Sadahira Takuya 定平卓也

Researcher Number	20733322
Other IDs
Affiliation (Current)	2025: 岡山大学, 医療開発領域, 研究准教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 岡山大学, 大学病院, 助教 2015 – 2017: 岡山大学, 大学病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 56030:Urology-related / Urology Except Principal Investigator Basic Section 56030:Urology-related / Urology / Basic Section 59010:Rehabilitation science-related / Basic Section 50010:Tumor biology-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Keywords	Principal Investigator 遺伝子治療 / 癌微小環境 / 代謝 / がん免疫 / アデノウイルス / REIC / 腫瘍 / 局所治療 / REIC/Dkk-3 / チェックポイント阻害薬 / 癌免疫 … More Except Principal Investigator … More 遺伝子治療 / 腫瘍学 / REIC / 局所治療 / REIC/Dkk-3 / 尿路性器感染症 / 尿路感染症 / 前立腺癌 / 間葉系幹細胞 / 幹細胞 / 腫瘍 / サルコペニア / フレイル / 体組成計 / ウェアラブルデバイス / 女性骨盤臓器脱 / 筋層浸潤性膀胱癌 / バイオサーファクタント / 間質性膀胱炎 / ホルモン治療 / 治療抵抗性前立腺癌 / 有熱性尿路感染症 / バイオマーカー / HMGB1 / 尿路性器癌 / microtubule / in vivo投与モデル / Dynamin / 癌 / in vivo投与法 / エンドサイトーシス / 細胞骨格 / in vivo投与 / 細胞内輸送 / 癌創薬 / 内視鏡 / 薬剤投与法 / 膀胱癌 / 癌免疫 / 尿路腫瘍 / がん免疫 / 融合タンパク質 / 癌抗原 / サイトカイン / CD147 / 免疫原性 / アデノウイルス / 癌ウイルス治療 / Dickkoph / SGTA / ステロイドホルモン / 腺管形成 / アンドロゲン / 前立腺肥大症 / 直腸細菌叢 / 感染予防 / 細菌叢 / 次世代シーケンサー / 膣内細菌叢 / 乳酸菌 / 性感染症 / 標的治療 / iPS細胞 / ips細胞 / REIC/DKK-3 / 癌幹細胞 / 前立腺がん / 細胞移植法 / 再生医学 / 組織除去 / 局所注入 / 細胞移植 / 再生 / 腎臓 / 細胞検出 / 分化 / 腎幹細胞 / 病的ストレス / 腎移植 Less

膣内細菌叢から紐解く反復性膀胱炎の病態解明
- Principal Investigator
  
  岩田健宏
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Okayama University
制限増殖型アデノウイルスを用いた超低侵襲内視鏡治療の開発
- Principal Investigator
  
  枝村康平
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Okayama University
Elucidation of the mechanism of effector cell exhaustion release using tumor local metabolic modification proteins.Principal Investigator
- Principal Investigator
  
  定平卓也
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Okayama University
ウェアラブルデバイスと体組成計を用いた、女性骨盤臓器脱患者のフレイル合併頻度調査
- Principal Investigator
  
  小林知子
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Okayama University
尿路感染におけるHMGB1の動態解析と尿中特異マーカーの可能性に関する探索的研究
- Principal Investigator
  
  和田耕一郎
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Shimane University
  Okayama University
Elucidation of the mechanism of oncogenic-steroid signaling axis in hormone therapy-resistant prostate cancer
- Principal Investigator
  
  Kobayashi Yasuyuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Okayama University
Establishment of the ultimate minimally invasive treatment for interstitial cystitis and elucidation of pathogenetic control
- Principal Investigator
  
  Watanabe Toyohiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Okayama University
A novel mechanism of effector T cell activation and its innovative cancer drug discoveryPrincipal Investigator
- Principal Investigator
  
  Sadahira Takuya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Okayama University
Establishment and application development of innovative ablation technology for bladder cancer
- Principal Investigator
  
  Edamura Kouhei
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Okayama University
Elucidation of molecular transport control systems based on cytoskeleton dynamics and new developments in innovative cancer drug discovery.
- Principal Investigator
  
