Kuwabara Masanari 桑原政成

Researcher Number	20728290
Other IDs	https://orcid.org/0000-0002-6601-4347
Affiliation (Current)	2024: 自治医科大学, 医学部, 准教授 2024: (財)冲中記念成人病研究所, その他部局等, 研究員
Affiliation (based on the past Project Information) *help	2023: (財)冲中記念成人病研究所, その他部局等, 研究員 2020 – 2021: (財)冲中記念成人病研究所, その他部局等, 研究員
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related
Keywords	Principal Investigator 高尿酸血症 / 心血管疾患 / 尿酸 / 離脱症候群 / キサンチンオキシダーゼ阻害薬 / 疫学 / 死亡 / 併用薬

Causes and Mechanisms of Xanthine Oxidase Inhibitor Withdrawal SyndromePrincipal Investigator
- Principal Investigator
  
  桑原政成
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Okinaka Memorial Institute for Medical Research
A study on the mechanism of xanthine oxidase inhibitor withdrawal syndromePrincipal Investigator
- Principal Investigator
  
  Kuwabara Masanari
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Okinaka Memorial Institute for Medical Research

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Xanthine oxidase inhibitors treatment or discontinuation effects on mortality: evidence of xanthine oxidase inhibitors withdrawal syndrome2024
- Author(s)
  Kuwabara Masanari、Nakai Michikazu、Sumita Yoko、Iwanaga Yoshitaka、Ae Ryusuke、Kodama Takahide、Hisatome Ichiro、Kamatani Naoyuki
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 14 Pages: 1289386-1289386
- DOI
  10.3389/fphar.2023.1289386
- Data Source
  KAKENHI-PROJECT-23K07493
[Journal Article] Impact of Hyper- and Hypo-Uricemia on Kidney Function2023
- Author(s)
  Miake Junichiro、Hisatome Ichiro、Tomita Katsuyuki、Isoyama Tadahiro、Sugihara Shinobu、Kuwabara Masanari、Ogino Kazuhide、Ninomiya Haruaki
- Journal Title
  
  Biomedicines
  
  Volume: 11 Issue: 5 Pages: 1258-1258
- DOI
  10.3390/biomedicines11051258
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20662, KAKENHI-PROJECT-23K07493, KAKENHI-PROJECT-23K10826
[Journal Article] Update in uric acid, hypertension, and cardiovascular diseases2023
- Author(s)
  Kuwabara Masanari、Kodama Takahide、Ae Ryusuke、Kanbay Mehmet、Andres-Hernando Ana、Borghi Claudio、Hisatome Ichiro、Lanaspa Miguel A.
- Journal Title
  
  Hypertension Research
  
  Volume: 46 Issue: 7 Pages: 1714-1726
- DOI
  10.1038/s41440-023-01273-3
- Data Source
  KAKENHI-PROJECT-23K07493
[Journal Article] Exploring the Multifaceted Nexus of Uric Acid and Health: A Review of Recent Studies on Diverse Diseases2023
- Author(s)
  Kuwabara Masanari、Fukuuchi Tomoko、Aoki Yuhei、Mizuta Einosuke、Ouchi Motoshi、Kurajoh Masafumi、Maruhashi Tatsuya、Tanaka Atsushi、Morikawa Nagisa、Nishimiya Kensuke、Akashi Naoyuki、Tanaka Yoshihiro、Otani Naoyuki、Morita Mihoko、et al.
- Journal Title
  
  Biomolecules
  
  Volume: 13 Issue: 10 Pages: 1519-1519
- DOI
  10.3390/biom13101519
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15507, KAKENHI-PROJECT-22KK0152, KAKENHI-PROJECT-21K11581, KAKENHI-PROJECT-22K08146, KAKENHI-PROJECT-23K07493, KAKENHI-PROJECT-21K15293, KAKENHI-PROJECT-20H00568
[Journal Article] 2023 update and perspectives2023
- Author(s)
  Mogi Masaki、Tanaka Atsushi、Node Koichi、Tomitani Naoko、Kuwabara Masanari、et al.
- Journal Title
  
  Hypertension Research
  
  Volume: 47 Issue: 1 Pages: 6-32
- DOI
  10.1038/s41440-023-01398-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07493, KAKENHI-PROJECT-23K09671
[Journal Article] Xanthinuria Type 1 with a Novel Mutation in Xanthine Dehydrogenase and a Normal Endothelial Function2022
- Author(s)
  Satoshi Miyazaki, hisatome I, et al
- Journal Title
  
  Intern. Med.
  
