Hosoda Ryusuke 細田隆介

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HOSODA RYUSUKE 細田隆介

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Researcher Number	20749428
Other IDs
Affiliation (Current)	2025: 札幌医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2025: 札幌医科大学, 医学部, 助教 2015 – 2023: 札幌医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47040:Pharmacology-related / General pharmacology Except Principal Investigator Basic Section 47040:Pharmacology-related
Keywords	Principal Investigator SIRT1 / オートファジー / マイトファジー / サルコペニア / ミトコンドリア / 筋ジストロフィー / アセチル化修飾 / SIRT3 / 骨格筋 / 老化 / 骨格筋・平滑筋 … More Except Principal Investigator … More RIPK3 / オートファジー / ネクロプトーシス / 糖尿病 / 急性腎障害 Less

サルコペニアにおけるミトコンドリア蛋白アセチル化修飾の役割解明Principal Investigator
- Principal Investigator
  
  細田隆介
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Sapporo Medical University
Roles of interplay between autophagy and necroptosis in aggravation of acute kidney injury by diabetes
- Principal Investigator
  
  久野篤史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Sapporo Medical University
蛋白アセチル化修飾を標的としたサルコペニア発症機序の解明と治療法開発Principal Investigator
- Principal Investigator
  
  細田隆介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Sapporo Medical University
Development of a novel therapeutics for muscular dystrophy by targeting mitophagy.Principal Investigator
- Principal Investigator
  
  Hosoda Ryusuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Sapporo Medical University
Role of mitophagy in treatment of muscular dystrophy by SIRT1 activationPrincipal Investigator
- Principal Investigator
  
  Hosoda Ryusuke
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Sapporo Medical University
Role of SIRT1 in mitophagy in the skeletal musclePrincipal Investigator
- Principal Investigator
  
  HOSODA RYUSUKE
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Sapporo Medical University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Patent

[Journal Article] Transcriptional dysregulation of autophagy in the muscle of a mouse model of Duchenne muscular dystrophy2024
- Author(s)
  Nakashima Ryuta、Hosoda Ryusuke、Tatekoshi Yuki、Iwahara Naotoshi、Saga Yukika、Kuno Atsushi
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 1365-1365
- DOI
  10.1038/s41598-024-51746-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K19373, KAKENHI-PROJECT-22K06632
[Journal Article] Resveratrol, a SIRT1 activator, attenuates aging-associated alterations in skeletal muscle and heart in mice.2023
- Author(s)
  Hosoda Ryusuke, Nakashima Ryuta, Yano Masaki, Iwahara Naotoshi, Asakura Seidai, Nojima Iyori, Saga Yukika, Kunimoto Risa, Horio Yoshiyuki, Kuno Atsushi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 152 Issue: 2 Pages: 112-122
- DOI
  10.1016/j.jphs.2023.04.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06632, KAKENHI-PROJECT-20K07068
[Journal Article] Different Antioxidative and Antiapoptotic Effects of Piceatannol and Resveratrol2020
- Author(s)
  Hosoda Ryusuke、Hamada Hiroki、Uesugi Daisuke、Iwahara Naotoshi、Nojima Iyori、Horio Yoshiyuki、Kuno Atsushi
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics
  
  Volume: 376 Issue: 3 Pages: 385-396
- DOI
  10.1124/jpet.120.000096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07102
[Journal Article] SIRT1 deficiency interferes with membrane resealing after cell membrane injury2019
- Author(s)
  Fujiwara Daisuke、Iwahara Naotoshi、Sebori Rio、Hosoda Ryusuke、Shimohama Shun、Kuno Atsushi、Horio Yoshiyuki
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 6 Pages: e0218329-e0218329
- DOI
  10.1371/journal.pone.0218329
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06965, KAKENHI-PROJECT-19K07102, KAKENHI-PROJECT-16H06280
[Journal Article] Resveratrol Ameliorates Mitophagy Disturbance and Improves Cardiac Pathophysiology of Dystrophin-deficient mdx Mice.2018
- Author(s)
  Kuno A, Hosoda R, Sebori R, Hayashi T, Sakuragi H, Tanabe M, Horio Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 8 Issue: 1 Pages: 15555-15555
- DOI
  10.1038/s41598-018-33930-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08600, KAKENHI-PROJECT-17K15582
[Journal Article] Resveratrol Decreases Oxidative Stress by Restoring Mitophagy and Improves the Pathophysiology of Dystrophin-Deficient mdx Mice.2018
- Author(s)
  Sebori R, Kuno A, Hosoda R, Hayashi T, Horio Y.
- Journal Title
  
  Oxid Med Cell Longev.
  
