Souma Tomokazu 相馬友和

Researcher Number	20722531
Affiliation (based on the past Project Information) *help	2016: 東北大学, 医学系研究科, 非常勤講師 2015: 東北大学, 医学(系)研究科(研究院), 非常勤講師 2014: 東北大学, 医学(系)研究科(研究院), 特別研究員(PD)
Review Section/Research Field	Principal Investigator Kidney internal medicine
Keywords	Principal Investigator 低酸素 / 線維化 / 貧血 / 腎エリスロポエチン産生細胞 / 低酸素応答 / 腎性貧血

Activating hypoxia response for improving functions of renal EPO producing cells.Principal Investigator
- Principal Investigator
  
  Souma Tomokazu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tohoku University

All 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling2016
- Author(s)
  Tomokazu Souma, Masahiro Nezu, Daisuke Nakano, Shun Yamazaki, Ikuo Hirano, Hiroki Sekine, Takashi Dan, Kotaro Takeda, Guo-Hua Fong, Akira Nishiyama, Sadayoshi Ito, Toshio Miyata, Masayuki Yamamoto, Norio Suzuki
- Journal Title
  
  Journal of the american society of nephlorogy
  
  Volume: 27 Issue: 2 Pages: 428-438
- DOI
  10.1681/asn.2014121184
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860625, KAKENHI-PLANNED-26111002, KAKENHI-PUBLICLY-26116702, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-25670157, KAKENHI-PROJECT-26860623
[Journal Article] Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity.2016
- Author(s)
  Souma T, Tompson SW, Thomson BR, Siggs OM, Kizhatil K, John S, Wiggs JL, Pasutto F, Craig JE, Jin J, Quaggin SE, Young TL.
- Journal Title
  
  J Clin Invest.
  
  Volume: 126 Issue: 7 Pages: 2575-2575
- DOI
  10.1172/jci85830
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860623
[Journal Article] Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression2016
- Author(s)
  Nezu M, Souma T, Yu L, Suzuki T, Saigusa D, Ito S, Suzuki N, Yamamoto M.
- Journal Title
  
  Kidney Int
  
  Volume: 91 Issue: 2 Pages: 387-401
- DOI
  10.1016/j.kint.2016.08.023
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-26460354, KAKENHI-PROJECT-26860623, KAKENHI-PROJECT-17K19680
[Journal Article] Nrf2 DEFICIENCY ALLEVIATES PERINATAL COMPLICATIONS IN PREGNANCY-ASSOCIATED HYPERTENSION MICE VIA ENHANCING PLACENTAL ANGIOGENESIS.2016
- Author(s)
  Nezu M, Souma T, Yu L, Sekine H, Moriguchi T, Takahashi N, Ito S, Suzuki N, Yamamoto M.
- Journal Title
  
  J Hypertens
  
  Volume: 34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860623
[Journal Article] A Novel Method for Anti-HLA Antibody Detection Using Personalized Peptide Arrays.2016
- Author(s)
  Liu P, Souma T, Wei AZ, Xie X, Luo X, Jin J.
- Journal Title
  
  Transplant Direct.
  
  Volume: 2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860623
[Journal Article] 腎線維化と腎性貧血2015
- Author(s)
  相馬友和、鈴木教郎
- Journal Title
  
  日本腎臓学会雑誌
  
  Volume: 57 Pages: 1193-1199
- Data Source
  KAKENHI-PROJECT-26860623
[Journal Article] Renal erythropoietin-producing cells in health and disease.2015
- Author(s)
  Souma T, Suzuki N, Yamamoto M
- Journal Title
  
  Front Physiol.
  
