Takahashi Naoki 高橋直樹

Researcher Number	20744204
Other IDs
Affiliation (Current)	2025: 地方独立行政法人埼玉県立病院機構埼玉県立がんセンター(臨床腫瘍研究所), 病院消化器内科, 医長
Affiliation (based on the past Project Information) *help	2021: 地方独立行政法人埼玉県立病院機構埼玉県立がんセンター(臨床腫瘍研究所), 病院消化器内科, 医長 2017 – 2020: 埼玉県立がんセンター(臨床腫瘍研究所), 病院消化器内科, 医長
Review Section/Research Field	Principal Investigator Tumor diagnostics Except Principal Investigator Digestive surgery
Keywords	Principal Investigator 次世代シークエンサー / 免疫染色 / HER2陽性胃癌 / gastric cancer / trastuzumab / ハーセプチン / HER2 / 胃癌 Except Principal Investigator 抗上皮成長因子受容体抗体 / 個別化医療 … More / 個別化治療 / 遺伝子変異 / 上皮成長因子受容体 / 大腸癌 / 循環腫瘍DNA Less

Detection of acquired resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer using circulating tumor DNA
- Principal Investigator
  
  Nakamura Keishi
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kanazawa University
Translational research to evaluate the resistant mechanism of anti-HER2 antibody by using immunohistochemistry and next-generation sequencing in HER2-positive gastric patients.Principal Investigator
- Principal Investigator
  
  Takahashi Naoki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Research Institute for Clinical Oncology, Saitama Cancer Center

All 2021 2019 2018 2017

All Journal Article Presentation

[Journal Article] Genome-wide Discovery of a Novel Gene-expression Signature for the Identification of Lymph Node Metastasis in Esophageal Squamous Cell Carcinoma.2019
- Author(s)
  Sonohara F, Gao F, Iwata N, Kanda M, Koike M, Takahashi N, Yamada Y, Kodera Y, Wang X, Goel A.
- Journal Title
  
  Ann Surg.
  
  Volume: 269 Issue: 5 Pages: 879-886
- DOI
  10.1097/sla.0000000000002622
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15010
[Journal Article] Transcriptomic expression profiling identifies ITGBL1, an epithelial to mesenchymal transition (EMT)-associated gene, is a promising recurrence prediction biomarker in colorectal cancer.2019
- Author(s)
  Matsuyama T, Ishikawa T, Takahashi N, Yamada Y, Yasuno M, Kawano T, Uetake H, Goel A.
- Journal Title
  
  Mol Cancer
  
  Volume: 18 Issue: 1 Pages: 19-19
- DOI
  10.1186/s12943-019-0945-y
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15010
[Journal Article] A comprehensive methylation signature identifies lymph node metastasis in esophageal squamous cell carcinoma.2019
- Author(s)
  Roy R, Kandimalla R, Sonohara F, Koike M, Kodera Y, Takahashi N, Yamada Y, Goel A.
- Journal Title
  
  Int J Cancer
  
  Volume: 144 Issue: 5 Pages: 1160-1169
- DOI
  10.1002/ijc.31755
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15010
[Journal Article] A Prospective, Multicenter Phase II Study of the Efficacy and Feasibility of 15-minute Panitumumab Infusion Plus Irinotecan for Oxaliplatin- and Irinotecan-refractory, KRAS Wild-type Metastatic Colorectal Cancer (Short Infusion of Panitumumab Trial).2018
- Author(s)
  Akiyoshi K, Hamaguchi T, Yoshimura K, Takahashi N, Honma Y, Iwasa S, Takashima A, Kato K, Yamada Y, Onodera H, Takeshita S, Yasui H, Sakai G, Akatsuka S, Ogawa K, Horita Y, Nagai Y, Shimada Y.
- Journal Title
  
  Clin Colorectal Cancer.
  
  Volume: 17 Issue: 1 Pages: e83-e89
- DOI
  10.1016/j.clcc.2017.10.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15010
[Journal Article] Patterns of Relapse after Definitive Chemoradiotherapy in Stage II/III (Non-T4) Esophageal Squamous Cell Carcinoma.2018
- Author(s)
  Sudo K, Kato K, Kuwabara H, Sasaki Y, Takahashi N, Shoji H, Iwasa S, Honma Y, Okita NT, Takashima A, Hamaguchi T, Yamada Y, Ito Y, Itami J, Fukuda T, Tobinai K, Boku N.
- Journal Title
  
  Oncology.
  
