Kurashige Takashi 倉重毅志

… Alternative Names

倉重毅志クラシゲタカシ

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Researcher Number	20710627
Other IDs	https://orcid.org/0000-0002-5206-5979
Affiliation (Current)	2025: 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, 医師
Affiliation (based on the past Project Information) *help	2023 – 2024: 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, 医師 2014: 広島大学, 大学病院, 医科診療医
Review Section/Research Field	Principal Investigator Neurology Except Principal Investigator Basic Section 52020:Neurology-related / Medium-sized Section 52:General internal medicine and related fields
Keywords	Principal Investigator KL-6 / ムチン / GNE-myopathy / 自己貪食空胞 / シアル酸 Except Principal Investigator 筋萎縮性側索硬化症 / ALS / TMEM106B / OPTN / 逆行性進展 … More / necroptosis / リピート / 眼咽頭遠位型ミオパチー / 原因遺伝子 / ロングリードシーケンサー Less

Necroptosisを介したALSの運動神経変性の病態機序と新規治療の探索
- Principal Investigator
  
  丸山博文
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Hiroshima University
Identification and analysis of novel genes of amyotrophic lateral screlosis
- Principal Investigator
  
  川上秀史
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Hiroshima University
MUC1によるオートファジー経路の調節を介したGNE-myopathyの病態解明Principal Investigator
- Principal Investigator
  
  倉重毅志
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Hiroshima University

All 2023 2022 2021 Other

All Journal Article Presentation

[Journal Article] CGG repeat expansion in LRP12 in amyotrophic lateral sclerosis2023
- Author(s)
  Kume Kodai Kurashige Takashi Muguruma Keiko Morino Hiroyuki、...Kawakami Hideshi
- Journal Title
  
  The American Journal of Human Genetics
  
  Volume: 110 Issue: 7 Pages: 1086-1097
- DOI
  10.1016/j.ajhg.2023.05.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04818, KAKENHI-PROJECT-21H02718, KAKENHI-PROJECT-21H03812, KAKENHI-PROJECT-23K24996
[Journal Article] ‘Raisin bread sign’ feature of pontine autosomal dominant microangiopathy and leukoencephalopathy2023
- Author(s)
  Kikumoto Mai、Kurashige Takashi、Ohshita Tomohiko、Kume Kodai、Kikumoto Osamu、Nezu Tomohisa、Aoki Shiro、Ochi Kazuhide、Morino Hiroyuki、Nomura Eiichi、Yamashita Hiroshi、Kaneko Mayumi、Maruyama Hirofumi、Kawakami Hideshi
- Journal Title
  
  Brain Communications
  
  Volume: 5 Issue: 6 Pages: 281-281
- DOI
  10.1093/braincomms/fcad281
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KJ2329, KAKENHI-PROJECT-21H04818
[Journal Article] TDP-43 Accumulation Within Intramuscular Nerve Bundles of Patients With Amyotrophic Lateral Sclerosis2022
- Author(s)
  Kurashige Takashi、Morino Hiroyuki、Murao Tomomi、Izumi Yuishin、Sugiura Tomohito、Kuraoka Kazuya、Kawakami Hideshi、Torii Tsuyoshi、Maruyama Hirofumi
- Journal Title
  
  JAMA Neurology
  
  Volume: 79 Issue: 7 Pages: 693-693
- DOI
  10.1001/jamaneurol.2022.1113
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04818, KAKENHI-PROJECT-20K07887
[Journal Article] Comparison of two families with and without ataxia harboring novel variants in PRKCG2022
- Author(s)
  Tada Yui、Kume Kodai、Noguchi Soma、Sekiya Tomoko、Nishinaka Kazuto、Ishiguchi Hiroshi、Koh Jinsoo、Emori Seiji、Nakayama Yoshiaki、Kurashige Takashi、Izumi Yuishin、Ito Hidefumi、Sakai Norio、Kawakami Hideshi
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 67 Issue: 10 Pages: 595-599
- DOI
  10.1038/s10038-022-01057-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04818
[Journal Article] Knockdown of optineurin controls C2C12 myoblast differentiation via regulating myogenin and MyoD expressions2022
- Author(s)
  Ishikawa Kenichi、Araki Mutsuko、Nagano Yoshito、Motoda Atsuko、Shishido Takeo、Kurashige Takashi、Takahashi Tetsuya、Morino Hiroyuki、Kawakami Hideshi、Matsumoto Masayasu、Maruyama Hirofumi
- Journal Title
  
  Differentiation
  
  Volume: 123 Pages: 1-8
- DOI
  10.1016/j.diff.2021.11.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04818, KAKENHI-PROJECT-20K07887
[Journal Article] FXTAS is difficult to differentiate from neuronal intranuclear inclusion disease through skin biopsy: a case report2021
- Author(s)
  Toko Megumi、Ohshita Tomohiko、Kurashige Takashi、Morino Hiroyuki、Kume Kodai、Yamashita Hiroshi、Sobue Gen、Iwasaki Yasushi、Sone Jun、Kawakami Hideshi、Maruyama Hirofumi
- Journal Title
  
