Tsukuda Senko 九十田千子

Researcher Number	20710263
Other IDs
Affiliation (based on the past Project Information) *help	2018: 国立研究開発法人理化学研究所, 生命医科学研究センター, 研究員 2016 – 2017: 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 特別研究員
Review Section/Research Field	Principal Investigator Virology
Keywords	Principal Investigator 感染症 / ウィルス / HBV / ウイルス / 局在制御 / 宿主因子 / NTCP / 受容体 / B型肝炎ウイルス / B型肝炎

Identification of host factors that regulate host susceptibility to hepatitis B virus infection and analysis of mechanisms.Principal Investigator
- Principal Investigator
  
  Tsukuda Senko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Institute of Physical and Chemical Research

All 2019 2018 2017 2016

All Journal Article Presentation Book

[Book] Encyclopedia of Signaling Molecules, 2nd Edition2017
- Author(s)
  Tsukuda S, Iwamoto M, Watashi K
- Total Pages
  4700
- Publisher
  Springer Nature
- Data Source
  KAKENHI-PROJECT-16K19145
[Book] Encyclopedia of Signaling Molecules Second Edition -NTCP-2017
- Author(s)
  Senko TsukudaMasashi IwamotoKoichi Watashi
- Publisher
  Springer, Cham
- ISBN
  9783319671987
- Data Source
  KAKENHI-PROJECT-16K19145
[Journal Article] Troglitazone Impedes the Oligomerization of Sodium Taurocholate Cotransporting Polypeptide and Entry of Hepatitis B Virus Into Hepatocytes2019
- Author(s)
  Fukano Kento、Tsukuda Senko、Oshima Mizuki、Suzuki Ryosuke、Aizaki Hideki、Ohki Mio、Park Sam-Yong、Muramatsu Masamichi、Wakita Takaji、Sureau Camille、Ogasawara Yuki、Watashi Koichi
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 9 Pages: 3257-3257
- DOI
  10.3389/fmicb.2018.03257
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09034, KAKENHI-PROJECT-16K08383, KAKENHI-PROJECT-16K19145, KAKENHI-PROJECT-17H04085
[Journal Article] Concept of Viral Inhibitors via NTCP.2019
- Author(s)
  1)Tsukuda S, Fukano K, Watashi K, Wakita T.
- Journal Title
  
  Semin Liver Dis.
  
  Volume: 39 Issue: 01 Pages: 78-95
- DOI
  10.1055/s-0038-1676804
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19145, KAKENHI-PROJECT-17H04085
[Journal Article] A new strategy to identify hepatitis B virus entry inhibitors by AlphaScreen technology targeting the envelope-receptor interaction.2018
- Author(s)
  Saso W, Tsukuda S, Ohashi H, Fukano K, Morishita R, Matsunaga S, Ohki M, Ryo A, Park SY, Suzuki R, Aizaki H, Muramatsu M, Sureau C, Wakita T, Matano T, Watashi K.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 印刷中 Issue: 2 Pages: 374-379
- DOI
  10.1016/j.bbrc.2018.04.187
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19145, KAKENHI-PROJECT-18J14277, KAKENHI-PROJECT-15K09034, KAKENHI-PROJECT-17K15076, KAKENHI-PROJECT-17H04085
[Journal Article] A Single Adaptive Mutation in Sodium Taurocholate Cotransporting Polypeptide Induced by Hepadnaviruses Determines Virus Species Specificity2018
- Author(s)
  Takeuchi Junko S.、Fukano Kento、Iwamoto Masashi、Tsukuda Senko、Suzuki Ryosuke、Aizaki Hideki、Muramatsu Masamichi、Wakita Takaji、Sureau Camille、Watashi Koichi
- Journal Title
  
