebuchi Yuki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  The University of Tokyo
Optimization for usage of molecular targeted drugs on cancer therapy
- Principal Investigator
  
  Suzuki Hiroshi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  The University of Tokyo
Analysis on the pharmacological mechanism of W9 peptide and development for the novel drug based on the strong potential for chondrocyte differentiationPrincipal Investigator
- Principal Investigator
  
  Ikebuchi Yuki
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  The University of Tokyo
Analysis on the spatiotemporal regulation of osteoclasts maturation via the osteocytic apoptosisPrincipal Investigator
- Principal Investigator
  
  Ikebuchi Yuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
Analysis on the influence of RANKL reverse signaling in the development of rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  Ikebuchi Yuki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
Analysis on the regulatory mechanism of sclerostin expression coupled with RANKL-reverse signalingPrincipal Investigator
- Principal Investigator
  
  IKEBUCHI Yuki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
Research on Drug-Induced Liver Injury Associated with MetabolicActivation by CYP
- Principal Investigator
  
  HISAKA Akihiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo

All 2021 2020 2019 2018 2017 2014 2012 Other

All Journal Article Presentation

[Journal Article] RANKL as a key figure in bridging between the bone and immune system: Its physiological functions and potential as a pharmacological target2021
- Author(s)
  Honma Masashi、Ikebuchi Yuki、Suzuki Hiroshi
- Journal Title
  
  Pharmacology & Therapeutics
  
  Volume: 218 Pages: 107682-107682
- DOI
  10.1016/j.pharmthera.2020.107682
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22676, KAKENHI-PROJECT-18H02918
[Journal Article] Mechanisms of RANKL delivery to the osteoclast precursor cell surface2020
- Author(s)
  Honma Masashi、Ikebuchi Yuki、Suzuki Hiroshi
- Journal Title
  
  Journal of Bone and Mineral Metabolism
  
  Volume: 39 Issue: 1 Pages: 27-33
- DOI
  10.1007/s00774-020-01157-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22676, KAKENHI-PROJECT-18H02918
[Journal Article] 骨吸収と骨形成のカップリングにおけるRANKL逆シグナルの関与2019
- Author(s)
  本間雅、池淵祐樹、鈴木洋史
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 71 Pages: 608-614
- NAID
  40021933906
- Data Source
  KAKENHI-PROJECT-19K22676
[Journal Article] カップリング・シグナル受容分子としてのRANKL2019
- Author(s)
  本間雅、池淵祐樹、鈴木洋史
- Journal Title
  
  THE BONE
  
  Volume: 33 Pages: 57-61
- Data Source
  KAKENHI-PROJECT-19K22676
[Journal Article] RANKL逆シグナルによる骨代謝制御2019
- Author(s)
  本間雅、池淵祐樹、鈴木洋史
- Journal Title
  
  生化学
  
  Volume: 91 Pages: 529-532
- Data Source
  KAKENHI-PROJECT-18H02918
[Journal Article] 骨形成・吸収におけるRANKリガンドシグナルの新たな役割2019
- Author(s)
  池淵祐樹、本間雅、鈴木洋史
- Journal Title
  
  血液内科
  
  Volume: 79 Pages: 100-105
- NAID
  40021979045
- Data Source
  KAKENHI-PROJECT-19K22676
[Journal Article] RANKL逆シグナルによる骨代謝制御2019
- Author(s)
  本間雅、池淵祐樹、鈴木洋史
- Journal Title
  
  生化学
  
  Volume: 91 Pages: 529-532
- Data Source
  KAKENHI-PROJECT-19K22676
[Journal Article] カップリング・シグナル受容分子としてのRANKL2019
- Author(s)
  本間雅、池淵祐樹、鈴木洋史
- Journal Title
  
  THE BONE
  
  Volume: 33 Pages: 57-61
- Data Source
  KAKENHI-PROJECT-18H02918
[Journal Article] RANKL逆シグナル経路を標的とした新たな創薬の可能性2019
- Author(s)
  本間雅、池淵祐樹、鈴木洋史
- Journal Title
  
