Ode Hirotaka 大出裕高

Researcher Number	20754162
Other IDs	https://orcid.org/0000-0001-8624-2382
Affiliation (Current)	2024: 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, 研究員
Affiliation (based on the past Project Information) *help	2023: 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, 研究員 2017 – 2019: 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, 研究員
Review Section/Research Field	Principal Investigator Basic Section 54030:Infectious disease medicine-related / Virology
Keywords	Principal Investigator 配列多様性 / HIV / ウイルスゲノム / ナノポアシークエンス / 1分子シークエンス / タンパク質立体構造 / ウィルス / ドッキングシミュレーション / タンパク質-タンパク質相互作用 / HIV-1 … More / タンパク質複合体構造予測 / Vif / APOBEC3 / APOBEC3G Less

1分子シークエンスによる感染者内HIVのウイルスゲノム全長配列多様性の解明Principal Investigator
- Principal Investigator
  
  大出裕高
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  National Hospital Organization Nagoya Medical Center
Clarification of interaction machinery between antiviral factor APOBEC3G and HIV-1 VifPrincipal Investigator
- Principal Investigator
  
  Ode Hirotaka
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  National Hospital Organization Nagoya Medical Center

All 2023 2019 2018 2017

All Journal Article Presentation

[Journal Article] Identifying integration sites of the HIV-1 genome with intact and aberrant ends through deep sequencing2019
- Author(s)
  Ode Hirotaka、Kobayashi Ayumi、Matsuda Masakazu、Hachiya Atsuko、Imahashi Mayumi、Yokomaku Yoshiyuki、Iwatani Yasumasa
- Journal Title
  
  Journal of Virological Methods
  
  Volume: 267 Pages: 59-65
- DOI
  10.1016/j.jviromet.2019.03.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08872, KAKENHI-PROJECT-19H03482
[Journal Article] Discovery of 4-oxoquinolines, a new chemical class of anti-HIV-1 compounds2019
- Author(s)
  Shiroishi-Wakatsuki Tomomi、Maejima-Kitagawa Masami、Hamano Akiko、Murata Daigo、Sukegawa Sayaka、Matsuoka Kazuhiro、Ode Hirotaka、Hachiya Atsuko、Imahashi Mayumi、Yokomaku Yoshiyuki、Nomura Nobuhiko、Sugiura Wataru、Iwatani Yasumasa
- Journal Title
  
  Antiviral Research
  
  Volume: 162 Pages: 101-109
- DOI
  10.1016/j.antiviral.2018.12.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08872, KAKENHI-PROJECT-18K14685
[Journal Article] Structural basis of chimpanzee APOBEC3H dimerization stabilized by double-stranded RNA2018
- Author(s)
  Matsuoka Tatsuya、Nagae Takayuki、Ode Hirotaka、Awazu Hiroaki、Kurosawa Teppei、Hamano Akiko、Matsuoka Kazuhiro、Hachiya Atsuko、Imahashi Mayumi、Yokomaku Yoshiyuki、Watanabe Nobuhisa、Iwatani Yasumasa
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 46 Issue: 19 Pages: 10368-10379
- DOI
  10.1093/nar/gky676
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08872, KAKENHI-PROJECT-18K14685
[Journal Article] Compound heterozygous TYK2 mutations underlie primary immunodeficiency with T-cell lymphopenia2018
- Author(s)
  Nemoto Michiko、Hattori Hiroyoshi、Maeda Naoko、Akita Nobuhiro、Muramatsu Hideki、Moritani Suzuko、Kawasaki Tomonori、Maejima Masami、Ode Hirotaka、Hachiya Atsuko、Sugiura Wataru、Yokomaku Yoshiyuki、Horibe Keizo、Iwatani Yasumasa
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 6956-6956
- DOI
  10.1038/s41598-018-25260-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04740, KAKENHI-PROJECT-16K08654, KAKENHI-PROJECT-17K08872, KAKENHI-PROJECT-18K05818, KAKENHI-PROJECT-15K09678
[Journal Article] Distribution of norovirus genotypes and subtypes in river water by ultra-deep sequencing-based analysis2017
- Author(s)
  Boonchan M.、Motomura K.、Inoue K.、Ode H.、Chu P.Y.、Lin M.、Iwatani Y.、Ruchusatsawat K.、Guntapong R.、Tacharoenmuang R.、Chantaroj S.、Tatsumi M.、Takeda N.、Sangkitporn S.
- Journal Title
  
