Takefuji Mikito 竹藤幹人

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TAKEFUJI MIKITO 竹藤幹人

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Researcher Number	20709117
Other IDs
Affiliation (Current)	2025: 名古屋大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2020 – 2024: 名古屋大学, 医学部附属病院, 講師 2018 – 2019: 名古屋大学, 医学系研究科, 助教 2014 – 2017: 名古屋大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine Except Principal Investigator Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Basic Section 53020:Cardiology-related
Keywords	Principal Investigator 心不全 / キナーゼ / 心筋細胞 / 低分子量RhoA / 低分子量Rho / リン酸化 Except Principal Investigator 骨格筋 / 運動 / マイオカイン / 加齢関連疾患 … More / 心筋炎 / 心腎血管疾患 / microRNA / 持久性運動 Less

Role of exercise-regulated myokines in aging-related diseases
- Principal Investigator
  
  大内乗有
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Nagoya University
Atypical kinaseが修飾する心臓の拡張調節機序とHFpEF病態の解明Principal Investigator
- Principal Investigator
  
  竹藤幹人
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Nagoya University
劇症型心筋炎における急性期管理法の確立および低侵襲早期診断マーカーの探索と開発
- Principal Investigator
  
  奥村貴裕
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Nagoya University
Identification and characterization of novel microRNAs secreted from muscle
- Principal Investigator
  
  Ouchi Noriyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Nagoya University
Role of myokines in preventing the development of age-related diseases
- Principal Investigator
  
  大内乗有
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Nagoya University
The role of GPCR in cardiac diastolic dysfunctionPrincipal Investigator
- Principal Investigator
  
  Takefuji Mikito
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Nagoya University
The role of protein kinase N in cardiomyocytePrincipal Investigator
- Principal Investigator
  
  TAKEFUJI MIKITO
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Nagoya University
Novel molecular mechanism of Rho related kinase modifying heart failure condition and development of therapeutic drugPrincipal Investigator
- Principal Investigator
  
  TAKEFUJI MIKITO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Nagoya University

All 2022 2021 2020 2019 2017 2015

All Journal Article

[Journal Article] Neuron-derived neurotrophic factor protects against dexamethasone-induced skeletal muscle atrophy2022
- Author(s)
  Ozaki Yuta、Ohashi Koji、Otaka Naoya、Ogawa Hayato、Kawanishi Hiroshi、Takikawa Tomonobu、Fang Lixin、Tatsumi Minako、Takefuji Mikito、Enomoto Takashi、Darwish Mohamed、Iijima Yoko、Iijima Takatoshi、Murohara Toyoaki、Ouchi Noriyuki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 593 Pages: 5-12
- DOI
  10.1016/j.bbrc.2022.01.028
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21753, KAKENHI-PROJECT-22K19495, KAKENHI-PROJECT-20H03344, KAKENHI-PROJECT-20H00571
[Journal Article] Factor Xa inhibitor, edoxaban ameliorates renal injury after subtotal nephrectomy by reducing epithelial‐mesenchymal transition and inflammatory response2022
- Author(s)
  Fang Lixin、Ohashi Koji、Ogawa Hayato、Otaka Naoya、Kawanishi Hiroshi、Takikawa Tomonobu、Ozaki Yuta、Takahara Kunihiko、Tatsumi Minako、Takefuji Mikito、Murohara Toyoaki、Ouchi Noriyuki
- Journal Title
  
  Physiological Reports
  
  Volume: 10 Issue: 5
- DOI
  10.14814/phy2.15218
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21753, KAKENHI-PROJECT-20H00571
[Journal Article] Corticotropin releasing hormone receptor 2 antagonist, RQ-00490721, for the prevention of pressure overload-induced cardiac dysfunction2022
- Author(s)
  Mori Yu、Tsuchihira Ayako、Yoshida Tatsuya、Yoshida Satoya、Fujiuchi Akiyoshi、Ohmi Masashi、Isogai Yumi、Sakaguchi Teruhiro、Eguchi Shunsuke、Tsuda Takuma、Kato Katsuhiro、Ohashi Koji、Ouchi Noriyuki、Park Hyi-Man、Murohara Toyoaki、Takefuji Mikito
- Journal Title
  
  Biomedicine & Pharmacotherapy
  
  Volume: 146 Pages: 112566-112566
- DOI
  10.1016/j.biopha.2021.112566
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03674, KAKENHI-PROJECT-21H02911
[Journal Article] LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and prevents cardiac dysfunction during ischemia2021
- Author(s)
  Ishihama Sohta、Ouchi Noriyuki、Sakaguchi Teruhiro、Tsuda Takuma、Kato Katsuhiro、Yagyu Hiroaki、Wettschureck Nina、Kubota Naoto、Offermanns Stefan、Kadowaki Takashi、Murohara Toyoaki、Takefuji Mikito
- Journal Title
  
