Ozawa Shin-ichiro 小澤新一郎

Researcher Number	20724868
Other IDs	https://orcid.org/0000-0001-7350-2069
Affiliation (Current)	2024: 北里大学, 薬学部, 助教
Affiliation (based on the past Project Information) *help	2018 – 2023: 北里大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Keywords	Principal Investigator フラグメントマッピング / フラグメントベース創薬 / インシリコ創薬 / cryptic pocket / ポケット構造予測 / バーチャルスクリーニング / PPI阻害剤 / アロステリック部位 / タンパク質間相互作用 / アロステリック阻害剤 / サブポケット探索 / インシリコ・スクリーニング / インシリコ・フラグメントマッピング

Development of knowledge-based computational method for drug discovery targeting cryptic pocketsPrincipal Investigator
- Principal Investigator
  
  小澤新一郎
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Kitasato University
Development of novel computational method for identification of druggable cryptic pocket on protein surfacePrincipal Investigator
- Principal Investigator
  
  OZAWA Shin-ichiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Kitasato University
Development of in silico fragment mapping method for discovery of small-molecule PPI inhibitorsPrincipal Investigator
- Principal Investigator
  
  Ozawa Shin-ichiro
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Kitasato University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Book

[Book] 月刊ファインケミカル2020
- Author(s)
  谷口敦彦、伊藤進也、永田和宏、小澤新一郎、大上雅史、寺島健仁、岡田至、冨澤元博
- Total Pages
  78
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-20K15974
[Journal Article] The stability of NPM1 oligomers regulated by acidic disordered regions controls the quality of liquid droplets2023
- Author(s)
  Okuwaki Mitsuru、Ozawa Shin-Ichiro、Ebine Shuhei、Juichi Motoki、Umeki Tadanobu、Niioka Kazuki、Kikuchi Taiyo、Tanaka Nobutada
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 174 Issue: 5 Pages: 461-476
- DOI
  10.1093/jb/mvad061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06085
[Journal Article] The Stat3 inhibitor F0648-0027 is a potential therapeutic against rheumatoid arthritis2022
- Author(s)
  Kaneko Yosuke、Ozawa Shin-ichiro、Sato Yuiko、Kobayashi Tami、Matsumoto Tatsuaki、Miyamoto Kana、Kobayashi Shu、Harato Kengo、Hirono Shuichi、Matsumoto Morio、Nakamura Masaya、Niki Yasuo、Miyamoto Takeshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 636 Pages: 133-140
- DOI
  10.1016/j.bbrc.2022.10.106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H03057, KAKENHI-PROJECT-20K15974
[Journal Article] Synthesis and Evaluation of a Novel Series of 2,7-Substituted-6-tetrazolyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Selective Peroxisome Proliferator-Activated Receptor γ Partial Agonists2021
- Author(s)
  Morishita Ko、Ito Yuma、Otake Kazuya、Takahashi Kenji、Yamamoto Megumi、Kitao Tatsuya、Ozawa Shin-ichiro、Hirono Shuichi、Shirahase Hiroaki
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 69 Issue: 4 Pages: 333-351
- DOI
  10.1248/cpb.c20-00841
- NAID
  130008013955
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2021-04-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15974
[Journal Article] (<i>S</i>)-1,2,3,4-Tetrahydroisoquinoline Derivatives Substituted with an Acidic Group at the 6-Position as a Selective Peroxisome Proliferator-Activated Receptor γ Partial Agonist2019
- Author(s)
  Morishita Ko、Miike Tomohiro、Takeda Shigemitsu、Fukui Masaki、Ito Yuma、Kitao Tatsuya、Ozawa Shin-ichiro、Hirono Shuichi、Shirahase Hiroaki
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 67 Issue: 11 Pages: 1211-1224
- DOI
  10.1248/cpb.c19-00541
- NAID
  130007740348
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2019-11-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14875
[Journal Article] Identifying Inhibitors of USP7-HDM2 Protein-Protein Interaction (PPI) by the <i>in Silico</i> Fragment-mapping Method2019
- Author(s)
  Misawa Kensuke、Ozawa Shin-ichiro、Yoshida Tomoki、Nakagome Izumi、Yamaotsu Noriyuki、Hirono Shuichi
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 139 Issue: 5 Pages: 827-835
- DOI
  10.1248/yakushi.19-00006
- NAID
  130007641006
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2019-05-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14875
[Journal Article] Structure-based virtual screening for novel chymase inhibitors by in silico fragment mapping2019
- Author(s)
  Ozawa Shin-ichiro、Takahashi Miki、Yamaotsu Noriyuki、Hirono Shuichi
- Journal Title
  
