Kaji Noriyuki 梶典幸

Researcher Number	20779318
Other IDs	https://orcid.org/0000-0001-7423-5679
Affiliation (Current)	2025: 麻布大学, 獣医学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2024: 麻布大学, 獣医学部, 講師 2019 – 2021: 麻布大学, 獣医学部, 助教 2016 – 2018: 東京大学, 大学院農学生命科学研究科(農学部), 助教
Review Section/Research Field	Principal Investigator Basic Section 42030:Animal life science-related / Veterinary medical science Except Principal Investigator Basic Section 52010:General internal medicine-related
Keywords	Principal Investigator 消化管 / 消化管運動 / カハール介在細胞 / 炎症 / 一酸化窒素 / 神経 / マクロファージ / オンコスタチンM / セロトニン / カハール間質細胞 … More / 腸内細菌 / 腸管神経 / 老化 / 間葉系細胞 / 組織修復・再生 / 腸炎 / 可塑性 / ICC … More Except Principal Investigator 過敏性 / 位置合わせ / 深層学習 / パターン分類 / 消化管運動 / トリプトファン代謝産物 / 炎症 / 脳腸相関 / トリプトファン / 細胞内Ca / 微小電極アレイ / 内在神経 / 平滑筋 / ペースメーカ / 炎症性腸疾患 / 過敏性腸症候群 / 消化管 Less

Function of Oncostatin M in the process of homeostasis and its disruption in the gastrointestinal musculature.Principal Investigator
- Principal Investigator
  
  梶典幸
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Azabu University
Evaluation of excitation coordination disorder underlying gut hypersensitivity in functional micro-image
- Principal Investigator
  
  中山晋介
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Nagoya University
Crosstalk between interstitial cells of Cajal and gut microbiotaPrincipal Investigator
- Principal Investigator
  
  梶典幸
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Azabu University
Visualization of micro-coordination in the GI tract reflecting irritability and inflammatory reactions: Elucidation of pathological conditions and development of treatment strategy
- Principal Investigator
  
  Nakayama Shinsuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Nagoya University
Survival and death signaling in interstitial pacemaker cells induced by nitric oxidePrincipal Investigator
- Principal Investigator
  
  KAJI NORIYUKI
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Azabu University
  The University of Tokyo
Analysis of plasticity of interstitial cells of Cajal and its molecular mechanism by cell fate tracing methodPrincipal Investigator
- Principal Investigator
  
  Kaji Noriyuki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Veterinary medical science
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Investigation of periodontal disease development and Porphyromonas gulae FimA genotype distribution in small dogs2024
- Author(s)
  Yasuda Junya、Yasuda Hidemi、Nomura Ryota、Matayoshi Saaya、Inaba Hiroaki、Gongora Enrique、Iwashita Naoki、Shirahata So、Kaji Noriyuki、Akitomo Tatsuya、Mitsuhata Chieko、Uchiyama Jumpei、Fukuyama Tomoki、Matsumoto-Nakano Michiyo、Nakano Kazuhiko、Murakami Masaru
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 5360-5360
- DOI
  10.1038/s41598-024-55842-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15001, KAKENHI-PROJECT-22K08580
[Journal Article] Fuzapladib reduces postsurgical inflammation in the intestinal muscularis externa2023
- Author(s)
  KAJI Noriyuki、IWAOKA Kosuzu、NAKAMURA Shinichiro、TSUKAMOTO Atsushi
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 85 Issue: 11 Pages: 1151-1156
- DOI
  10.1292/jvms.23-0257
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15001
[Journal Article] Toceranib phosphate (Palladia) reverses type 1 diabetes by preserving islet function in mice2023
- Author(s)
  KISHI Kazuhisa、YONEZAWA Tomohiro、KAJI Noriyuki、GOTO Momo、NONOSHITA Yuma、IIO Aki、TSURU Yoshiharu、HORI Masatoshi
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 85 Issue: 7 Pages: 781-789
- DOI
  10.1292/jvms.23-0154
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15001
[Journal Article] Interstitial cells of Cajal in gastrointestinal inflammatory diseases2023
- Author(s)
  Kaji N, Hori M
- Journal Title
  
