Akamatsu Shusuke 赤松秀輔

… Alternative Names

Shusuke Akamatsu 赤松秀輔

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Researcher Number	20767248
Other IDs	https://orcid.org/0000-0002-1394-7506
Affiliation (Current)	2025: 名古屋大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2022 – 2025: 名古屋大学, 医学系研究科, 教授 2023: 名古屋大学, 医学研究科, 教授 2021 – 2022: 京都大学, 医学研究科, 准教授 2020: 京都大学, 医学研究科, 講師 2017 – 2019: 京都大学, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 56030:Urology-related / Urology Except Principal Investigator Basic Section 56030:Urology-related / Basic Section 49020:Human pathology-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Urology
Keywords	Principal Investigator 前立腺癌 / 単一細胞遺伝子発現解析 / 神経内分泌前立腺癌 / 空間遺伝子発現解析 / シングルセル核シーケンス / ロングリードシーケンス / 多重免疫染色 / 単一細胞核シーケンス / ロングリードRNAシーケンス / ロングリードシーケンス解析 … More / 分子サブタイプ / 神経内分泌化 / スクリーニング / 固形癌 / 可塑性 / 血中遊離DNA解析 / 相同組み換え遺伝子異常 / BRCA paradox / 経時的DNA解析 / cfDNA / CDK12 / ATM / BRCA / DNA修復遺伝子 / 相同組み換え修復関連遺伝子 / 血中遊離DNA / 去勢抵抗性前立腺癌 / レトロトランスポゾン遺伝子 / 神経内分泌癌 / 細胞株 / PDX / PEG10 … More Except Principal Investigator 前立腺癌 / 癌 / 腎細胞癌 / 空間的トランスクリプトーム解析 / 導管内癌 / 患者由来ゼノグラフト / 相同組換え修復関連遺伝子 / CDK12 / PDX / PARP阻害薬 / ATM阻害薬 / 去勢抵抗性前立腺癌 / CDK12異常前立腺癌 / c-MYC / トランスクリプトーム / LNCap / ホルモン治療抵抗性 / エンハンサーRNA / エンハンサー / アンドロゲン / 患者組織由来ゼノグラフト / 泌尿器 / 腫瘍間質相互作用 / 前転移ニッチ / 転移形成 / 薬剤抵抗性 / 患者癌組織由来ゼノグラフト / エクソソーム / 腎癌 / CTC / バイオマーカー / 薬剤感受性 / cfDNA Less

Spatial transcriptome analysis of intraductal and invasive cancer cells in prostate cancer
- Principal Investigator
  
  都築豊徳
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Aichi Medical University
Establishment of genomic pathology based tumor subtyping system for solid cancers by single cell spatial transcriptome sequencingPrincipal Investigator
- Principal Investigator
  
  赤松秀輔
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Nagoya University
次世代遺伝子発現解析法に立脚したシーケンスレスながん分子サブタイプ規定法の開発Principal Investigator
- Principal Investigator
  
  赤松秀輔
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Nagoya University
患者由来ゼノグラフトを用いたCDK12変異前立腺癌のPARP阻害薬不応性の克服
- Principal Investigator
  
  後藤崇之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kyoto University
Development of innovative therapies for solid tumors by regulating plasticityPrincipal Investigator
- Principal Investigator
  
  Akamatsu Shusuke
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Nagoya University
  Kyoto University
Identification of the enhancer sequences that are controlled by androgen receptor
- Principal Investigator
  
  Fujita Jun
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kyoto University
Elucidating biological characteristics of DNA repair gene mutations in prostate cancer utilizing cell-free DNA analysisPrincipal Investigator
- Principal Investigator
  
  Akamatsu Shusuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kyoto University
Development of innovative cancer diagnostic and therapeutic seeds focusing on tissue specific exosomics using xenotransplantation model
- Principal Investigator
  
  Ogawa Osamu
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Kyoto University
Development of retrotransposon gene PEG10 targeting treatment for neuroendocrine prostate cancerPrincipal Investigator
- Principal Investigator
  