  Letters in Applied Microbiology
  
  Volume: 65 Issue: 1 Pages: 98-104
- DOI
  10.1111/lam.12750
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08872, KAKENHI-PROJECT-17K19874, KAKENHI-PROJECT-15H04740
[Journal Article] Mapping Region of Human Restriction Factor APOBEC3H Critical for Interaction with HIV-1 Vif2017
- Author(s)
  Nakashima Masaaki、Tsuzuki Shinya、Awazu Hiroaki、Hamano Akiko、Okada Ayaka、Ode Hirotaka、Maejima Masami、Hachiya Atsuko、Yokomaku Yoshiyuki、Watanabe Nobuhisa、Akari Hirofumi、Iwatani Yasumasa
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: 429 Issue: 8 Pages: 1262-1276
- DOI
  10.1016/j.jmb.2017.03.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08872, KAKENHI-PROJECT-15H04740, KAKENHI-PROJECT-16H05194
[Journal Article] Production of HIV-1 vif mRNA Is Modulated by Natural Nucleotide Variations and SLSA1 RNA Structure in SA1D2prox Genomic Region2017
- Author(s)
  Nomaguchi Masako、Doi Naoya、Yoshida Tomoya、Koma Takaaki、Adachi Shun、Ode Hirotaka、Iwatani Yasumasa、Yokoyama Masaru、Sato Hironori、Adachi Akio
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 8 Pages: 2542-2542
- DOI
  10.3389/fmicb.2017.02542
- NAID
  120006937675
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08824, KAKENHI-PROJECT-17K08860, KAKENHI-PROJECT-17K08872, KAKENHI-PROJECT-15H04740, KAKENHI-PROJECT-17H06907
[Presentation] ナノポアシーケンスによるHIV-1 RNA ゲノムの近全長配列解析と薬剤耐性遺伝子検査への応用2023
- Author(s)
  松田昌和、大出裕高、重見麗、山村喜美、森美喜子、今橋真弓、横幕能行、岩谷靖雅
- Organizer
  第37回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-23K07938
[Presentation] ナノポアシーケンスを利用した宿主内 HIV-1 のゲノム配列多様性解析2023
- Author(s)
  大出裕高、松田昌和、重見麗、山村喜美、森美喜子、今橋真弓、横幕能行、岩谷靖雅
- Organizer
  第37回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-23K07938
[Presentation] 東海地域において検出されたUnique recombinant forms（URFs）症例の分子疫学的解析と考察2023
- Author(s)
  重見麗、山村喜美、松田昌和、大出裕高、森美喜子、笠原嵩翔、今橋真弓、横幕能行、岩谷靖雅
- Organizer
  第37回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-23K07938
[Presentation] 抗ウイルス因子APOBEC3Hの分子構造に対する多型変異R105Gの影響2019
- Author(s)
  大出裕高、中田佳宏、松岡和弘、今橋真弓、蜂谷敦子、横幕能行、岩谷靖雅
- Organizer
  第67回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] 抗HIV-1因子APOBEC3Hにおける多型変異R105Gの分子構造への影響2019
- Author(s)
  大出裕高、中田佳宏、松岡和弘、今橋真弓、蜂谷敦子、横幕能行、岩谷靖雅
- Organizer
  第33回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] HIV-1 VIF PPLP REGION PLAYS A CRITICAL ROLE IN THE VIFMEDIATED APOBEC3 UBIQUITINATION/DEGRADATION2019
- Author(s)
  Kazuhiro Matsuoka, Akiko Hamano, Hirotaka Ode, Yoshihiro Nakata, Sayaka Sukegawa, Atsuko Hachiya, Mayumi Imahashi, Yoshiyuki Yokomaku, Yasumasa Iwatani
- Organizer
  The 2019 CSHL meeting on retroviruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] Multiple pathways to avoid IFN-β sensitivity of HIV-1 by mutants in capsid2018
- Author(s)
  Saito A.、Mamede J.I.、Sultana T.、Ode H.、Nohata K.、Nakayama E.E.、Iwatani Y.、Hope T.J.、Shioda T.
- Organizer
  The 2018 Cold Spring Harbor Laboratory meeting on retroviruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] A novel detection approach of HIV-1 integration sites based on split read mapping2018