  Volume: 61 Issue: 9 Pages: 1383-1386
- DOI
  10.2169/internalmedicine.7897-21
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2022-05-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08074, KAKENHI-PROJECT-20K17168, KAKENHI-PROJECT-21K11581, KAKENHI-PROJECT-17K11191
[Journal Article] Temporal trends in the prevalence and characteristics of hypouricaemia: a descriptive study of medical check-up and administrative claims data2022
- Author(s)
  Koto Ruriko、Sato Izumi、Kuwabara Masanari、Seki Tomotsugu、Kawakami Koji
- Journal Title
  
  Clinical Rheumatology
  
  Volume: in press Issue: 7 Pages: 2113-2119
- DOI
  10.1007/s10067-022-06071-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17168
[Journal Article] Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes2022
- Author(s)
  Peili Li, Yasutaka Kurata, Fikri Taufiq, et al
- Journal Title
  
  Molecular Biology Reports
  
  Volume: online ahead of print Issue: 7 Pages: 0-0
- DOI
  10.1007/s11033-022-07378-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08074, KAKENHI-PROJECT-20K17168, KAKENHI-PROJECT-19K08557, KAKENHI-PROJECT-22K06979
[Journal Article] Association Between Kidney Function Decline and Baseline TNFR Levels or Change Ratio in TNFR by Febuxostat Chiefly in Non-diabetic CKD Patients With Asymptomatic Hyperuricemia2021
- Author(s)
  Gohda Tomohito、Yanagisawa Naotake、Murakoshi Maki、Ueda Seiji、Nishizaki Yuji、Nojiri Shuko、Ohashi Yasuo、Ohno Iwao、Shibagaki Yugo、Imai Naohiko、Iimuro Satoshi、Kuwabara Masanari、Hayakawa Hiroshi、Kimura Kenjiro、Hosoya Tatsuo、Suzuki Yusuke
- Journal Title
  
  Frontiers in Medicine
  
  Volume: 8 Pages: 634932-634932
- DOI
  10.3389/fmed.2021.634932
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17168, KAKENHI-PROJECT-20K08617
[Journal Article] Therapeutic Strategies for the Treatment of Chronic Hyperuricemia: An Evidence-Based Update2021
- Author(s)
  Cicero Arrigo F. G.、Fogacci Federica、Kuwabara Masanari、Borghi Claudio
- Journal Title
  
  Medicina
  
  Volume: 57 Issue: 1 Pages: 58-58
- DOI
  10.3390/medicina57010058
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17168
[Journal Article] The Role of Uric Acid in the Acute Myocardial Infarction: A Narrative Review2021
- Author(s)
  Demiray Atalay、Afsar Baris、Covic Adrian、Kuwabara Masanari、Ferro Charles J.、Lanaspa Miguel A.、Johnson Richard J.、Kanbay Mehmet
- Journal Title
  
  Angiology
  
  Volume: 73 Issue: 1 Pages: 9-17
- DOI
  10.1177/00033197211012546
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17168
[Journal Article] Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation2021
- Author(s)
  Andres-Hernando Ana、Cicerchi Christina、Kuwabara Masanari、Orlicky David J.、Sanchez-Lozada Laura Gabriela、Nakagawa Takahiko、Johnson Richard J.、Lanaspa Miguel A.
- Journal Title
  
  Nature Metabolism
  
  Volume: 3 Issue: 9 Pages: 1189-1201
- DOI
  10.1038/s42255-021-00454-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17168
[Journal Article] Uric Acid as a Risk Factor for Chronic Kidney Disease and Cardiovascular Disease　― Japanese Guideline on the Management of Asymptomatic Hyperuricemia ―2021
- Author(s)
  Hisatome Ichiro、Li Peili、Miake Junichiro、Taufiq Fikri、Mahati Endang、Maharani Nani、Utami Sulistiyati Bayu、Kuwabara Masanari、Bahrudin Udin、Ninomiya Haruaki
- Journal Title
  
  Circ J
  
  Volume: 85 Issue: 2 Pages: 130-138
- DOI
  10.1253/circj.CJ-20-0406
- NAID
  130007975319
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2021-01-25
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20662, KAKENHI-PROJECT-18K08074, KAKENHI-PROJECT-20K17168
[Journal Article] Factors Influencing Change in Serum Uric Acid After Administration of the Sodium‐Glucose Cotransporter 2 Inhibitor Luseogliflozin in Patients With Type 2 Diabetes Mellitus2021
- Author(s)
  Chino Yukihiro、Kuwabara Masanari、Hisatome Ichiro
- Journal Title
  
  The Journal of Clinical Pharmacology
  
  Volume: 62 Issue: 3 Pages: 366-375
- DOI
  10.1002/jcph.1970
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17168
[Journal Article] Serum Urate Trajectory in Young Adulthood and Incident Cardiovascular Disease Events by Middle Age: CARDIA Study2021
- Author(s)
  Morikawa Nagisa、Bancks Michael P.、Yano Yuichiro、Kuwabara Masanari、Gaffo Angelo L.、Duprez Daniel A.、Gross Myron D.、Jacobs David R.
- Journal Title
  
