Nakaoku Takashi 中奥敬史

Researcher Number	20779491
Other IDs	https://orcid.org/0000-0002-6588-8659
Affiliation (Current)	2025: 国立研究開発法人国立がん研究センター, 研究所, ユニット長
Affiliation (based on the past Project Information) *help	2024 – 2025: 国立研究開発法人国立がん研究センター, 研究所, ユニット長 2017 – 2020: 国立研究開発法人国立がん研究センター, 研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 50:Oncology and related fields / Tumor therapeutics
Keywords	Principal Investigator 薬剤耐性 / チロシンキナーゼ阻害剤 / RET / 分子標的治療 / キナーゼ / ゲノム解析 / ゲノム / がんゲノム医療 / キナーゼ阻害剤 / シグナル伝達 … More / 癌 / 肺腺がん / RET融合遺伝子 / 非小細胞肺がん / NF-kB / 非小細胞肺癌 Less

がん免疫療法に対する応答性決定因子としてのRNAプロセッシング異常の解析Principal Investigator
- Principal Investigator
  
  中奥敬史
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
Detection of oncodomains using mutation accumulation as an IndicatorPrincipal Investigator
- Principal Investigator
  
  中奥敬史
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  National Cancer Center Japan
Development of RET inhibitor based on the interaction between the kinase protein and inhibitorPrincipal Investigator
- Principal Investigator
  
  Nakaoku Takashi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
Identification of signaling pathway involving drug resistant in RET-rearranged lung cancerPrincipal Investigator
- Principal Investigator
  
  Nakaoku Takashi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  National Cancer Center Japan

All 2020 2018 2017

All Journal Article Presentation Book

[Book] 遺伝子解析研究の新時代2018
- Author(s)
  中奥敬史、河野隆志
- Total Pages
  4
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-17K15036
[Journal Article] REToma: a cancer subtype with a shared driver oncogene2020
- Author(s)
  Kohno T, Tabata J, Nakaoku T.
- Journal Title
  
