Otomo Takanobu 大友孝信

Researcher Number	20742589
Other IDs	https://orcid.org/0000-0001-8490-7299
Affiliation (Current)	2025: 川崎医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2025: 川崎医科大学, 医学部, 教授 2019: 川崎医科大学, 医学部, 教授 2016 – 2018: 川崎医科大学, 医学部, 准教授 2015: 大阪大学, 生命機能研究科, 特別研究員(PD)
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics / Pediatrics
Keywords	Principal Investigator オートファジー / エンドサイトーシス / ライソゾーム / リソソーム / リソソーム蓄積病 / ライソゾーム酸性環境 / 小胞輸送 / ライソゾーム病 / ムコ多糖症 / リソソーム蓄積症 / 細胞内輸送 / VPS33A / EPG5

ライソゾーム酵素の細胞内新規輸送経路の同定と、その制御による疾患克服への応用Principal Investigator
- Principal Investigator
  
  大友孝信
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kawasaki Medical School
小胞輸送病とライソゾーム病を包括する新しい疾患概念の確立と治療開発への基盤研究Principal Investigator
- Principal Investigator
  
  大友孝信
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kawasaki Medical School
遺伝性希少疾患の病態解析から明らかにするリソソーム機能異常の分子基盤Principal Investigator
- Principal Investigator
  
  大友孝信
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Pediatrics
- Research Institution
  Kawasaki Medical School
Understanding the common pathomechanisms underlying lysosomal and autophagic diseasesPrincipal Investigator
- Principal Investigator
  
  Otomo Takanobu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Pediatrics
- Research Institution
  Kawasaki Medical School
Pathophysiology of lysosomal storage disease and lysophagyPrincipal Investigator
- Principal Investigator
  
  Otomo Takanobu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Pediatrics
- Research Institution
  Kawasaki Medical School
  Osaka University

All 2024 2023 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Impaired lysosomal acidity maintenance in acid lipase-deficient cells leads to defective autophagy2024
- Author(s)
  Moriwaki Takahito、Terawaki Seigo、Otomo Takanobu
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 300 Issue: 3 Pages: 105743-105743
- DOI
  10.1016/j.jbc.2024.105743
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24307
[Journal Article] HOPS, CORVET and newly-identified Hybrid tethering complexes contribute differentially towards multiple modes of endocytosis2023
- Author(s)
  Terawaki Seigo、Vasilev Filipp、Moriwaki Takahito、Otomo Takanobu
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 18734-18734
- DOI
  10.1038/s41598-023-45418-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24307
[Journal Article] Biallelic VPS35L pathogenic variants cause 3C/Ritscher-Schinzel-like syndrome through dysfunction of retriever complex.2020
- Author(s)
  Kato K, Okuno Y, Vasilev FF, Otomo T, Oishi H, Muramatsu H, Kawano Y, Oka Y, Nakazawa Y, Ogi T, Takahashi Y, Saitoh S.
- Journal Title
  