  Volume: 3 Pages: 167-167
- DOI
  10.3389/fphys.2015.00167
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26860623, KAKENHI-PLANNED-26111002, KAKENHI-PUBLICLY-26116702, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-25670157
[Journal Article] Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes.2015
- Author(s)
  Tojo Y, Sekine H, Hirano I, Pan X, Souma T, Tsujita T, Kawaguchi S, Takeda N, Takeda K, Fong GH, Dan T, Ichinose M, Miyata T, Yamamoto M, Suzuki N.
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 35 Issue: 15 Pages: 2658-2672
- DOI
  10.1128/mcb.00161-15
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860623, KAKENHI-PROJECT-26860625, KAKENHI-PLANNED-26111002, KAKENHI-PLANNED-26111003, KAKENHI-PUBLICLY-26116702, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-25461113, KAKENHI-PROJECT-25670157
[Journal Article] Indoxyl sulfate down-regulates SLCO4C1 transporter through up-regulation of GATA32014
- Author(s)
  Yu L, Moriguchi T, Souma T, Takai J, Satoh H, Morito N, Engel JD, Yamamoto M
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 8 Issue: 11 Pages: 1929-1941
- DOI
  10.1128/mcb.01659-13
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-12J07924, KAKENHI-PROJECT-24590371, KAKENHI-PROJECT-24591223, KAKENHI-PROJECT-24659142, KAKENHI-PROJECT-26860623
[Journal Article] 腎エリスロポエチン産生細胞と腎臓病2014
- Author(s)
  袮津昌宏、相馬友和、山本雅之
- Journal Title
  
  日本臨牀
  
  Volume: 72 Pages: 1691-1700
- Data Source
  KAKENHI-PROJECT-26860623
[Presentation] アンジオポエチン受容体TEKの機能欠失変異は発達緑内障の原因である。2016
- Author(s)
  相馬友和、Stuart Topmson、Benjamin Thomson、Terri Youna、Susan Quaggin
- Organizer
  日本生化学会
- Place of Presentation
  仙台市（仙台国際センター）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860623
[Presentation] Nrf2 activation in tubular cells prevents progression of AKI to CKD.2015
- Author(s)
  Nezu M, Souma T, Ito S, Suzuki N, Yamamoto M
- Organizer
  ASN Kidney week 2015
- Place of Presentation
  San Diego, California
- Year and Date
  2015-11-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860623
[Presentation] Exploring the Nexus of Angiopoietin-Tie2 Signaling by Mass-Spectrometry for Establishing Therapeutic Strategies for Diabetic Nephropathy
- Author(s)
  Souma T, Jin J, and Quaggin S
- Organizer
  ASN Kidney Week 2014
- Place of Presentation
  Philadelphia, Pennsylvania
- Year and Date
  2014-11-13 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-26860623
[Presentation] Genetic Activation of Hypoxia-Signaling Restores Erythropoietin Synthesis in Renal Myofibroblasts
- Author(s)
  Souma T, Nezu M, Ito S, Suzuki N, and Yamamoto M.
- Organizer
  ASN Kidney Week 2014
- Place of Presentation
  Philadelphia, Pennsylvania
- Year and Date
  2014-11-13 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-26860623

1. SUZUKI Norio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. NEZU Masahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 平野育生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 山本雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Souma Tomokazu 相馬 友和

Research Projects

Research Products

Co-Researchers

Activating hypoxia response for improving functions of renal EPO producing cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nrf2 DEFICIENCY ALLEVIATES PERINATAL COMPLICATIONS IN PREGNANCY-ASSOCIATED HYPERTENSION MICE VIA ENHANCING PLACENTAL ANGIOGENESIS.2016

Author(s)

Journal Title

Data Source

[Journal Article] A Novel Method for Anti-HLA Antibody Detection Using Personalized Peptide Arrays.2016

Author(s)

Journal Title

Data Source

[Journal Article] 腎線維化と腎性貧血2015

Author(s)

Journal Title

Data Source

[Journal Article] Renal erythropoietin-producing cells in health and disease.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Indoxyl sulfate down-regulates SLCO4C1 transporter through up-regulation of GATA32014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 腎エリスロポエチン産生細胞と腎臓病2014

Author(s)

Journal Title

Data Source

[Presentation] アンジオポエチン受容体TEKの機能欠失変異は発達緑内障の原因である。2016

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Nrf2 activation in tubular cells prevents progression of AKI to CKD.2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Exploring the Nexus of Angiopoietin-Tie2 Signaling by Mass-Spectrometry for Establishing Therapeutic Strategies for Diabetic Nephropathy

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Genetic Activation of Hypoxia-Signaling Restores Erythropoietin Synthesis in Renal Myofibroblasts

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

Souma Tomokazu 相馬友和