  Volume: 2018 Issue: 1 Pages: 9179270-9179270
- DOI
  10.1155/2018/9179270
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08600, KAKENHI-PROJECT-17K15582
[Journal Article] Pterostilbene and Its Glucoside Induce Type ⅩⅦ Collagen Expression.2017
- Author(s)
  Hamada H, Shimoda K, Horio Y, Ono T, Hosoda R, Nakayama N, Urano K.
- Journal Title
  
  Natural Product Communications
  
  Volume: 12 Pages: 85-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15582
[Journal Article] Pterostilbene and Its Glucoside Induce Type ⅩⅦ Collagen Expression2017
- Author(s)
  Hiroki Hamada, Kei Shimoda, Yoshiyuki Horio, Tsubasa Ono, Ryusuke Hosoda, Noriyuki Nakayama and Koichi Urano
- Journal Title
  
  Natural Product Communications
  
  Volume: 12 Pages: 85-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18992
[Journal Article] 筋ジストロフィーの新治療法の開発2016
- Author(s)
  久野篤史、細田隆介、堀尾嘉幸
- Journal Title
  
  Medical Science Digest
  
  Volume: 42 Pages: 642-646
- Data Source
  KAKENHI-PROJECT-15K18992
[Journal Article] Sirt1-deficient mice have hypogonadotropic hypogonadism due to defective GnRH neuronal migration.2015
- Author(s)
  Di Sante G, Wang L, Wang C, Jiao X, Casimiro MC, Chen K, Pestell TG, Yaman I, Di Rocco A, Sun X, Horio Y, Powell MJ, He X, McBurney MW, Pestell RG.
- Journal Title
  