  Journal of Medical genetics
  
  Volume: 57 Issue: 4 Pages: 245-253
- DOI
  10.1136/jmedgenet-2019-106213
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H00783, KAKENHI-PROJECT-17H01877, KAKENHI-PROJECT-17H05088, KAKENHI-PROJECT-17K10075, KAKENHI-PROJECT-20K21583, KAKENHI-PROJECT-19K23823, KAKENHI-PROJECT-20H05700, KAKENHI-PROJECT-18K19585, KAKENHI-PROJECT-20H00629
[Journal Article] Starvation-induced autophagy via calcium-dependent TFEB dephosphorylation is suppressed by Shigyakusan2020
- Author(s)
  Ikari Sumiko、Lu Shiou-Ling、Hao Feike、Imai Kenta、Araki Yasuhiro、Yamamoto Yo-hei、Tsai Chao-Yuan、Nishiyama Yumi、Shitan Nobukazu、Yoshimori Tamotsu、Otomo Takanobu、Noda Takeshi
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 3 Pages: 0230156-0230156
- DOI
  10.1371/journal.pone.0230156
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06111, KAKENHI-PROJECT-17H05088
[Journal Article] Mucopolysaccharidosis-Plus Syndrome2020
- Author(s)
  Vasilev Filipp、Sukhomyasova Aitalina、Otomo Takanobu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 2 Pages: 421-421
- DOI
  10.3390/ijms21020421
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05088, KAKENHI-PROJECT-18F18094
[Journal Article] Mutation in VPS33A affects metabolism of glycosaminoglycans: a new type of mucopolysaccharidosis with severe systemic symptoms2017
- Author(s)
  Kondo H, Maksimova N, Otomo T*,Kato H, Imai A, Asano Y, Kobayashi K, Nojima S, Nakaya A, Hamada Y, Irahara K, Gurinova E, Sukhomyasova A, Nogovicina A, Savvina M, Yoshimori T, Ozono K Sakai N*
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 26 Pages: 173-183
- DOI
  10.1093/hmg/ddw377
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-25111002, KAKENHI-PROJECT-15H05673, KAKENHI-PROJECT-15K19378, KAKENHI-PROJECT-15K08423, KAKENHI-PROJECT-16K19404, KAKENHI-PROJECT-15K09139
[Presentation] INVESTIGATION OF THE PROTEIN STABILITY OF VPS33A, A RESPONSIBLE MOLECULE FOR MPSPS2019
- Author(s)
  Vasilev F., Kawakami Y., Otomo T.
- Organizer
  日本ライソゾーム病研究会
- Data Source
  KAKENHI-PROJECT-17H05088
[Presentation] ライソゾーム関連遺伝子ノックアウト細胞における形態学的考察2019
- Author(s)
  川上由貴子、Filipp Vasilev、大友孝信
- Organizer
  日本ライソゾーム病研究会
- Data Source
  KAKENHI-PROJECT-17H05088
[Presentation] INVESTIGATION OF THE PROTEIN STABILITY OF VPS33A, A RESPONSIBLE MOLECULE FOR MPSPS2019
- Author(s)
  Vasilev F, Kawakami Y, Otomo T
- Organizer
  日本ライソゾーム病研究会
- Data Source
  KAKENHI-PROJECT-18F18094
[Presentation] Understanding pathomechanisms of lysosomal storage disorders with cellular models using genome-editing technology2019
- Author(s)
  Takanobu Otomo,Yukiko Kawakami, Filipp F. Vasilev, Junko Matsuda
- Organizer
  米国先天代謝異常学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05088
[Presentation] Mucopolysaccharidosis-plus syndrome: report of two new cases2018
- Author(s)
  Vasilev F., Kawakami Y., Gurinova E., Sukhomyasova A., Maksimova N., Matsuda J., Otomo T.
- Organizer
  第60回日本先天代謝異常学会
- Data Source
  KAKENHI-PROJECT-17H05088
[Presentation] Mucopolysaccharidosis-plus syndrome: report of two new cases2018
- Author(s)
  Vasilev F., Kawakami Y., Gurinova E., Sukhomyasova A., Maksimova N., Matsuda J., Otomo T.
- Organizer
  第60回日本先天代謝異常学会
- Data Source
  KAKENHI-PROJECT-18F18094
[Presentation] ゲノム編集技術を用いた、ライソゾーム病の包括的理解への挑戦2018
- Author(s)
  大友孝信、川上由貴子、Filipp Vasilev、松田純子
- Organizer
  第60回日本先天代謝異常学会
- Data Source
  KAKENHI-PROJECT-17H05088
[Presentation] ゲノム編集技術を用いた、ライソゾーム病の包括的理解への挑戦2018
- Author(s)
  大友孝信、川上由貴子、Filipp Vasilev、松田純子
- Organizer
  第60回日本先天代謝異常学会
- Data Source
  KAKENHI-PROJECT-18F18094

1. VASILEV FILIPP

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
2. OGI Tomoo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 吉森保

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 荒木保弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Otomo Takanobu 大友 孝信

Research Projects

Research Products

Co-Researchers

ライソゾーム酵素の細胞内新規輸送経路の同定と、その制御による疾患克服への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

小胞輸送病とライソゾーム病を包括する新しい疾患概念の確立と治療開発への基盤研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

遺伝性希少疾患の病態解析から明らかにするリソソーム機能異常の分子基盤Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Understanding the common pathomechanisms underlying lysosomal and autophagic diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathophysiology of lysosomal storage disease and lysophagyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Impaired lysosomal acidity maintenance in acid lipase-deficient cells leads to defective autophagy2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HOPS, CORVET and newly-identified Hybrid tethering complexes contribute differentially towards multiple modes of endocytosis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biallelic VPS35L pathogenic variants cause 3C/Ritscher-Schinzel-like syndrome through dysfunction of retriever complex.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Starvation-induced autophagy via calcium-dependent TFEB dephosphorylation is suppressed by Shigyakusan2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mucopolysaccharidosis-Plus Syndrome2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutation in VPS33A affects metabolism of glycosaminoglycans: a new type of mucopolysaccharidosis with severe systemic symptoms2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] INVESTIGATION OF THE PROTEIN STABILITY OF VPS33A, A RESPONSIBLE MOLECULE FOR MPSPS2019

Author(s)

Organizer

Data Source

[Presentation] ライソゾーム関連遺伝子ノックアウト細胞における形態学的考察2019

Author(s)

Organizer

Data Source

[Presentation] INVESTIGATION OF THE PROTEIN STABILITY OF VPS33A, A RESPONSIBLE MOLECULE FOR MPSPS2019

Author(s)

Organizer

Data Source

[Presentation] Understanding pathomechanisms of lysosomal storage disorders with cellular models using genome-editing technology2019

Author(s)

Organizer

Data Source

Otomo Takanobu 大友孝信