  Journal of Smooth Muscle Research
  
  Volume: 59 Issue: 0 Pages: 1-13
- DOI
  10.1540/jsmr.59.1
- ISSN
  0916-8737, 1884-8796
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03125, KAKENHI-PROJECT-21K15001
[Journal Article] Transcriptome analysis of mesenchymal stromal cells of the large and small intestinal smooth muscle layers reveals a unique gastrointestinal stromal signature2023
- Author(s)
  Chaen Takashi、Kurosawa Tamaki、Kishi Kazuhisa、Kaji Noriyuki、Ikemoto-Uezumi Madoka、Uezumi Akiyoshi、Hori Masatoshi
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 34 Pages: 101478-101478
- DOI
  10.1016/j.bbrep.2023.101478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15001, KAKENHI-PROJECT-22K11845
[Journal Article] Dental pulp stem cells as a therapy for congenital entero-neuropathy.2022
- Author(s)
  Yoshimaru, K., Yamaza, Y., Kajioka, S., Sonoda, S., Yanagi, Y., Matsuura, T., Yoshizumi, J., Oda, Y., Iwata, N., Takai, C., Nakayama, S., Taguchi, T.
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1
- DOI
  10.1038/s41598-022-10077-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19584, KAKENHI-PROJECT-19H03558, KAKENHI-PROJECT-23K21447
[Journal Article] Classification of Pacemaker Dynamics in the Mouse Intestine by Field Potential Microimaging2022
- Author(s)
  Iwata, N., Takai, C., Mochizuki, N., Yamauchi, M., Kaji, N., Kasahara, Y., Nakayama, S.
- Journal Title
  
  Biosensors and Bioelectronics X:
  
  Volume: 10 Pages: 1001111-1001111
- DOI
  10.1016/j.biosx.2022.100111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03558, KAKENHI-PROJECT-22K19584
[Journal Article] Npr2 mutant mice show vasodilation and undeveloped adipocytes in mesentery2021
- Author(s)
  Sogawa-Fujiwara Chizuru、Fujiwara Yasuhiro、Hanagata Atsuki、Yang Qunhui、Mihara Taiki、Kaji Noriyuki、Kunieda Tetsuo、Hori Masatoshi
- Journal Title
  
  BMC Research Notes
  
  Volume: 14 Issue: 1
- DOI
  10.1186/s13104-021-05853-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14604, KAKENHI-PROJECT-20K15678
[Journal Article] Development of a quantitative method for evaluating small intestinal motility using ultrasonography in mice2019
- Author(s)
  Kishi Kazuhisa、Kaji Noriyuki、Endo Mari、Tsuru Yoshiharu、Oikawa Tetsuro、Hori Masatoshi
- Journal Title
  
  Exp. Anim.
  
  Volume: 68 Issue: 3 Pages: 381-389
- DOI
  10.1538/expanim.19-0030
- NAID
  130007689886
- ISSN
  0007-5124, 1341-1357, 1881-7122
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14604
[Journal Article] Neural anti-inflammatory action mediated by two types of acetylcholine receptors in the small intestine2019
- Author(s)
  Kimura Hitomi、Imura Yu-ki、Tomiyasu Hirotaka、Mihara Taiki、Kaji Noriyuki、Ohno Koichi、Unno Toshihiro、Tanahashi Yasuyuki、Jan Tong-Rong、Tsubone Hirokazu、Ozaki Hiroshi、Hori Masatoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 5887-5887
- DOI
  10.1038/s41598-019-41698-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14604, KAKENHI-PROJECT-17H05043
[Journal Article] Hyperglycemia in the early stages of type 1 diabetes accelerates gastric emptying through increased networks of interstitial cells of Cajal2019
- Author(s)
  Kishi Kazuhisa、Kaji Noriyuki、Kurosawa Tamaki、Aikiyo Satoshi、Hori Masatoshi
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 10 Pages: e0222961-e0222961
- DOI
  10.1371/journal.pone.0222961
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14604
[Journal Article] Serotonin 3 receptor signaling regulates 5-fluorouracil mediated apoptosis indirectly via TNF-α production by enhancing serotonin release from enterochromaffin cells2019
- Author(s)
  Mikawa Shoma、Kondo Makoto、Kaji Noriyuki、Mihara Taiki、Yoshitake Ryohei、Nakagawa Takayuki、Takamoto Masaya、Nishimura Ryohei、Shimada Shoichi、Ozaki Hiroshi、Hori Masatoshi
- Journal Title
  
