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Takefuji Mikito  竹藤 幹人

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TAKEFUJI MIKITO  竹藤 幹人

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Researcher Number 20709117
Other IDs
Affiliation (Current) 2025: 名古屋大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help 2020 – 2024: 名古屋大学, 医学部附属病院, 講師
2018 – 2019: 名古屋大学, 医学系研究科, 助教
2014 – 2017: 名古屋大学, 医学部附属病院, 助教
Review Section/Research Field
Principal Investigator
Basic Section 53020:Cardiology-related / Cardiovascular medicine
Except Principal Investigator
Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Basic Section 53020:Cardiology-related
Keywords
Principal Investigator
心不全 / キナーゼ / 心筋細胞 / 低分子量RhoA / 低分子量Rho / リン酸化
Except Principal Investigator
骨格筋 / 運動 / マイオカイン / 加齢関連疾患 … More / 心筋炎 / 心腎血管疾患 / microRNA / 持久性運動 Less
  • Research Projects

    (8 results)
  • Research Products

    (14 results)
  • Co-Researchers

    (15 People)
  •  Role of exercise-regulated myokines in aging-related diseases

    • Principal Investigator
      大内 乗有
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
    • Research Institution
      Nagoya University
  •  Atypical kinaseが修飾する心臓の拡張調節機序とHFpEF病態の解明Principal Investigator

    • Principal Investigator
      竹藤 幹人
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Nagoya University
  •  劇症型心筋炎における急性期管理法の確立および低侵襲早期診断マーカーの探索と開発

    • Principal Investigator
      奥村 貴裕
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Nagoya University
  •  Identification and characterization of novel microRNAs secreted from muscle

    • Principal Investigator
      Ouchi Noriyuki
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
    • Research Institution
      Nagoya University
  •  Role of myokines in preventing the development of age-related diseases

    • Principal Investigator
      大内 乗有
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
    • Research Institution
      Nagoya University
  •  The role of GPCR in cardiac diastolic dysfunctionPrincipal Investigator

    • Principal Investigator
      Takefuji Mikito
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Nagoya University
  •  The role of protein kinase N in cardiomyocytePrincipal Investigator

    • Principal Investigator
      TAKEFUJI MIKITO
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Nagoya University
  •  Novel molecular mechanism of Rho related kinase modifying heart failure condition and development of therapeutic drugPrincipal Investigator

    • Principal Investigator
      TAKEFUJI MIKITO
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Nagoya University

All 2022 2021 2020 2019 2017 2015

All Journal Article

  • [Journal Article] Neuron-derived neurotrophic factor protects against dexamethasone-induced skeletal muscle atrophy2022

    • Author(s)
      Ozaki Yuta、Ohashi Koji、Otaka Naoya、Ogawa Hayato、Kawanishi Hiroshi、Takikawa Tomonobu、Fang Lixin、Tatsumi Minako、Takefuji Mikito、Enomoto Takashi、Darwish Mohamed、Iijima Yoko、Iijima Takatoshi、Murohara Toyoaki、Ouchi Noriyuki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 593 Pages: 5-12

    • DOI

      10.1016/j.bbrc.2022.01.028

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21753, KAKENHI-PROJECT-22K19495, KAKENHI-PROJECT-20H03344, KAKENHI-PROJECT-20H00571
  • [Journal Article] Factor Xa inhibitor, edoxaban ameliorates renal injury after subtotal nephrectomy by reducing epithelial‐mesenchymal transition and inflammatory response2022

    • Author(s)
      Fang Lixin、Ohashi Koji、Ogawa Hayato、Otaka Naoya、Kawanishi Hiroshi、Takikawa Tomonobu、Ozaki Yuta、Takahara Kunihiko、Tatsumi Minako、Takefuji Mikito、Murohara Toyoaki、Ouchi Noriyuki
    • Journal Title

      Physiological Reports

      Volume: 10 Issue: 5

    • DOI

      10.14814/phy2.15218

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K21753, KAKENHI-PROJECT-20H00571
  • [Journal Article] Corticotropin releasing hormone receptor 2 antagonist, RQ-00490721, for the prevention of pressure overload-induced cardiac dysfunction2022

    • Author(s)
      Mori Yu、Tsuchihira Ayako、Yoshida Tatsuya、Yoshida Satoya、Fujiuchi Akiyoshi、Ohmi Masashi、Isogai Yumi、Sakaguchi Teruhiro、Eguchi Shunsuke、Tsuda Takuma、Kato Katsuhiro、Ohashi Koji、Ouchi Noriyuki、Park Hyi-Man、Murohara Toyoaki、Takefuji Mikito
    • Journal Title

