TAKEMOTO Ai 竹本愛

Researcher Number	20706494
Affiliation (Current)	2025: 公益財団法人がん研究会, がん化学療法センター基礎研究部, 主任研究助手
Affiliation (based on the past Project Information) *help	2024: 公益財団法人がん研究会, がん化学療法センター基礎研究部, 主任研究助手 2021: 公益財団法人がん研究会, がん化学療法センター基礎研究部, 研究員 2020: 公益財団法人がん研究会, がん化学療法センター基礎研究部, 主任研究助手 2013 – 2019: 公益財団法人がん研究会, がん化学療法センター基礎研究部, 研究員 2014: 公益財団法人がん研究会, がん化学療法センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Tumor biology Except Principal Investigator Complex systems
Keywords	Principal Investigator がん転移 / 血小板 / ペプチド阻害剤 / CLEC-2 / in vivoスクリーニング / 核小体 / リボソーム Except Principal Investigator 再生医療 / 数理モデル / 臨床 … More / 数理科学 / 計算機科学 / 遺伝子 / 細胞・組織 / 癌 Less

新規創製CLEC-2結合ペプチドの解析によるがんに関連した血小板活性化制御法の開発Principal Investigator
- Principal Investigator
  
  竹本愛
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research
Identification and analysis of novel metastasis regulators by the metastasis-step focused in vivo screeningPrincipal Investigator
- Principal Investigator
  
  TAKEMOTO Ai
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research
Integrated analysis and regulation of cellular diversity for disease treatment
- Principal Investigator
  
  FUJITA Naoya
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Japanese Foundation for Cancer Research
Functional analysis of Merm1 promoting tumor metastasisPrincipal Investigator
- Principal Investigator
  
  TAKEMOTO Ai
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Japanese Foundation for Cancer Research
Functional analysis of the novel metastasis-promoting factor Merm1Principal Investigator
- Principal Investigator
  
  TAKEMOTO Ai
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Tumor biology
- Research Institution
  Japanese Foundation for Cancer Research

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Book

[Book] がんの転移治療の新たなターゲット：がん細胞―血小板相互作用2016
- Author(s)
  竹本愛, 藤田直也
- Total Pages
  7
- Publisher
  日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-15K18419
[Book] 「がん微小環境の病態理解と制御」血小板・エクソソーム2016
- Author(s)
  竹本愛
- Total Pages
  7
- Publisher
  医学のあゆみ
- Data Source
  KAKENHI-PROJECT-15K18419
[Book] 「特集1血小板と悪性腫瘍」がんの転移治療の新たなターゲット：がん細胞―血小板相互作用2016
- Author(s)
  竹本愛、藤田直也
- Total Pages
  6
- Publisher
  日本血栓止血学会誌
- Data Source
  KAKENHI-PROJECT-15K18419
[Book] 実験医学増刊　がん微小環境と標的治療、第4章-5. がん悪性化に関わる血小板の凝集機構を標的とした治療2015
- Author(s)
  竹本愛、藤田直也
- Total Pages
  6
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-25890022
[Journal Article] Soluble PD-L1 works as a decoy in lung cancer immunotherapy via alternative polyadenylation2022
- Author(s)
  Sagawa Ray、Sakata Seiji、Gong Bo、Seto Yosuke、Takemoto Ai、Takagi Satoshi、Ninomiya Hironori、Yanagitani Noriko、Nakao Masayuki、Mun Mingyon、Uchibori Ken、Nishio Makoto、Miyazaki Yasunari、Shiraishi Yuichi、Ogawa Seishi、Kataoka Keisuke、Fujita Naoya、Takeuchi Kengo、Katayama Ryohei
- Journal Title
  
  JCI Insight
  
  Volume: 7 Issue: 1 Pages: 1-19
- DOI
  10.1172/jci.insight.153323
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21554, KAKENHI-PROJECT-20K16370, KAKENHI-PLANNED-17H06327, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-19H03524, KAKENHI-PROJECT-20K07399
[Journal Article] Platelet-derived lysophosphatidic acid mediated LPAR1 activation as a therapeutic target for osteosarcoma metastasis2021
- Author(s)
  Takagi Satoshi、Sasaki Yuki、Koike Sumie、Takemoto Ai、Seto Yosuke、Haraguchi Mizuki、Ukaji Takao、Kawaguchi Tokuichi、Sugawara Minoru、Saito Masanori、Funauchi Yuki、Ae Keisuke、Matsumoto Seiichi、Fujita Naoya、Katayama Ryohei
- Journal Title
  