  Watanabe Masami
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Okayama University
Study on prostatic cell proliferation mechanism by REIC/Dkk-3 gene
- Principal Investigator
  
  Takamoto Atsushi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Okayama University
Basic research on next-generation gene therapy using restricted-replication adenovirus
- Principal Investigator
  
  Kobayashi Yasuyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Okayama University
Adaptive immunity optimization targeting the novel cancer antigen CD147 and its application development in urinary genital tumors
- Principal Investigator
  
  Nasu Yasutomo
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Okayama University
The mechanism of release from immune exhaustion in tumor by a novel checkpoint inhibitorPrincipal Investigator
- Principal Investigator
  
  Sadahira Takuya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Okayama University
Establishment of a new gene therapy strategy for prostate cancer stem cells
- Principal Investigator
  
  HUANG PENG
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Okayama University
Study on the analysis of genitourinary tract infections using a next generation sequencer
- Principal Investigator
  
  Wada Koichiro
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Shimane University
  Okayama University
制限増殖型アデノウィルスを用いた次世代遺伝子治療の基盤研究
- Principal Investigator
  
  江原伸
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Okayama University
Optimisation of a cancer detection and isolation technique using hTERT promoter, and establishment of its applicational foundation
- Principal Investigator
  
  Ueki Hideo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Okayama University
Regeneration strategy of the functional renal corpuscle using renal stem cells
- Principal Investigator
  
  Watanabe Masami
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Urology
- Research Institution
  Okayama University
Analysis of pathological stress control mechanism in kidney tissue stem cells
- Principal Investigator
  
  Araki Moto
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Okayama University

All 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Efficacy of Lactobacillus vaginal suppositories for the prevention of recurrent cystitis: A phase II clinical trial2021
- Author(s)
  Sadahira T, Wada K, Araki M, Mitsuhata R, Yamamoto M, Maruyama Y, Iwata T, Watanabe M, Watanabe T, Kariyama R, Nasu Y and Ishii A
- Journal Title
  
  International Journal of Urology
  
  Volume: 28 Issue: 10 Pages: 1026-1031
- DOI
  10.1111/iju.14636
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10017, KAKENHI-PROJECT-17K11183
[Journal Article] 非淋菌性尿道炎に対する1 日200 mg sitafloxacin 投与法2020
- Author(s)
  和田耕一郎、定平卓也、荒木元朗、渡邉豊彦、那須保友
- Journal Title
  
  日本化学療法学会雑誌
  
  Volume: 68 Pages: 181-185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11183
[Journal Article] Impact of Lactobacillus probiotics on biofilm formed by Pseudomonas aeruginosa2019
- Author(s)
  Satoko Matsuo, Koichiro Wada, Takuya Sadahira, Ritsuko Mitsuhata, Masumi Yamamoto, Ayano Ishii, Reiko Kariyama, Toyohiko Watanabe, Yasutomo Nasu
- Journal Title
  
  European Urology
  
  Volume: 18 Issue: 1 Pages: e548-e548
- DOI
  10.1016/s1569-9056(19)30403-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11183
[Journal Article] 再発性尿路感染症に対するプロバイオティクスの有効性2018
- Author(s)
  定平卓也、和田耕一郎、三井將雄、石井亜矢乃、荒木元朗、渡部昌実、渡邉豊彦、那須保友
- Journal Title
  
  西日本泌尿器科
  
  Volume: 80 Pages: 505-509
- NAID
  40021694717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11183
[Journal Article] Exogenous DKK-3/REIC inhibits Wnt/β-catenin signaling and cell proliferation in human kidney cancer KPK12017
- Author(s)
  Xu Jiaqi、Sadahira Takuya、Kinoshita Rie、Li ShunAi、Huang Peng、Wada Koichiro、Araki Motoo、Ochiai Kazuhiko、Noguchi Hirofumi、Sakaguchi Masakiyo、Nasu Yasutomo、Watanabe Masami
- Journal Title
  
