Hipolito Chris HIPOLITO CHRIS

Researcher Number	20759914
Other IDs
Affiliation (based on the past Project Information) *help	2015 – 2019: 筑波大学, 医学医療系, 助教
Review Section/Research Field	Principal Investigator Tumor therapeutics / Drug development chemistry Except Principal Investigator Structural biochemistry
Keywords	Principal Investigator cancer signaling / RaPID system / in vitro selection / macrocyclic peptides / tumor angiogenesis / ALK1 receptor / BMP signaling / ALK1 / macrocyclic peptide / angiogenesis … More / In vitro selection / Macrocyclic peptides / cancer / TGFbeta / signaling / receptors … More Except Principal Investigator 癌 / 薬理学 / バイオテクノロジー / 構造変化 / 蛋白質 / 機能 / 立体構造 / 膜タンパク質 / タンパク質 / 生体分子 / ATP / 機能-構造相関 / 分子メカニズム / 膜蛋白質 / P糖蛋白質 / ABC輸送体 Less

Structural Basis for drug transport by ABC transporters
- Principal Investigator
  
  Kodan Atsushi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University
Targeting ALK1 using macrocyclic peptides: A novel approach for the regulation of angiogenesis in cancerPrincipal Investigator
- Principal Investigator
  
  Hipolito Chris
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  University of Tsukuba
Restoring tissue homeostasis by regulating TGF-beta signaling by using macrocyclic peptidesPrincipal Investigator
- Principal Investigator
  
  Hipolito Chris
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Tsukuba

All 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] Methods in Molecular Biology2018
- Author(s)
  Kusakizako T, Tanaka Y, Hipolito CJ, Suga H, Nureki O.
- Total Pages
  21
- Publisher
  Humana Press, New York, NY
- ISBN
  9781493974528
- Data Source
  KAKENHI-PROJECT-17K15017
[Journal Article] A current perspective on applications of macrocyclic-peptide-based high-affinity ligands.2016
- Author(s)
  Leenheer, D.; ten Dijke, P.; Hipolito C. J.
- Journal Title
  
  Biopolymers. Peptide Science.
  
  Volume: 106(6) Issue: 6 Pages: 889-900
- DOI
  10.1002/bip.22900
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06073
[Journal Article] Combined Use of Oligopeptides, Fragment Libraries, and Natural Compounds: A Comprehensive Approach To Sample the Druggability of Vascular Endothelial Growth Factor.2016
- Author(s)
  Bayo;-Puxan N, Rodriguez-Mias R, Goldflam M, Kotev M, Ciudad S, Hipolito CJ, Varese M, Suga H, Campos-Olivas R, Barril X, Guallar V, Teixidó M, Garcia J, Giralt E.
- Journal Title
  
  ChemMedChem
  
  Volume: 11(8) Issue: 8 Pages: 928-939
- DOI
  10.1002/cmdc.201500467
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06073
[Journal Article] LCP crystallization and X-ray diffraction analysis of VcmN, a MATE transporter from Vibrio cholerae.2016
- Author(s)
  2.Kusakizako, T.; Tanaka, Y.; Hipolito, C. J.; Kuroda, T.; Ishitani, R.; Suga, H.; Nureki, O.
- Journal Title
  
  Acta Crystallogr. F Struct. Biol. Commun.
  