  Oncogene
  
  Volume: 40 Issue: 36 Pages: 5548-5558
- DOI
  10.1038/s41388-021-01956-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21554, KAKENHI-PROJECT-20K16370, KAKENHI-PLANNED-17H06327, KAKENHI-PROJECT-19H03524, KAKENHI-ORGANIZER-17H06324
[Journal Article] Novel knock-in mouse model for the evaluation of the therapeutic efficacy and toxicity of human podoplanin-targeting agents.2021
- Author(s)
  Ukaji T, Takemoto A, Shibata H, Kakino M, Takagi S, Katayama R, Fujita N
- Journal Title
  
  Cancer Science
  
  Volume: In press Issue: 6 Pages: 2299-2313
- DOI
  10.1111/cas.14891
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07216, KAKENHI-PROJECT-19K22572, KAKENHI-PLANNED-17H06327
[Journal Article] Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer2021
- Author(s)
  Mizuta Hayato、Okada Koutaroh、Araki Mitsugu、Adachi Jun、Takemoto Ai、Kutkowska Justyna、Maruyama Kohei、Friboulet Luc、Katayama Kazuhiro、Ma Biao、Sasakura Yoko、Sagae Yukari、Kukimoto-Niino Mutsuko、Shirouzu Mikako、Takagi Satoshi、Simizu Siro、Nishio Makoto、Okuno Yasushi、Fujita Naoya、Katayama Ryohei, et al
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 1261-1261
- DOI
  10.1038/s41467-021-21396-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21554, KAKENHI-PLANNED-17H06327, KAKENHI-PROJECT-19H03524, KAKENHI-PROJECT-18K06137, KAKENHI-PROJECT-19K22572, KAKENHI-PROJECT-18K06594, KAKENHI-ORGANIZER-17H06324
[Journal Article] A safety study of newly generated anti-podoplanin-neutralizing antibody in cynomolgus monkey (Macaca fascicularis).2018
- Author(s)
  Ukaji T, Takemoto A, Katayama R, Takeuchi K, Fujita N
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 70 Pages: 33322-33336
- DOI
  10.18632/oncotarget.26055
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07216, KAKENHI-ORGANIZER-17H06324, KAKENHI-PLANNED-17H06327
[Journal Article] Podoplanin - an emerging cancer biomarker and therapeutic target.2018
- Author(s)
  Krishnan H, Rayes J, Miyashita T, Ishii G, Retzbach EP, Sheehan SA, Takemoto A, Chang YW, Yoneda K, Asai J, Jensen L, Chalise L, Natsume A, Goldberg GS.
- Journal Title
  
  Cancer Sci.
  
  Volume: 印刷中 Issue: 5 Pages: 1292-1299
- DOI
  10.1111/cas.13580
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06356, KAKENHI-PROJECT-16H05436, KAKENHI-PROJECT-18K07216, KAKENHI-PROJECT-16H01747
[Journal Article] Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation.2017
- Author(s)
  Miyata K, Takemoto A, Okumura S, Nishio M, Fujita N.
- Journal Title
  
  Scientific Reports
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K18419
[Journal Article] A critical role of platelet TGF-b release in podoplanin-mediated tumour invasion and metastasis2017
- Author(s)
  Takemoto A, Okitaka M, Takagi S, Takami M, Sato S, Nishio M, Okumura S, Fujita N
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 42186-42186
- DOI
  10.1038/srep42186
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K18419, KAKENHI-ORGANIZER-17H06324, KAKENHI-PLANNED-17H06327
[Journal Article] Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation2017
- Author(s)
  Kenichi Miyata, Ai Takemoto, Sakae Okumura, Makoto Nishio, Naoya Fujita
- Journal Title
  
  Sci. Rep.
  