- Author(s)
  Ode H.、Matsuda M.、Imahashi M.、Hachiya A.、Yokomaku Y.、Iwatani Y.
- Organizer
  The 2018 Cold Spring Harbor Laboratory meeting on retroviruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] Computational simulations to understand APOBEC3H interaction with double-stranded RNA2018
- Author(s)
  Ode H.、Matsuoka T.、Nagae T.、Hamano A.、Matsuoka K.、Hachiya A.、Imahashi M.、Yokomaku Y.、Watanabe N.、Iwatani Y.
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] 抗HIV因子APOBEC3Hタンパク質の構造解析2018
- Author(s)
  松岡達矢、永江峰幸、大出裕高、濱野章子、松岡和弘、蜂谷敦子、今橋真弓、横幕能行、渡邉信久、岩谷靖雅
- Organizer
  第32回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] ドルテグラビルに対するHIV-1耐性獲得の分子機構の解明2018
- Author(s)
  蜂谷敦子、Kirby KA、大出裕高、Puray-Chavez M、近田貴敬、村越勇人、久保田舞、重見麗、岡崎玲子、松田昌和、今橋真弓、杉浦亙、Brumme ZL、滝口雅文、横幕能行、岩谷靖雅、Sarafianos SG、IHAC cohort members
- Organizer
  第32回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] 東海ブロックで流行するHIV-1のインテグラーゼ阻害剤に対する影響とアミノ酸変異の経年的検討2018
- Author(s)
  重見麗、岡﨑玲子、大出裕高、松田昌和、鶴見寿、矢野邦夫、奥村暢将、谷口晴記、池谷健、伊藤公人、松下正、中畑征史、小暮あゆみ、今村淳治、今橋真弓、岩谷靖雅、杉浦亙、吉村和久、蜂谷敦子、横幕能行
- Organizer
  第32回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] 宿主抗ウイルス因子APOBEC3Hタンパク質の結晶構造解析2018
- Author(s)
  松岡達矢、永江峰幸、大出裕高、濱野章子、松岡和弘、蜂谷敦子、今橋真弓、渡邉信久、岩谷靖雅
- Organizer
  日本生化学会中部支部第82回例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] Biochemical characteristics of the HIV-1 Vif PPLP motif region2018
- Author(s)
  Matsuoka K.、Ode H.、Hamano A.、Matsuoka T.、Sukegawa S.、Hachiya A.、Imahashi M.、Yokomaku Y.、Iwatani Y.
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] Cooperative cellular and humoral immunity may contribute to the efficient control of HIV-1 replication in macaques2018
- Author(s)
  Seki Y.、Saito A.、Harada S.、Washizaki A.、Murata M.、Hikichi Y.、Yoshimura K.、Ishii H.、Satou Y.、Saiful I.M.、Ode H.、Iwatani Y.、Yoshida T.、Yasutomi Y.、Matano T.、Miura T.、Akari H.
- Organizer
  The 36th Annual Symposium on Nonhuman Primate Models for AIDS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] Distinct role of the 182th amino acid residue between HIV-1 and HIV-2 capsids in CPSF6 binding2018
- Author(s)
  Nohata K.、Saito A.、Ode H.、Ohmori H.、Nakayama E.E.、Iwatani Y.、Shioda T.
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] 抗HIV-1療法による口腔細菌叢への影響に関する研究2018
- Author(s)
  大出裕高、今橋真弓、松田昌和、濱野章子、羽柴知恵子、重見麗、岡﨑玲子、蜂谷敦子、今村淳治、中畑征史、小暮あゆみ、横幕能行、岩谷靖雅
- Organizer
  第32回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] Structural insights of chimpanzee APOBEC3H-RNA duplex complex into Vif interaction2018
- Author(s)
  Matsuoka T.、Nagae T.、Ode H.、Hamano A.、Matsuoka K.、Imahashi M.、Hachiya A.、Yokomaku Y.、Watanabe N.、Iwatani Y.
- Organizer
  The 2018 Cold Spring Harbor Laboratory meeting on retroviruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] The primate APOBEC3H crystal structure and insight into its interaction with HIV-1/SIVcpz Vif2018
- Author(s)
  Matsuoka T.、Nagae T.、Ode H.、Hamano A.、Matsuoka K.、Imahashi M.、Hachiya A.、Yokomaku Y.、Watanabe N.、Iwatani Y.
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] Next-generation sequencerを用いた複数の遺伝子型ウイルスが関与したNorovirus集団感染事例の解析2018