  Shusuke Akamatsu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kyoto University
Genomic analysis of circulating cell-free DNA to achieve precision medicine for advanced urological cancers
- Principal Investigator
  
  Yamasaki Toshinari
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  Kyoto University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen2023
- Author(s)
  Najnin Rifat Ara、Al Mahmud Md Rasel、Rahman Md Maminur、Takeda Shunichi、Sasanuma Hiroyuki、Tanaka Hisashi、Murakawa Yasuhiro、Shimizu Naoto、Akter Salma、Takagi Masatoshi、Sunada Takuro、Akamatsu Shusuke、He Gang、Itou Junji、Toi Masakazu、Miyaji Mary、Tsutsui Kimiko M.、Keeney Scott、Yamada Shintaro
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 1 Pages: 111909-111909
- DOI
  10.1016/j.celrep.2022.111909
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06122, KAKENHI-PROJECT-21K07148, KAKENHI-PROJECT-22KF0209, KAKENHI-PROJECT-20K09539, KAKENHI-PROJECT-20KK0186
[Journal Article] Clinical Utility of Germline Genetic Testing in Japanese Men Undergoing Prostate Biopsy2022
- Author(s)
  Akamatsu Shusuke, Terada Naoki, Takata Ryo、...、Yamamoto Michio、...、Ogawa Osamu
- Journal Title
  
  JNCI Cancer Spectrum
  
  Volume: 6 Issue: 1
- DOI
  10.1093/jncics/pkac001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K12648, KAKENHI-PROJECT-21K09434, KAKENHI-PROJECT-21K11787, KAKENHI-PROJECT-20K09539, KAKENHI-PROJECT-23K21469
[Journal Article] A case of microsatellite instability-high clinically advanced castration-resistant prostate cancer showing a remarkable response to pembrolizumab sustained over at least 18 months2022
- Author(s)
  Shimizu Kosuke、Sano Takeshi、Mizuno Kei、Sunada Takuro、Makita Noriyuki、Hagimoto Hiroki、Goto Takayuki、Sawada Atsuro、Fujimoto Masakazu、Ichioka Kentaro、Ogawa Osamu、Kobayashi Takashi、Akamatsu Shusuke
- Journal Title
  
  Molecular Case Studies
  
  Volume: 8 Issue: 4 Pages: a006194-a006194
- DOI
  10.1101/mcs.a006194
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09539
[Journal Article] Prognostic significance of pathogenic variants in BRCA1, BRCA2, ATM and PALB2 genes in men undergoing hormonal therapy for advanced prostate cancer2022
- Author(s)
  Kimura H、Mizuno K、Shiota M、Narita S、Terada N、Fujimoto N、Ogura K、Hatano S、Iwasaki Y、Hakozaki N、Ishitoya S、Sumiyoshi T、Goto T、Kobayashi T、Nakagawa H、Kamoto T、Eto M、Habuchi T、Ogawa O、Momozawa Y、Akamatsu S
- Journal Title
  
  British Journal of Cancer
  
  Volume: 127 Issue: 9 Pages: 1680-1690
- DOI
  10.1038/s41416-022-01915-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09539
[Journal Article] Clinical significance of <scp>IDC‐P</scp> as predictive factor after intensity‐modulated radiation therapy2022
- Author(s)
  Aizawa Rihito、Tsuzuki Toyonori、Haga Hironori、Nakamura Kiyonao、Ogata Takashi、Inoue Takahiro、Kobayashi Takashi、Akamatsu Shusuke、Goto Takayuki、Ogawa Osamu、Mizowaki Takashi
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 7 Pages: 2425-2433
- DOI
  10.1111/cas.15392
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06933, KAKENHI-PROJECT-20K09539
[Journal Article] Development and validation of prediction model for incident overactive bladder: The Nagahama study2022
- Author(s)
  Funada Satoshi、Luo Yan、Yoshioka Takashi、Setoh Kazuya、Tabara Yasuharu、Negoro Hiromitsu、Yoshimura Koji、Matsuda Fumihiko、Efthimiou Orestis、Ogawa Osamu、Furukawa Toshi A、Kobayashi Takashi、Akamatsu Shusuke
- Journal Title
  