  Journal of Virology
  
  Volume: 93 Issue: 5 Pages: 04132-18
- DOI
  10.1128/jvi.01432-18
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09034, KAKENHI-PROJECT-16K19145, KAKENHI-PROJECT-16J40232, KAKENHI-PROJECT-17H04085, KAKENHI-PROJECT-17K15708
[Journal Article] Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide2018
- Author(s)
  Kaneko M, Futamura Y, Tsukuda S, Kondoh Y, Sekine T, Hirano H, Fukano K, Ohashi H, Saso W, Morishita R, Matsunaga S, Kawai F, Ryo A, Park S-Y, Suzuki R, Aizaki H, Ohtani N, Sureau C, Wakita T, Osada H, Watashi K
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 2769-2769
- DOI
  10.1038/s41598-018-20987-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05366, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-15K09034, KAKENHI-PROJECT-16K19145, KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-17H04085, KAKENHI-PROJECT-16H04699
[Journal Article] A new class of hepatitis B and D virus entry inhibitors, proanthocyanidin and its analogs, that directly act on the viral large surface proteins.2017
- Author(s)
  Tsukuda S, Watashi K, Hojima T, Isogawa M, Iwamoto M, Omagari K, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Saito A, Tanaka Y, Mizokami M, Sureau C, Wakita T
- Journal Title
  
  Hepatology
  
  Volume: 65 Issue: 4 Pages: 1104-1116
- DOI
  10.1002/hep.28952
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15J03185, KAKENHI-PROJECT-26461015, KAKENHI-PROJECT-16K19145, KAKENHI-PROJECT-26460565
[Journal Article] Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity.2017
- Author(s)
  Shimura S, Watashi K, Fukano K, Peel M, Sluder A, Kawai F, Iwamoto M, Tsukuda S, Takeuchi S J, Miyake T, Sugiyama M, Ogasawara Y, Park SY, Tanaka Y, Kusuhara H, Mizokami M, Sureau C, Wakita T
- Journal Title
  
  J Hepatol
  
  Volume: 66 Issue: 4 Pages: 685-692
- DOI
  10.1016/j.jhep.2016.11.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15J03185, KAKENHI-PROJECT-16K19145, KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-16J40232, KAKENHI-PROJECT-17K15708
[Journal Article] Fungus-Derived Neoechinulin B as a Novel Antagonist of Liver X Receptor, Identified by Chemical Genetics Using a Hepatitis C Virus Cell Culture System2016
- Author(s)
  Nakajima S, Watashi K, Ohashi H, Kamisuki S, Izaguirre-Carbonell J, Kwon AT, Suzuki H, Kataoka M, Tsukuda S, Okada M, Moi ML, Takeuchi T, Arita M, Suzuki R, Aizaki H, Kato T, Suzuki T, Hasegawa H, Takasaki T, Sugawara F, Wakita T
- Journal Title
  