  Mol Endocrinol
  
  Volume: ２９ Issue: 1 Pages: 200-212
- DOI
  10.1007/s11060-014-1686-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08312, KAKENHI-PROJECT-15K18992
[Patent] Type17コラーゲンの産生促進剤2017
- Inventor(s)
  濱田博喜、細田隆介、小野翼
- Industrial Property Rights Holder
  香港友池有限公司
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Acquisition Date
  2018
- Data Source
  KAKENHI-PROJECT-17K15582
[Presentation] サルコペニアの骨格筋で増加するアセチル化蛋白の網羅的解析2023
- Author(s)
  細田隆介
- Organizer
  第97回日本薬理学会年会・第44回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-22K06632
[Presentation] 加齢によるサルコペニアの骨格筋で増加するアセチル化蛋白の網羅的解析2023
- Author(s)
  細田隆介
- Organizer
  第74回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-22K06632
[Presentation] レスベラトロールはオートTreatment with resveratrol attenuates aging-related loss of muscle mass and function in mice.ファジーを活性化して加齢による筋委縮と運動機能低下を軽減する2022
- Author(s)
  Ryusuke Hosoda, Atsushi Kuno, Ryuta Nakashima, Seidai Asakura, Naotoshi Iwahara, Iyori Nojima, Risa Kunimoto, Yoshiyuki Horio.
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07102
[Presentation] 骨格筋におけるSIRT1の活性化はオートファジー活性を維持して加齢に伴うサルコペニアを改善する2022
- Author(s)
  細田隆介
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K06632
[Presentation] The activation of SIRT1 in skeletal muscle preserves autophagic activity and improves age-related sarcopenia2022
- Author(s)
  細田隆介
- Organizer
  第96回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06632
[Presentation] 骨格筋におけるSIRT1の活性化はオートファジー活性を維持して加齢によるサルコペニアを改善する2022
- Author(s)
  細田隆介
- Organizer
  第73回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-22K06632
[Presentation] レスベラトロールは加齢による筋委縮を抑制し運動機能を維持する2021
- Author(s)
  Hosoda R, Kuno A, Asakura S, Iwahara N, Nojima I, Kunimoto R, Horio Y.
- Organizer
  第43回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07102
[Presentation] Treatment with resveratrol attenuates aging-related loss of muscle mass and function in mice.2021
- Author(s)
  Hosoda R, Kuno A, Asakura S, Iwahara N, Nojima I, Kunimoto R, Horio Y.
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07102
[Presentation] レスベラトロールはオートファジーを活性化して加齢による筋委縮と運動機能低下を軽減する2021
- Author(s)
  細田隆介、久野篤史、中島龍汰、朝倉聖大、岩原直敏、野島伊世里、國本梨沙、堀尾嘉幸
- Organizer
  第72回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-19K07102
[Presentation] 植物由来ポリフェノールであるピセアタンノールとレスベラトロールのSIRT1活性化を介した細胞保護作用の比較2020
- Author(s)
  細田隆介久野篤史濱田博喜堀尾嘉幸
- Organizer
  第71回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-19K07102
[Presentation] Deletion of SIRT1 in the skeletal muscle decreases type IIa oxidative muscle fiber in mice.2020
- Author(s)
  Hosoda R, Kuno A, Asakura S, Horio Y.
- Organizer
  Experimental Biology 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07102
[Presentation] マイトファジー活性を標的とした筋ジストロフィーの新規治療法開発2019
- Author(s)
  細田隆介、久野篤史、堀尾嘉幸
- Organizer
  第70回薬理学会北部会
- Data Source
  KAKENHI-PROJECT-19K07102
[Presentation] 骨格筋SIRT1は筋障害を軽減して筋機能を維持する2018
- Author(s)
  細田隆介、久野篤史、堀尾嘉幸
- Organizer
  第69回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-17K15582
[Presentation] 骨格筋特異的SIRT1欠損マウスは筋障害が増加し筋機能が低下する2018
- Author(s)
  細田隆介、久野篤史、堀尾嘉幸
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K15582
[Presentation] 骨格筋SIRT1は筋機能の維持と筋膜障害の軽減にはたらく2018
- Author(s)
  細田隆介、久野篤史、堀尾嘉幸
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17K15582
[Presentation] Deletion of SIRT1 in the cardiomyocyte exacerbates doxorubicin-induced cardiotoxicity in mice.2018
- Author(s)
  Ryusuke Hosoda, Atsushi Kuno, Yoshiyuki Horio
- Organizer
  18th World Congress of Basic and Clinical Pharmacology.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15582
[Presentation] Deletion of SIRT1 in the cardiomyocyte exacerbates doxorubicin-induced cardiotoxicity in mice.2018
- Author(s)
  Ryusuke Hosoda , Atsushi Kuno, Yoshiyuki Horio
- Organizer
  The 18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15582
[Presentation] Deletion of SIRT1 in the cardiomyocyte aggravates doxorubicin-induced cardiotoxicity in mice.2018
- Author(s)
  Ryusuke Hosoda, Atsushi Kuno, Yoshiyuki Horio
- Organizer
  Keystone Symposia "Mitochondrial Biology"
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15582
[Presentation] SIRT1 in the cardiomyocyte protects mitochondria and the heart against doxorubicin treatment in mice.2018
- Author(s)
  Ryusuke Hosoda , Atsushi Kuno, Yoshiyuki Horio
- Organizer
  Keystone Symposia Conference ”Mitochondrial Biology”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15582
[Presentation] Prl2c3はSIRT1により負に発現制御を受ける老化誘導タンパクである2017
- Author(s)
  細田隆介、堀本浩平、國本梨沙、山下利春、瀬堀理生、久野篤史、堀尾嘉幸
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-17K15582
[Presentation] SIRT1により負の制御を受ける Prl2c3は老化誘導タンパクである2017
- Author(s)
  細田隆介、堀本浩平、國本梨沙、山下利春、瀬堀理生、久野篤史、堀尾嘉幸
- Organizer
  第68回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-17K15582
[Presentation] Resveratrol restores autophagy and improve cardiac dysfunction in a mouse model of Duchenne muscular dystrophy2017
- Author(s)
  久野篤史, 細田隆介, 瀬堀理生, 堀尾嘉幸
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール、長崎新聞文化ホールアストピア (長崎県長崎市)
- Year and Date
  2017-03-14
- Data Source
  KAKENHI-PROJECT-15K18992
[Presentation] Protective role of SIRT1 in the cardiomyocyte in doxorubicin-induced cardiotoxicity2017
- Author(s)
  Ryusuke Hosoda, Kuno Atsushi, Sebori Rio, Yoshiyuki Horio
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール、長崎新聞文化ホールアストピア (長崎県長崎市)
- Year and Date
  2017-03-14
- Data Source
  KAKENHI-PROJECT-15K18992
[Presentation] Protective role of SIRT1 in the cardiomyocyte in doxorubicin cardiotoxicity in mice.2017
- Author(s)
  Ryusuke Hosoda , Atsushi Kuno, Yoshiyuki Horio
- Organizer
  Keystone Symposia "Aging and Mechanisms of Aging-Related Disease"
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15582
[Presentation] マウス線維芽細胞での細胞老化におけるIGFBP5の役割2016
- Author(s)
  細田隆介, 久野篤史, 戸田悠基, 斎藤慶樹, 瀬堀理生, 林貴士, 堀尾嘉幸
- Organizer
  第89回日本薬理学年会
- Place of Presentation
  パシフィコ横浜会議センター（横浜市）
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15K18992
[Presentation] 筋ジストロフィーの心筋障害におけるオートファジー不全の意義2016
- Author(s)
  久野篤史, 細田隆介, 瀬堀理生, 堀尾嘉幸
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜 (神奈川県横浜市)
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K18992
[Presentation] Impaired autophagy induced by activated mTORC1 underlies development of dystrophic cardiomyopathy.2016
- Author(s)
  Atsushi Kuno, Ryusuke Hosoda, Rio Sebori, Yoshiyuki Horio
- Organizer
  American Heart Association 2016 Scientific Sessions
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18992
[Presentation] Ablation of SIRT1 in the cardiomyocyte aggravates doxorubicin cardiotoxicity in mice: Possible role of accumulation of deleted mtDNA.2016
- Author(s)
  Ryusuke Hosoda, Atsushi Kuno, Rio Sebori, Yoshiyuki Horio
- Organizer
  American Heart Association 2016 Scientific Sessions
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18992
[Presentation] ドキソルビシン誘導性心筋障害に対するSIRT1の役割解明2016
- Author(s)
  細田隆介、久野篤史、瀬堀理生、堀尾嘉幸
- Organizer
  第67回薬理学会北部会
- Place of Presentation
  北海道大学学術交流会館 (北海道札幌市)
- Data Source
  KAKENHI-PROJECT-15K18992
[Presentation] 心筋におけるSIRT1の欠損はドキソルビシン誘導性心筋障害を悪化させる2016
- Author(s)
  細田隆介, 久野篤史, 瀬堀理生, 堀尾嘉幸
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜 (神奈川県横浜市)
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K18992
[Presentation] ピセアタンノールとレスベラトロールの酸化ストレスに対する細胞保護効果の比較2015
- Author(s)
  細田隆介, 久野篤史, 瀬堀理生, 濱田博喜, 堀尾嘉幸
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド（神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K18992