- Author(s)
  三好龍也、内野清子、元岡大祐、中村昇太、大出裕高、岩谷靖雅、本村和嗣
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] HIV-1感染におけるHIV-1 Vif PPLPモチーフ領域の役割2018
- Author(s)
  松岡和弘、濱野章子、大出裕高、松岡達矢、助川明香、蜂谷敦子、今橋真弓、横幕能行、岩谷靖雅
- Organizer
  第32回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] Visualization of viral DNA dynamics during INSTI-resistant HIV-1 replication2017
- Author(s)
  Hachiya A.、Kirby K. A.、Puray-Chavez M.、Matsuda M.、Ode H.、Shigemi U.、Okazaki R.、Yokomaku Y.、Sarafianos S. G.、Iwatani Y.
- Organizer
  第31回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] HIV-1カプシド領域の変異は宿主因子との相互作用を変化させることでIFN感受性を制御する2017
- Author(s)
  Sultana T.、齊藤　暁、大出　裕高、岩谷　靖雅、中山　英美、塩田　達雄
- Organizer
  第31回近畿エイズ研究会学術集会
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] Bi-functional entry inhibitors sensitize macaque-tropic human immunodeficiency virus type 1 (HIV-1mt) to antibodies generated in HIV-1mt-infected macaques2017
- Author(s)
  Harada S.、Hikichi Y.、Seki Y.、Saito A.、Yoshida T.、Ode H.、Iwatani Y.、Yasutomi Y.、Miura T.、Matano T.、Akari H.、Yoshimura K.
- Organizer
  35th Annual Symposium on Nonhuman Primate Models for AIDS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] Analysis of structural and functional roles of the HIV-1 Vif PPLP motif region2017
- Author(s)
  Iwatani Y.、Hamano A.、Ode H.、Kubota M.、Tsuzuki S.、Matsuoka M.、Yokomaku Y.、Watanabe N.、Hachiya A.
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] Mutations in viral capsid modulate IFN-beta sensitivity of HIV-12017
- Author(s)
  Saito A.、Sultana T.、Ode H.、Iwatani Y.、Nakayama E. E.、Shioda T.
- Organizer
  The 16th Awaji International Forum on Infection and Immunity
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] Comprehensive deep sequencing method for HIV-1 integration sites in human genome2017
- Author(s)
  Ode H.、Inoue A.、Matsuda M.、Hachiya A.、Yokomaku Y.、Iwatani, Y.
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] Mutations in viral capsid modulate IFN-beta sensitivity of HIV-12017
- Author(s)
  Sultana T.、Saito A.、Ode H.、Iwatani Y.、Nakayama E. E.、Shioda T.
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] カプシド領域の変異は HIV-1 の IFN 感受性を制御する2017
- Author(s)
  齊藤　暁、Sultana T.、大出　裕高、岩谷　靖雅、中山　英美、塩田　達雄
- Organizer
  第31回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] Deep Sequencing技術を利用したHIV-1 のゲノム組込部位の網羅的解析法の開発2017
- Author(s)
  大出　裕高、井上　歩美、松田　昌和、蜂谷　敦子、横幕　能行、岩谷　靖雅
- Organizer
  第31回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] Characterization of HIV-1mt long-term latent infection in cynomolgus macaques2017
- Author(s)
  Seki Y.、Saito A.、Satou Y.、Harada S.、Yoshimura K.、Ode H.、Iwatani Y.、Ishii H.、Yoshida T.、Washizaki A.、Murata M.、Yasutomi Y.、Matano T.、Miura T.、Akari H.
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08872
[Presentation] カニクイザルにおける HIV-1mt 長期潜伏感染の解析2017
- Author(s)
  関　洋平、齊藤　暁、佐藤　賢文、原田　恵嘉、吉村　和久、大出　裕高、岩谷　靖雅、石井　洋、SaifulIslam M.、芳田　剛、村田　めぐみ、鷲崎　彩夏、保富　康宏、俣野　哲朗、三浦　智行、明里　宏文
- Organizer
  第31回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K08872