  Volume: 7 Issue: 1 Pages: 4059-4059
- DOI
  10.1038/s41598-017-04324-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06324, KAKENHI-PLANNED-17H06327
[Journal Article] Targeting a novel domain in podoplanin for inhibiting platelet-mediated tumor metastasis.2016
- Author(s)
  Sekiguchi T, Takemoto A, Takagi S, Takatori K, Sato S, Takami M, Fujita N.
- Journal Title
  
  Oncotarget
  
  Volume: 7 Issue: 4 Pages: 3934-3934
- DOI
  10.18632/oncotarget.6598
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18419, KAKENHI-PROJECT-26640108
[Journal Article] Nuclear envelope expansion is crucial for proper chromosomal segregation during a closed mitosis2016
- Author(s)
  Takemoto A, Kawashima SA, Li JJ, Jeffery L, Yamatsugu K, Elemento O, Nurse P.
- Journal Title
  
  Journal of Cell Science
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18419
[Journal Article] Platelets promote osteosarcoma cell growth through activation of the PDGFR-Akt signaling axis.2014
- Author(s)
  Satoshi Takagi, Ai Takemoto, Miho Takami, Tomoko Oh-hara, and Naoya Fujita
- Journal Title
  
  Cancer Sci.
  
  Volume: 105 Issue: 8 Pages: 983-988
- DOI
  10.1111/cas.12464
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22112008, KAKENHI-PROJECT-25830125, KAKENHI-PROJECT-25890022
[Presentation] Osteosarcoma promotes pulmonary metastasis via the release of　lysophosphatidic acid from activated platelets2021
- Author(s)
  高木聡、小池清恵、竹本愛、菅原稔、藤田直也、片山量平
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-17H06327
[Presentation] Discovery of the FLT3 inhibitor gilteritinib as a novel therapeutic strategy to overcome ALK-TKI resistance2021
- Author(s)
  水田隼斗、竹本愛、高木聡、清水史郎、西尾誠人、藤田直也、片山量平
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-17H06327
[Presentation] FLT3阻害薬ギルテリチニブは多剤耐性ALK陽性肺がんの耐性を克服する2021
- Author(s)
  水田隼斗、高木聡、竹本愛、西尾誠人、藤田直也、清水史郎、片山量平
- Organizer
  第25回日本がんがん分子標的治療学会
- Data Source
  KAKENHI-PLANNED-17H06327
[Presentation] 血小板活性化因子Podoplaninを介した腫瘍細胞社会ダイバーシティーの理解と制御2020
- Author(s)
  高木聡, 片山量平, 宇梶太雄, 竹本愛, 藤田直也
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K07216
[Presentation] Regulation of cellular diversity in tumor microenvironment by platelet activation-inducing molecule Podoplanin2020
- Author(s)
  Satoshi Takagi, Ryohei Katayama, Ai Takemoto, Naoya Fujita
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-17H06327
[Presentation] 血小板活性化因子Podoplaninが作り出すがん免疫逃避環境の解析2020
- Author(s)
  古賀美菜穂, 小池清恵, 藤田直也, 竹本愛, 片山量平, 高木聡
- Organizer
  新学術領域「細胞第バース」第5回公開シンポジウムポスター発表
- Data Source
  KAKENHI-PROJECT-18K07216
[Presentation] Targeting podoplanin-platelet interaction for suppressing tumor progression.2019
- Author(s)
  Ai Takemoto, Takao Ukaji, Satoshi Takagi, Ryohei Katayama, Naoya Fujita
- Organizer
  Podoplanin meeting 2019
- Data Source
  KAKENHI-PROJECT-18K07216
[Presentation] Targeting podoplanin-platelet interaction for the treatment of osteosarcoma2019
- Author(s)
  Ai Takemoto, Takao Ukaji, Miho Takami, Shigeo Sato, Ryohei Katayama, Naoya Fujita
- Organizer
  11th JCA-AACR Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07216
[Presentation] ポドプラニン中和抗体による骨肉腫増殖抑制とその分子機構2019
- Author(s)
  竹本愛、片山量平, 藤田直也
- Organizer
  第23回日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-18K07216
[Presentation] Development of a humanized anti-podoplanin antibody inhibiting tumor-dependent platelet activation2019
- Author(s)
  Ai Takemoto, Nobuhiko Gyobu, Mamoru Kakino, Shinya Fujihara, Naoki Goda, Junya Maeda, Miho Takami, Takao Ukaji, Satoshi Takagi, Ryohei Katayama, Kazue Tsuji-Takayama, Kenji Ichihara, Shinobu Nakayama, Yoshiyuki Ohsugi, and Naoya Fujita
- Organizer
  The 24th JFCR-ISCC Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07216
[Presentation] Inhibition of Podoplanin-induced platelet activation for suppressing cancer progression2019
- Author(s)
  Ai Takemoto
- Organizer
  Cell Communication Disorders leading to Cancer and Other Diseases NLS seminar
- Invited
- Data Source
  KAKENHI-PROJECT-18K07216
[Presentation] Development of a humanized anti-podoplanin antibody inhibiting tumor-dependent platelet activation.2019
- Author(s)