  BIO Clinica
  
  Volume: 34 Pages: 773-777
- Data Source
  KAKENHI-PROJECT-18H02918
[Journal Article] 骨吸収と骨形成のカップリングにおけるRANKL逆シグナルの関与2019
- Author(s)
  本間雅、池淵祐樹、鈴木洋史
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 71 Pages: 608-614
- NAID
  40021933906
- Data Source
  KAKENHI-PROJECT-18H02918
[Journal Article] 骨形成・吸収におけるRANKリガンドシグナルの新たな役割2019
- Author(s)
  池淵祐樹、本間雅、鈴木洋史
- Journal Title
  
  血液内科
  
  Volume: 79 Pages: 100-105
- NAID
  40021979045
- Data Source
  KAKENHI-PROJECT-18H02918
[Journal Article] The clustering-induction of RANKL molecules could stimulate early osteroblast differentiation2019
- Author(s)
  E. Sone, D. Noshiro, Y. Ikebuchi, M. Nakagawa, M. Khan, Y. Tamura, M. Ikeda, M. Oki, R. Murali, T. Fujimori, T. Yoda, M. Honma, H. Suzuki, T. Ando, and K. Aoki
- Journal Title
  
  Biophys. Biochem. Res. Commun.
  
  Volume: 509 Issue: 2 Pages: 435-440
- DOI
  10.1016/j.bbrc.2018.12.093
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26119003, KAKENHI-PROJECT-16H05445, KAKENHI-PROJECT-18H02918, KAKENHI-PROJECT-17F17124, KAKENHI-PROJECT-16H06280, KAKENHI-PROJECT-19H01068
[Journal Article] RANKL逆シグナル経路を標的とした新たな創薬の可能性2019
- Author(s)
  本間雅、池淵祐樹、鈴木洋史
- Journal Title
  
  BIO Clinica
  
  Volume: 34 Pages: 773-777
- Data Source
  KAKENHI-PROJECT-19K22676
[Journal Article] Coupling of bone resorption and formation by RANKL reverse signalling.2018
- Author(s)
  Ikebuchi Y, Aoki S, Honma M, Hayashi M, Sugamori Y, Khan M, Kariya Y, Kato G, Tabata Y, Penninger JM, Udagawa N, Aoki K, Suzuki H
- Journal Title
  
  Nature
  
  Volume: 561 Issue: 7722 Pages: 195-200
- DOI
  10.1038/s41586-018-0482-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19776, KAKENHI-PROJECT-16H05445, KAKENHI-PROJECT-16H05508, KAKENHI-PROJECT-18H02918, KAKENHI-PROJECT-16H06261, KAKENHI-PROJECT-17F17124, KAKENHI-PROJECT-16K11818, KAKENHI-PROJECT-16K20419, KAKENHI-PROJECT-18K04734
[Journal Article] RANKL結合ペプチドによる骨形成促進メカニズムの検討2018
- Author(s)
  曽根絵梨、Masud Khan、能代大輔、池淵祐樹、本間雅、田村幸彦、菅森泰隆、鈴木洋史、宇田川信之、青木和宏
- Journal Title
  
  日本骨形態計測学会雑誌
  
  Volume: 28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02918
[Journal Article] RANKL逆シグナルによる骨吸収と骨形成の共役2018
- Author(s)
  本間雅, 池淵祐樹
- Journal Title
  
  First Author's
  
  Volume: - Pages: 095
- DOI
  10.7875/first.author.2018.095
- Open Access
- Data Source
  KAKENHI-PROJECT-16H05445, KAKENHI-PROJECT-18H02918
[Journal Article] Regulatory mechanisms of RANKL presentation to osteoclast precursors2014
- Author(s)
  Masashi Honma, Yuki Ikebuchi, Yoshiaki Kariya, Hiroshi Suzuki
- Journal Title
  