  J Virol
  
  Volume: 90(20) Issue: 20 Pages: 9058-74
- DOI
  10.1128/jvi.00856-16
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24115003, KAKENHI-PROJECT-16K19145, KAKENHI-PROJECT-26460565
[Presentation] Oligomerization of NTCP induces hepatitis B virus internalization,2018
- Author(s)
  Kento Fukano, Senko Tsukuda, Mio Ohki, Sam-Yong Park, Ryosuke Suzuki, Hideki Aizaki, Masamichi Muramatsu, Takaji Wakita, Yuki Ogasawara, Koichi Watashi,
- Organizer
  International HBV Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19145
[Presentation] 感染培養系を用いたHBV創薬と侵入機構の解析2017
- Author(s)
  九十田千子
- Organizer
  第13回肝免疫・ウイルス・フロンティア（Liver2017）
- Invited
- Data Source
  KAKENHI-PROJECT-16K19145
[Presentation] NTCPを利用したHBV創薬研究およびNTCPを介したHBV侵入機構の解析2017
- Author(s)
  九十田千子, 渡士幸一, 小嶋聡一, 脇田隆字
- Organizer
  生命科学系学会合同年次大会 (ConBio2017)
- Invited
- Data Source
  KAKENHI-PROJECT-16K19145
[Presentation] B型肝炎ウイルスを標的とするproanthocyanidinの同定と作用機序の解析2017
- Author(s)
  九十田千子、小嶋聡一、脇田隆字
- Organizer
  第53回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-16K19145
[Presentation] 1.Identification of a new class of HBV and HDV entry inhibitor, proanthocyanidin2017
- Author(s)
  Tsukuda S, Watashi K, Kojima S, Wakita T
- Organizer
  AASLD The Liver Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19145
[Presentation] Retinoid inhibitors abolish the host permissiveness to hepatitis B virus infection by modulating the expression of NTCP2016
- Author(s)
  Tsukuda S, Watashi K, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Saito A, Tanaka Y, Mizokami M, Wakita T
- Organizer
  23rd International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Kyoto International Conference Center
- Year and Date
  2016-10-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19145
[Presentation] Proanthocyanidin and its analogs are new class of HBV and HDV entry inhibitors that target the viral preS1 region2016
- Author(s)
  Tsukuda S, Watashi K, Hojima T, Isogawa M, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Saito A, Tanaka Y, Mizokami M, Wakita T
- Organizer
  International meeting on molecular biology of hepatitis B viruses
- Place of Presentation
  Yonsei University
- Year and Date
  2016-09-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19145
[Presentation] B型肝炎ウイルスを標的とした新規侵入阻害剤の同定と作用機序の解析2016
- Author(s)
  九十田千子, 小嶋聡一, 脇田隆字
- Organizer
  第52回日本肝臓学会総会
- Place of Presentation
  ニューホテルオータニ幕張/東京ベイ幕張ホテル
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16K19145
[Presentation] Inhibition of HBV entry process through targeting host and viral molecules2016
- Author(s)
  Tsukuda S, Watashi K, Hamada Y, Isogawa M, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Saito A, Tanaka Y, Mizokami M, Wakita T.
- Organizer
  4th Taiwan-Korea-Japan Research Symposium on Hepatitis B Virus
- Place of Presentation
  Humanities and Social Sciences Building, Taiwan
- Year and Date
  2016-04-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19145
[Presentation] Characterization of origomeric flavonoids as a novel class of anti-HBV entry inhibitors that directly target viral envelope protein.2016
- Author(s)
  Tsukuda S, Watashi K, Hojima T, Isogawa M, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Saito A, Tanaka Y, Mizokami M, Wakita T
- Organizer
  第64回日本ウイルス学術集会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-16K19145
[Presentation] B型肝炎ウイルス粒子を直接標的とする侵入阻害剤proanthocyanidin2016
- Author(s)
  九十田千子、渡士幸一、濱田義知、齊藤安貴子、五十川正記、田中義正、鈴木亮介、相崎英樹、小嶋聡一、杉山真也、田中靖人、溝上雅史、脇田隆字.
- Organizer
  第26回抗ウイルス療法学会総会
- Place of Presentation
  名古屋東急ホテル、名古屋市立大学
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-16K19145

1. 相崎英樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 脇田隆字

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 近藤恭光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tsukuda Senko 九十田 千子

Research Projects

Research Products

Co-Researchers

Identification of host factors that regulate host susceptibility to hepatitis B virus infection and analysis of mechanisms.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Encyclopedia of Signaling Molecules, 2nd Edition2017

Author(s)

Total Pages

Publisher

Data Source

[Book] Encyclopedia of Signaling Molecules Second Edition -NTCP-2017

Author(s)

Publisher

ISBN

Data Source

[Journal Article] Troglitazone Impedes the Oligomerization of Sodium Taurocholate Cotransporting Polypeptide and Entry of Hepatitis B Virus Into Hepatocytes2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Concept of Viral Inhibitors via NTCP.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A new strategy to identify hepatitis B virus entry inhibitors by AlphaScreen technology targeting the envelope-receptor interaction.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Single Adaptive Mutation in Sodium Taurocholate Cotransporting Polypeptide Induced by Hepadnaviruses Determines Virus Species Specificity2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A new class of hepatitis B and D virus entry inhibitors, proanthocyanidin and its analogs, that directly act on the viral large surface proteins.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fungus-Derived Neoechinulin B as a Novel Antagonist of Liver X Receptor, Identified by Chemical Genetics Using a Hepatitis C Virus Cell Culture System2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] Oligomerization of NTCP induces hepatitis B virus internalization,2018

Author(s)

Organizer

Data Source

[Presentation] 感染培養系を用いたHBV創薬と侵入機構の解析2017

Author(s)

Organizer

Data Source

[Presentation] NTCPを利用したHBV創薬研究およびNTCPを介したHBV侵入機構の解析2017

Author(s)

Organizer

Data Source

[Presentation] B型肝炎ウイルスを標的とするproanthocyanidinの同定と作用機序の解析2017

Author(s)

Organizer

Data Source

[Presentation] 1.Identification of a new class of HBV and HDV entry inhibitor, proanthocyanidin2017

Author(s)

Organizer

Data Source

Tsukuda Senko 九十田千子