  Carcinogenesis
  
  Volume: in press Issue: 2 Pages: 123-129
- DOI
  10.1093/carcin/bgz184
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04298, KAKENHI-PROJECT-18K19594, KAKENHI-PROJECT-19K16817
[Journal Article] A secondary RET mutation in the activation loop conferring resistance to vandetanib.2018
- Author(s)
  Nakaoku T, Kohno T, Araki M, Niho S, Chauhan R, Knowles PP, Tsuchihara K, Matsumoto S, Shimada Y, Mimaki S, Ishii G, Ichikawa H, Nagatoishi S, Tsumoto K, Okuno Y, Yoh K, McDonald NQ, Goto K
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 625-625
- DOI
  10.1038/s41467-018-02994-7
- NAID
  120006406830
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15036, KAKENHI-PROJECT-16H02420
[Presentation] Targeting RET-VUS in precision oncology using molecular dynamics simulation2020
- Author(s)
  Takashi Nakaoku, Junya Tabata, Mitsugu Araki, Yasushi Okuno, Takashi Kohno
- Organizer
  第79回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K16817
[Presentation] Druggable oncogene fusions and resistance mechanisms in lung cancer2018
- Author(s)
  Takashi Nakaoku, Mitsugu Araki, Seiji Niho, Rakhee Chauhan, Phillip P. Knowles, Katsuya Tsuchihara6, Shingo Matsumoto, Yoko Shimada, Sachiyo Mimaki, Genichiro Ishii, Hitoshi Ichikawa, Yasushi Okuno, Kiyotaka Yoh, Neil Q. McDonald, Koichi Goto, Takashi Kohno
- Organizer
  The 6th JCA-AACR Special Joint Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15036
[Presentation] A secondary RET mutation allosterically conferring resistance to vandetanib2018
- Author(s)
  Takashi Nakaoku, Takashi Kohno, Mitsugu Araki, Seiji Niho, Rakhee Chauhan, Phillip P. Knowles, Katsuya Tsuchihara, Shingo Matsumoto, Yoko Shimada, Sachiyo Mimaki, Genichiro Ishii, Hitoshi Ichikawa, Yasushi Okuno, Kiyotaka Yoh, Neil Q. McDonald, Koichi Goto
- Organizer
  AACR annual meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15036
[Presentation] Molecular targeted therapy for lung cancer based on driver oncogenes such as RET and NRG1 fusions2018
- Author(s)
  Takashi Nakaoku, Takashi Kohno
- Organizer
  第77回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K15036
[Presentation] RET S904F変異によるアロステリック効果を介したバンデタニブ耐性機構2018
- Author(s)
  中奥敬史、仁保誠治、土原一哉、松本慎吾、市川仁、葉　清隆、後藤功一、河野隆志
- Organizer
  第59回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15036
[Presentation] A Secondary RET Mutation in the Activation Loop Conferring Resistance to Vandetanib Through Allosteric Effects2018
- Author(s)
  Takashi Nakaoku, Mitsugu Araki, Seiji Niho, Rakhee Chauhan, Phillip P. Knowles, Katsuya Tsuchihara, Shingo Matsumoto, Yoko Shimada, Sachiyo Mimaki, Genichiro Ishii, Hitoshi Ichikawa, Satoru Nagatoishi, Kouhei Tsumoto, Yasushi Okuno, Kiyotaka Yoh, Neil Q. McDonald, Koichi Goto, Takashi Kohno
- Organizer
  Cambridge Healthtech Institute's 2018 Drug Discovery Chemistry conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15036
[Presentation] Identification of mechanisms of drug resistance in RET-rearranged lung cancer2017
- Author(s)
  Takashi Nakaoku, Takashi Kohno
- Organizer
  18th World Conference on Lung Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15036
[Presentation] RET融合遺伝子陽性肺がんにおける薬剤耐性メカニズムの解明2017
- Author(s)
  中奥敬史、河野隆志
- Organizer
  第58回日本肺癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K15036
[Presentation] RET融合遺伝子陽性肺がんにおける薬剤耐性メカニズムの解明2017
- Author(s)
  中奥敬史、大塚綾香、河野隆志
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K15036
[Presentation] 6.RET融合遺伝子陽性肺がんにおける薬剤耐性メカニズムの解明2017
- Author(s)
  中奥敬史、河野隆志
- Organizer
  金沢大学がん進展制御研究所　共同利用・共同研究拠点シンポジウム
- Data Source
  KAKENHI-PROJECT-17K15036

1. 吉野龍ノ介 (50817575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 河野隆志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakaoku Takashi 中奥 敬史

Research Projects

Research Products

Co-Researchers

がん免疫療法に対する応答性決定因子としてのRNAプロセッシング異常の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Detection of oncodomains using mutation accumulation as an IndicatorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of RET inhibitor based on the interaction between the kinase protein and inhibitorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of signaling pathway involving drug resistant in RET-rearranged lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 遺伝子解析研究の新時代2018

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] REToma: a cancer subtype with a shared driver oncogene2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A secondary RET mutation in the activation loop conferring resistance to vandetanib.2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] Targeting RET-VUS in precision oncology using molecular dynamics simulation2020

Author(s)

Organizer

Data Source

[Presentation] Druggable oncogene fusions and resistance mechanisms in lung cancer2018

Author(s)

Organizer

Data Source

[Presentation] A secondary RET mutation allosterically conferring resistance to vandetanib2018

Author(s)

Organizer

Data Source

[Presentation] Molecular targeted therapy for lung cancer based on driver oncogenes such as RET and NRG1 fusions2018

Author(s)

Organizer

Data Source

[Presentation] RET S904F変異によるアロステリック効果を介したバンデタニブ耐性機構2018

Author(s)

Organizer

Data Source

[Presentation] A Secondary RET Mutation in the Activation Loop Conferring Resistance to Vandetanib Through Allosteric Effects2018

Author(s)

Organizer

Data Source

[Presentation] Identification of mechanisms of drug resistance in RET-rearranged lung cancer2017

Author(s)

Organizer

Data Source

[Presentation] RET融合遺伝子陽性肺がんにおける薬剤耐性メカニズムの解明2017

Author(s)

Organizer

Data Source

[Presentation] RET融合遺伝子陽性肺がんにおける薬剤耐性メカニズムの解明2017

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Organizer

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Nakaoku Takashi 中奥敬史