1. 久野篤史 (30468079)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
2. 藤谷直樹 (10374191)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 野島伊世里 (10827398)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. 岩原直敏 (00613085)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. 堀尾嘉幸 (30181530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
6. 山田崇史 (50583176)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 矢野俊之 (40444913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 田中希尚 (60533362)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 嵯峨幸夏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hosoda Ryusuke 細田 隆介

HOSODA RYUSUKE 細田 隆介

Research Projects

Research Products

Co-Researchers

サルコペニアにおけるミトコンドリア蛋白アセチル化修飾の役割解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles of interplay between autophagy and necroptosis in aggravation of acute kidney injury by diabetes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

蛋白アセチル化修飾を標的としたサルコペニア発症機序の解明と治療法開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel therapeutics for muscular dystrophy by targeting mitophagy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of mitophagy in treatment of muscular dystrophy by SIRT1 activationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of SIRT1 in mitophagy in the skeletal musclePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Transcriptional dysregulation of autophagy in the muscle of a mouse model of Duchenne muscular dystrophy2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Resveratrol, a SIRT1 activator, attenuates aging-associated alterations in skeletal muscle and heart in mice.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Different Antioxidative and Antiapoptotic Effects of Piceatannol and Resveratrol2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SIRT1 deficiency interferes with membrane resealing after cell membrane injury2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Resveratrol Ameliorates Mitophagy Disturbance and Improves Cardiac Pathophysiology of Dystrophin-deficient mdx Mice.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Resveratrol Decreases Oxidative Stress by Restoring Mitophagy and Improves the Pathophysiology of Dystrophin-Deficient mdx Mice.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pterostilbene and Its Glucoside Induce Type ⅩⅦ Collagen Expression.2017

Author(s)

Journal Title

Data Source

[Journal Article] Pterostilbene and Its Glucoside Induce Type ⅩⅦ Collagen Expression2017

Author(s)

Journal Title

Data Source

[Journal Article] 筋ジストロフィーの新治療法の開発2016

Hosoda Ryusuke 細田隆介

HOSODA RYUSUKE 細田隆介