  Current Osteoporosis Reports
  
  Volume: 12(1) Issue: 1 Pages: 115-120
- DOI
  10.1007/s11914-014-0189-0
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PLANNED-22136015, KAKENHI-PROJECT-24390349, KAKENHI-PROJECT-24659668, KAKENHI-PROJECT-24890048, KAKENHI-PROJECT-25670632
[Journal Article] Establishment of optimized in vitro assay methods for evaluating osteocyte functions.2014
- Author(s)
  Honma M, Ikebuchi Y, Kariya Y, Suzuki H.
- Journal Title
  
  Journal of Bone and Mineral Metabolism
  
  Volume: [Epub ahead of print]
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670632
[Presentation] RANK-RANKLによる骨代謝制御機構の解析と新たな骨粗鬆症治療薬の可能性2020
- Author(s)
  池淵祐樹
- Organizer
  埼玉医科大学　卒後教育委員会後援学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22676
[Presentation] RANK-RANKLによる骨代謝制御機構の解析と新たな骨粗鬆症治療薬の可能性2020
- Author(s)
  池淵祐樹
- Organizer
  埼玉医科大学　卒後教育委員会後援学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02918
[Presentation] 骨吸収と骨形成のカップリングにおけるRANKL逆シグナルの寄与2019
- Author(s)
  池淵祐樹
- Organizer
  第5回日本骨免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02918
[Presentation] RANK-RANKLを介したカップリング制御機構と新たな創薬の可能性2019
- Author(s)
  池淵祐樹
- Organizer
  第37回日本骨代謝学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02918
[Presentation] Develoment of a novel biologic agent for treating RA2019
- Author(s)
  Honma M., Kurata R., Ikebuchi Y., Kariya Y., Suzuki H.
- Organizer
  European Calcified Tissue Society Congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02918
[Presentation] RANK-RANKLを介したカップリング制御機構と新たな創薬の可能性2019
- Author(s)
  池淵祐樹
- Organizer
  第37回日本骨代謝学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22676
[Presentation] 骨吸収と骨形成のカップリングにおけるRANKL逆シグナルの寄与2019
- Author(s)
  池淵祐樹
- Organizer
  第5回日本骨免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22676
[Presentation] Develoment of a novel biologic agent for treating RA2019
- Author(s)
  Honma M., Kurata R., Ikebuchi Y., Kariya Y., Suzuki H.
- Organizer
  European Calcified Tissue Society Congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22676
[Presentation] Osteoblastic RANKL acts as an osteogenic signal acceptor recognizing vesicular RANK secreted from osteoclasts2018
- Author(s)
  Honma, M.、Ikebuchi, Y.、Suzuki, H.
- Organizer
  ASEMV 2018 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02918
[Presentation] Development of a novel chimeric protein construct aiming to improve therapeutic efficacy against rheumatoid arthritis2018
- Author(s)
  Kurata, R.、Honma, M.、Ikebuchi, Y.、Kariya, Y.、Suzuki, H.
- Organizer
  AAPS PharmSci 360
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02918
[Presentation] Osteoblastic RANKL acts as an osteogenic signal acceptor for vesicular RANK derived from maturing osteoclasts.2018
- Author(s)
  Honma, M.、Ikebuchi, Y.、Kariya, Y.、Suzuki, H.
- Organizer
  AAPS PharmSci 360
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02918
[Presentation] A stimulatory mechanism of RANKL-binding peptide on osteoblast differentiation2018
- Author(s)
  Sone, E.、Noshiro, D.、Ikebuchi, Y.、Khan, M.、Sugamori, Y.、Tamura, Y.、Yoda, T.、Honma, M.、Aoki, K.
- Organizer
  32nd IADR Southeast Asian Division Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02918
[Presentation] RANKL逆シグナルによる骨吸収と骨形成のカップリング2018
- Author(s)
  池淵祐樹
- Organizer
  第21回　骨代謝研究会
- Data Source
  KAKENHI-PROJECT-18H02918
[Presentation] 骨吸収と骨形成のカップリングにおける RANKL の役割2018
- Author(s)
  本間雅、池淵祐樹、鈴木洋史
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-26713045
[Presentation] 骨芽細胞に発現するRANKLはカップリング・シグナルを受容する2018
- Author(s)
  池淵祐樹、本間雅、苅谷嘉明、鈴木洋史
- Organizer
  第40回　生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-18H02918
[Presentation] 関節リウマチに関する新規バイオロジクスの創製検討2018
- Author(s)
  藏田玲美、本間雅、池淵祐樹、苅谷嘉明、鈴木洋史
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-18H02918
[Presentation] カップリング機構におけるRANKLの役割2017
- Author(s)
  本間雅、池淵祐樹、林円香、青木和宏、苅谷嘉顕、鈴木洋史
- Organizer
  第59回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-26713045
[Presentation] Predicting High-Risk Patients for the Onset of Drug-Induced Liver Injury2012
- Author(s)
  Takaaki Ishida, Yuki Ikebuchi, Masashi Honma, Kousei Ito, Hiroshi Suzuki
- Organizer
  日本薬物動態学会第27回年会
- Data Source
  KAKENHI-PROJECT-22390020
[Presentation] 患者の疾患背景に基づいた薬物誘発性肝障害の発症リスク評価2012
- Author(s)
  池淵祐樹、伊藤晃成、本間雅、山本武人、鈴木洋史
- Organizer
  第12回東京大学生命科学シンポジウム
- Place of Presentation
  東京(東京大学）
- Data Source
  KAKENHI-PROJECT-22390020
[Presentation] Analysis on the regulatory mechanisms of osteocytic RANKL presentation to osteoclast precursors.
- Author(s)
  Yuki Ikebuchi
- Organizer
  第8回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  熊本
- Year and Date
  2014-11-15 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-25670632
[Presentation] 成熟破骨細胞形成における骨細胞RANKL提示機構の解析
- Author(s)
  池淵祐樹
- Organizer
  新学術領域「統合的多階層生体機能学領域の確立とその応用」若手ワークショップ2014
- Place of Presentation
  熱海
- Year and Date
  2014-09-21 – 2014-09-23
- Data Source
  KAKENHI-PROJECT-25670632