  The FASEB Journal
  
  Volume: 35 Issue: 12 Pages: 1-11
- DOI
  10.1096/fj.202100882r
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03674, KAKENHI-PROJECT-19H03651
[Journal Article] Omentin attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-knockout mice2021
- Author(s)
  Fang Lixin、Ohashi Koji、Otaka Naoya、Ogawa Hayato、Hiramatsu-Ito Mizuho、Kawanishi Hiroshi、Bando Yasuko K、Shibata Rei、Shimizu Yuuki、Kato Katsuhiro、Takikawa Tomonobu、Ozaki Yuta、Takefuji Mikito、Murohara Toyoaki、Ouchi Noriyuki
- Journal Title
  
  Cardiovascular Research
  
  Volume: ー Issue: 6 Pages: 1597-1610
- DOI
  10.1093/cvr/cvab179
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17519, KAKENHI-PROJECT-19H03651, KAKENHI-PROJECT-21H02911, KAKENHI-PROJECT-20K08401, KAKENHI-PROJECT-20K21753, KAKENHI-PROJECT-20H00571
[Journal Article] Adverse Effect of Circadian Rhythm Disorder on Reparative Angiogenesis in Hind Limb Ischemia2021
- Author(s)
  Tsuzuki Kazuhito、Shimizu Yuuki、Suzuki Junya、Pu Zhongyue、Yamaguchi Shukuro、Fujikawa Yusuke、Kato Katsuhiro、Ohashi Koji、Takefuji Mikito、Bando Yasuko K.、Ouchi Noriyuki、Calvert John W.、Shibata Rei、Murohara Toyoaki
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 10 Issue: 16
- DOI
  10.1161/jaha.121.020896
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17519, KAKENHI-PROJECT-19H03651, KAKENHI-PROJECT-20K08401, KAKENHI-PROJECT-20K21753, KAKENHI-PROJECT-20H00571
[Journal Article] Important Role of Concomitant Lymphangiogenesis for Reparative Angiogenesis in Hindlimb Ischemia.2021
- Author(s)
  Pu Z, Shimizu Y, Tsuzuki K, Suzuki J, Hayashida R, Kondo K, Fujikawa Y, Unno K, Ohashi K, Takefuji M, Bando YK, Ouchi N, Calvert JW, Shibata R, Murohara T.
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: - Issue: 6 Pages: 2006-2018
- DOI
  10.1161/atvbaha.121.316191
- NAID
  120007178394
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02805, KAKENHI-PROJECT-19K17519, KAKENHI-PROJECT-19H03651, KAKENHI-PROJECT-21H02911, KAKENHI-PROJECT-20K08401, KAKENHI-PROJECT-20K21753, KAKENHI-PROJECT-20H00571
[Journal Article] Prognostic impact of transcardiac gradient of follistatin-like 1 reflecting hemodynamics in patients with dilated cardiomyopathy2021
- Author(s)
  Oishi Hideo、Okumura Takahiro、Ohashi Koji、Kimura Yuki、Kazama Shingo、Shibata Naoki、Arao Yoshihito、Kato Hiroo、Kuwayama Tasuku、Yamaguchi Shogo、Tatsumi Minako、Kondo Toru、Hiraiwa Hiroaki、Morimoto Ryota、Takefuji Mikito、Ouchi Noriyuki、Murohara Toyoaki
- Journal Title
  
  Journal of Cardiology
  
  Volume: 78 Issue: 6 Pages: 524-532
- DOI
  10.1016/j.jjcc.2021.07.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21753, KAKENHI-PROJECT-20H00571
[Journal Article] A novel selective PPARα modulator, pemafibrate promotes ischemia-induced revascularization through the eNOS-dependent mechanisms.2020
- Author(s)
  Kawanishi H, Ohashi K, Ogawa H, Otaka N, Takikawa T, Fang L, Ozaki Y, Takefuji M, Murohara T, Ouchi N.
- Journal Title
  
  PLoS One.
  
  Volume: 15 Issue: 6 Pages: e0235362-e0235362
- DOI
  10.1371/journal.pone.0235362
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21753, KAKENHI-PROJECT-18K19541, KAKENHI-PROJECT-20H00571
[Journal Article] Adipolin/C1q/Tnf-related protein 12 prevents adverse cardiac remodeling after myocardial infarction.2020
- Author(s)
  Takikawa T, Ohashi K, Ogawa H, Otaka N, Kawanishi H, Fang L, Ozaki Y, Eguchi S, Tatsumi M, Takefuji M, Murohara T, Ouchi N.
- Journal Title
  
  PLoS One.
  