  Ai Takemoto, Nobuhiko Gyobu, Mamoru Kakino, Shinya Fujihara, Naoki Goda, Junya Maeda, Miho Takami, Takao Ukaji, Satoshi Takagi, Ryohei Katayama, Kazue Tsuji-Takayama, Kenji Ichihara, Shinobu Nakayama, Yoshiyuki Ohsugi, and Naoya Fujita
- Organizer
  The 24th ISCC Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06327
[Presentation] がん誘発性血栓症における腫瘍由来ポドプラニンの寄与2019
- Author(s)
  竹本愛
- Organizer
  第67回日本心臓病学会学術集会／バイエル循環器病研究助成第 26 回研究発表会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07216
[Presentation] サルポドプラニンの血小板凝集誘導活性におけるPLAG4ドメインの役割2018
- Author(s)
  宇梶太雄, 竹本愛, 藤田直也
- Organizer
  第27回日本がん転移学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07216
[Presentation] がんと血小板の結合を標的とする化合物の探索と解析2018
- Author(s)
  竹本愛, 片山量平, 藤田直也
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07216
[Presentation] がんと血小板の結合を標的とする化合物の探索と解析2018
- Author(s)
  竹本愛、片山量平、藤田直也
- Organizer
  第７７回　日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-17H06327
[Presentation] サルポドプラニンの血小板凝集誘導活性におけるPLAG4ドメインの役割2018
- Author(s)
  宇梶太雄、竹本愛、藤田直也
- Organizer
  第27回日本がん転移学会学術集会
- Data Source
  KAKENHI-PLANNED-17H06327
[Presentation] 低転移性の結腸がん細胞を用いたin vivoスクリーニングによる新規がん転移制御因子の探索2018
- Author(s)
  木村美紗, 藤田直也, 竹本愛
- Organizer
  第22回日本癌分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07216
[Presentation] ポドプラニンが誘導する血小板TGF- 放出による転移促進機構2017
- Author(s)
  竹本愛、藤田直也
- Organizer
  第26回日本がん転移学会学術集会
- Data Source
  KAKENHI-PLANNED-17H06327
[Presentation] Identification and targeting of an additional platelet aggregation-stimulating domain (PLAG4) on podoplanin/Aggrus for cancer therapy2016
- Author(s)
  竹本愛、西尾誠人、藤田直也
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  別府国際コンベンションセンター
- Year and Date
  2016-05-31
- Data Source
  KAKENHI-PROJECT-15K18419
[Presentation] Suppression of platelet aggregation and tumor metastasis by anti-podoplanin mAb recognizing a novel CLEC-2 binding domain2016
- Author(s)
  Sekiguchi T, Takemoto A, Fujita N
- Organizer
  AACR Annual Meeting 2016
- Place of Presentation
  New Orleans, LA
- Year and Date
  2016-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18419
[Presentation] The role of podoplanin-mediated platelet aggregation in tumor growth in vivo2016
- Author(s)
  宮田憲一、竹本愛、藤田直也
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K18419
[Presentation] The blockade of a novel domain by anti-podoplanin mAb suppresses platelet aggregation and tumor metastasis2016
- Author(s)
  関口貴哉、竹本愛、藤田直也
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K18419
[Presentation] Podoplanin expressed on highly metastatic tumor cell surface induces EMT through platelet aggregation and metastasis2016
- Author(s)
  竹本愛、高木聡、藤田直也
- Organizer
  第75回　日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-15K18419
[Presentation] Aggrus依存的な血小板凝集はEMTを介してがん転移を促進する2015
- Author(s)
  竹本愛, 大原智子, 藤田直也
- Organizer
  第19回日本がん分子標的治療学会学術集会
- Place of Presentation
  松山全日空ホテル
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-15K18419
[Presentation] 腫瘍依存的な血小板凝集を標的にしたがん治療2015
- Author(s)
  藤田直也, 竹本愛
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-08
- Invited
- Data Source
  KAKENHI-PROJECT-15K18419
[Presentation] 血小板はPDGFR-Akt経路活性化を介して骨肉腫の悪性化に寄与する
- Author(s)
  竹本愛、高木聡、高見美穂、大原智子、藤田直也
- Organizer
  平成26年度がん若手研究者ワークショップ
- Place of Presentation
  蓼科
- Year and Date
  2014-09-03 – 2014-09-06
- Data Source
  KAKENHI-PROJECT-25890022
[Presentation] Aggrus-induced platelet aggregation promotes tumor metastasis by enhancing EMT
- Author(s)
  Ai Takemoto, Satoshi Takagi, Mina Okitaka, Miho Takami, Shigeo Sato, Tomoko Oh-hara, and Naoya Fujita
- Organizer
  Joint International Symposium on TGF-beta Family and Cancer Signal Network in Tumor Microenvironment
- Place of Presentation
  Tsukuba
- Year and Date
  2015-01-12 – 2015-01-13
- Data Source
  KAKENHI-PROJECT-25890022
[Presentation] 血小板はPDGFR-Akt経路活性化を介して骨肉腫の悪性化に寄与する
- Author(s)
  竹本愛、高木聡、高見美穂、大原智子、藤田直也
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25890022
[Presentation] Aggrus依存的な血小板凝集はEMTを介してがん転移を促進する
- Author(s)
  竹本愛、大原智子、藤田直也
- Organizer
  第19回日本がん分子標的治療学会学術集会
- Place of Presentation
  松山
- Year and Date
  2015-06-10 – 2015-06-12
- Data Source
  KAKENHI-PROJECT-25890022