1. HONMA Masashi (60401072)

# of Collaborated Projects: 8 results

# of Collaborated Products: 17 results
2. 苅谷嘉顕 (20633168)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. Suzuki Hiroshi (80206523)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. HISAKA Akihiro (80420206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. YAMAMOTO Takehito (00376469)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. ITO Kousei (30323405)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 宇田川信之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 安藤敏夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

IKEBUCHI Yuki 池淵 祐樹

Research Projects

Research Products

Co-Researchers

Analysis of the roles of RANKL reverse signaling in the autoimmune disease development

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel signal modifying molecules based on comprehensive decoding of Wnt signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis on the regulatory mechanism of bone remodeling based on cellular senescence in osteocytesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of osteocytic membrane vesicles in osteoclast activation under daily activities

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis on the physiological role of osteocytic small extracellular vesicles in the bone remodelingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Optimization for usage of molecular targeted drugs on cancer therapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis on the pharmacological mechanism of W9 peptide and development for the novel drug based on the strong potential for chondrocyte differentiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis on the spatiotemporal regulation of osteoclasts maturation via the osteocytic apoptosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis on the influence of RANKL reverse signaling in the development of rheumatoid arthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis on the regulatory mechanism of sclerostin expression coupled with RANKL-reverse signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on Drug-Induced Liver Injury Associated with MetabolicActivation by CYP

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] RANKL as a key figure in bridging between the bone and immune system: Its physiological functions and potential as a pharmacological target2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mechanisms of RANKL delivery to the osteoclast precursor cell surface2020

Author(s)

Journal Title

DOI

Data Source

IKEBUCHI Yuki 池淵祐樹