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Wakita Sachiko  脇田 幸子

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WAKITA SACHIKO  脇田 幸子

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Researcher Number 20782981
Other IDs
Affiliation (Current) 2025: 三重大学, 医学系研究科, 技術員
Affiliation (based on the past Project Information) *help 2024: 三重大学, 医学系研究科, 技術員
2023: 三重大学, 医学系研究科, 技術専門員
2021 – 2022: 三重大学, 医学系研究科, 技術員
2017 – 2022: 三重大学, 医学部, 技術員
Review Section/Research Field
Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 45010:Genetics-related / Medium-sized Section 52:General internal medicine and related fields
Except Principal Investigator
Basic Section 48040:Medical biochemistry-related / Human genetics
Keywords
Principal Investigator
iPS細胞 / 小核 / トリソミックレスキュー / ダウン症 / dCas9 / SNP / トリソミックレスキュ― / iPS / 遺伝子編集 / エクソソーム … More / 染色体 / CRISPR/Cas / トリソミー / ダウン症候群 / Cas9 / 染色体消去 … More
Except Principal Investigator
CRISPR / 染色体 / iPS細胞 / Down症候群 / トリソミー / CRISPR/Cas / 染色体消去 / 染色体治療 / 遺伝子 / Cre-loxP / ゲノム編集 / CRISPR/Cas9 / 核型正常化 / ハプロタイプフェイジング / トリソミックレスキュー Less
  • Research Projects

    (5 results)
  • Research Products

    (12 results)
  • Co-Researchers

    (8 People)
  •  DNA修復阻害によるトリソミックレスキュー法の構築Principal Investigator

    • Principal Investigator
      脇田 幸子
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Mie University
  •  Establishing the type I CRISPR platform for extra chromosome elimination through epigenetic modulation

    • Principal Investigator
      橋詰 令太郎
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      Mie University
  •  Constructing an Acquired Trisomic Rescue Method Using ExosomesPrincipal Investigator

    • Principal Investigator
      WAKITA SACHIKO
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 45010:Genetics-related
    • Research Institution
      Mie University
  •  Search for micronucleus migration trigger proteins and their application to acquired trisomic rescuePrincipal Investigator

    • Principal Investigator
      WAKITA SACHIKO
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Mie University
  •  Trisomic rescue induction by allele-specific chromosome breakage using genome editing technique

    • Principal Investigator
      Hara Mari
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Human genetics
    • Research Institution
      Mie University

All 2023 2022 2020 2019 2018

All Journal Article Presentation

  • [Journal Article] Experimental method for haplotype phasing across the entire length of chromosome 21 in trisomy 21 cells using a chromosome elimination technique2022

    • Author(s)
      Sachiko Wakita, Mari Hara, Yasuji Kitabatake, Keiji Kawatani, Hiroki Kurahashi, Ryotaro Hashizume
    • Journal Title

      Journal of human genetics

      Volume: 67 Issue: 10 Pages: 565-572

    • DOI

      10.1038/s10038-022-01049-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K06835, KAKENHI-PROJECT-20K06758
  • [Presentation] ゲノム編集技術によるダウン症候群由来細胞の核型修正を通じた細胞再生2023

    • Author(s)
      脇田幸子、原万里、宮川世志幸、北畠康司、倉橋浩樹、橋詰令太郎
    • Organizer
      第2回 ダウン症基礎研究会
    • Data Source
      KAKENHI-PROJECT-21K06835
  • [Presentation] Gene signatures in genetically homogeneous trisomy 21 and euploid at the induced pluripotent stem cell level2023

    • Author(s)
      Ryotaro Hashizume, Sachiko Wakita, Mari Hara, Hirofumi Sawada, Shin-ichiro Takebayashi, Yasuji Kitabatake, Yoshitaka Miyagawa, Yoshifumi S Hirokawa, Hiroshi Imai, and Hiroki Kurahashi
    • Organizer
      Human Genetics Asia 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06835
  • [Presentation] CRISPR/Cas9システムの染色体削減と核型修正への応用2022

    • Author(s)
      橋詰令太郎、脇田幸子、原万里、澤田博文、竹林慎一郎、北畠康司、宮川世志幸、倉橋浩樹
    • Organizer
      日本人類遺伝学会第67回大会
    • Data Source
      KAKENHI-PROJECT-20K06758
  • [Presentation] CRISPR/Cas9を用いた染色体切断による異数性細胞からの染色体除去は可能か?2022

    • Author(s)
      橋詰令太郎、脇田幸子、原万里、北畠康司、宮川世志幸、倉橋浩樹
    • Organizer
      第111回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-21K06835
  • [Presentation] CRISPR/Cas9システムの染色体削減と核型修正への応用 Extra chromosome 21 elimination using the CRISPR-Cas9 platform in the iPS cell model for Down syndrome2022

    • Author(s)
      橋詰 令太郎、脇田 幸子、原 万里、澤田 博文、竹林 慎一郎、北畠 康司、宮川 世志幸、倉橋 浩樹
    • Organizer
      日本人類遺伝学会第67回大会
    • Data Source
      KAKENHI-PROJECT-21K06835
  • [Presentation] CRISPR/Casシステムを用いた トリソミックレスキューの誘導2020

    • Author(s)
      脇田幸子、原万里、河谷沙由花、橋詰令太郎
    • Organizer
      日本人類遺伝学会第65回大会
    • Data Source
      KAKENHI-PROJECT-20K06758
  • [Presentation] CRISPR/Casシステムを用いた過剰21番染色体消去の誘導2019

    • Author(s)
      脇田 幸子
    • Organizer
      第2回ダウン症会議
    • Data Source
      KAKENHI-PROJECT-18K19513
  • [Presentation] ゲノム編集技術を用いた染色体再編成による染色体排除は、トリソミー細胞の染色体に対する高精度phasingを可能とする2018

    • Author(s)
      脇田 幸子
    • Organizer
      第63回人類遺伝学会
    • Data Source
      KAKENHI-PROJECT-18K19513
  • [Presentation] 染色体消去による21番染色体のchromosome phasingの試み2018

    • Author(s)
      脇田 幸子
    • Organizer
      第25回遺伝子診療学会
    • Data Source
      KAKENHI-PROJECT-18K19513
  • [Presentation] 染色体消去によるトリソミックレスキュー技術の構築2018

    • Author(s)
      脇田幸子
    • Organizer
      日本人類遺伝学会第63回大会
    • Data Source
      KAKENHI-PROJECT-16K15242
  • [Presentation] 染色体消去による21番染色体のchromosome phasingの試み2018

    • Author(s)
      脇田幸子
    • Organizer
      第25回日本遺伝子診療学会大会
    • Data Source
      KAKENHI-PROJECT-16K15242
  • 1.  Hashizume Ryotaro (50456662)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 5 results
  • 2.  Hara Mari (30176383)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 3.  Miyagawa yoshitaka (90415604)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 4.  Ichishi Masako (80632372)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  Inui masafumi (20643498)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  河野 光雄 (00234097)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  倉橋 浩樹 (30243215)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 8.  北畠 康司 (80506494)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results

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