1. FUJITA Naoya (20280951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
2. 高木聡 (20582240)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. 田崎創平 (50713020)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 片山量平 (60435542)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
5. TAKAMI Miho

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. SATO Shigeo

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. OH-HARA Tomoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. MIYATA Kenichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. SEKIGUCHI Takaya

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. 夏目敦至

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKEMOTO Ai 竹本 愛

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新規創製CLEC-2結合ペプチドの解析によるがんに関連した血小板活性化制御法の開発Principal Investigator

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Identification and analysis of novel metastasis regulators by the metastasis-step focused in vivo screeningPrincipal Investigator

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Integrated analysis and regulation of cellular diversity for disease treatment

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Functional analysis of Merm1 promoting tumor metastasisPrincipal Investigator

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Functional analysis of the novel metastasis-promoting factor Merm1Principal Investigator

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[Book] がんの転移治療の新たなターゲット：がん細胞―血小板相互作用2016

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[Book] 「がん微小環境の病態理解と制御」 血小板・エクソソーム2016

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[Book] 「特集1血小板と悪性腫瘍」 がんの転移治療の新たなターゲット：がん細胞―血小板相互作用2016

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[Book] 実験医学増刊 がん微小環境と標的治療、第4章-5. がん悪性化に関わる血小板の凝集機構を標的とした治療2015

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[Journal Article] Soluble PD-L1 works as a decoy in lung cancer immunotherapy via alternative polyadenylation2022

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[Journal Article] Platelet-derived lysophosphatidic acid mediated LPAR1 activation as a therapeutic target for osteosarcoma metastasis2021

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[Journal Article] Novel knock-in mouse model for the evaluation of the therapeutic efficacy and toxicity of human podoplanin-targeting agents.2021

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[Journal Article] Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer2021

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[Journal Article] A safety study of newly generated anti-podoplanin-neutralizing antibody in cynomolgus monkey (Macaca fascicularis).2018

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[Journal Article] Podoplanin - an emerging cancer biomarker and therapeutic target.2018

TAKEMOTO Ai 竹本愛

[Book] 「がん微小環境の病態理解と制御」血小板・エクソソーム2016

[Book] 「特集1血小板と悪性腫瘍」がんの転移治療の新たなターゲット：がん細胞―血小板相互作用2016

[Book] 実験医学増刊　がん微小環境と標的治療、第4章-5. がん悪性化に関わる血小板の凝集機構を標的とした治療2015

[Presentation] Osteosarcoma promotes pulmonary metastasis via the release of　lysophosphatidic acid from activated platelets2021