  Volume: 15 Issue: 12 Pages: e0243483-e0243483
- DOI
  10.1371/journal.pone.0243483
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21753, KAKENHI-PROJECT-18H02805, KAKENHI-PROJECT-18K19541, KAKENHI-PROJECT-20H00571
[Journal Article] Cardiomyocytes capture stem cell-derived, anti-apoptotic microRNA-214 via clathrin-mediated endocytosis in acute myocardial infarction.2019
- Author(s)
  Eguchi S, Takefuji M, Sakaguchi T, Ishihama S, Mori Y, Tsuda T, Takikawa T, Yoshida T, Ohashi K, Shimizu Y, Hayashida R, Kondo K, Bando YK, Ouchi N, Murohara T.
- Journal Title
  
  J Biol Chem.
  
  Volume: 294 Issue: 31 Pages: 11665-11674
- DOI
  10.1074/jbc.ra119.007537
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19541, KAKENHI-PROJECT-17H04175, KAKENHI-PROJECT-19H03651, KAKENHI-PROJECT-17K09571, KAKENHI-PROJECT-18H02805
[Journal Article] Protein Kinase N Promotes Stress-Induced Cardiac Dysfunction Through Phosphorylation of Myocardin-Related Transcription Factor A and Disruption of Its Interaction With Actin.2019
- Author(s)
  Sakaguchi T, Takefuji M, Wettschureck N, Hamaguchi T, Amano M, Kato K, Tsuda T, Eguchi S, Ishihama S, Mori Y, Yura Y, Yoshida T, Unno K, Okumura T, Ishii H, Shimizu Y, Bando YK, Ohashi K, Ouchi N, Enomoto A, Offermanns S, Kaibuchi K, Murohara T.
- Journal Title
  
  Circulation.
  
  Volume: 140 Issue: 21 Pages: 1737-1752
- DOI
  10.1161/circulationaha.119.041019
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19541, KAKENHI-PROJECT-17H04175, KAKENHI-PROJECT-19H03651, KAKENHI-PROJECT-17K09571, KAKENHI-PROJECT-18H02805, KAKENHI-PROJECT-17K09573, KAKENHI-PROJECT-17K07383
[Journal Article] Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction.2017
- Author(s)
  Tsuda T, Takefuji M, Wettschureck N, Kotani K, Morimoto R, Okumura T, Kaur H, Eguchi S, Sakaguchi T, Ishihama S, Kikuchi R, Unno K, Matsushita K, Ishikawa S, Offermanns S, Murohara T.
- Journal Title
  
  J Exp Med.
  
  Volume: 214 Issue: 7 Pages: 1877-1877
- DOI
  10.1084/jem.20161924
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09141, KAKENHI-PROJECT-17K09571, KAKENHI-PROJECT-26461128
[Journal Article] Akt-dependent Girdin phosphorylation regulates repair processes after acute myocardial infarction.2015
- Author(s)
  Hayano S, Takefuji M, Maeda K, Noda T, Ichimiya H, Kobayashi K, Enomoto A, Asai N, Takahashi M, Murohara T.
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 88 Pages: 55-63
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461127

1. MUROHARA Toyoaki (90299503)

# of Collaborated Projects: 6 results

# of Collaborated Products: 4 results
2. Ouchi Noriyuki (00595514)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
3. 天野睦紀 (90304170)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 大橋浩二 (10595515)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
5. 榎本篤 (20432255)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 奥村貴裕 (60635598)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KAIBUCHI Kozo (00169377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 吉田恭子 (00242967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 鈴木忠樹 (30527180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SHIBATA Rei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. BANDO Yasuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. KONDO Kazuhisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. ISHIKAWA Shizukiyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. KOTANI Kazuhiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 清水優樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Takefuji Mikito 竹藤 幹人

TAKEFUJI MIKITO 竹藤 幹人

Research Projects

Research Products

Co-Researchers

Role of exercise-regulated myokines in aging-related diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Atypical kinaseが修飾する心臓の拡張調節機序とHFpEF病態の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

劇症型心筋炎における急性期管理法の確立および低侵襲早期診断マーカーの探索と開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification and characterization of novel microRNAs secreted from muscle

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of myokines in preventing the development of age-related diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of GPCR in cardiac diastolic dysfunctionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of protein kinase N in cardiomyocytePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel molecular mechanism of Rho related kinase modifying heart failure condition and development of therapeutic drugPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Neuron-derived neurotrophic factor protects against dexamethasone-induced skeletal muscle atrophy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Factor Xa inhibitor, edoxaban ameliorates renal injury after subtotal nephrectomy by reducing epithelial‐mesenchymal transition and inflammatory response2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Corticotropin releasing hormone receptor 2 antagonist, RQ-00490721, for the prevention of pressure overload-induced cardiac dysfunction2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and prevents cardiac dysfunction during ischemia2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Omentin attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-knockout mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adverse Effect of Circadian Rhythm Disorder on Reparative Angiogenesis in Hind Limb Ischemia2021

Author(s)

Takefuji Mikito 竹藤幹人

TAKEFUJI MIKITO 竹藤幹人