      Biomedicine & Pharmacotherapy

      Volume: 146 Pages: 112566-112566

    • DOI

      10.1016/j.biopha.2021.112566

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03674, KAKENHI-PROJECT-21H02911
  • [Journal Article] LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and prevents cardiac dysfunction during ischemia2021

    • Author(s)
      Ishihama Sohta、Ouchi Noriyuki、Sakaguchi Teruhiro、Tsuda Takuma、Kato Katsuhiro、Yagyu Hiroaki、Wettschureck Nina、Kubota Naoto、Offermanns Stefan、Kadowaki Takashi、Murohara Toyoaki、Takefuji Mikito
    • Journal Title

      The FASEB Journal

      Volume: 35 Issue: 12 Pages: 1-11

    • DOI

      10.1096/fj.202100882r

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03674, KAKENHI-PROJECT-19H03651
  • [Journal Article] Omentin attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-knockout mice2021

    • Author(s)
      Fang Lixin、Ohashi Koji、Otaka Naoya、Ogawa Hayato、Hiramatsu-Ito Mizuho、Kawanishi Hiroshi、Bando Yasuko K、Shibata Rei、Shimizu Yuuki、Kato Katsuhiro、Takikawa Tomonobu、Ozaki Yuta、Takefuji Mikito、Murohara Toyoaki、Ouchi Noriyuki
    • Journal Title

      Cardiovascular Research

      Volume: ー Issue: 6 Pages: 1597-1610

    • DOI

      10.1093/cvr/cvab179

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K17519, KAKENHI-PROJECT-19H03651, KAKENHI-PROJECT-21H02911, KAKENHI-PROJECT-20K08401, KAKENHI-PROJECT-20K21753, KAKENHI-PROJECT-20H00571
  • [Journal Article] Adverse Effect of Circadian Rhythm Disorder on Reparative Angiogenesis in Hind Limb Ischemia2021

    • Author(s)
      Tsuzuki Kazuhito、Shimizu Yuuki、Suzuki Junya、Pu Zhongyue、Yamaguchi Shukuro、Fujikawa Yusuke、Kato Katsuhiro、Ohashi Koji、Takefuji Mikito、Bando Yasuko K.、Ouchi Noriyuki、Calvert John W.、Shibata Rei、Murohara Toyoaki
    • Journal Title

      Journal of the American Heart Association

      Volume: 10 Issue: 16

    • DOI

      10.1161/jaha.121.020896

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K17519, KAKENHI-PROJECT-19H03651, KAKENHI-PROJECT-20K08401, KAKENHI-PROJECT-20K21753, KAKENHI-PROJECT-20H00571
  • [Journal Article] Important Role of Concomitant Lymphangiogenesis for Reparative Angiogenesis in Hindlimb Ischemia.2021

    • Author(s)
      Pu Z, Shimizu Y, Tsuzuki K, Suzuki J, Hayashida R, Kondo K, Fujikawa Y, Unno K, Ohashi K, Takefuji M, Bando YK, Ouchi N, Calvert JW, Shibata R, Murohara T.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: - Issue: 6 Pages: 2006-2018

    • DOI

      10.1161/atvbaha.121.316191

    • NAID

      120007178394

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02805, KAKENHI-PROJECT-19K17519, KAKENHI-PROJECT-19H03651, KAKENHI-PROJECT-21H02911, KAKENHI-PROJECT-20K08401, KAKENHI-PROJECT-20K21753, KAKENHI-PROJECT-20H00571
  • [Journal Article] Prognostic impact of transcardiac gradient of follistatin-like 1 reflecting hemodynamics in patients with dilated cardiomyopathy2021

    • Author(s)
      Oishi Hideo、Okumura Takahiro、Ohashi Koji、Kimura Yuki、Kazama Shingo、Shibata Naoki、Arao Yoshihito、Kato Hiroo、Kuwayama Tasuku、Yamaguchi Shogo、Tatsumi Minako、Kondo Toru、Hiraiwa Hiroaki、Morimoto Ryota、Takefuji Mikito、Ouchi Noriyuki、Murohara Toyoaki
    • Journal Title

      Journal of Cardiology

      Volume: 78 Issue: 6 Pages: 524-532

    • DOI

      10.1016/j.jjcc.2021.07.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K21753, KAKENHI-PROJECT-20H00571
  • [Journal Article] A novel selective PPARα modulator, pemafibrate promotes ischemia-induced revascularization through the eNOS-dependent mechanisms.2020

    • Author(s)
      Kawanishi H, Ohashi K, Ogawa H, Otaka N, Takikawa T, Fang L, Ozaki Y, Takefuji M, Murohara T, Ouchi N.
    • Journal Title

      PLoS One.