  Oncology Letters
  
  Volume: 14 Pages: 5638-5642
- DOI
  10.3892/ol.2017.6833
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11138, KAKENHI-PROJECT-17H00769, KAKENHI-PROJECT-16H05404, KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-16K18440
[Journal Article] Synergistic effects of the immune checkpoint inhibitor CTLA-4 combined with the growth inhibitor lycorine in a mouse model of renal cell carcinoma2017
- Author(s)
  Li Xiezhao、Xu Peng、Wang Chongshan、Xu Naijin、Xu Abai、Xu Yawen、Sadahira Takuya、Araki Motoo、Wada Koichiro、Matsuura Eiji、Watanabe Masami、Zheng Junxia、Sun Pinghua、Huang Peng、Nasu Yasutomo、Liu Chunxiao
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 13 Pages: 21177-21186
- DOI
  10.18632/oncotarget.15505
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11138
[Journal Article] Robust cancer-specific gene expression by a novel cassette with hTERT and CMV promoter elements.2017
- Author(s)
  Sakaguchi M, Sadahira T, Ueki H, Kinoshita R, Murata H, Yamamoto KI, Futami J, Nasu Y, Ochiai K, Kumon H, Huh NH, Watanabe M.
- Journal Title
  
  Oncology Reports
  
  Volume: 38 Issue: 2 Pages: 1108-1114
- DOI
  10.3892/or.2017.5710
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11004, KAKENHI-PROJECT-16K19037, KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-16K18440
[Presentation] Best Management for Antimicrobial Prophylaxis in Prostate Biopsy2020
- Author(s)
  Koichiro Wada, Takuya Sadahira, Motoo Araki, Takehiro Iwata, Ayano Ishii, Toyohiko Watanabe, Yasutomo Nasu
- Organizer
  40th Congress of the Societe Internationale dUrologie
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11183
[Presentation] 尿路性器感染症POCT 外来で求められる迅速検査－尿路感染症領域のPOCTと課題2020
- Author(s)
  和田耕一郎，定平卓也，山本満寿美，光畑律子，石井亜矢乃，狩山玲子，渡邉豊彦，那須保友
- Organizer
  第94回日本感染症学会総会・学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-17K11183
[Presentation] Best Management for UTI Caused by Quinolone-Resistant Pathogens2020
- Author(s)
  Koichiro Wada, Takuya Sadahira, Motoo Araki, Takehiro Iwata, Ayano Ishii, Toyohiko Watanabe, Yasutomo Nasu
- Organizer
  40th Congress of the Societe Internationale dUrologie
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11183
[Presentation] 尿路感染症における多剤耐性の現状2019
- Author(s)
  和田耕一郎，定平卓也，山本満寿美，光畑律子，石井亜矢乃，狩山玲子，渡邉豊彦，那須保友
- Organizer
  第93回日本感染症学会総会・学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-17K11183
[Presentation] 当科における尿中ESBL産生大腸菌の分離状況と薬剤感受性2019
- Author(s)
  和田耕一郎，山本満寿美，定平卓也，石井亜矢乃，渡辺豊彦, 那須保友
- Organizer
  第67回日本化学療法学会総会
- Data Source
  KAKENHI-PROJECT-17K11183
[Presentation] Impact of Lactobacillus probiotics on biofilm formed by Pseudomonas aeruginosa2019
- Author(s)
  Satoko Matsuo, Koichiro Wada, Takuya Sadahira, Ritsuko Mitsuhata, Masumi Yamamoto, Ayano Ishii, Reiko Kariyama, Toyohiko Watanabe, Yasutomo Nasu
- Organizer
  European Association of Urology 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11183
[Presentation] Mycoplasmal and non-chlamydial non-gonococcal urethritis2019
- Author(s)
  Koichiro Wada, Takuya Sadahira, Motoo Araki, Takehiro Iwata, Ayano Ishii, Toyohiko Watanabe, Yasutomo Nasu
- Organizer
  AAUS (Asian Ass of UTI & STI) Symposium in UAA (Urological Association of Asia)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11183
[Presentation] タゾバクタム/セフトロザンの尿路感染症における有用性2019
- Author(s)
  和田耕一郎、定平卓也、山本満寿美、石井亜矢乃、渡邉豊彦、那須保友
- Organizer
  第67回日本化学療法学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K11183
[Presentation] 反復性膀胱炎に対する乳酸菌膣坐剤の再発予防効果に関する臨床的検討2019
- Author(s)
  石井亜矢乃、和田耕一郎、光畑律子、山本満寿美、定平卓也、岩田健宏、狩山玲子、小林泰之、荒木元朗、渡辺豊彦、那須保友
- Organizer
  第71回西日本泌尿器科学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11183
[Presentation] 第67回乳酸菌タブレットの直腸および膣内細菌叢に及ぼす影響に関する検討2019
- Author(s)
  和田耕一郎、定平卓也、石井亜矢乃、山本満寿美、三井將雄、狩山玲子、渡邉豊彦、那須保友
- Organizer
  日本化学療法学会西日本支部総会
- Data Source
  KAKENHI-PROJECT-17K11183
[Presentation] 前立腺生検後の急性前立腺炎における原因微生物の遺伝子解析2019
- Author(s)
  和田耕一郎、定平卓也、荒木元朗、小林泰之、石井亜矢乃、渡邉豊彦、藤田竜二、竹中　皇、那須良次、津川昌也、津島知靖、那須保友、公文裕巳
- Organizer
  第107回日本泌尿器科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K11183
[Presentation] 当科におけるフロモキセフの使用経験と臨床的位置づけ2019
- Author(s)
  和田耕一郎，山本満寿美，三井將雄，定平卓也，石井亜矢乃，渡辺豊彦, 那須保友
- Organizer
  第67回日本化学療法学会総会
- Data Source
  KAKENHI-PROJECT-17K11183
[Presentation] 反復性膀胱炎に対する乳酸菌膣坐剤の再発抑制効果に関する臨床的検討2018
- Author(s)
  石井亜矢乃、山本満寿美、定平卓也、和田耕一郎、渡辺豊彦、狩山玲子、上原慎也、門田晃一、那須保友、公文裕巳
- Organizer
  第66回日本化学療法学会総会
- Data Source
  KAKENHI-PROJECT-17K11183
[Presentation] 緑膿菌尿路バイオフィルム感染症に対する乳酸菌プロバイオティクスに関する基礎的検討2018
- Author(s)
  光畑律子、狩山玲子、山本満寿美、定平卓也、石井亜矢乃、和田耕一郎
- Organizer
  第92回日本感染症学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-17K11183