1. IWATANI Yasumasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 横山勝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ode Hirotaka 大出 裕高

Research Projects

Research Products

Co-Researchers

1分子シークエンスによる感染者内HIVのウイルスゲノム全長配列多様性の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarification of interaction machinery between antiviral factor APOBEC3G and HIV-1 VifPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Identifying integration sites of the HIV-1 genome with intact and aberrant ends through deep sequencing2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discovery of 4-oxoquinolines, a new chemical class of anti-HIV-1 compounds2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural basis of chimpanzee APOBEC3H dimerization stabilized by double-stranded RNA2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Compound heterozygous TYK2 mutations underlie primary immunodeficiency with T-cell lymphopenia2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distribution of norovirus genotypes and subtypes in river water by ultra-deep sequencing-based analysis2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mapping Region of Human Restriction Factor APOBEC3H Critical for Interaction with HIV-1 Vif2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Production of HIV-1 vif mRNA Is Modulated by Natural Nucleotide Variations and SLSA1 RNA Structure in SA1D2prox Genomic Region2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] ナノポアシーケンスによるHIV-1 RNA ゲノムの近全長配列解析と薬剤耐性遺伝 子検査への応用2023

Author(s)

Organizer

Data Source

[Presentation] ナノポアシーケンスを利用した宿主内 HIV-1 のゲノム配列多様性解析2023

Author(s)

Organizer

Data Source

[Presentation] 東海地域において検出されたUnique recombinant forms（URFs）症例の分子 疫学的解析と考察2023

Author(s)

Organizer

Data Source

[Presentation] 抗ウイルス因子APOBEC3Hの分子構造に対する多型変異R105Gの影響2019

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[Presentation] 抗HIV-1因子APOBEC3Hにおける多型変異R105Gの分子構造への影響2019

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[Presentation] HIV-1 VIF PPLP REGION PLAYS A CRITICAL ROLE IN THE VIFMEDIATED APOBEC3 UBIQUITINATION/DEGRADATION2019

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[Presentation] Multiple pathways to avoid IFN-β sensitivity of HIV-1 by mutants in capsid2018

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Ode Hirotaka 大出裕高

[Presentation] ナノポアシーケンスによるHIV-1 RNA ゲノムの近全長配列解析と薬剤耐性遺伝子検査への応用2023

[Presentation] 東海地域において検出されたUnique recombinant forms（URFs）症例の分子疫学的解析と考察2023