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Hipolito Chris  HIPOLITO CHRIS

ORCIDConnect your ORCID iD *help
Researcher Number 20759914
Other IDs
Affiliation (based on the past Project Information) *help 2015 – 2019: 筑波大学, 医学医療系, 助教
Review Section/Research Field
Principal Investigator
Tumor therapeutics / Drug development chemistry
Except Principal Investigator
Structural biochemistry
Keywords
Principal Investigator
cancer signaling / RaPID system / in vitro selection / macrocyclic peptides / tumor angiogenesis / ALK1 receptor / BMP signaling / ALK1 / macrocyclic peptide / angiogenesis … More / In vitro selection / Macrocyclic peptides / cancer / TGFbeta / signaling / receptors … More
Except Principal Investigator
癌 / 薬理学 / バイオテクノロジー / 構造変化 / 蛋白質 / 機能 / 立体構造 / 膜タンパク質 / タンパク質 / 生体分子 / ATP / 機能-構造相関 / 分子メカニズム / 膜蛋白質 / P糖蛋白質 / ABC輸送体 Less
  • Research Projects

    (3 results)
  • Research Products

    (11 results)
  • Co-Researchers

    (3 People)
  •  Structural Basis for drug transport by ABC transporters

    • Principal Investigator
      Kodan Atsushi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Structural biochemistry
    • Research Institution
      Kyoto University
  •  Targeting ALK1 using macrocyclic peptides: A novel approach for the regulation of angiogenesis in cancerPrincipal Investigator

    • Principal Investigator
      Hipolito Chris
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Tumor therapeutics
    • Research Institution
      University of Tsukuba
  •  Restoring tissue homeostasis by regulating TGF-beta signaling by using macrocyclic peptidesPrincipal Investigator

    • Principal Investigator
      Hipolito Chris
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Drug development chemistry
    • Research Institution
      University of Tsukuba

All 2018 2017 2016 2015

All Journal Article Presentation Book

  • [Book] Methods in Molecular Biology2018

    • Author(s)
      Kusakizako T, Tanaka Y, Hipolito CJ, Suga H, Nureki O.
    • Total Pages
      21
    • Publisher
      Humana Press, New York, NY
    • ISBN
      9781493974528
    • Data Source
      KAKENHI-PROJECT-17K15017
  • [Journal Article] A current perspective on applications of macrocyclic-peptide-based high-affinity ligands.2016

    • Author(s)
      Leenheer, D.; ten Dijke, P.; Hipolito C. J.
    • Journal Title

      Biopolymers. Peptide Science.

      Volume: 106(6) Issue: 6 Pages: 889-900

    • DOI

      10.1002/bip.22900

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H06073
  • [Journal Article] Combined Use of Oligopeptides, Fragment Libraries, and Natural Compounds: A Comprehensive Approach To Sample the Druggability of Vascular Endothelial Growth Factor.2016

    • Author(s)
      Bayo;-Puxan N, Rodriguez-Mias R, Goldflam M, Kotev M, Ciudad S, Hipolito CJ, Varese M, Suga H, Campos-Olivas R, Barril X, Guallar V, Teixidó M, Garcia J, Giralt E.
    • Journal Title

      ChemMedChem

      Volume: 11(8) Issue: 8 Pages: 928-939

    • DOI

      10.1002/cmdc.201500467

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H06073
  • [Journal Article] LCP crystallization and X-ray diffraction analysis of VcmN, a MATE transporter from Vibrio cholerae.2016

    • Author(s)
      2.Kusakizako, T.; Tanaka, Y.; Hipolito, C. J.; Kuroda, T.; Ishitani, R.; Suga, H.; Nureki, O.
    • Journal Title

      Acta Crystallogr. F Struct. Biol. Commun.

      Volume: 72(Pt 7) Issue: 7 Pages: 552-557

    • DOI

      10.1107/s2053230x16008931

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H06073, KAKENHI-PROJECT-14J09020, KAKENHI-PROJECT-25291011
  • [Journal Article] <i>In Vitro</i> Selected Macrocyclic Peptides: Tools for Regulating the Conformational Freedom of Transmembrane Proteins2016

    • Author(s)
      Hipolito CJ, Nishio K, Suga H.
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 136 Issue: 2 Pages: 191-196

    • DOI

      10.1248/yakushi.15-00229-4

    • NAID

      130005121477

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2016-02-01
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H06073
  • [Journal Article] Selection-based discovery of macrocyclic peptides for the next generation therapeutics.2015

    • Author(s)
      T. Morioka; N.D. Loik; C.J. Hipolito; Y. Goto; H. Suga
    • Journal Title

      Current opinion in chemical biology

      Volume: 26C Pages: 34-41

    • DOI

      10.1016/j.cbpa.2015.01.023

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26220204, KAKENHI-PROJECT-15H06073
  • [Presentation] Identification of macrocyclic peptides which bind to CD442018

    • Author(s)
      Nohara Goto, Yizhen Yin, Christopher John Hipolito, Hiroyuki Suzuki, Hiroaki Suga, Mitsuyasu Kato, Paraskevi Heldin, Constantinos Kolliopoulos, Theodoros Karalis
    • Organizer
      10th International Peptide Symposium
    • Data Source
      KAKENHI-PROJECT-17K15017
  • [Presentation] In vitro selection for macrocyclic peptide that regulate tumor angiogenesis and other ailments2017

    • Author(s)
      Christopher John Hipolito, Mitsuyasu Kato, Peter ten Dijke
    • Organizer
      TGFbeta Meeting
    • Data Source
      KAKENHI-PROJECT-17K15017
  • [Presentation] Restoring tissue homeostasis by using macrocyclic peptides2016

    • Author(s)
      Christopher John Hipolito, Stef Jansen, Wei Li, Mitsuyasu Kato, Peter ten Dijke
    • Organizer
      TGFbeta Meeting
    • Place of Presentation
      Leiden University Medical Center(Leiden, Netherland)
    • Year and Date
      2016-08-21
    • Data Source
      KAKENHI-PROJECT-15H06073
  • [Presentation] Macrocyclic peptide ligands that inhibit transporter function and improve protein crystallization.2015

    • Author(s)
      Hipolito, CJ, Suga H
    • Organizer
      11th Australian Peptide Conference
    • Place of Presentation
      Pepper Salt Resort, NSW, Australia
    • Year and Date
      2015-10-25
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H06073
  • [Presentation] Targeting ABC transporters with macrocyclic peptides.2015

    • Author(s)
      Hipolito CJ, Beis K, Suga H
    • Organizer
      International Conference on Circular Proteins.
    • Place of Presentation
      Moreton Island, Australia
    • Year and Date
      2015-11-01
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H06073
  • 1.  Kodan Atsushi (80360543)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  ten Dijke Peter
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  SUGA Hiroaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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