1. Nasu Yasutomo (20237572)

# of Collaborated Projects: 10 results

# of Collaborated Products: 3 results
2. Ueki Hideo (90537218)

# of Collaborated Projects: 9 results

# of Collaborated Products: 1 results
3. Araki Moto (90467746)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
4. Watanabe Toyohiko (30432644)

# of Collaborated Projects: 6 results

# of Collaborated Products: 13 results
5. Watanabe Masami (70444677)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. HUANG PENG (00610841)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
7. Wada Koichiro (20423337)

# of Collaborated Projects: 4 results

# of Collaborated Products: 18 results
8. 石井亜矢乃 (00423294)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
9. Kobayashi Yasuyuki (50366027)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. Edamura Kouhei (90535816)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 野口洋文 (50378733)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 岩田健宏 (00803082)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. Takamoto Atsushi (30716816)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 江原伸 (70379741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 竹居孝二 (40322226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 竹田哲也 (30302368)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 落合和彦 (30550488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 山田浩司 (80325092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 花井幸次 (60912730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 和田里章悟 (80833277)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 小川貢平 (90868556)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 丸山雄樹 (00803850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 小林知子 (90452581)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 濱田全紀 (00379736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 堅山佳美 (90397886)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 狩山玲子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sadahira Takuya 定平 卓也

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Elucidation of the mechanism of effector cell exhaustion release using tumor local metabolic modification proteins.Principal Investigator

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A novel mechanism of effector T cell activation and its innovative cancer drug discoveryPrincipal Investigator

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The mechanism of release from immune exhaustion in tumor by a novel checkpoint inhibitorPrincipal Investigator

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Sadahira Takuya 定平卓也