      Volume: 15 Issue: 6 Pages: e0235362-e0235362

    • DOI

      10.1371/journal.pone.0235362

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K21753, KAKENHI-PROJECT-18K19541, KAKENHI-PROJECT-20H00571
  • [Journal Article] Adipolin/C1q/Tnf-related protein 12 prevents adverse cardiac remodeling after myocardial infarction.2020

    • Author(s)
      Takikawa T, Ohashi K, Ogawa H, Otaka N, Kawanishi H, Fang L, Ozaki Y, Eguchi S, Tatsumi M, Takefuji M, Murohara T, Ouchi N.
    • Journal Title

      PLoS One.

      Volume: 15 Issue: 12 Pages: e0243483-e0243483

    • DOI

      10.1371/journal.pone.0243483

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K21753, KAKENHI-PROJECT-18H02805, KAKENHI-PROJECT-18K19541, KAKENHI-PROJECT-20H00571
  • [Journal Article] Cardiomyocytes capture stem cell-derived, anti-apoptotic microRNA-214 via clathrin-mediated endocytosis in acute myocardial infarction.2019

    • Author(s)
      Eguchi S, Takefuji M, Sakaguchi T, Ishihama S, Mori Y, Tsuda T, Takikawa T, Yoshida T, Ohashi K, Shimizu Y, Hayashida R, Kondo K, Bando YK, Ouchi N, Murohara T.
    • Journal Title

      J Biol Chem.

      Volume: 294 Issue: 31 Pages: 11665-11674

    • DOI

      10.1074/jbc.ra119.007537

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K19541, KAKENHI-PROJECT-17H04175, KAKENHI-PROJECT-19H03651, KAKENHI-PROJECT-17K09571, KAKENHI-PROJECT-18H02805
  • [Journal Article] Protein Kinase N Promotes Stress-Induced Cardiac Dysfunction Through Phosphorylation of Myocardin-Related Transcription Factor A and Disruption of Its Interaction With Actin.2019

    • Author(s)
      Sakaguchi T, Takefuji M, Wettschureck N, Hamaguchi T, Amano M, Kato K, Tsuda T, Eguchi S, Ishihama S, Mori Y, Yura Y, Yoshida T, Unno K, Okumura T, Ishii H, Shimizu Y, Bando YK, Ohashi K, Ouchi N, Enomoto A, Offermanns S, Kaibuchi K, Murohara T.
    • Journal Title

      Circulation.

      Volume: 140 Issue: 21 Pages: 1737-1752

    • DOI

      10.1161/circulationaha.119.041019

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19541, KAKENHI-PROJECT-17H04175, KAKENHI-PROJECT-19H03651, KAKENHI-PROJECT-17K09571, KAKENHI-PROJECT-18H02805, KAKENHI-PROJECT-17K09573, KAKENHI-PROJECT-17K07383
  • [Journal Article] Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction.2017

    • Author(s)
      Tsuda T, Takefuji M, Wettschureck N, Kotani K, Morimoto R, Okumura T, Kaur H, Eguchi S, Sakaguchi T, Ishihama S, Kikuchi R, Unno K, Matsushita K, Ishikawa S, Offermanns S, Murohara T.
    • Journal Title

      J Exp Med.

      Volume: 214 Issue: 7 Pages: 1877-1877

    • DOI

      10.1084/jem.20161924

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09141, KAKENHI-PROJECT-17K09571, KAKENHI-PROJECT-26461128
  • [Journal Article] Akt-dependent Girdin phosphorylation regulates repair processes after acute myocardial infarction.2015

    • Author(s)
      Hayano S, Takefuji M, Maeda K, Noda T, Ichimiya H, Kobayashi K, Enomoto A, Asai N, Takahashi M, Murohara T.
    • Journal Title

      J Mol Cell Cardiol

      Volume: 88 Pages: 55-63

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26461127
  • 1.  MUROHARA Toyoaki (90299503)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 4 results
  • 2.  Ouchi Noriyuki (00595514)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 8 results
  • 3.  天野 睦紀 (90304170)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  大橋 浩二 (10595515)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 7 results
  • 5.  榎本 篤 (20432255)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  奥村 貴裕 (60635598)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  KAIBUCHI Kozo (00169377)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  吉田 恭子 (00242967)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  鈴木 忠樹 (30527180)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  SHIBATA Rei
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  BANDO Yasuko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  KONDO Kazuhisa
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  ISHIKAWA Shizukiyo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  KOTANI Kazuhiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  清水 優樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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