  The FASEB Journal
  
  Volume: 33 Issue: 2 Pages: 1669-1680
- DOI
  10.1096/fj.201701200rr
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14604, KAKENHI-PROJECT-19K11440
[Journal Article] Disruption of the pacemaker activity of interstitial cells of Cajal via nitric oxide contributes to postoperative ileus2018
- Author(s)
  Kaji N, Nakayama S, Horiguchi K, Iino S, Ozaki H, Hori M
- Journal Title
  
  Neurogastroenterol Motil
  
  Volume: 15 Issue: 8
- DOI
  10.1111/nmo.13334
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221205, KAKENHI-PROJECT-16H06740, KAKENHI-PROJECT-16K15058, KAKENHI-PROJECT-18K14604
[Journal Article] Induction of myosin light chain kinase and CPI-17 by TGF-β accelerates contractile activity in intestinal epithelial cells2018
- Author(s)
  ISLAM Md. Shafiqul、KAJI Noriyuki、MIKAWA Shoma、YANG Qunhui、KUSABE Moriaki、HORI Masatoshi、OZAKI Hiroshi
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 80 Issue: 6 Pages: 977-984
- DOI
  10.1292/jvms.17-0684
- NAID
  130007412706
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14604
[Journal Article] Micro-coordination of Pacemaker Potentials in the Intestine of the Mouse.2017
- Author(s)
  Morishita H, Iwata N, Takai C, Mochizuki N, Kaji N, Hori M, Kajioka S, Nakayama S.
- Journal Title
  
  Gastroenterology
  
  Volume: 5085(17) Issue: 8 Pages: 35483-35485
- DOI
  10.1053/j.gastro.2017.04.016
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462445, KAKENHI-PROJECT-25221205, KAKENHI-PROJECT-16H06740, KAKENHI-PROJECT-16K15058
[Journal Article] The essential role of phospho-T38 CPI-17 in the maintenance of physiological blood pressure using genetically modified mice2017
- Author(s)
  Yang Q, Fujii W, Kaji N, Kakuta S, Kada K, Kuwahara M, Tsubone H, Ozaki H, Hori M
- Journal Title
  
  FASEB J
  
  Volume: 32(4) Issue: 4 Pages: 2095-2109
- DOI
  10.1096/fj.201700794r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25221205, KAKENHI-PROJECT-16H06740, KAKENHI-PROJECT-18K14604, KAKENHI-PROJECT-26712025
[Journal Article] Therapeutic Action of Honokiol on Postoperative Ileus via Downregulation of iNOS Gene Expression2017
- Author(s)
  Mihara T, Mikawa S, Kaji N, Endo M, Oikawa T, Tong-Rong J, Ozaki H, Hori M. Inflammation
- Journal Title
  