  Volume: 72(Pt 7) Issue: 7 Pages: 552-557
- DOI
  10.1107/s2053230x16008931
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06073, KAKENHI-PROJECT-14J09020, KAKENHI-PROJECT-25291011
[Journal Article] <i>In Vitro</i> Selected Macrocyclic Peptides: Tools for Regulating the Conformational Freedom of Transmembrane Proteins2016
- Author(s)
  Hipolito CJ, Nishio K, Suga H.
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 136 Issue: 2 Pages: 191-196
- DOI
  10.1248/yakushi.15-00229-4
- NAID
  130005121477
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2016-02-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H06073
[Journal Article] Selection-based discovery of macrocyclic peptides for the next generation therapeutics.2015
- Author(s)
  T. Morioka; N.D. Loik; C.J. Hipolito; Y. Goto; H. Suga
- Journal Title
  
  Current opinion in chemical biology
  
  Volume: 26C Pages: 34-41
- DOI
  10.1016/j.cbpa.2015.01.023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26220204, KAKENHI-PROJECT-15H06073
[Presentation] Identification of macrocyclic peptides which bind to CD442018
- Author(s)
  Nohara Goto, Yizhen Yin, Christopher John Hipolito, Hiroyuki Suzuki, Hiroaki Suga, Mitsuyasu Kato, Paraskevi Heldin, Constantinos Kolliopoulos, Theodoros Karalis
- Organizer
  10th International Peptide Symposium
- Data Source
  KAKENHI-PROJECT-17K15017
[Presentation] In vitro selection for macrocyclic peptide that regulate tumor angiogenesis and other ailments2017
- Author(s)
  Christopher John Hipolito, Mitsuyasu Kato, Peter ten Dijke
- Organizer
  TGFbeta Meeting
- Data Source
  KAKENHI-PROJECT-17K15017
[Presentation] Restoring tissue homeostasis by using macrocyclic peptides2016
- Author(s)
  Christopher John Hipolito, Stef Jansen, Wei Li, Mitsuyasu Kato, Peter ten Dijke
- Organizer
  TGFbeta Meeting
- Place of Presentation
  Leiden University Medical Center(Leiden, Netherland)
- Year and Date
  2016-08-21
- Data Source
  KAKENHI-PROJECT-15H06073
[Presentation] Macrocyclic peptide ligands that inhibit transporter function and improve protein crystallization.2015
- Author(s)
  Hipolito, CJ, Suga H
- Organizer
  11th Australian Peptide Conference
- Place of Presentation
  Pepper Salt Resort, NSW, Australia
- Year and Date
  2015-10-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06073
[Presentation] Targeting ABC transporters with macrocyclic peptides.2015
- Author(s)
  Hipolito CJ, Beis K, Suga H
- Organizer
  International Conference on Circular Proteins.
- Place of Presentation
  Moreton Island, Australia
- Year and Date
  2015-11-01
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06073

1. Kodan Atsushi (80360543)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. ten Dijke Peter

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. SUGA Hiroaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hipolito Chris HIPOLITO CHRIS

Research Projects

Research Products

Co-Researchers

Structural Basis for drug transport by ABC transporters

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Targeting ALK1 using macrocyclic peptides: A novel approach for the regulation of angiogenesis in cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Restoring tissue homeostasis by regulating TGF-beta signaling by using macrocyclic peptidesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Methods in Molecular Biology2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] A current perspective on applications of macrocyclic-peptide-based high-affinity ligands.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combined Use of Oligopeptides, Fragment Libraries, and Natural Compounds: A Comprehensive Approach To Sample the Druggability of Vascular Endothelial Growth Factor.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LCP crystallization and X-ray diffraction analysis of VcmN, a MATE transporter from Vibrio cholerae.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] <i>In Vitro</i> Selected Macrocyclic Peptides: Tools for Regulating the Conformational Freedom of Transmembrane Proteins2016

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Selection-based discovery of macrocyclic peptides for the next generation therapeutics.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] Identification of macrocyclic peptides which bind to CD442018

Author(s)

Organizer

Data Source

[Presentation] In vitro selection for macrocyclic peptide that regulate tumor angiogenesis and other ailments2017

Author(s)

Organizer

Data Source

[Presentation] Restoring tissue homeostasis by using macrocyclic peptides2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Macrocyclic peptide ligands that inhibit transporter function and improve protein crystallization.2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Targeting ABC transporters with macrocyclic peptides.2015

Author(s)

Organizer