  International Journal of Urology
  
  Volume: 29 Issue: 7 Pages: 748-756
- DOI
  10.1111/iju.14887
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04850, KAKENHI-PROJECT-20K09539
[Journal Article] Establishment and characterization of a novel treatment-related neuroendocrine prostate cancer cell line KUCaP132021
- Author(s)
  Kosuke Okasho, Takayuki Goto, Shusuke Akamatsu
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 7 Pages: 2781-2791
- DOI
  10.1111/cas.14935
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19568
[Journal Article] TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands.2020
- Author(s)
  Mahmud MRA, Ishii K, Lozano CB, Sainz ID, Toi M, Akamatsu S, Fukumoto M, Watanabe M, Takeda S, Ledesma FC, Sasanuma H.
- Journal Title
  
  Genes to Cells
  
  Volume: in press Issue: 7 Pages: 450-465
- DOI
  10.1111/gtc.12770
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04900, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-19K09686, KAKENHI-PROJECT-20K09539, KAKENHI-PROJECT-19K22684, KAKENHI-PROJECT-18K09131
[Journal Article] Clinical utility of androgen receptor gene aberrations in circulating cell-free DNA as a biomarker for treatment of castration-resistant prostate cancer2019
- Author(s)
  Sumiyoshi Takayuki、Mizuno Kei、Yamasaki Toshinari、Miyazaki Yu、Makino Yuki、Okasho Kosuke、Li Xin、Utsunomiya Noriaki、Goto Takayuki、Kobayashi Takashi、Terada Naoki、Inoue Takahiro、Kamba Tomomi、Fujimoto Akihiro、Ogawa Osamu、Akamatsu Shusuke
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 4030-4030
- DOI
  10.1038/s41598-019-40719-y
- NAID
  120006709427
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05511, KAKENHI-PROJECT-17H04327, KAKENHI-PROJECT-18H02680
[Journal Article] PEG10 is associated with treatment-induced neuroendocrine prostate cancer2019
- Author(s)
  Kim Soojin、Thaper Daksh、Bidnur Samir、Toren Paul、Akamatsu Shusuke、Bishop Jennifer L、Colins Colin、Vahid Sepideh、Zoubeidi Amina
- Journal Title
  
  Journal of Molecular Endocrinology
  
  Volume: 63 Issue: 1 Pages: 39-49
- DOI
  10.1530/jme-18-0226
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11133
[Journal Article] Clinical and molecular features of treatment-related neuroendocrine prostate cancer2018
- Author(s)
  Akamatsu Shusuke、Inoue Takahiro、Ogawa Osamu、Gleave Martin E
- Journal Title
  