  Volume: 94（1） Issue: 1 Pages: 47-54
- DOI
  10.1159/000480515
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19381, KAKENHI-PROJECT-17K15010
[Journal Article] Genome-wide discovery and identification of a novel miRNA signature for recurrence prediction in stage II and III colorectal cancer.2018
- Author(s)
  Kandimalla R, Gao F, Matsuyama T, Ishikawa T, Uetake H, Takahashi N, Yamada Y, Becerra CR, Kopetz S, Wang X, Goel A.
- Journal Title
  
  Clin Cancer Res
  
  Volume: 印刷中 Issue: 16 Pages: 3867-3877
- DOI
  10.1158/1078-0432.ccr-17-3236
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15010
[Journal Article] Comparison of Response to Chemotherapy between Ovarian and Extraovarian Metastasis of Gastric Cancer2017
- Author(s)
  Ishimoto U, Nakamura S, Sasaki Y, Takahashi N, Iwasa S, Honma Y, Okita N, Takashima A, Kato K, Hamaguchi T, Boku N.
- Journal Title
  
  Gan To Kagaku Ryoho.
  
  Volume: 44 Pages: 233-237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15010
[Journal Article] Safety, tolerability and pharmacokinetics of the fibroblast growth factor receptor inhibitor AZD4547 in Japanese patients with advanced solid tumours: a Phase I study.2017
- Author(s)
  Saka H, Kitagawa C, Kogure Y, Takahashi Y, Fujikawa K, Sagawa T, Iwasa S, Takahashi N, Fukao T, Tchinou C, Landers D, Yamada Y.
- Journal Title
  
  Invest New Drugs. 2017 Aug;35(4):451-462.
  
  Volume: 35 Issue: 4 Pages: 451-462
- DOI
  10.1007/s10637-016-0416-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15010
[Journal Article] Asymptomatic Pancreatic Metastasis from Renal Cell Carcinoma Diagnosed 21 Years after Nephrectomy.2017
- Author(s)
  Zianne M, Takahashi N, Tsujibata A, Miwa K, Goto Y, Matano Y.
- Journal Title
  
  Case Rep Gastrointest Med.
  
  Volume: 2017 Pages: 2017-2017
- DOI
  10.1155/2017/8765264
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15010
[Journal Article] CCAT1 and CCAT2 long noncoding RNAs, located within the 8q.24.21 ‘gene desert’, serve as important prognostic biomarkers in colorectal cancer2017
- Author(s)
  Ozawa T, Matsuyama T, Toiyama Y, Takahashi N, Ishikawa T, Uetake H, Yamada Y, Kusunoki M, Calin G, Goel A.
- Journal Title
  
  Annals of Oncology.
  
  Volume: 28 Issue: 8 Pages: 1882-1888
- DOI
  10.1093/annonc/mdx248
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15010, KAKENHI-PROJECT-26293301, KAKENHI-PROJECT-16K15612
[Presentation] RAS野生型転移性大腸癌患者における循環腫瘍DNA中のRAS, BRAF, PIK3CA変異の同定と腫瘍組織の変異との比較2021
- Author(s)
  澤田　武, 久保田英嗣, 中村慶史, 高橋直樹, 太田亮介, 井戸川雅史, 佐々木泰史, 時野隆至, 源　利成, 片岡洋望
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K10625
[Presentation] Comparison of HER2 expression by immunohistochemistry and HER2 copy number by digital PCR in tumor tissue during treatment with trastuzumab in the prospective cohort of metastatic HER2-positive gastric cancer patients.2019
- Author(s)
  Naoki Takahashi, Satoru Iwasa, Tomohiro Matsushima, Shoichi Miyazawa, Satoshi Shimizu, Yosuke Kumekawa, Takako Yoshii, Masako Asayama, Hiroki Hara.
- Organizer
  ASCO-GI 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15010
[Presentation] 663PChange in the molecular profile of tumor tissues during treatment with trastuzumab, as analyzed by next-generation sequencing and immunohistochemistry: A multicenter prospective biomarker study on HER2-positive gastric cancer2017
- Author(s)
  Takahashi N, Iwasa S, Sawada T, Sasaki Y, Taniguchi H, Oda I, Honda T, Kojima Y, Hara H, Honma Y, Takashima A, Kato K, Hamaguchi T, Yamada Y.
- Organizer
  ESMO 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15010
[Presentation] Plasma Levels of Pirnas as Biomarkers for Prognosis and Predicting Tumor Recurrence in Colorectal Cancer Patients2017
- Author(s)
  Ozawa T, Toiyama Y, Takahashi N, Nagasaka T, Fujiwara T, Yamada Y, Kusunoki M, Watanabe T, Goel A.
- Organizer
  DDW 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15010
[Presentation] ITGBL1 is a novel epithelial mesenchymal transition-associated prognostic biomarker in colorectal cancer2017
- Author(s)
  Takatoshi Matsuyama, Toshiaki Ishikawa, Naoki Takahashi, Yasuhide Yamada, Masamichi Yasuno, Tatsuyuki Kawano, Hiroyuki Uetake, and Ajay Goel
- Organizer
  AACR 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15010
[Presentation] Genome-wide discovery and identification of a novel microrna signature for recurrence prediction in colorectal cancer2017
- Author(s)
  Kandimalla R, Gao F, Matsuyama T, Ishikawa T, Uetake H, Takahashi N, Yamada Y, Becerra CR, Kopetz S, Wang X, Goel A.
- Organizer
  AACR 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15010