  Hypertension
  
  Volume: 78 Issue: 5 Pages: 1211-1218
- DOI
  10.1161/hypertensionaha.121.17555
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17168
[Presentation] シンポジウム痛風・尿酸核酸領域のアップデート～最近の論文まとめ読み～2024
- Author(s)
  桑原政成
- Organizer
  第57回日本痛風・尿酸核酸学会
- Data Source
  KAKENHI-PROJECT-23K07493
[Presentation] Xanthine oxidase inhibitors withdrawal syndrome2023
- Author(s)
  Masanari. Kuwabara, Michikazu Nakai, Yoko Sumita, Takahide Kodama
- Organizer
  ESC (European Society of Cardiology) Congress 2023, Amsterdam, Netherlands
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07493
[Presentation] シンポジウム高血圧の一成因としての高尿酸血症2023
- Author(s)
  桑原政成
- Organizer
  第45回日本高血圧学会
- Data Source
  KAKENHI-PROJECT-23K07493
[Presentation] 尿酸領域のアップデート2023
- Author(s)
  桑原政成
- Organizer
  第45回日本高血圧学会
- Data Source
  KAKENHI-PROJECT-23K07493
[Presentation] シンポジウム難治性高血圧の要因としてのフルクトース、尿酸の影響2023
- Author(s)
  桑原政成
- Organizer
  第71回日本心臓病学会
- Data Source
  KAKENHI-PROJECT-23K07493
[Presentation] シンポジウム　キサンチンオキシダーゼ阻害剤の有効性2022
- Author(s)
  桑原　政成
- Organizer
  第55回日本痛風・尿酸核酸学会総会
- Data Source
  KAKENHI-PROJECT-20K17168
[Presentation] シンポジウム「尿酸と腎update」高尿酸血症と心腎血管代謝疾患2021
- Author(s)
  桑原　政成
- Organizer
  第51回日本腎臓学会東部学術大会
- Data Source
  KAKENHI-PROJECT-20K17168
[Presentation] シンポジウム「循環器疾患予防のリスク管理の現状」高尿酸血症と心腎血管代謝疾患との関係2021
- Author(s)
  桑原　政成
- Organizer
  第69回日本心臓病学会学術集会
- Data Source
  KAKENHI-PROJECT-20K17168

1. 三明淳一朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 森田美穂子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 李佩俐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kuwabara Masanari 桑原 政成

Research Projects

Research Products

Co-Researchers

Causes and Mechanisms of Xanthine Oxidase Inhibitor Withdrawal SyndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A study on the mechanism of xanthine oxidase inhibitor withdrawal syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Xanthine oxidase inhibitors treatment or discontinuation effects on mortality: evidence of xanthine oxidase inhibitors withdrawal syndrome2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of Hyper- and Hypo-Uricemia on Kidney Function2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Update in uric acid, hypertension, and cardiovascular diseases2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exploring the Multifaceted Nexus of Uric Acid and Health: A Review of Recent Studies on Diverse Diseases2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 2023 update and perspectives2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Xanthinuria Type 1 with a Novel Mutation in Xanthine Dehydrogenase and a Normal Endothelial Function2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Temporal trends in the prevalence and characteristics of hypouricaemia: a descriptive study of medical check-up and administrative claims data2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association Between Kidney Function Decline and Baseline TNFR Levels or Change Ratio in TNFR by Febuxostat Chiefly in Non-diabetic CKD Patients With Asymptomatic Hyperuricemia2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Therapeutic Strategies for the Treatment of Chronic Hyperuricemia: An Evidence-Based Update2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Role of Uric Acid in the Acute Myocardial Infarction: A Narrative Review2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Uric Acid as a Risk Factor for Chronic Kidney Disease and Cardiovascular Disease ― Japanese Guideline on the Management of Asymptomatic Hyperuricemia ―2021

Kuwabara Masanari 桑原政成

[Journal Article] Uric Acid as a Risk Factor for Chronic Kidney Disease and Cardiovascular Disease　― Japanese Guideline on the Management of Asymptomatic Hyperuricemia ―2021

[Presentation] シンポジウム痛風・尿酸核酸領域のアップデート～最近の論文まとめ読み～2024

[Presentation] シンポジウム高血圧の一成因としての高尿酸血症2023

[Presentation] シンポジウム難治性高血圧の要因としてのフルクトース、尿酸の影響2023

[Presentation] シンポジウム　キサンチンオキシダーゼ阻害剤の有効性2022

[Presentation] シンポジウム「尿酸と腎update」高尿酸血症と心腎血管代謝疾患2021

[Presentation] シンポジウム「循環器疾患予防のリスク管理の現状」高尿酸血症と心腎血管代謝疾患との関係2021