  BMC Neurology
  
  Volume: 21 Issue: 1 Pages: 396-396
- DOI
  10.1186/s12883-021-02425-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04818, KAKENHI-PROJECT-19H03577
[Presentation] CGG repeat expansion in LRP12 in amyotrophic lateral sclerosis2023
- Author(s)
  久米広大、倉重毅志、六車恵子、川上秀史
- Organizer
  日本人類遺伝学会第68回大会
- Data Source
  KAKENHI-PROJECT-21H04818
[Presentation] LRP12 の CGG リピート伸長は筋萎縮性側索硬化症の原因となる2023
- Author(s)
  久米広大、倉重毅志、六車恵子、川上秀史
- Organizer
  第64回日本神経病理学会総会学術研究会/第66回日本神経化学会大会合同大会,
- Invited
- Data Source
  KAKENHI-PROJECT-21H04818
[Presentation] 孤発性筋萎縮性側索硬化症での中枢神経と骨格筋での病理所見の対比2023
- Author(s)
  倉重毅志、森野豊之、村尾智美、倉岡和矢、和泉唯信、大下智彦、丸山博文
- Organizer
  第64回日本神経病理学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-23K27518
[Presentation] CGG repeat expansion in LRP12 in amyotrophic lateral sclerosis2023
- Author(s)
  Kodai Kume, Takashi Kurashige, Keiko Muguruma, Hideshi Kawakami
- Organizer
  Neuroscience 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04818
[Presentation] 基底核の壊死病変と腎不全を呈したmtDNAに G13513A変異を有するMELASの一剖検例
- Author(s)
  倉重毅志, 元田敦子, 杉浦智仁, 中村毅, 山脇健盛, 有広光司, 松本昌泰
- Organizer
  第55回　日本神経病理学会学術研究会
- Place of Presentation
  学術総合センター（東京都千代田区）
- Year and Date
  2014-06-05 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-26870398
[Presentation] 幼少期より緩やかに進行する下肢近位筋筋力低下を呈した52歳男性例
- Author(s)
  篠崎ゆかり, 倉重毅志, 高橋哲也, 西野一三, 松本昌泰
- Organizer
  第55回　日本神経病理学会学術研究会
- Place of Presentation
  学術総合センター（東京都千代田区）
- Year and Date
  2014-06-05 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-26870398
[Presentation] Clinicopathological study of MELAS with necrosis of basal ganglia and mtDNA G13513A mutation proceeding chronic renal failure.
- Author(s)
  Kurashige T, Motoda A, Sugiura T, Nezu T, Nakamura T, Yamawaki T, Arihiro K, Matsumoto M
- Organizer
  18th International Congress of Neuropathology
- Place of Presentation
  Rio de Janeiro, Brazil
- Year and Date
  2014-09-14 – 2014-09-18
- Data Source
  KAKENHI-PROJECT-26870398
[Presentation] 縁取り空胞を伴う遠位型ミオパチーの病態にはMUC1減少が関連している．
- Author(s)
  倉重毅志, 高橋哲也 , 永野義人，杉江和馬，渡辺千種, 越智一秀, 丸山博文, 上野聡, 松本昌泰
- Organizer
  第55回　日本神経学会学術大会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26870398
[Presentation] 筋芽細胞分化におけるWntシグナル関連分子LRP6の細胞内局在
- Author(s)
  竹田育子, 高橋哲也, 越智一秀, 倉重毅志, 篠崎ゆかり, 中森正博, 丸山博文, 松本昌泰
- Organizer
  第55回　日本神経学会学術大会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26870398
[Presentation] KL-6/MUC1 is a novel diagnostic marker for GNE-myopathy
- Author(s)
  Kurashige T, Takahashi T, Nagano Y, Sugie K, Watanabe C, Maruyama H, Ueno S, Matsumoto M
- Organizer
  19th International Congress of the World Muscle Society
- Place of Presentation
  Berlin, Germany
- Year and Date
  2014-10-07 – 2014-10-11
- Data Source
  KAKENHI-PROJECT-26870398

1. 川上秀史 (70253060)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
2. 六車恵子 (30209978)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. 宮本達雄 (40452627)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 久米広大 (20592314)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. 多田有似 (90881285)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 丸山博文 (90304443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 森野豊之 (10397953)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 中森正博 (30881297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kurashige Takashi 倉重 毅志

倉重 毅志 クラシゲ タカシ

Research Projects

Research Products

Co-Researchers

Necroptosisを介したALSの運動神経変性の病態機序と新規治療の探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification and analysis of novel genes of amyotrophic lateral screlosis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

MUC1によるオートファジー経路の調節を介したGNE-myopathyの病態解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] CGG repeat expansion in LRP12 in amyotrophic lateral sclerosis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ‘Raisin bread sign’ feature of pontine autosomal dominant microangiopathy and leukoencephalopathy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TDP-43 Accumulation Within Intramuscular Nerve Bundles of Patients With Amyotrophic Lateral Sclerosis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison of two families with and without ataxia harboring novel variants in PRKCG2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Knockdown of optineurin controls C2C12 myoblast differentiation via regulating myogenin and MyoD expressions2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] FXTAS is difficult to differentiate from neuronal intranuclear inclusion disease through skin biopsy: a case report2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] CGG repeat expansion in LRP12 in amyotrophic lateral sclerosis2023

Author(s)

Organizer

Data Source

[Presentation] LRP12 の CGG リピート伸長は筋萎縮性側索硬化症の原因となる2023

Author(s)

Organizer

Data Source

[Presentation] 孤発性筋萎縮性側索硬化症での中枢神経と骨格筋での病理所見の対比2023

Author(s)

Organizer

Data Source

[Presentation] CGG repeat expansion in LRP12 in amyotrophic lateral sclerosis2023

Author(s)

Organizer

Data Source

[Presentation] 基底核の壊死病変と腎不全を呈したmtDNAに G13513A変異を有するMELASの一剖検例

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 幼少期より緩やかに進行する下肢近位筋筋力低下を呈した52歳男性例

Author(s)

Organizer

Place of Presentation

Year and Date

Kurashige Takashi 倉重毅志

倉重毅志クラシゲタカシ