  Journal of Molecular Graphics and Modelling
  
  Volume: 89 Pages: 102-108
- DOI
  10.1016/j.jmgm.2019.03.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14875
[Presentation] フラグメントベース手法に基づく新規DPP8阻害剤の同定2024
- Author(s)
  小澤新一郎、彌田桃香、佐々木瑠梨、田中信忠
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K06085
[Presentation] NPM1の多量体形成制御を介した液滴形成と核小体形成の制御2023
- Author(s)
  奥脇暢、小澤新一郎、田中信忠
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K06085
[Presentation] Discovery of DPP8 inhibitors using in silico fragment mapping method2023
- Author(s)
  Shin-ichiro Ozawa, Momoka Yada, Ruri Sasaki, Nobutada Tanaka
- Organizer
  IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC’23)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06085
[Presentation] インシリコ・フラグメントマッピング法によるDPP8阻害剤の探索2023
- Author(s)
  小澤新一郎、彌田桃香、佐々木瑠梨、田中信忠
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K15974
[Presentation] 新規DPP8阻害剤の開発を目的としたフラグメントベースバーチャルスクリーニング2023
- Author(s)
  小澤新一郎、彌田桃香、佐々木瑠梨、田中信忠
- Organizer
  第51回構造活性相関シンポジウム
- Data Source
  KAKENHI-PROJECT-23K06085
[Presentation] インシリコ・フラグメントマッピング法によるタンパク質-タンパク質間相互作用阻害剤の探索2022
- Author(s)
  小澤新一郎、北村祐万、広野修一、田中信忠
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K15974
[Presentation] DPP8阻害剤のフラグメントベースバーチャルスクリーニング2022
- Author(s)
  小澤新一郎、彌田桃香、佐々木瑠梨、田中信忠
- Organizer
  第50回構造活性相関シンポジウム
- Data Source
  KAKENHI-PROJECT-20K15974
[Presentation] インフルエンザウイルスRNAポリメラーゼのサブユニット間相互作用阻害剤のバーチャルスクリーニング2021
- Author(s)
  大岩瑞季、小澤新一郎、田中信忠
- Organizer
  第49回構造活性相関シンポジウム
- Data Source
  KAKENHI-PROJECT-20K15974
[Presentation] β-glucocerebrosidaseに対するallosteric activatorの相互作用様式の同定及び構造安定性解析2020
- Author(s)
  中込　泉，桑原　愛美，山乙　教之，吉田　智喜，小澤　新一郎，広野　修一
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K14875
[Presentation] 3D pharmacophore-based virtual screening for novel chymase inhibitors by in silico fragment mapping2019
- Author(s)
  Ozawa S, Takahashi M, Yamaotsu N, Hirono S
- Organizer
  VIII EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC’19)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14875
[Presentation] In silicoフラグメントマッピング法を用いたRac1-GEF間相互作用阻害剤の探索2019
- Author(s)
  小澤　新一郎，北村　祐万，広野　修一
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K14875
[Presentation] インフルエンザRNAポリメラーゼのサブユニット間相互作用阻害剤のin silicoフラグメントマッピング法による探索2019
- Author(s)
  宇田　康佑，小澤　新一郎，広野　修一
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K14875
[Presentation] Rac1-GEF間相互作用阻害剤の計算機的フラグメントベース創薬2019
- Author(s)
  小澤　新一郎，北村　祐万，広野　修一
- Organizer
  第47回構造活性相関シンポジウム
- Data Source
  KAKENHI-PROJECT-18K14875
[Presentation] In silicoフラグメントマッピング法によるインフルエンザRNAポリメラーゼのサブユニット間相互作用阻害剤の探索2019
- Author(s)
  宇田　康佑，小澤　新一郎，広野　修一
- Organizer
  第47回構造活性相関シンポジウム
- Data Source
  KAKENHI-PROJECT-18K14875
[Presentation] In silicoフラグメントマッピング法による計算機的フラグメントベース創薬　－タンパク質-タンパク質間相互作用（PPI）阻害剤探索への応用－2019
- Author(s)
  小澤　新一郎，広野　修一
- Organizer
  第43回白金シンポジウム
- Data Source
  KAKENHI-PROJECT-18K14875
[Presentation] Rac1-GEF間相互作用阻害剤のin silicoフラグメントマッピング法によるバーチャルスクリーニング2018
- Author(s)
  小澤　新一郎，北村　祐万，山乙　教之，中込　泉，吉田　智喜，広野　修一
- Organizer
  第6回がんと代謝研究会
- Data Source
  KAKENHI-PROJECT-18K14875
[Presentation] Discovery and development of Rac1-GEF interaction inhibitors using in silico fragment mapping method2018
- Author(s)
  Shin-ichiro Ozawa, Yuma Kitamura, Noriyuki Yamaotsu, Shuichi Hirono
- Organizer
  XXV EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14875

1. MIYAMOTO Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ozawa Shin-ichiro 小澤 新一郎

Research Projects

Research Products

Co-Researchers

Development of knowledge-based computational method for drug discovery targeting cryptic pocketsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel computational method for identification of druggable cryptic pocket on protein surfacePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of in silico fragment mapping method for discovery of small-molecule PPI inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 月刊ファインケミカル2020

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] The stability of NPM1 oligomers regulated by acidic disordered regions controls the quality of liquid droplets2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Stat3 inhibitor F0648-0027 is a potential therapeutic against rheumatoid arthritis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis and Evaluation of a Novel Series of 2,7-Substituted-6-tetrazolyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Selective Peroxisome Proliferator-Activated Receptor γ Partial Agonists2021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] (<i>S</i>)-1,2,3,4-Tetrahydroisoquinoline Derivatives Substituted with an Acidic Group at the 6-Position as a Selective Peroxisome Proliferator-Activated Receptor γ Partial Agonist2019

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Identifying Inhibitors of USP7-HDM2 Protein-Protein Interaction (PPI) by the <i>in Silico</i> Fragment-mapping Method2019

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Structure-based virtual screening for novel chymase inhibitors by in silico fragment mapping2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] フラグメントベース手法に基づく新規DPP8阻害剤の同定2024

Author(s)

Organizer

Data Source

[Presentation] NPM1の多量体形成制御を介した液滴形成と核小体形成の制御2023

Author(s)

Organizer

Data Source

[Presentation] Discovery of DPP8 inhibitors using in silico fragment mapping method2023

Author(s)

Organizer

Ozawa Shin-ichiro 小澤新一郎

[Presentation] In silicoフラグメントマッピング法による計算機的フラグメントベース創薬　－タンパク質-タンパク質間相互作用（PPI）阻害剤探索への応用－2019