1. 澤田武 (60345626)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. Nakamura Keishi (30608691)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. Sasaki Yasushi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. Iwasa Satoru

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. 庄司広和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takahashi Naoki 高橋 直樹

Research Projects

Research Products

Co-Researchers

Detection of acquired resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer using circulating tumor DNA

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Translational research to evaluate the resistant mechanism of anti-HER2 antibody by using immunohistochemistry and next-generation sequencing in HER2-positive gastric patients.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Genome-wide Discovery of a Novel Gene-expression Signature for the Identification of Lymph Node Metastasis in Esophageal Squamous Cell Carcinoma.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcriptomic expression profiling identifies ITGBL1, an epithelial to mesenchymal transition (EMT)-associated gene, is a promising recurrence prediction biomarker in colorectal cancer.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A comprehensive methylation signature identifies lymph node metastasis in esophageal squamous cell carcinoma.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Prospective, Multicenter Phase II Study of the Efficacy and Feasibility of 15-minute Panitumumab Infusion Plus Irinotecan for Oxaliplatin- and Irinotecan-refractory, KRAS Wild-type Metastatic Colorectal Cancer (Short Infusion of Panitumumab Trial).2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Patterns of Relapse after Definitive Chemoradiotherapy in Stage II/III (Non-T4) Esophageal Squamous Cell Carcinoma.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome-wide discovery and identification of a novel miRNA signature for recurrence prediction in stage II and III colorectal cancer.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison of Response to Chemotherapy between Ovarian and Extraovarian Metastasis of Gastric Cancer2017

Author(s)

Journal Title

Data Source

[Journal Article] Safety, tolerability and pharmacokinetics of the fibroblast growth factor receptor inhibitor AZD4547 in Japanese patients with advanced solid tumours: a Phase I study.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Asymptomatic Pancreatic Metastasis from Renal Cell Carcinoma Diagnosed 21 Years after Nephrectomy.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CCAT1 and CCAT2 long noncoding RNAs, located within the 8q.24.21 ‘gene desert’, serve as important prognostic biomarkers in colorectal cancer2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] RAS野生型転移性大腸癌患者における循環腫瘍DNA中のRAS, BRAF, PIK3CA変異の同定と腫瘍組織の変異との比較2021

Author(s)

Organizer

Data Source

[Presentation] Comparison of HER2 expression by immunohistochemistry and HER2 copy number by digital PCR in tumor tissue during treatment with trastuzumab in the prospective cohort of metastatic HER2-positive gastric cancer patients.2019

Author(s)

Organizer

Data Source

[Presentation] 663PChange in the molecular profile of tumor tissues during treatment with trastuzumab, as analyzed by next-generation sequencing and immunohistochemistry: A multicenter prospective biomarker study on HER2-positive gastric cancer2017

Author(s)

Organizer

Data Source

[Presentation] Plasma Levels of Pirnas as Biomarkers for Prognosis and Predicting Tumor Recurrence in Colorectal Cancer Patients2017

Author(s)

Organizer

Takahashi Naoki 高橋直樹