  Inflammation
  
  Volume: 40(4) Issue: 4 Pages: 1331-1341
- DOI
  10.1007/s10753-017-0576-7
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221205, KAKENHI-PROJECT-16H06740, KAKENHI-PROJECT-16J05803, KAKENHI-PROJECT-16K15058
[Presentation] 腸内細菌によるカハール間質細胞の恒常性維持機構の解明2023
- Author(s)
  林茉由、梶典幸
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K15001
[Presentation] Multipotent dental pulp stem cells of deciduous teeth improve gastrointestinal function in a murine model of entero-neuropathy2023
- Author(s)
  中山晋介、岩田尚子、高井千穂、梶岡俊一
- Organizer
  日本生理学会（第100回、京都）
- Data Source
  KAKENHI-PROJECT-19H03558
[Presentation] 神経節細胞僅少症マウス結腸の時間空間的電気活動研究2020
- Author(s)
  中山晋介、吉丸耕一朗、山座孝義、梶岡俊一
- Organizer
  第９７回日本生理学会
- Data Source
  KAKENHI-PROJECT-19H03558
[Presentation] Gastrin-releasing peptide modulates the pacemaker function of interstitial cells of Cajal2019
- Author(s)
  梶典幸、岸和寿、黒澤珠希、堀正敏
- Organizer
  第92回日本薬理学会年会（大阪国際会議場、大阪）
- Data Source
  KAKENHI-PROJECT-18K14604
[Presentation] 炎症病態における消化管ペースメーカー細胞の機能破綻とその治療法の探索2019
- Author(s)
  梶典幸、中山晋介、飯野哲、堀口和秀、堀正敏
- Organizer
  第140回日本薬理学会関東部会
- Invited
- Data Source
  KAKENHI-PROJECT-18K14604
[Presentation] ミオシンホスファターゼ阻害因子CPI-17欠損による消化管運動抑制2018
- Author(s)
  梶典幸、槙郁風、尾崎博、堀正敏
- Organizer
  第60回日本平滑筋学会総会（東京慈恵医科大学、東京）
- Data Source
  KAKENHI-PROJECT-18K14604
[Presentation] 術後イレウスにおける消化管ペースメーカー細胞Interstitial cells of Cajalの病態変化2016
- Author(s)
  梶典幸、中山晋介、堀口和秀、飯野哲、尾崎博、堀正敏
- Organizer
  第18回日本神経消化器病学会（合同学術集会）
- Place of Presentation
  北海道大学医学部学友会館フラテ（北海道札幌市）
- Year and Date
  2016-09-09
- Data Source
  KAKENHI-PROJECT-16H06740
[Presentation] 術後イレウスにおける消化管ペースメーカー細胞Interstitial cells of Cajalの病態変化2016
- Author(s)
  梶典幸、中山晋介、堀口和秀、飯野哲、尾崎博、堀正敏
- Organizer
  第159回日本獣医学会学術集会
- Place of Presentation
  日本大学藤沢キャンパス（神奈川県藤沢市）
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-16H06740

1. Nakayama Shinsuke (30192230)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. 鈴木治彦 (90283431)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 本田育美 (30273204)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KAJIOKA Syunichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. HORIGUCHI Kazuhide

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 堀正敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
7. 尾崎博

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. 飯野哲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kaji Noriyuki 梶 典幸

Research Projects

Research Products

Co-Researchers

Function of Oncostatin M in the process of homeostasis and its disruption in the gastrointestinal musculature.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of excitation coordination disorder underlying gut hypersensitivity in functional micro-image

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Crosstalk between interstitial cells of Cajal and gut microbiotaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Visualization of micro-coordination in the GI tract reflecting irritability and inflammatory reactions: Elucidation of pathological conditions and development of treatment strategy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Survival and death signaling in interstitial pacemaker cells induced by nitric oxidePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of plasticity of interstitial cells of Cajal and its molecular mechanism by cell fate tracing methodPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Investigation of periodontal disease development and Porphyromonas gulae FimA genotype distribution in small dogs2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fuzapladib reduces postsurgical inflammation in the intestinal muscularis externa2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Toceranib phosphate (Palladia) reverses type 1 diabetes by preserving islet function in mice2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Interstitial cells of Cajal in gastrointestinal inflammatory diseases2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Transcriptome analysis of mesenchymal stromal cells of the large and small intestinal smooth muscle layers reveals a unique gastrointestinal stromal signature2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dental pulp stem cells as a therapy for congenital entero-neuropathy.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Classification of Pacemaker Dynamics in the Mouse Intestine by Field Potential Microimaging2022

Author(s)

Journal Title

DOI

Kaji Noriyuki 梶典幸