  International Journal of Urology
  
  Volume: 25 Issue: 4 Pages: 345-351
- DOI
  10.1111/iju.13526
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11133
[Presentation] NEPCにおける系統的可塑性の可逆性を評価する高感度スクリーニング系の開発2024
- Author(s)
  福井智洋、赤松秀輔
- Organizer
  第33回泌尿器分子細胞研究会
- Data Source
  KAKENHI-PROJECT-21K19568
[Presentation] A highly sensitive screening system to evaluate the reversibility of lineage plasticity in NEPC using a novel NEPC cell line2024
- Author(s)
  福井智洋、赤松秀輔
- Organizer
  第111回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-21K19568
[Presentation] NEPCの系統的可塑性は可逆的か？新規NEPC細胞株を用いたドラッグスクリーニングによる検討2023
- Author(s)
  福井智洋、赤松秀輔
- Organizer
  第82回日本癌学会
- Data Source
  KAKENHI-PROJECT-21K19568
[Presentation] A highly-sensitive screening system to evaluate the reversibility of NEPC to prostate adenocarcinoma2023
- Author(s)
  Tomohiro Fukui, Shusuke Akamatsu
- Organizer
  20th UROLOGICAL ASSOCIATION OF ASIA CONGRESS 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19568
[Presentation] 前立腺癌のlineage plasticityを深掘する2023
- Author(s)
  福井智洋、赤松秀輔
- Organizer
  第38回前立腺癌シンポジウム
- Data Source
  KAKENHI-PROJECT-21K19568
[Presentation] 去勢抵抗性前立腺癌患者由来cell-free DNAの経時的解析2023
- Author(s)
  水野桂、赤松秀輔
- Organizer
  第7回Liquid Biopsy研究会
- Data Source
  KAKENHI-PROJECT-20H03814
[Presentation] CDK12 KOとTP53 KDの組み合わせでは臨床のCDK12 LOF前立腺癌にみられる高悪性度を模倣しない2021
- Author(s)
  上山裕樹、福井智洋、砂田拓郎、木村博子、後藤崇之、小林恭、赤松秀輔
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K09539
[Presentation] 治療関連内分泌前立腺癌患者由来の新規細胞株KUCaP13の樹立とその特徴2021
- Author(s)
  赤松秀輔
- Organizer
  第109回　日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-21K19568
[Presentation] 淡明型腎細胞癌における血漿遊離 DNA の VHL 遺伝子変異の検討2020
- Author(s)
  赤松秀輔
- Organizer
  第4回リキッドバイオプシー研究会
- Data Source
  KAKENHI-PROJECT-17H04327
[Presentation] Dynamic alteration of androgen receptor amplification status detected by ctDNA during treatment of castration-resistant prostate cancer2017
- Author(s)
  赤松　修輔
- Organizer
  37th Congress of the SIU
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04327
[Presentation] The retrotransposon-derived gene PEG10 directly binds with WWP2 and affects PTEN protein degradation in prostate cancer.2017
- Author(s)
  岡所広祐、赤松秀輔、川井禎久、水野桂、李新、住吉崇幸、牧野雄樹、後藤崇之、小林恭、井上貴博、小川修
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K11133

1. Yamasaki Toshinari (00607749)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. Ogawa Osamu (90260611)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 後藤崇之 (90806605)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. 小林恭 (00642406)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. 都築豊徳 (70627645)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. Fujita Jun (50173430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 井上貴博 (80511881)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 齊藤亮一 (30792270)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 武田俊一 (60188191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 澤田篤郎 (10784796)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 佐野剛視 (60866309)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 山本陽一朗 (00573247)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 佐々直人 (50437026)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 高原大志 (50790317)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 藤本明洋 (30525853)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 住吉崇幸 (30846100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 村川泰裕 (50765469)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 北野滋久 (60402682)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. YAMAMOTO Michio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 山口まり

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 笹沼博之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 溝脇尚志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 羽賀博典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 田原康玄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 松田文彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Akamatsu Shusuke 赤松 秀輔

Shusuke Akamatsu 赤松 秀輔

Research Projects

Research Products

Co-Researchers

Spatial transcriptome analysis of intraductal and invasive cancer cells in prostate cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of genomic pathology based tumor subtyping system for solid cancers by single cell spatial transcriptome sequencingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

次世代遺伝子発現解析法に立脚したシーケンスレスながん分子サブタイプ規定法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

患者由来ゼノグラフトを用いたCDK12変異前立腺癌のPARP阻害薬不応性の克服

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of innovative therapies for solid tumors by regulating plasticityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of the enhancer sequences that are controlled by androgen receptor

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating biological characteristics of DNA repair gene mutations in prostate cancer utilizing cell-free DNA analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of innovative cancer diagnostic and therapeutic seeds focusing on tissue specific exosomics using xenotransplantation model

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of retrotransposon gene PEG10 targeting treatment for neuroendocrine prostate cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genomic analysis of circulating cell-free DNA to achieve precision medicine for advanced urological cancers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical Utility of Germline Genetic Testing in Japanese Men Undergoing Prostate Biopsy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A case of microsatellite instability-high clinically advanced castration-resistant prostate cancer showing a remarkable response to pembrolizumab sustained over at least 18 months2022

Author(s)

Journal Title

DOI

Data Source

Akamatsu Shusuke 赤松秀輔

Shusuke Akamatsu 赤松秀輔